Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

EndorphiGen Ingredients & Drug Interactions

by Lidtke

EndorphiGen label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking EndorphiGen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

EndorphiGen is a dietary supplement by Lidtke with 3 active ingredients. Its ingredients are commonly taken for riboflavin deficiency, migraine prevention, general energy and metabolism support.Based on those ingredients, 230 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coenzyme Vitamin B6, Vitamin B2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against EndorphiGen by Lidtke

Ask about any prescription or over-the-counter medication and we check it for interactions with EndorphiGen by Lidtke — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of EndorphiGen by Lidtke

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Coenzyme Vitamin B6” is listed as a grouped ingredient — the label gives one combined amount (2 mg) without saying how much of each component you get.

EndorphiGen contains 3 active ingredients. Pyridoxal 5-phosphate is a form of vitamin B6, an essential nutrient involved in nerve function and metabolism.

Vitamin B2 (riboflavin) is another B vitamin that supports energy production and cellular health. The third ingredient is D-phenylalanine, an amino acid.

The capsule itself is made from plant-based material, and arrowroot is used as an inactive filler.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: help body maintain healthy endorphin levels.
  • We looked for evidence on: pain management, stress response, exercise recovery.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we have applies to pyridoxal 5-phosphate (vitamin B6). It's effective for sideroblastic anemia and vitamin B6 deficiency, likely effective for lowering homocysteine (a blood marker), and possibly effective for pregnancy-related nausea and vomiting.

We hold no effectiveness data for vitamin B2 or D-phenylalanine in the context of this product's intended use.

The evidence, ingredient by ingredient Riboflavin Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily orally, with mild side effects like nausea, headache, and heartburn reported occasionally. High doses over time can cause nerve damage (sensory neuropathy), especially above 1,000 mg daily or when total lifetime doses exceed 1,000 grams — though it can occur at lower amounts too.

Riboflavin is very safe overall and is excreted in excess through urine; at high doses it may cause nausea and bright yellow urine. For pregnancy, vitamin B6 carries mixed data — it's rated Likely Safe in some contexts and Possibly Unsafe in others, so discuss use with your doctor or midwife if you're pregnant or planning to be.

Both vitamin B6 and B2 are considered appropriate during breastfeeding at recommended levels. We have no pregnancy or breastfeeding safety data on file for D-phenylalanine.

Side effects, ingredient by ingredient Riboflavin Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin B6, Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 230 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking EndorphiGen, check with your doctor or pharmacist if you take antihypertensive drugs (blood pressure medications), amiodarone or other heart rhythm drugs, phenobarbital or phenytoin (seizure medications), levodopa for Parkinson's disease, or tetracycline antibiotics. No interactions are documented for D-phenylalanine, as we hold no data for that ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

EndorphiGen may be worth considering if you're interested in B-vitamin support, but it's important to check your current medications first — particularly if you take blood pressure drugs, seizure medications, heart rhythm drugs, or tetracycline antibiotics. If you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting, especially regarding vitamin B6.

Discuss this product with your own healthcare provider to make sure it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about EndorphiGen, straight from the product label.

Brand Lidtke
Barcode (UPC) 630610003902
Net contents 180 Vegan Capsule(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 257194
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for EndorphiGen by Lidtke, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
630610003902
IngredientAmount% DV
Pyridoxal 5-Phosphate3.5 mg--
Vitamin B22 mg115%
D-Phenylalanine500 mg--
Coenzyme Vitamin B62 mg100%

Other ingredients: Arrowroot, vegan Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Thank you for choosing EndorphiGen by Lidtke. We sincerely wish the best of health for you and your family.

Lidtke stands behind each product and guarantees customer satisfaction for 365 days from the date of purchase.

Formulation

Research shows stress and pain, such as muscle pain following exercise, often cause the release of endorphins. Lidtke EndorphiGen is designed to help your body maintain these healthy levels. Natural Endorphins: Ease minor pain Promote cardiovascular health Promote a cheerful mood

Superb quality since 1994

Maintain healthy endorphin levels to ease minor pain Such as minor pain from exercise

Purest on the planet

No added gluten, yeast, wheat, soy, milk, eggs, nuts, fish, shellfish, sugar, preservatives, artificial color or flavor, or other common allergens. Non-GMO.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: Keep out of reach of children.

If you are pregnant, lactating, taking any medications, or have a medical condition, consult your doctor.

Discontinue use if adverse reaction occurs. Do not use if seal is damaged or missing.

For children, consult your doctor.

No added gluten, yeast, wheat, soy, milk, eggs, nuts, fish, shellfish, sugar, preservatives, artificial color or flavor, or other common allergens.

Adverse events may be reported above.

Storage

Keep lid tightly closed. Keep in a cool, dry place.

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions (Adults): Take one (1) capsule three times daily on an empty stomach or as directed by your doctor. For increased support, take one (1) capsule six times daily or as directed by your doctor.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

EndorphiGen by Lidtke label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

EndorphiGen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in EndorphiGen by Lidtke

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B2

Interacts with
20 drugs
2 mg per serving Form: Riboflavin

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Vitamin B2 monograph & interactions

D-Phenylalanine

500 mg per serving

Coenzyme Vitamin B6

Interacts with
210 drugs
2 mg per serving

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Coenzyme Vitamin B6 monograph & interactions

Other (inactive) ingredients: Arrowroot, Vegan Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

EndorphiGen by Lidtke Drug Interactions

Want to check YOUR meds against EndorphiGen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
230Drugs
225 Moderate 5 Minor

Ingredients driving the most interactions

Coenzyme Vitamin B6 210
Vitamin B2 20

Individual Drug Interactions

The ingredients in EndorphiGen interact with 230 drugs. Click any drug to see the details.

2 of the 3 ingredients in EndorphiGen interact with drugs. Each result below shows which ingredient is responsible. Coenzyme Vitamin B6 Vitamin B2

Each ingredient & the kinds of drugs it affects

For each ingredient in EndorphiGen with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Coenzyme Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Coenzyme Vitamin B6 full monograph & interactions

Vitamin B21 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Vitamin B2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for EndorphiGen, from the product label.

Lidtke

See all Lidtke products
Name
Lidtke
City
Chandler
State
AZ
ZipCode
85226
Phone Number
1-800-404-8185
Web Address
www.lidtke.com
Pharmacist Counseling Corner

EndorphiGen by Lidtke: Common Questions

Does EndorphiGen by Lidtke interact with any medications?
Yes. Based on its ingredients, EndorphiGen has a known interaction with 230 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
EndorphiGen contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is EndorphiGen safe to take if I'm pregnant?
The pregnancy safety data for vitamin B6 is mixed — it's rated both Likely Safe and Possibly Unsafe depending on the context. Since the answer isn't clear-cut, talk with your doctor or midwife before taking it during pregnancy. Vitamin B2 is considered Likely Safe in pregnancy.
Can I take EndorphiGen if I'm breastfeeding?
Vitamin B6 and vitamin B2 are both rated Likely Safe during breastfeeding at normal recommended amounts. We don't have safety data on file for D-phenylalanine during breastfeeding, so ask your healthcare provider about that ingredient if it's a concern for you.
What does vitamin B6 actually do in this product?
Vitamin B6 is essential for nerve function and metabolism. This form is effective for treating B6 deficiency and sideroblastic anemia, likely effective for lowering homocysteine, and possibly effective for pregnancy-related nausea and vomiting.
Will high doses of EndorphiGen cause nerve damage?
The vitamin B6 in this product is generally well tolerated at doses under 100 mg daily. High doses over time — especially above 1,000 mg daily — can cause sensory neuropathy (nerve damage), though it can occur at lower amounts with prolonged use. Check the label for the exact dose per serving and discuss with your pharmacist if you're considering taking more than recommended.
What are the most common side effects I might notice?
With vitamin B6, the most common mild effects are nausea, headache, heartburn, and loss of appetite. Vitamin B2 may cause nausea at higher doses and can turn your urine bright yellow — this is harmless but noticeable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if EndorphiGen is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

EndorphiGen label
Go deeper

The Full Monographs Behind EndorphiGen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph →
Sources

Sources & How We Checked

EndorphiGen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team