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Dietary supplement

Daily Balance 20 Billion CFU Ingredients & Drug Interactions

by Renew Life

Daily Balance 20 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Daily Balance 20 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Daily Balance 20 Billion CFU is a dietary supplement by Renew Life with 3 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Daily Balance 20 Billion CFU by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Daily Balance 20 Billion CFU by Renew Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Daily Balance 20 Billion CFU by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 11 active ingredients.
  • “Daily Balance Probiotic Blend” is a proprietary blend — the label gives one combined amount (77 mg) without saying how much of each component you get.
  • “Lacto Probiotic blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Bifido Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Daily Balance contains 11 ingredients, most of them live probiotic bacteria intended to support gut health. The main strains are various Lactobacillus species (plantarum, acidophilus in two forms, casei in two forms, paracasei, and rhamnosus) and Bifidobacterium species (animalis lactis in two forms and breve).

You'll also find xylo-oligosaccharides, a type of prebiotic fiber that can feed the beneficial bacteria. The remaining ingredients are inactive — hypromellose, pectin, gellan gum, maltodextrin, rice, rice extract blend, and medium-chain triglycerides — which make up the capsule and help preserve the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health, immune health, respiratory health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Colic, Constipation, Helicobacter pylori, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance.

The evidence for these probiotic strains is mixed. Lactobacillus acidophilus (in both forms included here) is rated possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis, but possibly ineffective for atopic disease.

For acute respiratory distress syndrome, the evidence is too limited to rate. Bifidobacterium breve, also in this product, shows possibly ineffective results for age-related cognitive decline and sepsis, while allergic rhinitis, antibiotic-associated diarrhea, and atopic disease have insufficient evidence.

The evidence isn't established in our data for the other strains in this formula.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children, though you should check with your doctor before starting. Uncommon side effects from probiotics include stomach discomfort, abdominal pain, indigestion, gas, bloating, diarrhea, vomiting, and burping.

In rare cases, live probiotic organisms have been found in the bloodstream or other body sites — usually in people who are already very ill or have weakened immune systems; most experts think this happens when bacteria from the gut move to other parts of the body rather than from the supplement itself. Bifidobacterium breve is generally well tolerated but requires caution if you're very ill or immunocompromised.

Because safety data are limited, ask your healthcare provider before use, especially if you fall into a higher-risk category.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Breve.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check with your doctor or pharmacist before starting this product. Antibiotics can reduce how well the Lactobacillus acidophilus and Bifidobacterium breve strains in this supplement work.

Separating them by a few hours usually solves the problem, but your own provider can give you the best timing for your specific situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-strain probiotic designed to support digestive health, with some evidence backing a few of the strains for specific uses like antibiotic-associated diarrhea or IBS. The main thing to watch is timing with any antibiotics you take — separate them by a few hours so the antibiotic doesn't wipe out the live cultures.

If you're very ill, immunocompromised, or on other medications, talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Daily Balance 20 Billion CFU, straight from the product label.

Brand Renew Life
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 306946
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Daily Balance 20 Billion CFU by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrate1 Gram(s)1%
Lactobacillus plantarum UALp-050 NP--
Lactobacillus acidophilus LA-50 NP--
L. CASEI 4310 NP--
Xylo-oligosaccharides800 mg--
Lactobacillus casei UALc-030 NP--
Bifidobacterium animalis lactis UABla-120 NP--
Lactobacillus paracasei UALpc-040 NP--
Daily Balance Probiotic Blend77 mg--
Lacto Probiotic blend0 NP--
Lactobacillus rhamnosus LGG0 NP--
Lactobacillus acidophilus DDS-10 NP--
Bifido Probiotic Blend0 NP--
Bifidobacterium breve UABbr-110 NP--
Bifidobacterium animalis lactis BB-120 NP--

Other ingredients: Hypromellose, Pectin, Gellan Gum, Maltodextrin, Rice, Rice extract Blend, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

2 in 1 digestive support

Non GMO

Our promise to you Feel the difference or your money back We formulate with Multiple diverse strains Clinically tested strains Potency through expiration Feeling gutsy for 25 years and counting. Join us. Terms and conditions may apply.

Potency, quality and purity guaranteed through expiration.

Made in the USA of global ingredients.

Free of Gluten, Dairy and Soy

Formula

Probiotics 20 billion CFU per serving Prebiotics & probiotics to support: Digestive health Immune health Respiratory health Occasional bloating relief 10 diverse strains

2-in-1 Digestive Support: Prebiotics & Probiotics Clinically Tested Strains B. lactis, BB-12, L. rhamnosus, LGG, B. lactis, UABla-12, L. acidophilus, LA-5, L. paracasei, L. CASEI 431 Plant-based XOS, a prebiotic to help nourish your good gut bacteria Probiotics Strains to help relieve occasional bloating and abdominal discomfort Guaranteed Live Cultures

FDA Statement of Identity

Probiotics Supplement

Seals/Symbols

Non GMO Project Verified Nongmoproject.org

Precautions

Tamper evident: Do not use if safety seal on bottle is broken or missing.

Keep out of reach of children.

Consult your physician prior to using this product if you are pregnant, nursing, taking any medication or have a medical condition.

Suggested/Recommended/Usage/Directions

Directions: For best results, take two (2) capsules daily, with or without food.

Storage

Store at 14 degrees F (5 degrees C) or below. Keep refrigerated.

Brand IP Statement(s)

LGG, UABla-12, LA-5, L. CASEI 431, and BB-12 are trademarks of Chr. Hansen A/S. Copyright 2021

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Daily Balance 20 Billion CFU by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Daily Balance 20 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Daily Balance 20 Billion CFU by Renew Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Xylo-oligosaccharides

800 mg per serving

Daily Balance Probiotic Blend

77 mg per serving
  • › Lacto Probiotic blend
  • › Bifido Probiotic Blend

Other (inactive) ingredients: Hypromellose, Pectin, Gellan Gum, Maltodextrin, Rice, Rice extract Blend, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Daily Balance 20 Billion CFU by Renew Life Drug Interactions

Want to check YOUR meds against Daily Balance 20 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Daily Balance 20 Billion CFU interact with 182 drugs. Click any drug to see the details.

0 of the 3 ingredients in Daily Balance 20 Billion CFU interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Daily Balance 20 Billion CFU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Daily Balance 20 Billion CFU, from the product label.

Renew Life

Name
Renew Life Formulas, LLC
City
Durham
State
NC
ZipCode
27701
Phone Number
1-800-830-1800
Web Address
www.RenewLife.com
Pharmacist Counseling Corner

Daily Balance 20 Billion CFU by Renew Life: Common Questions

Does Daily Balance 20 Billion CFU by Renew Life interact with any medications?
Yes. Based on its ingredients, Daily Balance 20 Billion CFU has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Daily Balance 20 Billion CFU contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotics?
Not at the same time. The antibiotic can kill off the live bacteria in the probiotic, making both less effective. Your doctor or pharmacist can advise on how many hours apart to take them — it's usually a manageable fix.
Does this probiotic actually help with IBS or diarrhea?
The Lactobacillus acidophilus strains in here are rated possibly effective for both irritable bowel syndrome and antibiotic-associated diarrhea, so there's some evidence backing it — but results vary from person to person.
Are there common side effects?
Uncommon ones include gas, bloating, stomach discomfort, and indigestion when you first start. Most people tolerate probiotics well, but these GI effects can happen, especially when combining multiple strains.
Is this safe during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but the safety data for the other strains in this product aren't on file. Talk with your doctor or midwife before taking it while pregnant.
What are the inactive ingredients?
The capsule and formula include hypromellose, pectin, gellan gum, maltodextrin, rice, rice extract blend, and medium-chain triglycerides — all used to stabilize the live cultures and form the capsule.
Can people with weak immune systems take this?
Caution is needed if you're very ill or immunocompromised. Rare cases of probiotic bacteria entering the bloodstream have occurred in critically ill patients. Check with your doctor first if that applies to you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Daily Balance 20 Billion CFU is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Daily Balance 20 Billion CFU label
Sources

Sources & How We Checked

Daily Balance 20 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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