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Dietary supplement

D-Ribose 5.0 Powder 5,000 mg Ingredients & Drug Interactions

by Wonder Laboratories

D-Ribose 5.0 Powder 5,000 mg label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose 5.0 Powder 5,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose 5.0 Powder 5,000 mg is a dietary supplement by Wonder Laboratories with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains one active ingredient: D-ribose, 5,000 mg per serving. Ribose is a five-carbon sugar your cells use to make energy, and it's the sugar backbone of RNA (your cells' genetic messenger).

The product has no other inactive ingredients listed.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: energy source for cells and athletic performance.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Congestive heart failure (CHF), Coronary heart disease (CHD), Coronary artery bypass graft (CABG) surgery — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Possibly Ineffective" for McArdle disease.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for D-ribose is mixed and often limited. For athletic performance and McArdle disease (a rare genetic muscle disorder), the data suggests it's probably ineffective.

For restless legs syndrome, muscle soreness, heart failure, and recovery after heart bypass surgery, we don't have enough reliable evidence yet to say whether it works or doesn't. If you're considering ribose for any of these uses, talk it over with your doctor about whether a trial makes sense for you.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ribose is generally well tolerated for up to one month, but long-term safety hasn't been well studied. The most common side effects when taken by mouth are diarrhea, stomach discomfort, headache, nausea, and low blood sugar.

A few people have reported anxiety, lightheadedness, or increased appetite—and in some cases, lowering the dose resolved these effects. There isn't enough safety data to use ribose during pregnancy or while breastfeeding, so it's best avoided in those situations.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take insulin or any antidiabetes drugs (like metformin, sulfonylureas, or GLP-1 agonists). Both carry a moderate risk that ribose could lower your blood sugar too far.

No other medication interactions are documented in our data for the ingredients we hold.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

D-ribose might appeal to athletes or people with certain heart or muscle conditions, but the evidence for most uses is thin. The bigger concern is anyone on insulin or blood sugar medications—you'd need to coordinate with your doctor first because of the moderate risk of low blood sugar.

Talk with your own doctor or pharmacist before starting, especially if you're managing diabetes or take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose 5.0 Powder 5,000 mg, straight from the product label.

Brand Wonder Laboratories
Net contents 8 Ounce(s); 227 Gram(s)
Market status On market
Date entered into DSLD Nov 19, 2021
DSLD ID 260715
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 Level Teaspoon(s)
Maximum serving Sizes:
1.5 Level Teaspoon(s)
Servings per container
45
IngredientAmount% DV
Sugars5 Gram(s)--
Calories25 Calorie(s)--
D-Ribose5000 mg--
Total Carbohydrates5 Gram(s)2%

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

D-Ribose is the complex sugar that begins the metabolic process for production of adenosine triphosphate (or ATP) by your body's 70 trillion cells. Your body's cells produce D-Ribose naturally but not every cell can make it quickly. This is why supplementing with D-Ribose helps your body restore its energy levels, quickly and naturally.

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs).

Contains: No artificial color, flavor or sweetener, no preservatives, no starch, no milk, no lactose, no soy, no wheat, no yeast, no fish, and is sodium free.

Nutritionally supports healthy cardiovascular function and ATP energy production

Gluten free

Made in USA

General Statements

Whether you're just feeling sluggish and rundown, or you're a high performance athlete looking for that extra edge, D-Ribose is truly the absolute energy source.

Notice: This product is sold by weight and not by volume. You can be assured of proper weight even though some settling of contents may occur during shipping and handling.

Formula 4401

Precautions

Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing, consult your physician before taking this product.

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 1/2 level teaspoons daily, prior to exercise. During training, serious athletes may want to double the dosage.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose 5.0 Powder 5,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.5 Level Teaspoon(s) Dosage formPowder Servings per container45 Amounts shown are per serving.

D-Ribose

Interacts with
86 drugs
5000 mg per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories Drug Interactions

Want to check YOUR meds against D-Ribose 5.0 Powder 5,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in D-Ribose 5.0 Powder 5,000 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose 5.0 Powder 5,000 mg interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose 5.0 Powder 5,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose 5.0 Powder 5,000 mg, from the product label.

Wonder Laboratories

See all Wonder Laboratories products
Name
Wonder Laboratories
Street Address
115 S.C.T. Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories: Common Questions

Does D-Ribose 5.0 Powder 5,000 mg by Wonder Laboratories interact with any medications?
Yes. Based on its ingredients, D-Ribose 5.0 Powder 5,000 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose 5.0 Powder 5,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-ribose if I have diabetes?
Not without talking to your doctor first. Ribose lowers blood sugar in a dose-dependent way, so combining it with insulin or antidiabetes medications carries a moderate risk of low blood sugar (hypoglycemia). Your doctor may be able to monitor you or adjust your medications, but you need their input before starting.
Will D-ribose help my athletic performance?
The evidence suggests it's probably ineffective for athletic performance. While ribose is involved in how your cells make energy, the studies don't show it boosts your workouts or recovery.
Is D-ribose safe to take long-term?
Short-term use (up to one month) is generally well tolerated. But long-term safety hasn't been well studied, so we don't know what happens if you take it for months or years. If you're thinking about long-term use, check with your doctor.
What are the most common side effects?
When taken by mouth, the most common side effects are diarrhea, stomach discomfort, headache, and nausea. A few people have reported anxiety or lightheadedness, and in some cases lowering the dose helped.
Can I take D-ribose while pregnant or breastfeeding?
No. There isn't enough safety information, so it's best avoided in both pregnancy and breastfeeding. Talk with your doctor if you have questions about what's safe during these times.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose 5.0 Powder 5,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose 5.0 Powder 5,000 mg label
Go deeper

The Full Monographs Behind D-Ribose 5.0 Powder 5,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose 5.0 Powder 5,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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