Major interaction on record — check this product against your medications before combining. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Digest More Ingredients & Drug Interactions

by Renew Life

Digest More label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digest More against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Digest More is a dietary supplement by Renew Life with 8 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 2,150 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Marshmallow, Ginger, N-Acetyl D-Glucosamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digest More by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Digest More by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digest More by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 15 active ingredients.
  • “Sensitive Stomach Blend” is a proprietary blend — the label gives one combined amount (170 mg) without saying how much of each component you get.
  • “Plant-Based Enzyme Blend” is a proprietary blend — the label gives one combined amount (210 mg) without saying how much of each component you get.
  • “Protein Digestive Complex with SmartZYME” is a proprietary blend — the label doesn't break down how much of each component you get.

Digest More contains 15 active ingredients, most of them digestive enzymes designed to help break down different components of food. L-glutamine is an amino acid that supports gut and immune health.

Gamma oryzanol is a plant compound extracted from rice bran. Bromelain comes from pineapple and is a protein-digesting enzyme.

Protease, lipase, amylase, cellulase, lactase, diastase, invertase, pectinase, and phytase are all enzymes that break down proteins, fats, carbohydrates, cellulose, lactose, and fiber. Ginger is an herbal root known for digestive and anti-inflammatory properties.

Marshmallow and papaya are plant materials used traditionally to soothe digestion. N-acetyl D-glucosamine is a compound that supports joint and gut-lining health.

The product also contains one inactive ingredient: a vegetable capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: help reduce digestive discomfort.
  • We looked for evidence on: Dyspepsia, Diarrhea, Constipation, Crohn disease, Inflammatory bowel disease (IBD), Celiac disease — and 4 related terms.
  • The closest evidence on file: Glutamine is rated "Possibly Ineffective" for Crohn disease (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Radiation-induced diarrhea.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Dyspepsia, Celiac disease.

The evidence for most of this product's ingredients is limited. L-glutamine is effective for sickle cell disease and possibly effective for recovery after surgery, critical illness, and HIV-related wasting.

Gamma oryzanol is possibly effective for high cholesterol but is not well established for athletic performance or eczema. Bromelain, papaya, and the various enzymes have insufficient evidence to rate for their digestive uses.

Ginger is possibly effective for pregnancy-related nausea and vomiting and for menstrual pain, and possibly ineffective for exercise soreness. Marshmallow, lactase, and glucosamine lack established evidence for most digestive claims in our data, though lactase is effective for lactose intolerance.

Overall, a solid evidence base doesn't yet support Digest More for general digestive health—talk with your doctor or pharmacist about whether it fits your needs.

The evidence, ingredient by ingredient Glutamine Gamma-oryzanol Ginger Marshmallow Glucosamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated in typical supplement doses. L-glutamine, bromelain, ginger, lactase, and papaya fruit when ripe are safe for most people at recommended amounts.

However, people with kidney or liver disease should use glutamine only under medical supervision, and higher doses of ginger (5 grams daily or more) increase side effects. Common mild side effects from these ingredients include belching, bloating, diarrhea, constipation, nausea, and heartburn—mostly from the glutamine and enzymes.

Bromelain, ginger, and papaya may cause allergic reactions in sensitive individuals, especially those with latex allergy. Marshmallow, papaya latex, and unripe papaya should be avoided in pregnancy, and there isn't enough safety data for gamma oryzanol or glucosamine during pregnancy or breastfeeding—talk with your doctor before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Glutamine Gamma-oryzanol Ginger Marshmallow Glucosamine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 10 matched ingredients can interact with medications — Papaya, Marshmallow, Glucosamine, Glutamine, Bromelain, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 2,151 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Digest More, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, phenprocoumon, or aspirin-like medications), diabetes medications, heart medications (especially nifedipine or losartan), anticonvulsants (seizure drugs), lithium (for mood), tetracycline antibiotics, thyroid medication (levothyroxine), amiodarone (heart rhythm drug), cancer medications, or any drugs broken down by liver enzymes. The ginger and glucosamine in this product carry the most documented interactions—warfarin with glucosamine is the most serious (Major severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Digest More is aimed at people looking to support digestion with enzymes and botanical ingredients, but the evidence for its effectiveness isn't yet strong. If you take blood thinners (like warfarin), diabetes medications, heart or thyroid drugs, lithium, anticonvulsants, or cancer medications, you need to check this product with your pharmacist or doctor before starting—the interactions are real.

Even if you're generally healthy, it's worth a conversation with your healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digest More, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257534712
Net contents 135 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 243300
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digest More by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
135
UPC/BARCODE
631257534712
IngredientAmount% DV
L-Glutamine0 NP--
Gamma Oryzanol0 NP--
Amylase0 NP--
Bromelain0 NP--
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Ginger0 NP--
Diastase0 NP--
Marshmallow0 NP--
Papaya25 mg--
Invertase0 NP--
Pectinase, Phytase0 NP--
N-Acetyl D-Glucosamine0 NP--
Sensitive Stomach Blend170 mg--
Plant-Based Enzyme Blend210 mg--
Protein Digestive Complex with SmartZYME0 NP--
Fat Digestive SmartZYME Complex0 NP--
Carbohydrate, Fiber and Sugars Digestive SmartZYME Complex0 NP--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

DigestMORE is more than a digestive enzyme formula. It combines natural plant-sourced enzymes with soothing ingredients to help reduce digestive discomfort.

No Artificial Ingredients

Quality, purity, and potency guaranteed through expiration.

Manufactured in USA in a GMP facility.

Relieves Occasional Gas, Bloating & Indigestion Soothes & Nourishes the Digestive Tract Digests Proteins, Carbs, Fats & Dairy

Gluten free

Formula

Our exclusive SmartZYME process uses a fusion of up to three different strains of key enzymes to increase the potency of the formula. This multi-strain blending ensures that our enzymes are active over the wide range of pH levels found in the human digestive system.

The Enzyme for Sensitive Stomachs

Plant enzymes, L-glutamine and more

With SmartZYME Blend

Storage

Store in a cool, dry place at 77 degrees F (25C) or below.

Precautions

Keep out of reach of children.

Consult your healthcare professional before using this or any product if you are pregnant, nursing, or under medical supervision.

Tamper Evident: Do not use if safety seal under cap is broken or missing.

This product contains an ingredient derived from crustacean shells (shrimp, lobster, crab).

May contain traces of soy, milk, and wheat from ingredients used in the fermentation process to make enzymes.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Enzyme Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule with meals. May increase to 2 capsules if needed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digest More by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digest More label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digest More by Renew Life

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container135 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sensitive Stomach Blend

170 mg per serving

Plant-Based Enzyme Blend

210 mg per serving
  • › Protein Digestive Complex with SmartZYME
  • › Fat Digestive SmartZYME Complex
  • › Carbohydrate, Fiber and Sugars Digestive SmartZYME Complex

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digest More by Renew Life Drug Interactions

Want to check YOUR meds against Digest More?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,150Drugs
2 Major 927 Moderate 1,221 Minor

Ingredients driving the most interactions

Marshmallow 2,040
Ginger 1,007
N-Acetyl D-Glucosamine 170
L-Glutamine 50

Individual Drug Interactions

The ingredients in Digest More interact with 2,150 drugs. Click any drug to see the details.

4 of the 8 ingredients in Digest More interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Ginger N-Acetyl D-Glucosamine L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Digest More with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow full monograph & interactions

Ginger14 drug types · 1,007 drugs

Anticoagulant/Antiplatelet Drugs

Ginger may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs. However, research is conflicting.
Laboratory research suggests that ginger inhibits thromboxane synthetase and decreases platelet aggregation. However, this has not been demonstrated unequivocally in humans, with mixed results from clinical trials. Theoretically, excessive amounts of ginger might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking ginger with antidiabetes drugs might increase the risk of hypoglycemia.
Animal and human research suggests that ginger might increase insulin levels and/or decrease blood glucose levels.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Ginger might increase or decrease the levels of CYP3A4 substrates.
In vitro research and some case reports suggest that ginger inhibits CYP3A4 activity. Three case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are CYP3A4 substrates (imatinib, dabrafenib, and crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.
Conversely, other in vitro research suggests that ginger induces CYP3A4 activity, leading to reduced levels of CYP3A4 substrates. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, ginger might increase levels of losartan and the risk of hypotension.
In animal research, ginger increased the levels and hypotensive effects of a single dose of losartan. It is not clear if ginger alters the concentration or effects of losartan when taken continuously. Additionally, this interaction has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine (Procardia)

Ginger may have antiplatelet effects and increase the risk of bleeding if used with nifedipine.
Clinical research shows that combined treatment with ginger 1 gram plus nifedipine 10 mg significantly inhibits platelet aggregation when compared to nifedipine or ginger alone.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Ginger might increase the absorption and blood levels of P-glycoprotein (P-gp) substrates.
In vitro research and case reports suggest that ginger inhibits drug efflux by P-gp, potentially increasing absorption and serum levels of P-gp substrates. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking ginger and cancer medications that are P-gp substrates (trametinib, crizotinib). However, the causality of this interaction is unclear due to the presence of multiple interacting drugs and routes of administration.

Likelihood Possible Evidence D
Phenprocoumon (Marcoumar, Others)

Ginger might increase the risk of bleeding with phenprocoumon.
Phenprocoumon, a warfarin-related anticoagulant, might increase the international normalized ratio (INR) when taken with ginger. There is one case report of a 76-year-old woman with a stable INR on phenprocoumon that increased to greater than 10 when she began consuming dried ginger and ginger tea.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Ginger might increase the risk of bleeding with warfarin.
Laboratory research suggests that ginger might inhibit thromboxane synthetase and decrease platelet aggregation. In one case report, ginger increased the INR when taken with phenprocoumon, which has similar pharmacological effects as warfarin. In another case report, ginger increased the INR when taken with a combination of warfarin, hydrochlorothiazide, and acetaminophen. A longitudinal analysis suggests that taking ginger increases the risk of bleeding in patients taking warfarin for at least 4 months. However, research in healthy people suggests that ginger has no effect on INR, or the pharmacokinetics or pharmacodynamics of warfarin. Until more is known, monitor INRs closely in patients taking large amounts of ginger.

Likelihood Possible Evidence B
Calcium Channel Blockers

Theoretically, taking ginger with calcium channel blockers might increase the risk of hypotension.
Some animal and in vitro research suggests that ginger has hypotensive and calcium channel-blocking effects. Another animal study shows that concomitant administration of ginger and the calcium channel blocker amlodipine leads to greater reductions in blood pressure when compared with amlodipine alone.

Likelihood Unlikely Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, when taken prior to cyclosporine, ginger might decrease cyclosporine levels.
In an animal model, ginger juice taken 2 hours prior to cyclosporine administration reduced the maximum concentration and area under the curve of cyclosporine by 51% and 40%, respectively. This effect was not observed when ginger juice and cyclosporine were administered at the same time.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ginger might increase the levels of CYP1A2 substrates.
In vitro research shows that ginger inhibits CYP1A2 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, ginger might increase the levels of CYP2B6 substrates.
In vitro research shows that ginger inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, ginger might increase the levels of CYP2C9 substrates.
In vitro research shows that ginger inhibits CYP2C9 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Metronidazole (Flagyl)

Theoretically, ginger might increase levels of metronidazole.
In an animal model, ginger increased the absorption and plasma half-life of metronidazole. In addition, the elimination rate and clearance of metronidazole was significantly reduced.

Likelihood Possible Evidence D
Ginger full monograph & interactions

N-Acetyl D-Glucosamine4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
N-Acetyl D-Glucosamine full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digest More, from the product label.

Renew Life

Name
Renew Life Formulas
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Pharmacist Counseling Corner

Digest More by Renew Life: Common Questions

Does Digest More by Renew Life interact with any medications?
Yes. Based on its ingredients, Digest More has a known interaction with 2,150 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digest More contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have lactose in it?
The product contains the enzyme lactase, which breaks down lactose, but we don't have data on whether other ingredients or the capsule itself contain lactose. If you're lactose-intolerant, check the full label or contact the manufacturer to be sure.
Can I take this while pregnant?
L-glutamine and ripe papaya are likely safe in pregnancy, and ginger is possibly to likely safe. However, gamma oryzanol, bromelain, marshmallow, and glucosamine don't have enough safety data—the facts advise against them in pregnancy unless your doctor says it's okay. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I take this while breastfeeding?
L-glutamine, ginger, and lactase are likely safe while breastfeeding, but gamma oryzanol, bromelain, papaya, marshmallow, and glucosamine have little or no safety data. Check with your doctor or pharmacist before taking supplements while nursing.
What are the digestive enzymes actually for?
Each enzyme breaks down a different part of food: lipase breaks down fats, protease and bromelain break down proteins, amylase breaks down carbohydrates, lactase breaks down milk sugar, and cellulase breaks down plant fiber. Together they're meant to aid digestion, though the evidence that they work for this purpose isn't strong.
What are the most common side effects?
Belching, bloating, diarrhea, constipation, nausea, and heartburn are the most common, mainly from the glutamine and enzymes. Allergic reactions are rare but possible, especially in people allergic to latex or pineapple.
Should I take this with food or on an empty stomach?
The product facts don't specify, so check the label or ask your pharmacist. Since it contains digestive enzymes meant to work on food, taking it with meals likely makes sense, but that's something to confirm with the manufacturer or your healthcare provider.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digest More is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digest More label
Go deeper

The Full Monographs Behind Digest More’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Gamma-oryzanol

Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...

Read the full Gamma-oryzanol monograph → Herb & supplement monograph

Ginger

Interacts with 1,007 drugs

Ginger is a widely used culinary spice with a long history in traditional medicine, and it has the strongest evidence for helping with nausea and vomiting, including from motion sickness, pr...

Read the full Ginger monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph →
Sources

Sources & How We Checked

Digest More's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 176 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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