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Dietary supplement

DIM (3,3'-Diindolylmethane) Ingredients & Drug Interactions

by Fresh Nutrition

DIM (3,3'-Diindolylmethane) label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DIM (3,3'-Diindolylmethane) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DIM (3,3'-Diindolylmethane) is a dietary supplement by Fresh Nutrition with 1 active ingredient. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 269 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 3,3'-Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DIM (3,3'-Diindolylmethane) by Fresh Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with DIM (3,3'-Diindolylmethane) by Fresh Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DIM (3,3'-Diindolylmethane) by Fresh Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: DIM (3,3'-diindolylmethane), a compound found in cruciferous vegetables like broccoli and cabbage. It comes in a vegetarian capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Diindolylmethane's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: balance hormones.
  • We looked for evidence on: Premenstrual syndrome (PMS), Mastalgia, Benign prostatic hyperplasia (BPH), menopause symptoms, hormonal acne.
  • The closest evidence on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Mastalgia, Premenstrual syndrome (PMS).

The evidence for DIM isn't established in the data we hold. Studies don't provide reliable support for its use in benign prostate enlargement, breast cancer, colorectal cancer, cervical cell changes, or breast pain (mastalgia).

If you're considering it for any of these, talk with your doctor about whether the current evidence supports it for your situation.

The evidence, ingredient by ingredient Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DIM is generally well tolerated in short-term studies, but long-term safety hasn't been well established. Common side effects include diarrhea, gas, headache, nausea, rash, and vomiting.

A very rare serious side effect — a severe allergic rash with systemic symptoms (DRESS) — has been reported. One case of stroke was reported in a woman taking DIM alongside other supplements, though her underlying health conditions made her stroke risk high already, and it's unclear if DIM played a role.

The safety data advises against DIM during pregnancy and breastfeeding because of its potential effects on hormones and insufficient safety information.

Side effects, ingredient by ingredient Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 269 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking DIM, double-check with your doctor or pharmacist if you're on estrogen-based medications (like birth control or hormone replacement therapy) — DIM might change how they work. Also flag any diuretic or water-pill medications, and mention any other prescription drugs, since DIM may affect how your liver processes a broad range of medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

DIM is generally well tolerated for short-term use but has significant interactions with estrogen medications, water pills, and a large class of other drugs. If you take any prescription medication, especially hormonal birth control, hormone replacement therapy, or diuretics, check with your doctor or pharmacist before starting.

Long-term safety is unclear, so this isn't something to take indefinitely without professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DIM (3,3'-Diindolylmethane), straight from the product label.

Brand Fresh Nutrition
Barcode (UPC) 850012956402
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 241924
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DIM (3,3'-Diindolylmethane) by Fresh Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
850012956402
IngredientAmount% DV
3,3'-Diindolylmethane500 mg--

Other ingredients: Vegetarian Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vegan

Non GMO Gluten free Soy free

DIM (3,3'-Diindolylmethane) DIM (3,3'-Diindolylmethane) is produced in the body through the consumption of cruciferous vegetables such as cabbage, brussel sprouts, cauliflower, and broccoli. Studies have linked DIM to the balance hormones and metabolize estrogen.

No artificial colors. No artificial flavors. No preservatives. Made with Non-GMO, all natural ingredients!

Quality Verified Third Party Tested For Quality And Purity To provide our consumers with complete confidence in our product quality, every batch is 3rd party tested for quality & purity.

May assist estrogen metabolism Detoxification support May balance hormones

Fresh Nutrition produces the most potent and highest quality DIM. Our raw materials are carefully sourced and cultivated; contain no fillers, additives, and are manufactured domestically in a cGMP facility. Thank you for choosing Fresh!

General Statements

Fresh Nutrition Our goal is to create high-quality natural products using both organic and responsibly sourced ingredients to optimize health and well-being.

All natural

Suggested/Recommended/Usage/Directions

Recommended Dosage Take three (3) capsules daily with sufficient water before a meal.

Formula

Made with Non-GMO, all natural ingredients!

Concentrated cruciferous vegetables

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DIM (3,3'-Diindolylmethane) by Fresh Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DIM (3,3'-Diindolylmethane) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DIM (3,3'-Diindolylmethane) by Fresh Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

3,3'-Diindolylmethane

Interacts with
269 drugs
500 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

3,3'-Diindolylmethane monograph & interactions

Other (inactive) ingredients: Vegetarian Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

DIM (3,3'-Diindolylmethane) by Fresh Nutrition Drug Interactions

Want to check YOUR meds against DIM (3,3'-Diindolylmethane)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
269Drugs
116 Moderate 153 Minor

Ingredients driving the most interactions

3,3'-Diindolylmethane 269

Individual Drug Interactions

The ingredients in DIM (3,3'-Diindolylmethane) interact with 269 drugs. Click any drug to see the details.

1 of the 1 ingredient in DIM (3,3'-Diindolylmethane) interact with drugs. Each result below shows which ingredient is responsible. 3,3'-Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in DIM (3,3'-Diindolylmethane) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

3,3'-Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
3,3'-Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DIM (3,3'-Diindolylmethane), from the product label.

Fresh Nutrition

See all Fresh Nutrition products
Name
Fresh Nutrition by Excelsior Nutrition Inc.
Street Address
1601 Dove St
City
Newport Beach
State
California
ZipCode
92660
Web Address
www.fresh-nutrition.com
Pharmacist Counseling Corner

DIM (3,3'-Diindolylmethane) by Fresh Nutrition: Common Questions

Does DIM (3,3'-Diindolylmethane) by Fresh Nutrition interact with any medications?
Yes. Based on its ingredients, DIM (3,3'-Diindolylmethane) has a known interaction with 269 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DIM (3,3'-Diindolylmethane) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take DIM if I'm on birth control or hormone replacement therapy?
Probably not without checking first. DIM might increase or decrease the effects of estrogens, and large doses could interfere with hormone replacement therapy. Talk with your doctor before combining DIM with any estrogen medication.
What are the most common side effects?
Diarrhea, gas, headache, nausea, rash, and vomiting. A very rare serious reaction — a severe allergic rash — has been reported in the literature.
Is it safe to take DIM long-term?
Long-term safety hasn't been well established. The data shows it's generally well tolerated in short-term studies, but we don't have enough information to know if it's safe over months or years.
Can I take DIM while pregnant or breastfeeding?
The safety data advises against it. There isn't enough information to know either way, and DIM may affect hormones, so talk with your doctor or pharmacist for personalized advice.
Does DIM actually work for prostate health, cancer prevention, or breast pain?
The evidence isn't established. We don't hold reliable data showing DIM works for benign prostate enlargement, breast cancer, colorectal cancer, cervical cell changes, or breast pain — it's all unproven.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DIM (3,3'-Diindolylmethane) is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DIM (3,3'-Diindolylmethane) label
Go deeper

The Full Monographs Behind DIM (3,3'-Diindolylmethane)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

DIM (3,3'-Diindolylmethane)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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