Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Devil's Claw Extract 1000 mg Veg Capsules Ingredients & Drug Interactions

by BulkSupplements.com

Devil's Claw Extract 1000 mg Veg Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Devil's Claw Extract 1000 mg Veg Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Devil's Claw Extract 1000 mg Veg Capsules is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis pain, lower back pain, joint pain and stiffness.Based on those ingredients, 805 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Devil's Claw root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: devil's claw root extract at 1000 mg per capsule. Devil's claw is a plant traditionally used to address joint and back discomfort.

The capsule itself is made from hypromellose, a plant-based capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: joint pain and inflammation support.
  • We looked for evidence on: Back pain, Osteoarthritis, Rheumatoid arthritis (RA), Tendinopathy, arthralgia, musculoskeletal inflammation.
  • The strongest evidence on file: Devil's Claw is rated "Possibly Effective" for Back pain (Natural Medicines).
  • Also on file: Devil's Claw is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Devil's Claw is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA), Tendinopathy.

Devil's claw is possibly effective for back pain and osteoarthritis based on the evidence we have on file. For atherosclerosis (narrowed arteries), the evidence isn't strong enough to rate it either way.

If you're considering it for back pain or joint discomfort, talk with your doctor about whether it fits your situation and how it compares to other options.

The evidence, ingredient by ingredient Devil's Claw

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Devil's claw is generally well tolerated for short-term use in healthy adults, but digestive upset is common — about 9 to 18 percent of people reported gastrointestinal complaints in trials, and roughly 8 percent experienced diarrhea. Allergic skin reactions, heartburn, loss of appetite, and loss of taste have also been reported.

Rarely, gastrointestinal bleeding has occurred, and in one case a person stopped taking it after four days due to a throbbing headache, ringing in the ears, and other symptoms. Avoid devil's claw during pregnancy — it may affect the uterus and safety hasn't been established.

Don't take it while breastfeeding either, because there isn't enough safety information. If you're pregnant, trying to conceive, or breastfeeding, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Devil's Claw

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Devil's Claw.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 806 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take any blood thinners (especially warfarin), drugs broken down by your liver's CYP2C19, CYP2C9, or CYP3A4 enzymes (a huge category that includes many heart, cancer, and psychiatric medications), stomach acid reducers like H2-blockers or proton pump inhibitors, or any drug that relies on P-glycoprotein transport. Because 805 medications are affected across these categories, it's best to run your full medication list through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Devil's claw may help with back pain or osteoarthritis, but it interacts with a lot of medications through how your liver processes drugs and how your stomach handles acid. If you take a blood thinner, heartburn medication, or any regular prescription, check with your pharmacist or doctor before starting this — the interaction list is long enough that it's worth the five minutes.

Pregnant people and those breastfeeding should skip it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Devil's Claw Extract 1000 mg Veg Capsules, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X003L0Q2P9
Net contents 120 Veg Capsule(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 312885
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
60
UPC/BARCODE
X003L0Q2P9
IngredientAmount% DV
Devil's Claw root extract1000 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Devil's Claw Extract 1000 mg per serving

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 2 capsules once daily, or as directed by a physician.

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, additives

Storage

Store in a dry, cool place

General Statements

New Scan me

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Devil's Claw Extract 1000 mg Veg Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Devil's Claw root extract

Interacts with
805 drugs
1000 mg per serving

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort....

Devil's Claw root extract monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Devil's Claw Extract 1000 mg Veg Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
805Drugs
733 Moderate 72 Minor

Ingredients driving the most interactions

Devil's Claw root extract 805

Individual Drug Interactions

The ingredients in Devil's Claw Extract 1000 mg Veg Capsules interact with 805 drugs. Click any drug to see the details.

1 of the 1 ingredient in Devil's Claw Extract 1000 mg Veg Capsules interact with drugs. Each result below shows which ingredient is responsible. Devil's Claw root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Devil's Claw Extract 1000 mg Veg Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Devil's Claw root extract7 drug types · 805 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that devil's claw might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that devil's claw might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that devil's claw might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, Devil's claw might increase the activity of warfarin.
In one case report, purpura occurred in a patient taking warfarin and devil's claw concurrently. This might indicate over-anticoagulation. It is unclear if this was due to Devil's claw or other contributing factors.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, devil's claw might decrease the effectiveness of H2-blockers.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of H2-blockers.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.
In vitro research shows that devil's claw inhibits P-glycoprotein, which transports many drugs out of cells. This might increase intracellular levels of P-glycoprotein substrates, although it is unclear if this effect would be clinically important.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, devil's claw might decrease the effectiveness of PPIs.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of PPIs.

Likelihood Possible Evidence D
Devil's Claw root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Devil's Claw Extract 1000 mg Veg Capsules, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com: Common Questions

Does Devil's Claw Extract 1000 mg Veg Capsules by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Devil's Claw Extract 1000 mg Veg Capsules has a known interaction with 805 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Devil's Claw Extract 1000 mg Veg Capsules contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is devil's claw used for?
Devil's claw is possibly effective for back pain and osteoarthritis based on the research we have. It's a plant extract traditionally used to address joint and back discomfort, though results vary from person to person.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against it. Devil's claw may affect the uterus and safety hasn't been established in pregnancy. While breastfeeding, there isn't enough information to know whether it's safe. Talk with your doctor if you're pregnant, trying to conceive, or nursing.
What side effects should I watch for?
Most commonly, people report digestive upset — diarrhea, heartburn, nausea, and loss of appetite are the main ones, affecting about 9 to 18 percent of users. Allergic skin reactions, headache, ringing in the ears, and dizziness are less common. Rarely, gastrointestinal bleeding has occurred.
Is devil's claw safe to take long-term?
The evidence we have supports short-term use in healthy adults. We don't have solid data on long-term safety, so if you're thinking of taking it regularly, discuss that with your doctor or pharmacist.
Why does this product interact with so many medications?
Devil's claw may slow how your liver breaks down drugs (through three major enzyme systems) and may interfere with medications that reduce stomach acid by increasing acid production instead. Because thousands of medications rely on these processes, the interaction list is long — but interaction doesn't automatically mean you can't take them together, just that your doctor or pharmacist needs to know and monitor you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Devil's Claw Extract 1000 mg Veg Capsules is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Devil's Claw Extract 1000 mg Veg Capsules label
Go deeper

The Full Monographs Behind Devil's Claw Extract 1000 mg Veg Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Devil's Claw

Interacts with 805 drugs

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort. The evidence is moderate at best, and p...

Read the full Devil's Claw monograph →
Sources

Sources & How We Checked

Devil's Claw Extract 1000 mg Veg Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Devil's Claw 18 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
  4. Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. PubMed
  5. Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. PubMed
  6. Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
  9. Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. PubMed
  10. Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. PubMed
  11. Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2 DOI
  12. Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
  13. Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
  14. Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
  15. Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
  16. Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.
  17. Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81.
  18. Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296.

See these in context on the Devil's Claw monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team