Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Cruciferous Complete Ingredients & Drug Interactions

by SP Standard Process

Cruciferous Complete label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cruciferous Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Cruciferous Complete is a dietary supplement by SP Standard Process with 4 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 64 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Potassium, Vitamin K. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cruciferous Complete by SP Standard Process

Ask about any prescription or over-the-counter medication and we check it for interactions with Cruciferous Complete by SP Standard Process — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cruciferous Complete by SP Standard Process

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains four active ingredients: potassium, vitamin K, kale, and Brussels sprouts, along with a proprietary blend. Potassium is an electrolyte that helps your heart, muscles, and nerves work properly.

Vitamin K supports blood clotting and bone health. Kale and Brussels sprouts are cruciferous vegetables — nutrient-dense whole foods.

The capsules also contain gelatin, water, and calcium stearate as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Hemorrhagic disease — rated "Effective" (Vitamin K) (Natural Medicines).
  • On file: Hypoprothrombinemia — rated "Effective" (Vitamin K) (Natural Medicines).
  • On file: Warfarin anticoagulation — rated "Effective" (Vitamin K) (Natural Medicines).
  • On file: Vitamin K-dependent clotting factors deficiency (VKCFD) — rated "Effective" (Vitamin K) (Natural Medicines).
  • On file: Osteoporosis — rated "Possibly Effective" (Vitamin K) (Natural Medicines).

Vitamin K is effective for correcting vitamin K deficiency (hypoprothrombinemia), vitamin K-dependent clotting factor deficiency, and managing warfarin anticoagulation, and it's possibly effective for osteoporosis. Kale's evidence for cancer prevention, inflammatory bowel disease, and menopausal symptoms is insufficient — we don't have reliable data to rate how well it works for those uses.

Potassium's effectiveness for specific conditions isn't rated in the data we hold.

The evidence, ingredient by ingredient Potassium Vitamin K Kale

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is fine, but the facts note that supplements can cause dangerously high blood levels in some people, especially those with kidney disease — use only under medical guidance. Orally, potassium is generally well tolerated, though common side effects include abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting.

Rare serious effects are heart rhythm problems, low blood pressure, and confusion. Vitamin K is generally well tolerated by mouth; the most common side effects are nausea, stomach upset, and diarrhea.

Both potassium and vitamin K are rated likely safe in pregnancy and lactation, though the facts advise checking with your doctor before using potassium supplements during these periods. Kale eaten as food is considered safe during pregnancy and breastfeeding; concentrated supplement forms are less studied.

Side effects, ingredient by ingredient Potassium Vitamin K Kale

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Potassium, Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 64 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take warfarin or any blood thinner — vitamin K can make it stop working. Also check if you're on blood pressure medications called ACE inhibitors (like lisinopril), ARBs (like losartan), or potassium-sparing diuretics (like spironolactone) — potassium in this product can raise your blood potassium to unsafe levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product is worth considering if you want the nutrients from cruciferous vegetables in capsule form — but only if you don't take warfarin or blood pressure medications that interact with potassium. If you're on any of those drugs, or if you have kidney disease, talk with your doctor or pharmacist before starting it.

Even if none of those apply to you, it's worth a quick check of your medications on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cruciferous Complete, straight from the product label.

Brand SP Standard Process
Barcode (UPC) 812122010658
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 256496
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cruciferous Complete by SP Standard Process, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
812122010658
IngredientAmount% DV
Calories3 Calorie(s)--
Potassium10 mg1%
Vitamin K4 mcg4%
Proprietary Blend500 mg--
Kale0 NP--
Brussels Sprouts0 NP--

Other ingredients: Gelatin, Water, Calcium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: One capsule per day, or as directed.

Formulation

GF Gluten-free

General Statements

Whole Food Supplements Since 1929

Precautions

Caution: This product is processed in a facility that manufactures other products containing soy, milk, egg, wheat, peanut, tree nuts, fish, and shellfish.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cruciferous Complete by SP Standard Process label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cruciferous Complete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cruciferous Complete by SP Standard Process

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Potassium

Interacts with
62 drugs
10 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Vitamin K

Interacts with
2 drugs
4 mcg per serving

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K monograph & interactions

Proprietary Blend

500 mg per serving
  • › Kale
  • › Brussels Sprouts

Other (inactive) ingredients: Gelatin, Water, Calcium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cruciferous Complete by SP Standard Process Drug Interactions

Want to check YOUR meds against Cruciferous Complete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
64Drugs
2 Major 62 Moderate

Ingredients driving the most interactions

Potassium 62
Vitamin K 2

Individual Drug Interactions

The ingredients in Cruciferous Complete interact with 64 drugs. Click any drug to see the details.

2 of the 4 ingredients in Cruciferous Complete interact with drugs. Each result below shows which ingredient is responsible. Potassium Vitamin K

Each ingredient & the kinds of drugs it affects

For each ingredient in Cruciferous Complete with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

Vitamin K1 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cruciferous Complete, from the product label.

SP Standard Process

See all SP Standard Process products
Name
Standard Process Inc.
Street Address
PO Box 904
City
Palmyra
State
WI
ZipCode
53156
Pharmacist Counseling Corner

Cruciferous Complete by SP Standard Process: Common Questions

Does Cruciferous Complete by SP Standard Process interact with any medications?
Yes. Based on its ingredients, Cruciferous Complete has a known interaction with 64 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cruciferous Complete contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have vitamin K in it?
Yes, it contains vitamin K, which is one of its four active ingredients. Vitamin K supports blood clotting and bone health, and it's effective for correcting vitamin K deficiency. If you take warfarin (Coumadin), this matters — vitamin K can interfere with the drug's ability to thin your blood.
Can I take this if I'm pregnant or breastfeeding?
Both potassium and vitamin K are rated likely safe in pregnancy and lactation. However, the facts note that potassium from food is fine but supplements should only be used under medical guidance during pregnancy, and you should check with your doctor before using supplements while breastfeeding. Kale as food is considered safe in both periods; concentrated supplement forms are less studied.
What are the side effects of this product?
Potassium can cause abdominal pain, belching, diarrhea, nausea, and vomiting. Vitamin K may cause mild gastrointestinal effects like nausea, stomach upset, and diarrhea. Rare serious effects from high potassium levels include heart rhythm problems and low blood pressure — this is why people with kidney disease need to be careful.
Is it safe if I have kidney disease?
Potassium supplements can cause dangerously high blood levels in people with kidney disease. If you have kidney problems, talk with your doctor or pharmacist before taking this product.
Why does this product have potassium in it?
Potassium is an electrolyte that helps your heart, muscles, and nerves work properly. It's found naturally in cruciferous vegetables like kale and Brussels sprouts. The potassium in this supplement may support that baseline nutrient intake.
Is there potassium in the Brussels sprouts in this product?
Brussels sprouts do contain potassium naturally, but we hold no interaction data for Brussels sprouts as an ingredient. The 'Potassium' listed is a separate ingredient — if you're concerned about total potassium intake, talk with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cruciferous Complete label
Go deeper

The Full Monographs Behind Cruciferous Complete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph → Herb & supplement monograph

Kale

Kale is a nutrient-dense leafy green vegetable that is rich in vitamins, minerals, fiber, and antioxidants. Eaten as a normal food it is very healthy for most people, but it is a whole food...

Read the full Kale monograph →
Sources

Sources & How We Checked

Cruciferous Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Kale 2 references
  1. Vitamin K - Health Professional Fact Sheet — NIH Office of Dietary Supplements Source
  2. Lutein and Zeaxanthin — NIH Office of Dietary Supplements Source

See these in context on the Kale monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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