Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Diatrol Ingredients & Drug Interactions

by Traditional Nutritionals

Diatrol label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Diatrol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Diatrol is a dietary supplement by Traditional Nutritionals with 6 active ingredients. Its ingredients are commonly taken for blood sugar support in type 2 diabetes, weight loss and appetite control, insulin sensitivity.Based on those ingredients, 1,157 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema sylvestre leaf powder, Hydroxycitric Acid, Cinnamon (Cinnamomum cassia) bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Diatrol by Traditional Nutritionals

Ask about any prescription or over-the-counter medication and we check it for interactions with Diatrol by Traditional Nutritionals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Diatrol by Traditional Nutritionals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “Proprietary Sugar Balance Complex” is a proprietary blend — the label gives one combined amount (1,100 mg) without saying how much of each component you get.

Diatrol contains six active ingredients. Chromium supports blood glucose control and is likely effective for chromium deficiency, though possibly ineffective for prediabetes.

Vanadyl sulfate is a form of vanadium; the evidence for its effectiveness isn't established in the data we hold. Gymnema sylvestre leaf powder is an herbal extract — evidence for its use is also insufficient to rate.

Cinnamon bark extract and cinnamon bark powder come from cassia cinnamon; again, effectiveness isn't established. Hydroxycitric acid is the active compound from garcinia fruit extract, and its effectiveness is also unestablished.

The product also contains gelatin capsules and magnesium stearate as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: help normalize blood sugar levels.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Hypoglycemia, Metabolic syndrome, Dyslipidemia, Hyperlipidemia — and 4 related terms.
  • The strongest evidence on file: Chromium is rated "Possibly Effective" for Diabetes (Natural Medicines).
  • Also on file: Chromium is rated "Possibly Ineffective" for Impaired glucose tolerance (Prediabetes).
  • Also on file: Vanadium is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Hyperlipidemia, Impaired glucose tolerance (prediabetes).

The only ingredient with a clear effectiveness rating is chromium, which is likely effective for chromium deficiency. For diabetes and other conditions, chromium is rated possibly effective — meaning there's some promise but limited solid proof.

For prediabetes, chromium is rated possibly ineffective. The remaining active ingredients — vanadyl sulfate, gymnema, cinnamon extracts, and hydroxycitric acid — all lack sufficient reliable evidence to establish effectiveness for any condition in the data we hold.

That doesn't mean they don't work; it means the research to date hasn't been strong enough to make a clear call.

The evidence, ingredient by ingredient Chromium Vanadium Gymnema Cassia Cinnamon Garcinia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chromium is generally well tolerated at typical supplement doses, but long-term or high-dose use may pose risks — gastrointestinal irritation, headaches, insomnia, and mood changes are most common, while rare cases of kidney and liver damage have been reported. Vanadyl sulfate is well tolerated below 1.8 mg daily, but higher doses may cause stomach upset and diarrhea; long-term high doses carry a rare risk of kidney damage.

Gymnema is generally well tolerated short-term but can lower blood sugar, and rare cases of liver inflammation (hepatitis) have been reported. Cinnamon bark contains coumarin, which at very high doses over time might harm the liver; one case of a hypoglycemic seizure was reported in a trial, though causality is unclear.

Hydroxycitric acid is generally tolerated short-term, but rare reports of liver injury and heart inflammation exist. Rashes and skin reactions have been reported with both cinnamon and vanadium exposure.

Side effects, ingredient by ingredient Chromium Vanadium Gymnema Cassia Cinnamon Garcinia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Vanadium, Garcinia, Gymnema, Chromium, Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,158 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Diatrol, double-check with your doctor or pharmacist if you take insulin (moderate risk of low blood sugar), antidiabetes drugs like metformin or sulfonylureas (moderate additive blood-sugar lowering), blood thinners or antiplatelet drugs (moderate increased bleeding risk), levothyroxine/Synthroid (moderate — may lower levels by about 17%), serotonergic drugs like SSRIs (moderate risk of serotonin syndrome), or hepatotoxic medications (moderate additive liver-damaging effects). You should also confirm any drugs cleared through liver enzymes CYP1A2 or CYP2C9.

Use the medication search tool on this page to check your full list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Diatrol is marketed for blood sugar support and may be worth considering if you have chromium deficiency or are interested in botanical approaches to glucose control — but its other ingredients lack established proof of benefit. The main concern is risk of low blood sugar if you take insulin or diabetes medications; you'll need to check your exact medications and discuss this product with your doctor or pharmacist before starting.

If you have liver disease, are on blood thinners, or take antidepressants, talk it over first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Diatrol, straight from the product label.

Brand Traditional Nutritionals
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 183387
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Diatrol by Traditional Nutritionals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
30
IngredientAmount% DV
Chromium1000 mcg--
Vanadyl Sulfate600 mcg--
Gymnema sylvestre leaf powder0 NP--
Cinnamon (Cinnamomum cassia) bark extract0 NP--
Proprietary Sugar Balance Complex1100 mg--
Cinnamon bark powder0 NP--
Hydroxycitric Acid1000 mg--

Other ingredients: Gelatin Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease, but rather to simply offer specific nutritional support.

General Statements

Sugar balance complex Formulated to help normalize blood-sugar levels.

Tip: Helps to bind the sugar so you can reduce the spike after eating high glycemic foods.

Made in USA

Suggested/Recommended/Usage/Directions

Suggested use Take 3 capsules with breakfast and 3 capsules with dinner. For superior results, take 12 capsules daily for at least 2 months or until fasting glucose level is under 120 mg/dl. Then reduce to 6 capsules daily for about 6 months. Some are then able to discontinue the formula totally, while others find that occasional use is best.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Diatrol by Traditional Nutritionals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Diatrol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Diatrol by Traditional Nutritionals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chromium

Interacts with
178 drugs
1000 mcg per serving Form: Chromium Polynicotinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Vanadyl Sulfate

Interacts with
208 drugs
600 mcg per serving

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athle...

Vanadyl Sulfate monograph & interactions

Proprietary Sugar Balance Complex

1100 mg per serving

Hydroxycitric Acid

Interacts with
704 drugs
1000 mg per serving Form: Garcinia cambogia

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...

Hydroxycitric Acid monograph & interactions

Other (inactive) ingredients: Gelatin Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Diatrol by Traditional Nutritionals Drug Interactions

Want to check YOUR meds against Diatrol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,157Drugs
806 Moderate 351 Minor

Ingredients driving the most interactions

Gymnema sylvestre leaf powder 851
Hydroxycitric Acid 704
Cinnamon (Cinnamomum cassia) bark extract 442
Vanadyl Sulfate 208
Chromium 178

Individual Drug Interactions

The ingredients in Diatrol interact with 1,157 drugs. Click any drug to see the details.

5 of the 6 ingredients in Diatrol interact with drugs. Each result below shows which ingredient is responsible. Gymnema sylvestre leaf powder Hydroxycitric Acid Cinnamon (Cinnamomum cassia) bark extract Vanadyl Sulfate Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Diatrol with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema sylvestre leaf powder6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema sylvestre leaf powder full monograph & interactions

Hydroxycitric Acid4 drug types · 704 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.

Likelihood Possible Evidence D
Hydroxycitric Acid full monograph & interactions

Cinnamon (Cinnamomum cassia) bark extract2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon (Cinnamomum cassia) bark extract full monograph & interactions

Vanadyl Sulfate2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research shows that the sodium orthovanadate form of vanadium prolongs clotting time, likely through inhibition of thrombin and factor Xa.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A few very small clinical studies in patients with type 2 diabetes show that the vanadyl sulfate form of vanadium increases insulin sensitivity and might lower blood glucose levels.

Likelihood Probable Evidence B
Vanadyl Sulfate full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Diatrol, from the product label.

Traditional Nutritionals

See all Traditional Nutritionals products
Name
Healthy Items
City
San Diego
State
CA
Phone Number
877-499-5881
Web Address
HealthyItems.com
Pharmacist Counseling Corner

Diatrol by Traditional Nutritionals: Common Questions

Does Diatrol by Traditional Nutritionals interact with any medications?
Yes. Based on its ingredients, Diatrol has a known interaction with 1,157 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Diatrol contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on insulin or diabetes medication?
Not without checking with your doctor first. Multiple ingredients in Diatrol can lower blood sugar — chromium, vanadyl sulfate, gymnema, and cinnamon all have this effect — so combined with your medication, your blood sugar could drop too low. Your doctor may need to adjust your insulin or diabetes drug dose.
What's hydroxycitric acid, and why is it in here?
Hydroxycitric acid (HCA) is the main active compound from garcinia fruit extract. The product includes it for its theorized role in glucose and lipid control, though we don't have solid evidence it works for any condition. It does carry a moderate risk of bleeding if you take blood thinners, and a reported case of serotonin syndrome when combined with an SSRI antidepressant.
Is it safe if I'm pregnant or breastfeeding?
For chromium, small amounts from food or prenatal vitamins are considered likely safe in pregnancy, but extra supplement doses should be avoided unless your doctor recommends them. Vanadyl sulfate safety data is lacking — the facts advise against supplement doses in pregnancy and while breastfeeding. Gymnema and hydroxycitric acid also lack sufficient safety data during pregnancy and lactation. Cinnamon bark in food amounts is likely safe, but concentrated supplement doses aren't well-studied in pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice based on your situation.
What are the most common side effects?
From chromium: gastrointestinal irritation, headaches, insomnia, and mood changes. From vanadyl sulfate: stomach upset, diarrhea, and gas when doses exceed the safe upper limit. From gymnema: it's generally tolerated short-term. From cinnamon and hydroxycitric acid: the most common are diarrhea, nausea, headache, and gastrointestinal discomfort. Rashes have been reported with both cinnamon and vanadium exposure.
Can this harm my liver?
Yes, potentially. Cinnamon bark contains coumarin, which at very high doses over time might cause liver damage. Hydroxycitric acid from garcinia has been linked to rare cases of hepatitis and liver injury. If you take other medications that can harm the liver, the risk may be higher. Avoid large or prolonged doses, and talk with your doctor if you have liver disease.
Does this actually help with blood sugar control?
Chromium is likely effective for chromium deficiency and possibly effective for diabetes, meaning some research supports it but the evidence isn't bulletproof. The other four active ingredients — vanadyl sulfate, gymnema, cinnamon, and hydroxycitric acid — don't have enough solid evidence to say they work for any condition. If you're considering this product for diabetes support, discuss it with your doctor first, especially since it interacts with diabetes medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Diatrol label
Go deeper

The Full Monographs Behind Diatrol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Vanadium

Interacts with 208 drugs

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and...

Read the full Vanadium monograph → Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Garcinia

Interacts with 704 drugs

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies...

Read the full Garcinia monograph →
Sources

Sources & How We Checked

Diatrol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 144 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
  13. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  14. Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
  15. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
  16. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
  17. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  18. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
  19. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
  20. Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
  21. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther 2006;8:636-43. PubMed
  22. John-Kalarickal J, Pearlman G, Carlson HE. New medications which decrease levothyroxine absorption. Thyroid 2007;17:763-5. PubMed
  23. Yazaki Y, Faridi Z, Ma Y, et al. A pilot study of chromium picolinate for weight loss. J Altern Complement Med 2010;16:291-9. PubMed
  24. Davis ML, Seaborn CD, and Stoecker BJ. Effects of over-the-counter drugs on chromium retention and urinary excretion in rats. Nutrition Research 1995;15(2):201-210.
  25. Young P, Turiansky G, Bonner M, and et al. Acute generalized exanthematous pustulosis induced by chromium picolinate. J.Am Acad.Dermatol. 1999;41(5 Pt 2):820-823. PubMed
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Gymnema 12 references
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Cassia Cinnamon 20 references
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Garcinia 44 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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