Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Cucumber Extract Powder 500 mg Ingredients & Drug Interactions

by BulkSupplements.com

Cucumber Extract Powder 500 mg label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cucumber Extract Powder 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cucumber Extract Powder 500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for hydration and skin care, cooling and soothing puffy eyes, mild diuretic effect.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cucumber Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Cucumber Extract Powder 500 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Cucumber Extract Powder 500 mg by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Cucumber Extract Powder 500 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Cucumber Fruit Extract at 500 mg per serving. It also includes maltodextrin as an inactive ingredient (a filler to give the powder form and bulk).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cucumber product and its label doesn't state a use — see Cucumber's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on cucumber extract doesn't establish reliable support for burns, diabetes control, cholesterol levels, blood pressure, or joint pain — all the uses listed carry a rating of insufficient evidence. That means the data available isn't strong enough yet to say whether it works for these purposes.

The evidence, ingredient by ingredient Cucumber

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cucumber is widely eaten as food and is generally well tolerated by most people, including when taken as an extract in oral form. Serious side effects are rare; anaphylaxis (a severe allergic reaction) has been reported in isolated cases.

Topically, mild allergic reactions like skin irritation or eczema can occur in sensitive people. There isn't enough data on concentrated cucumber extract in pregnancy or while breastfeeding — eating whole cucumber is considered fine, but the safety of this extract formulation hasn't been studied in these periods.

Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or breastfeeding before you start this supplement.

Side effects, ingredient by ingredient Cucumber

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cucumber.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (such as insulin, metformin, sulfonylureas, or GLP-1 agonists), double-check with your pharmacist before starting this product — there's a documented Moderate-severity risk that cucumber extract could lower your blood sugar too much.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take antidiabetes medication, this product needs a conversation with your pharmacist or doctor first — the blood-sugar-lowering effect could compound with your drugs. For other uses, the evidence isn't established yet.

Pregnant or breastfeeding? Check with your healthcare provider because concentrated extract safety hasn't been studied in those situations.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cucumber Extract Powder 500 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X002KUJANH
Net contents 1 Kilogram(s); 35.3 Ounce(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 330676
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cucumber Extract Powder 500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
500 mg
Maximum serving Sizes:
500 mg
Servings per container
2000
UPC/BARCODE
X002KUJANH
IngredientAmount% DV
Cucumber Fruit Extract500 mg--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cucumber Extract Powder 500 mg per serving

Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten

Color may vary

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 500 mg (about 1/5 tsp) once or twice daily, or as directed by a physician.

General Statements

Use an accurate milligram scale.

New

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cucumber Extract Powder 500 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cucumber Extract Powder 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cucumber Extract Powder 500 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size500 mg Dosage formPowder Servings per container2000 Amounts shown are per serving.

Cucumber Fruit Extract

Interacts with
86 drugs
500 mg per serving

Cucumber is a common food vegetable that is mostly water and is generally safe to eat. As a supplement or skincare ingredient it is popular for hydrat...

Cucumber Fruit Extract monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cucumber Extract Powder 500 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Cucumber Extract Powder 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cucumber Fruit Extract 86

Individual Drug Interactions

The ingredients in Cucumber Extract Powder 500 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cucumber Extract Powder 500 mg interact with drugs. Each result below shows which ingredient is responsible. Cucumber Fruit Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cucumber Extract Powder 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cucumber Fruit Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, cucumber seed might have additive effects with antidiabetes drugs and may increase the risk of hypoglycemia.
Animal research shows that cucumber seed extract can decrease blood glucose levels. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cucumber Fruit Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cucumber Extract Powder 500 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Cucumber Extract Powder 500 mg by BulkSupplements.com: Common Questions

Does Cucumber Extract Powder 500 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Cucumber Extract Powder 500 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cucumber Extract Powder 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have diabetes?
If you take antidiabetes medication to manage your blood sugar, you need to talk with your doctor or pharmacist first. Cucumber seed extract can theoretically add to the blood-sugar-lowering effect of your drugs and raise the risk of low blood sugar (hypoglycemia). Close monitoring is needed if you do decide to use it together.
Is cucumber extract safe to take?
Cucumber extract is generally well tolerated when taken by mouth. Serious side effects are very rare — anaphylaxis has been reported in isolated cases. Most people don't experience problems with it.
Is there any evidence this works for diabetes, cholesterol, or high blood pressure?
The evidence we have on cucumber extract for these conditions isn't reliable enough to say it works. All of them are rated as having insufficient evidence. More research is needed.
Can I take this while pregnant or breastfeeding?
There isn't enough data on concentrated cucumber extract in pregnancy or while breastfeeding. Whole cucumber as food is considered fine, but the safety of this supplement extract formulation hasn't been studied in these situations. Talk with your doctor or pharmacist for personalized advice.
What's in this powder besides the cucumber extract?
The active ingredient is 500 mg of cucumber fruit extract. Maltodextrin is added as an inactive ingredient (filler) to give the powder its bulk and form.
Are there any food allergies I should know about?
Anaphylaxis (a severe allergic reaction) with cucumber has been reported, though it's very rare. If you have a known cucumber or gourd allergy, avoid this product and check with your pharmacist or allergist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cucumber Extract Powder 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cucumber Extract Powder 500 mg label
Go deeper

The Full Monographs Behind Cucumber Extract Powder 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cucumber

Interacts with 86 drugs

Cucumber is a common food vegetable that is mostly water and is generally safe to eat. As a supplement or skincare ingredient it is popular for hydration and soothing the skin, but solid hum...

Read the full Cucumber monograph →
Sources

Sources & How We Checked

Cucumber Extract Powder 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cucumber 4 references
  1. Fiume MM, Bergfeld WF, Belsito DV, et al. Safety assessment of Cucumis sativus (cucumber)-derived ingredients as used in cosmetics. Int J Toxicol. 2014;33(2 suppl):47S-64S.
  2. Vlaicu PC, Rusu LC, Ledesma A, et al. Cucumber anaphylaxis in a latex-sensitized patient. J Investig Allergol Clin Immunol. 2011;21(3):236-9.
  3. Minaiyan M, Zolfaghari B, Kamal A. Effect of hydroalcoholic and buthanolic extract of Cucumis sativus seeds on blood glucose level of normal and streptozotocin-induced diabetic rats. Iran J Basic Med Sci. 2011;14(5):436-42.
  4. Zachariae CO. Cucumber contact dermatitis. Contact Dermatitis. 2000;43(4):240-1. DOI

See these in context on the Cucumber monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team