D-Mannose Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose is a dietary supplement by Nature's Craft with 4 active ingredients. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.Based on those ingredients, 979 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cranberry Fruit Juice, Powder, Dandelion Herb Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against D-Mannose by Nature's Craft
Ask about any prescription or over-the-counter medication and we check it for interactions with D-Mannose by Nature's Craft — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of D-Mannose by Nature's Craft
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains four ingredients: D-mannose, hibiscus flower extract, cranberry fruit juice powder, and dandelion herb extract. The two active ingredients with established roles are D-mannose, a simple sugar your body uses in certain metabolic pathways, and cranberry and dandelion, both traditional botanical supplements.
Cellulose is listed as an inactive ingredient — a filler commonly used in capsules.
Does it work?
Moderate evidence
D-mannose is likely effective for a rare genetic condition called carbohydrate-deficient glycoprotein syndrome type 1b, but it's rated possibly ineffective for urinary tract infections — so if that's why you're considering this, the evidence doesn't support its use. Cranberry is possibly effective for urinary tract infections, though again, the data aren't strong.
For dandelion and the other conditions listed in the facts — joint pain, tonsillitis, postoperative swelling and pain — there isn't enough reliable evidence to rate it one way or the other. The evidence for most of what this product claims simply isn't established.
How safe is it?
Well-documented data
D-mannose is generally well tolerated short-term, but long-term safety data are limited. The most common side effects are bloating, diarrhea, and nausea — loose stools and diarrhea are more likely if you take a single dose above 200 mg/kg.
Pregnancy safety data are not available; breastfeeding safety isn't well studied either. Cranberry is likely safe in pregnancy and generally well tolerated, though at very high doses (several liters of juice daily) it can cause gastrointestinal upset.
Dandelion is generally well tolerated as food but less studied at supplement doses; it can occasionally cause diarrhea, heartburn, and stomach discomfort, and rarely, allergic reactions including anaphylaxis in sensitive individuals (especially those allergic to ragweed or related plants). Breastfeeding safety for dandelion isn't well studied.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), cholesterol-lowering statins (especially atorvastatin), blood pressure medications like nifedipine, potassium-sparing diuretics (water pills that preserve potassium), diabetes medications, lithium, fluoroquinolone antibiotics, or any drugs processed through your liver's CYP3A4 or CYP1A2 enzyme systems. Cranberry and dandelion together affect a wide range of medications — the interaction tool on this page can help you cross-check your exact prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product mixes D-mannose with cranberry and dandelion — two botanical supplements with significant interactions with common medications, from blood thinners to diabetes drugs to statins. If you take any prescription medications, check them against our interaction tool before starting.
The evidence for effectiveness beyond rare genetic conditions is weak, and long-term safety data are limited. Talk it over with your doctor or pharmacist before adding this to your routine.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose, straight from the product label.
| Brand | Nature's Craft |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 296649 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose by Nature's Craft, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| D-Mannose | 1000 mg | -- |
| Hibiscus Flower Extract | 100 mg | -- |
| Cranberry Fruit Juice, Powder | 150 mg | -- |
| Dandelion Herb Extract | 100 mg | -- |
Other ingredients: Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take two (2) veggie capsules once a day. For best results, take 20-30 min before a meal with an 8oz. glass of water or as directed by your healthcare professional.
Precautions
Caution: Do not exceed recommended dose.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
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Please Recycle.
Formulation
Herbal complex
Natural cleansing support Urinary tract support Bladder health Urinary system
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Made in the USA with Global Ingredients 3rd Party Lab Verified Made in an FDA Inspected Facility Sourced from a GMP Certified Facility
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose by Nature's Craft label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose by Nature's Craft
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Vegetable Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsHibiscus Flower Extract
Cranberry Fruit Juice, Powder
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
Cranberry Fruit Juice, Powder monograph & interactionsDandelion Herb Extract
Interacts with457 drugs
Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for thes...
Dandelion Herb Extract monograph & interactionsOther (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.
D-Mannose by Nature's Craft Drug Interactions
HelloPharmacist Interaction Report
D-Mannose by Nature's Craft has interactions documented for two of its four ingredients.
Through its cranberry and dandelion content, this product affects a substantial number of medications — most seriously, cranberry may increase levels of cholesterol-lowering statins like atorvastatin, potentially causing muscle damage and liver problems (a Moderate severity interaction).
Read the full breakdown — every affected drug type, severity by severity
Cranberry also affects blood thinners like warfarin and the blood pressure drug nifedipine (both Moderate), as well as a broad category of drugs processed through the liver's CYP3A4 enzyme system — meaning many common medications could be affected. There's also a Minor interaction with pain relievers like diclofenac and with CYP2C9 substrates, though the research on the latter is conflicting.
Dandelion adds seven more drug interactions, all Moderate severity. The biggest concerns are potassium-sparing diuretics (water pills that preserve potassium), blood thinners and antiplatelet drugs, diabetes medications, and antibiotics in the fluoroquinolone family.
Dandelion may also interfere with drugs metabolized by CYP1A2 enzymes, with lithium levels, and with glucuronidated drugs (those processed through a specific liver pathway).
D-mannose itself has no documented interactions. We could not check hibiscus flower extract — we hold no data for it.
Altogether, these interactions span 980 individual medications. Check your exact prescriptions with the tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against D-Mannose?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in D-Mannose interact with 979 drugs. Click any drug to see the details.
2 of the 4 ingredients in D-Mannose interact with drugs. Each result below shows which ingredient is responsible. Cranberry Fruit Juice, Powder Dandelion Herb Extract
Aerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAzilsartanEdarbi
How Azilsartan interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Azilsartan, Chlorthalidone interactionBudesonide, FormoterolSymbicort
How Budesonide, Formoterol interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Budesonide, Formoterol interactionBupivacaine, MeloxicamZynrelef Kit
How Bupivacaine, Meloxicam interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Bupivacaine, Meloxicam interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Carvedilol interactionCelecoxibCelebrex, Elyxyb
How Celecoxib interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Celecoxib interactionFluoxetineProzac, Sarafem
How Fluoxetine interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Fluoxetine interactionFlurbiprofenAnsaid, Flurbiprofen, Flurprofen, Froben, Froben SR, Ocufen
How Flurbiprofen interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Flurbiprofen interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Fluvastatin interactionFomoterolForadil
How Fomoterol interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Fomoterol interactionFormoterolAtimos Modulite, Foradil Aerolizer, Foradil Certihaler, Oxis Turbohaler, Perforomist
How Formoterol interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Formoterol interactionFormoterol Fumarate, GlycopyrrolateBevespi Aerosphere
How Formoterol Fumarate, Glycopyrrolate interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Formoterol Fumarate, Glycopyrrolate interactionFosphenytoinCerebyx
How Fosphenytoin interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Fosphenytoin Sodium interactionHydrochlorothiazide, IrbesartanAvalide
How Hydrochlorothiazide, Irbesartan interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Hydrochlorothiazide, Irbesartan interactionHydrochlorothiazide, ValsartanDiovan HCT
How Hydrochlorothiazide, Valsartan interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Hydrochlorothiazide, Valsartan interactionIndomethacinIndo-Lemmon, Indocin, Indocin SR, Indomethagan, Tivorbex
How Indomethacin interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Indomethacin interactionIrbesartanAprovel, Avapro
How Irbesartan interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Irbesartan interactionIrbesartan, HydrochlorothiazideCoAprovel
How Irbesartan, Hydrochlorothiazide interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Irbesartan, Hydrochlorothiazide interactionLesinuradZurampic
How Lesinurad interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Lesinurad interactionLesinurad, AllopurinolDuzallo
How Lesinurad, Allopurinol interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Lesinurad, Allopurinol interactionLumiracoxibPrexige
How Lumiracoxib interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Lumiracoxib interactionMefenamic AcidPonstel
How Mefenamic Acid interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Mefenamic Acid interactionMeloxicamAnjeso, Mobic, Qmiiz ODT, Vivlodex
How Meloxicam interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Meloxicam interactionMephenytoinMesantoin
How Mephenytoin interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Mephenytoin interactionMontelukast SodiumSingulair
How Montelukast Sodium interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Montelukast Sodium interactionNebivolol Hydrochloride, ValsartanByvalson
How Nebivolol Hydrochloride, Valsartan interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Nebivolol Hydrochloride, Valsartan interactionPhenobarbital, PhenytoinDilantin with PB
How Phenobarbital, Phenytoin interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Phenobarbital, Phenytoin interactionPhenytoinDi-Phen, Dilantin, Dilantin Infatabs, Dilantin injection, Dilantin Kapseals, Phenytek
How Phenytoin interacts with D-Mannose — through 1 ingredient. Tap an ingredient for the detail:
Cranberry Fruit Juice, PowderCytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Cranberry Fruit Juice, Powder + Phenytoin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in D-Mannose with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Cranberry Fruit Juice, Powder
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Dandelion Herb Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.
Antidiabetes Drugs
Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.
Glucuronidated Drugs
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.
Lithium
Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.
Potassium-Sparing Diuretics
Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.
Quinolone Antibiotics
Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.
Brand information
Manufacturer and brand details for D-Mannose, from the product label.
Nature's Craft
See all Nature's Craft products- Name
- Nature's Craft
- City
- Pomona
- State
- NY
- ZipCode
- 10970
- Phone Number
- 408-599-3841
- Web Address
- shopnaturescraft.com
D-Mannose by Nature's Craft: Common Questions
Does D-Mannose by Nature's Craft interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does D-mannose actually prevent or treat urinary tract infections?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
D-mannose
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is sti...
Read the full D-mannose monograph → Herb & supplement monographCranberry
Interacts with 712 drugsCranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. It is not a reliable treatment for an act...
Read the full Cranberry monograph → Herb & supplement monographDandelion
Interacts with 457 drugsDandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...
Read the full Dandelion monograph →Sources & How We Checked
D-Mannose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 66 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
- Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 2008;180:1367-72. PubMed
- Mohammed Abdul MI, Jiang X, Williams KM, et al. Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects. Br J Pharmacol 2008;154:1691-700. PubMed
- McMurdo MET, Argo I, Phillips G, et al. Cranberry or trimethoprim for the prevention of recurrently urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 2009;63:389-95.
- Mergenhagen KA, Sherman O. Elevated International Normalized Ratio after concurrent ingestion of cranberry sauce and warfarin. Am J Health-Syst Pharm 2008;65:2113-6. PubMed
- Ansell J, McDonough M, Zhao Y, et al. The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial. J Clin Pharmacol 2009;49:824-30. PubMed
- Haber SL, Cauthon KA, Raney EC. Cranberry and warfarin interaction: a case report and review of the literature. Consult Pharm 2012;27:58-65. PubMed
- Hamann GL, Campbell JD, George CM. Warfarin-cranberry juice interaction. Ann Pharmacother 2011;45:e17. PubMed
- Roberts D, Flanagan P. Case report: Cranberry juice and warfarin. Home Healthc Nurse 2011;29:92-7.
- Garcia-Calatayud, S., Larreina Cordoba, J. J., and Lozano De La Torre MJ. [Severe cranberry juice poisoning]. An.Esp.Pediatr. 2002;56(1):72-73.
- Patel, D. A., Gillespie, B., Sobel, J. D., Leaman, D., Nyirjesy, P., Weitz, M. V., and Foxman, B. Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: results of a prospective cohort study. Am J Obstet.Gy PubMed
- Isele, H. [Fatal bleeding under warfarin plus cranberry juice. Is it due to salicylic acid?]. MMW.Fortschr.Med 3-11-2004;146(11):13.
- Linsenmeyer, T. A., Harrison, B., Oakley, A., Kirshblum, S., Stock, J. A., and Millis, S. R. Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospecti
- McMurdo, M. E., Bissett, L. Y., Price, R. J., Phillips, G., and Crombie, I. K. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 2005;34(3):256- PubMed
- Sylvan, L. and Justice, N. P. Possible interaction between warfarin and cranberry juice. Am Fam.Physician 9-15-2005;72(6):1000.
- Niklasson, A. and Andren, L. [Interaction between Waran and cranberry juice]. Lakartidningen 3-15-2006;103(11):853-854.
- Rindone, J. P. and Murphy, T. W. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther 2006;13(3):283-284. PubMed
- Uesawa, Y. and Mohri, K. Effects of cranberry juice on nifedipine pharmacokinetics in rats. J Pharm Pharmacol 2006;58(8):1067-1072. PubMed
- Valentova, K., Stejskal, D., Bednar, P., Vostalova, J., Cihalik, C., Vecerova, R., Koukalova, D., Kolar, M., Reichenbach, R., Sknouril, L., Ulrichova, J., and Simanek, V. Biosafety, antioxidant status, and metabolites in urine after consumption of dried
- Royer, D. J., George, J. N., and Terrell, D. R. Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages. Eur J Haematol 2010;84(5):421-429. PubMed
- Stapleton, A. E., Dziura, J., Hooton, T. M., Cox, M. E., Yarova-Yarovaya, Y., Chen, S., and Gupta, K. Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo.Clin.Proc. PubMed
- Doad GJ, Kabange W. Cranberry juice, atorvastatin and back pain. J Med Assoc Ga 2014;103(1):14.
- Griffiths AP, Beddall A, Pegler S. Fatal haemopericardium and gastrointestinal haemorrhage due to possible interaction of cranberry juice with warfarin. J R Soc Promot Health 2008;128(6):324-6. PubMed
- Mellen CK, Ford M, Rindone JP. Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients. Br J Clin Pharmacol 2010;70(1):139-42. PubMed
- Ushijima K, Tsuruoka S, Tsuda H, Hasegawa G, Obi Y, Kaneda T, Takahashi M, Maekawa T, Sasaki T, Koshimizu TA, Fujimura A. Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects. Br J Clin Pharmaco PubMed
- Ngo N, Brantley SJ, Carrizosa DR, et al. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010;2010(2):83-91.
- Williams G, Stothart CI, Hahn D, Stephens JH, Craig JC, Hodson EM. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev 2023;11(11):CD001321. PubMed
Dandelion 27 references
- Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
- Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7. PubMed
- Hussain Z, Waheed A, Qureshi RA, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res 2004;18:73-7. PubMed
- Racz-Kotilla E, Racz G, Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med 1974;26:212-7. PubMed
- Zhu M, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci 1999;88:632-4. PubMed
- Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
- Chivato T, Juan F, Montoro A, Laguna R. Anaphylaxis induced by ingestion of a pollen compound. J Investig Allergol Clin Immunol 1996;6:208-9.
- Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
- Lovell CR, Rowan M. Dandelion dermatitis. Contact Dermatitis 1991;25:185-8. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Martín-Muñoz MF, Bartolome B, Caminoa M, et al. Bee pollen: a dangerous food for allergic children. Identification of responsible allergens. Allergol Immunopathol (Madr) 2010;38:263-5. PubMed
- Neef H, Cilli F, Declerck PJ, et al. Platelet anti-aggregating activity of Taraxacum officinale Weber. Phytotherapy Research 1996;10:s138-s140.
- Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
- Posadzki, P., Watson, L. K., and Ernst, E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med 2013;13(1):7-12. PubMed
- Wakelin, S. H., Marren, P., Young, E., and Shaw, S. Compositae sensitivity and chronic hand dermatitis in a seven-year-old boy. Br J Dermatol 1997;137(2):289-291. PubMed
- Ingber, A. Seasonal allergic contact dermatitis from Taraxacum officinale (dandelion) in an Israeli florist. Contact Dermatitis 2000;43(1):49.
- Rodriguez, B., Rodriguez, A., de Barrio, M., Tornero, P., and Baeza, M. L. Asthma induced by canary food mix. Allergy Asthma Proc. 2003;24(4):265-268.
- Syhaieva, I. A. [Efficiency of specific immunotherapy in treatment of patients with seasonal allergic rhinitis]. Lik.Sprava. 2006;(1-2):51-53.
- Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. PubMed
- Goksu, E., Eken, C., Karadeniz, O., and Kucukyilmaz, O. First report of hypoglycemia secondary to dandelion (Taraxacum officinale) ingestion. Am J Emerg.Med 2010;28(1):111-112. PubMed
- Fernandez-Gonzalez, D., Gonzalez-Parrado, Z., Vega-Maray, A. M., Valencia-Barrera, R. M., Camazon-Izquierdo, B., De, Nuntiis P., and Mandrioli, P. Platanus pollen allergen, Pla a 1: quantification in the atmosphere and influence on a sensitizing populati
- Liang, K. L., Su, M. C., Shiao, J. Y., Wu, S. H., Li, Y. H., and Jiang, R. S. Role of pollen allergy in Taiwanese patients with allergic rhinitis. J Formos.Med Assoc. 2010;109(12):879-885. PubMed
- Yang, Y., Zhao, Y., Wang, C. S., Wang, X. D., and Zhang, L. [Prevalence of sensitization to aeroallergens in 10 030 patients with allergic rhinitis]. Zhonghua Er.Bi Yan.Hou Tou.Jing.Wai Ke Za Zhi 2011;46(11):914-920.
- Davies, M. G. and Kersey, P. J. Contact allergy to yarrow and dandelion. Contact Dermatitis 1986;14(4):256-257. PubMed
- Collins JM and Miller DR. Dandelion green bezoar following antrectomy and vagotomy - case report. J Kansas Med Soc 1966;67(6):303-304.
- Moriarty B, Pinney JH, Owen-Casey MP, Rustin MH, Deroide F, Laing C, Davenport A. Digital necrosis from dandelion tea. Br J Dermatol. 2013 Jul;169(1):227-30. PubMed
- Onal S, Timur S, Okutucu B, Zihnioglu F. Inhibition of alphaglucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep Biochem Biotechnol 2005;35:29-36.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC