Major interaction on record — check this product against your medications before combining. Based on 4 of 7 ingredients. Check your meds →
Dietary supplement

CreaPlex Creatine Ingredients & Drug Interactions

by Professional Botanicals

CreaPlex Creatine label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CreaPlex Creatine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

CreaPlex Creatine is a dietary supplement by Professional Botanicals with 7 active ingredients. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 680 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Lemon Balm powder, Stevia, Brown Rice Protein. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CreaPlex Creatine by Professional Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with CreaPlex Creatine by Professional Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of CreaPlex Creatine by Professional Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 29 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (550 mg) without saying how much of each component you get.
  • “EDS” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Brown Rice Protein” is listed as a grouped ingredient — the label gives one combined amount (1.50 Gram(s)) without saying how much of each component you get.

CreaPlex Creatine contains 29 ingredients total, including multiple amino acids and digestive enzymes. The active amino acids include glycine, aspartic acid, tryptophan, methionine, serine, tyrosine, histidine, lysine, phenylalanine, threonine, and others, along with proteolytic enzymes (protease and lipase for digestion) and stevia as a sweetener.

The product also contains several inactive ingredients as fillers and binders to form the powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle support and strength training.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle soreness, Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Aging, muscle strength — and 3 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.

The evidence for CreaPlex Creatine is mixed and limited. Glycine is possibly effective for schizophrenia, but most of its other uses lack reliable evidence.

Tryptophan appears possibly ineffective for depression. Tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory, but possibly ineffective for athletic performance.

Lysine is possibly effective for cold sores. Methionine is possibly effective for neural tube birth defects.

Serine and several other amino acids are possibly effective for schizophrenia. For most other conditions listed on the ingredients — athletic performance, fatigue, muscle strength, anxiety, and many others — the evidence in our data is insufficient to rate effectiveness.

The digestive enzymes and stevia similarly lack established evidence for their claimed uses in this product.

The evidence, ingredient by ingredient Stevia Lemon Balm Rice Protein Creatine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 13 of the 16 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 16 of 16.
  • General safety write-ups exist for 16 of 16.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the amino acids in CreaPlex Creatine are generally well tolerated at typical doses, though long-term safety data are limited for several. Glycine is rarely associated with mild sedation, irritability, insomnia, fatigue, memory issues, headache, nausea, vomiting, and GI upset — all of which resolve quickly if you stop taking it.

Tryptophan can cause drowsiness, diarrhea, headache, nausea, and stomach upset; it was involved in a contamination scare in 1989 (eosinophilia-myalgia syndrome), though that specific outbreak was traced to a single manufacturer and is unlikely with current products. Phenylalanine, tyrosine, serine, and threonine may cause headache, nausea, insomnia, or GI distress at higher doses.

Stevia is generally well tolerated but may cause bloating, dizziness, headache, nausea, or muscle pain. Protease rarely causes allergic reactions.

Pregnancy and breastfeeding safety varies by ingredient: aspartic acid, tryptophan, serine, phenylalanine, and several others advise against supplement doses in pregnancy or lactation due to insufficient data; others are listed as likely safe from food amounts but lack data on supplement doses.

Side effects, ingredient by ingredient Stevia Lemon Balm Rice Protein Creatine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 8 of the 16 matched ingredients can interact with medications — Lysine, L-tryptophan, Lemon Balm, Phenylalanine, Stevia, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; lithium; Parkinson's medications.
  • For scale: 680 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking CreaPlex Creatine, check with your pharmacist if you use levodopa or baclofen (phenylalanine interferes with both), CNS depressants like sedatives or pain medications (tryptophan adds to drowsiness), serotonergic antidepressants or migraine drugs (tryptophan increases serotonin effects), clozapine (glycine may reduce effectiveness), thyroid hormone or lithium (tyrosine and stevia may interfere), blood pressure or diabetes medications (stevia may increase effects), MAOIs (phenylalanine raises hypertension risk), NMDA antagonists like memantine (threonine may reduce effectiveness), or 5-HT4 agonists for gastroparesis (lysine may reduce effect).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

CreaPlex Creatine is an amino acid and enzyme blend intended for athletic and muscular support, but evidence for most uses is limited or mixed. If you take levodopa (for Parkinson's), clozapine (for schizophrenia), thyroid medication, blood pressure drugs, diabetes medication, CNS depressants, serotonergic antidepressants, lithium, baclofen, an MAOI, or memantine, talk to your pharmacist before adding this product.

If you're pregnant or breastfeeding, check with your doctor first — several ingredients lack safety data in these situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 17 of 29 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CreaPlex Creatine, straight from the product label.

Brand Professional Botanicals
Barcode (UPC) 898175001119
Net contents 135 Gram(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 274287
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CreaPlex Creatine by Professional Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6.75 Gram(s)
Maximum serving Sizes:
6.75 Gram(s)
Servings per container
20
UPC/BARCODE
898175001119
IngredientAmount% DV
Glycine0 NP--
Aspartic Acid0 NP--
Proprietary Blend550 mg--
Amylase0 NP--
Tryptophan0 NP--
Protease0 NP--
Lipase0 NP--
Stevia0 NP--
Methionine0 NP--
Cellulase0 NP--
Arginine0 NP--
Leucine0 NP--
Serine0 NP--
Tyrosine0 NP--
Histidine0 NP--
Isoleucine0 NP--
Lysine0 NP--
Phenylalanine0 NP--
Threonine0 NP--
Valine0 NP--
Glutamic Acid0 NP--
Alanine0 NP--
Proline0 NP--
Cystine0 NP--
EDS0 NP--
Brown Rice Protein1.5 Gram(s)--
Creatine4.5 Gram(s)--
Creatine Pyruvate1.125 Gram(s)--
Creatine Monohydrate2.25 Gram(s)--
Di-Creatine Malate1.125 Gram(s)--
Amino Acids0 NP--
Lemon Balm powder0 NP--
natural Lemon-Lime flavors0 NP--
Lo Han Guo extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Creatine supplementation supports healthy muscle. Great addition to any strength training routine.

Gluten free Non GMO

Premium quality

Powder drink

Formula

Our formula provides 3 creatine sources for improved absorption, and added brown rice protein provides essential amino acids.

EDS: Added enzymes for better absorption & breakdown.

Suggested/Recommended/Usage/Directions

Usage: Mix two scoops to 8-12 oz. of water. Experts recommend loading for best results. To load: Take 1 serving 4x a day for 5 days. To maintain: Take 30 min before workout or directly after. Drink an extra 16 oz. of water per day for every serving used.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made in USA

General Statements

Est. 1980

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CreaPlex Creatine by Professional Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CreaPlex Creatine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CreaPlex Creatine by Professional Botanicals

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size6.75 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

550 mg per serving

Brown Rice Protein

Interacts with
23 drugs
1.5 Gram(s) per serving

Rice protein is a plant-based protein powder made from rice that offers an easy way to add protein to your diet, especially if you avoid dairy or anim...

Brown Rice Protein monograph & interactions
  • › Amino Acids

Creatine

No known
interactions
4.5 Gram(s) per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Creatine monograph & interactions
Interaction report

CreaPlex Creatine by Professional Botanicals Drug Interactions

Want to check YOUR meds against CreaPlex Creatine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
680Drugs
256 Major 190 Moderate 234 Minor

Ingredients driving the most interactions

Lemon Balm powder 264
Stevia 259
Brown Rice Protein 23

Individual Drug Interactions

The ingredients in CreaPlex Creatine interact with 680 drugs. Click any drug to see the details.

3 of the 7 ingredients in CreaPlex Creatine interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm powder Stevia Brown Rice Protein

Each ingredient & the kinds of drugs it affects

For each ingredient in CreaPlex Creatine with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm powder2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm powder full monograph & interactions

Stevia3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia full monograph & interactions

Brown Rice Protein1 drug type · 23 drugs

Ace Inhibitors (Aceis)

In laboratory research, hydrolyzed rice protein inhibits angiotensin-converting enzyme (ACE). In animal research, the inhibition of ACE is correlated with a reduction in systolic blood pressure. So far, this effect has not been shown in humans. Theoretically, concomitant use of rice protein and ACE inhibitors may increase the risk of blood pressure becoming too low. Use with caution. ACE inhibitors include benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik).

Likelihood Possible Evidence D
Brown Rice Protein full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CreaPlex Creatine, from the product label.

Professional Botanicals

See all Professional Botanicals products
Name
Professional Botanicals
City
Ogden
State
UT
ZipCode
84404
Phone Number
877-745-0850
Web Address
ProfessionalBotanicals.com
Pharmacist Counseling Corner

CreaPlex Creatine by Professional Botanicals: Common Questions

Does CreaPlex Creatine by Professional Botanicals interact with any medications?
Yes. Based on its ingredients, CreaPlex Creatine has a known interaction with 680 medications, including 256 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CreaPlex Creatine contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is tryptophan doing in a creatine product?
Tryptophan is an amino acid included as part of the product's amino acid blend. While creatine itself is not listed as a primary ingredient here, the blend contains multiple amino acids (tryptophan, phenylalanine, tyrosine, and others) that work together. Tryptophan is a precursor to serotonin and may support mood and cognition, though evidence is limited.
Will this help my athletic performance?
The evidence in our data does not support that. Tyrosine is possibly ineffective for athletic performance, and most other amino acids here lack reliable evidence for that use. If you're looking for a sports supplement, ask your pharmacist about better-studied options.
Is it safe to take while I'm pregnant?
No single answer fits all ingredients. Aspartic acid, tryptophan, serine, and phenylalanine are advised against in supplement doses during pregnancy due to insufficient safety data. Others like methionine are likely safe in food amounts but haven't been studied as supplements in pregnancy. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
Several ingredients lack safety data during breastfeeding — aspartic acid, tryptophan, serine, phenylalanine, and others are flagged as not enough data or advised against. Breastfeeding safety hasn't been established for most of the amino acids at supplement doses. Check with your healthcare provider first.
What are the digestive enzymes (protease and lipase) for?
These are enzymes meant to aid digestion and nutrient absorption. Protease breaks down proteins and lipase breaks down fats. They're generally well tolerated, though protease may rarely cause allergic reactions in sensitive people.
Does the stevia in here interact with any of my medications?
Stevia can interact with lithium (it may raise lithium levels), blood pressure medications (it may lower blood pressure further), and diabetes drugs (it may lower blood sugar more). If you take any of these, mention the stevia to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CreaPlex Creatine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CreaPlex Creatine label
Go deeper

The Full Monographs Behind CreaPlex Creatine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Rice Protein

Interacts with 23 drugs

Rice protein is a plant-based protein powder made from rice that offers an easy way to add protein to your diet, especially if you avoid dairy or animal products. It is generally considered...

Read the full Rice Protein monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph →
Sources

Sources & How We Checked

CreaPlex Creatine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 202 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Aspartic Acid 1 reference
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI

See these in context on the Aspartic Acid monograph →

L-tryptophan 18 references
  1. Messiha FS. Fluoxetine: adverse effects and drug-drug interactions. J Toxicol Clin Toxicol 1993;31:603-30. PubMed
  2. Devoe LD, Castillo RA, Searle NS. Maternal dietary substrates and human fetal biophysical activity. The effects of tryptophan and glucose on fetal breathing movements. Am J Obstet Gynecol 1986;155:135-9. DOI
  3. Lieberman HR, Corkin S, Spring BJ. The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr 1985;42:366-70. PubMed
  4. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
  5. Sullivan EA, Kamb ML, Jones JL, et al. The natural history of eosinophilia-myalgia syndrome in a tryptophan-exposed cohort in South Carolina. Arch Intern Med 1996;156:973-9. DOI
  6. Philen RM, Hill RH, Flanders WD, et al. Tryptophan contaminants associated with eosinophilia-myalgia syndrome. Am J Epidemiol 1993;138:154-9. PubMed
  7. Bohme A, Wolter M, Hoelzer D. L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. Ann Hematol 1998;77:235-8. PubMed
  8. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  9. Priori R, Conti F, Luan FL, et al. Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents. Eur J Pediatr 1994;153:344-6..
  10. Klein R, Berg PA. A comparative study on antibodies to nucleoli and 5-hydroxytryptamine in patients with fibromyalgia syndrome and tryptophan-induced eosinophilia-myalgia syndrome. Clin Investig 1994;72:541-9.. PubMed
  11. Simat TJ, Kleeberg KK, Muller B, Sierts A. Synthesis, formation, and occurrence of contaminants in biotechnologically manufactured L-tryptophan. Adv Exp Med Biol 1999;467:469-80.. PubMed
  12. Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev 2002;(1):CD003198. PubMed
  13. Kilbourne EM, Philen RM, Kamb ML, Falk H. Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:81-8.
  14. Horwitz RI, Daniels SR. Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:60-72.
  15. Shapiro S. Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique. J Rheumatol Suppl 1996;46:44-58.
  16. Mayeno AN, Gleich GJ. The eosinophilia-myalgia syndrome: lessons from Germany. Mayo Clin Proc 1994;69:702-4. PubMed
  17. Carr L, Ruther E, Berg PA, Lehnert H. Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. Mayo Clin Proc 1994;69:620-5. PubMed
  18. Ullrich SS, Fitzgerald PCE, Giesbertz P, Steinert RE, Horowitz M, Feinle-Bisset C. Effects of intragastric administration of tryptophan on the blood glucose response to a nutrient drink and energy intake, in lean and obese men. Nutrients 2018;10(4). pii: PubMed

See these in context on the L-tryptophan monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
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Serine 3 references
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Tyrosine 4 references
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Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
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Lysine 7 references
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Phenylalanine 23 references
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Threonine 4 references
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Proline 4 references
  1. Jennings A, MacGregor A, Spector T, Cassidy A. Amino acid intakes are associated with bone mineral density and prevalence of low bone mass in women: Evidence from discordant monozygotic twins. J Bone Miner Res. 2016;31(2):326-35. PubMed
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Rice Protein 6 references
  1. Joy JM, Lowery RP, Wilson JM, et al. The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance. Nutr J 2013;12:86. PubMed
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  4. Amended final report on the safety assessment of Oryza sativa (rice) bran oil, Oryza sativa (rice) germ oil, rice bran acid, Oryza sativa (rice) bran wax, hydrogenated rice bran wax, Oryza sativa (rice) bran extract, Oryza sativa (rice) extract, Oryza sat
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Creatine 86 references
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Lemon Balm 12 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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