Cranberry Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cranberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cranberry is a dietary supplement by GNC Herbal Plus Whole Herb with 1 active ingredient. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cranberry by GNC Herbal Plus Whole Herb
Ask about any prescription or over-the-counter medication and we check it for interactions with Cranberry by GNC Herbal Plus Whole Herb — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cranberry by GNC Herbal Plus Whole Herb
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: cranberry. It comes as a whole-herb capsule, so you're getting the plant material itself rather than an isolated extract.
The capsule also holds inactive ingredients (gelatin, cellulose, and soy lecithin) that serve as binders and fillers.
Does it work?
Moderate evidence
Cranberry is possibly effective for urinary tract infections (UTIs) — that's the best-supported use in our data. For age-related cognitive decline, benign prostatic hyperplasia, cancer, nonalcoholic fatty liver disease, and chronic fatigue syndrome, the evidence isn't established well enough to rate.
If you're thinking about cranberry for something other than UTIs, talk with your pharmacist about what the research actually shows.
How safe is it?
Well-documented data
Cranberry taken by mouth is generally well tolerated, though the most common side effects are diarrhea and stomach discomfort. In very large amounts — several liters of juice a day — it can cause more serious gastrointestinal upset.
There's also a report of skin redness and itching in one person. One important note: concentrated supplement doses haven't been well studied, so ask your provider before starting, especially if you're using a tablet or extract rather than food amounts of cranberry.
Meds to double-check
Moderate interaction found
Before taking this cranberry supplement, check with your pharmacist if you're on a statin (cholesterol drug like atorvastatin), a blood thinner (warfarin), a calcium channel blocker for blood pressure (like nifedipine), or an NSAID painkiller (like diclofenac). Cranberry may raise levels of these drugs and increase side effects.
Use the medication checker on this page to be sure.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Cranberry supplements are worth considering if you're dealing with recurrent UTIs and want to explore the evidence-based options. But if you take any prescription medications — especially cholesterol drugs, blood thinners, blood pressure meds, or NSAIDs — you'll want to check with your pharmacist first.
Cranberry can interact with quite a few drugs, and the interaction with statins in particular has caused real harm. Concentrated supplements are less well studied than food amounts, so ask your provider before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cranberry, straight from the product label.
| Brand | GNC Herbal Plus Whole Herb |
|---|---|
| Barcode (UPC) | 048107090104 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2013 |
| DSLD ID | 18301 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cranberry by GNC Herbal Plus Whole Herb, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Cranberry | 500 mg | -- |
Other ingredients: Gelatin, Cellulose, Soy Lecithin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
GNC HERBAL PLUS(R) WHOLE HERB
FDA Statement of Identity
HERBAL SUPPLEMENT
Formula
500 mg
No Sugar, No Starch, No Artificial Colors, No Artificial Flavors, Sodium Free, No Wheat, No Gluten, No Corn, No Dairy, Yeast Free.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one to two capsules daily.
Precautions
WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.
Discontinue use two weeks prior to surgery.
KEEP OUT OF REACH OF CHILDREN.
General Statements
Material verified by TLC. Conforms to USP <2091> for weight. Meets USP <2040> disintegration.
Lot No./Best By:
CODE 191431 AMG
Supports a Healthy Urinary Tract* Whole Herb
FDA Disclaimer Statement
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cranberry by GNC Herbal Plus Whole Herb label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cranberry by GNC Herbal Plus Whole Herb
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Cranberry
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry monograph & interactionsOther (inactive) ingredients: Gelatin, Cellulose, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.
Cranberry by GNC Herbal Plus Whole Herb Drug Interactions
HelloPharmacist Interaction Report
GNC Herbal Plus Whole Herb Cranberry has documented interactions with a number of medications.
The most serious concern is with cholesterol-lowering drugs called statins (like atorvastatin). Cranberry may slow how your body clears these drugs, raising their levels and risk of side effects — one patient on atorvastatin developed muscle breakdown and liver problems after consuming cranberry juice daily for 2 weeks.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also interacts with blood thinners (warfarin), calcium channel blockers used for blood pressure (like nifedipine), and nonsteroidal anti-inflammatory drugs (NSAIDs like diclofenac). With warfarin, the evidence is mixed: some cases show cranberry juice raised bleeding risk, but other research doesn't confirm this.
With nifedipine, animal studies suggest cranberry may raise drug levels. With diclofenac, lab studies hint at an interaction, but human studies haven't found one.
Altogether, these interactions span 702 individual medications.
Cranberry may also affect a broader class of medications broken down by liver enzymes called CYP3A4 and CYP2C9 — check your exact prescriptions with the tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cranberry?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cranberry interact with 712 drugs. Click any drug to see the details.
1 of the 1 ingredient in Cranberry interact with drugs. Each result below shows which ingredient is responsible. Cranberry
AbrocitinibCibinqo
How Abrocitinib interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Abrocitinib interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Acetaminophen, Ibuprofen interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAgomelatineValdoxan
How Agomelatine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Agomelatine interactionAzilsartanEdarbi
How Azilsartan interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Azilsartan, Chlorthalidone interactionBudesonide, FormoterolSymbicort
How Budesonide, Formoterol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Budesonide, Formoterol interactionBupivacaine, MeloxicamZynrelef Kit
How Bupivacaine, Meloxicam interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Bupivacaine, Meloxicam interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Carvedilol interactionCelecoxibCelebrex, Elyxyb
How Celecoxib interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Celecoxib interactionDiclofenacZorvolex
How Diclofenac interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates, Diclofenac (voltaren, Others) Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Diclofenac interactionDiclofenac PotassiumCambia, Cataflam, Cataflam IR, Voltaren Rapide, Voltarol Rapid
How Diclofenac Potassium interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates, Diclofenac (voltaren, Others) Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Diclofenac Potassium interactionDiclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
How Diclofenac Sodium interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryDiclofenac (voltaren, Others), Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
Read the full Cranberry + Diclofenac Sodium interactionDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
How Diclofenac Sodium, Misoprostol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates, Diclofenac (voltaren, Others) Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
How Diclofenac Epolamine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryDiclofenac (voltaren, Others), Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
Read the full Cranberry + Diclofenac Epolamine interactionDiphenhydramine Hydrochloride, Naproxen SodiumAleve PM
How Diphenhydramine Hydrochloride, Naproxen Sodium interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Diphenhydramine Hydrochloride, Naproxen Sodium interactionFamotidine, IbuprofenDuexis
How Famotidine, Ibuprofen interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Famotidine, Ibuprofen interactionFluoxetineProzac, Sarafem
How Fluoxetine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Fluoxetine interactionFlurbiprofenAnsaid, Flurbiprofen, Flurprofen, Froben, Froben SR, Ocufen
How Flurbiprofen interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Flurbiprofen interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Fluvastatin interactionFomoterolForadil
How Fomoterol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Fomoterol interactionFormoterolAtimos Modulite, Foradil Aerolizer, Foradil Certihaler, Oxis Turbohaler, Perforomist
How Formoterol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Formoterol interactionFormoterol Fumarate, GlycopyrrolateBevespi Aerosphere
How Formoterol Fumarate, Glycopyrrolate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Formoterol Fumarate, Glycopyrrolate interactionFosphenytoinCerebyx
How Fosphenytoin interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Fosphenytoin Sodium interactionGliclazideDiamicron
How Gliclazide interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Glipizide, Metformin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
CranberryCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry + Glyburide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cranberry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Cranberry, from the product label.
Cranberry by GNC Herbal Plus Whole Herb: Common Questions
Does Cranberry by GNC Herbal Plus Whole Herb interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is cranberry safe to take while I'm pregnant or breastfeeding?
What are the most common side effects?
Can I use this instead of antibiotics for a UTI?
Does cranberry actually work for preventing UTIs?
Why does the product say to ask my provider before using it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cranberry is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cranberry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cranberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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