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Dietary supplement

Enhanced Super Digestive Enzymes Ingredients & Drug Interactions

by Life Extension

Enhanced Super Digestive Enzymes label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Enhanced Super Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Enhanced Super Digestive Enzymes is a dietary supplement by Life Extension with 9 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Whole papaya. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Enhanced Super Digestive Enzymes by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Enhanced Super Digestive Enzymes by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Enhanced Super Digestive Enzymes by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.
  • “Pancreatin Alternative 8x Blend” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.
  • “Vegetarian Digestive Enzyme Blend” is a proprietary blend — the label gives one combined amount (290 mg) without saying how much of each component you get.

This product contains 9 active ingredients: several digestive enzymes including amylase, lactase, cellulase, protease II, protease III, and lipase, along with a pancreatin alternative blend and a vegetarian digestive enzyme blend that break down different types of food. It also includes whole papaya, which contains papain and other compounds.

The capsules themselves are made from vegetable cellulose, with rice flour, maltodextrin, and vegetable stearate as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Enhanced digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, bloating, gas, indigestion.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

Lactase is effective for lactose intolerance—it helps break down the milk sugar (lactose) that some people can't digest on their own. For other uses in this product like prematurity or colic, the evidence isn't strong enough to rate.

The effectiveness of the other digestive enzymes and papaya for their intended purposes hasn't been established in the data we hold, nor has papaya's effectiveness for diabetes, colorectal cancer, aging skin, or hair loss been reliably demonstrated.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Lactase Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated when used as directed, though rare cases of allergic reactions (contact dermatitis and allergic rhinitis) have been reported in workers exposed to the powder. The protease enzymes are generally well tolerated for most adults but may cause digestive upset or allergic reactions; they should be avoided in pregnancy unless prescribed.

Lipase is generally well tolerated in supplement form, but people with serious digestive conditions should use it only under medical guidance. Papaya fruit is safe as food, but unripe papaya, papaya latex, and seeds should be avoided; concentrated papaya supplements are less well studied.

During pregnancy, unripe papaya and large amounts should be avoided, and supplement amounts have little safety data. Nausea, vomiting, and allergic reactions including severe ones have been reported, and papaya may trigger hypersensitivity reactions in people allergic to latex.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lipase Lactase Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Papaya.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Moderate interactions are documented with antidiabetes drugs (blood sugar medications), warfarin and other blood thinners, amiodarone (a heart rhythm drug), and levothyroxine (thyroid replacement)—all through the papaya in this product. Check your exact medications before starting, especially if you're on any of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is meant to support digestion through its mix of enzymes and whole papaya. If you take diabetes medications, blood thinners, heart rhythm drugs, or thyroid medications, talk with your doctor or pharmacist before starting—papaya can interact with several of these.

Even if you don't take those drugs, check your full medication list on this page first, and mention this supplement to your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enhanced Super Digestive Enzymes, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870127215
Net contents 100 Vegetarian Capsules
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 59057
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enhanced Super Digestive Enzymes by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsules
Maximum serving Sizes:
2 Vegetarian Capsules
Servings per container
50
UPC/BARCODE
737870127215
IngredientAmount% DV
Amylase0 NP--
Lactase0 NP--
Amylase0 NP--
Cellulase0 NP--
Protease II0 NP--
Pancreatin Alternative 8x Blend400 mg--
Protease III0 NP--
Lipase0 NP--
Vegetarian Digestive Enzyme Blend290 mg--
Protease III0 NP--
Whole papaya200 mg--

Other ingredients: Vegetable Cellulose, Rice Flour, Maltodextrin, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Optimal Nutrient And Energy Release From Food

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take two (2) capsules immediately before meal or as recommended by a healthcare practitioner. Some people prefer to take after meals.

Formulation

Suitable for vegetarians.

Non-GMO

Storage

Store tightly closed in a cool, dry place.

Precautions

WARNINGS: -Keep out of reach of children.

-DO NOT EXCEED RECOMMENDED DOSE. -Do not purchase if outer seal is broken or damaged.

-When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

General

Q01272H

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Enhanced Super Digestive Enzymes by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Enhanced Super Digestive Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Enhanced Super Digestive Enzymes by Life Extension

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsules Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pancreatin Alternative 8x Blend

400 mg per serving

Vegetarian Digestive Enzyme Blend

290 mg per serving

Whole papaya

Interacts with
92 drugs
200 mg per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Whole papaya monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Rice Flour, Maltodextrin, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enhanced Super Digestive Enzymes by Life Extension Drug Interactions

Want to check YOUR meds against Enhanced Super Digestive Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
92Drugs
92 Moderate

Ingredients driving the most interactions

Whole papaya 92

Individual Drug Interactions

The ingredients in Enhanced Super Digestive Enzymes interact with 92 drugs. Click any drug to see the details.

1 of the 9 ingredients in Enhanced Super Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Whole papaya

Each ingredient & the kinds of drugs it affects

For each ingredient in Enhanced Super Digestive Enzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Whole papaya4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Whole papaya full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Enhanced Super Digestive Enzymes, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Enhanced Super Digestive Enzymes by Life Extension: Common Questions

Does Enhanced Super Digestive Enzymes by Life Extension interact with any medications?
Yes. Based on its ingredients, Enhanced Super Digestive Enzymes has a known interaction with 92 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enhanced Super Digestive Enzymes contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually help with digestion?
The enzymes in it are designed to break down different foods—protein, carbs, and fat—so they may help if your own digestion is slow or incomplete. That said, the evidence we hold doesn't establish that the enzyme blend itself works for digestive problems. If you have ongoing digestion trouble, talk with your doctor first to rule out underlying issues.
Is it safe to take if I'm pregnant?
Lactase alone is likely safe in pregnancy. However, the papaya in this product is a concern: unripe papaya and large amounts should be avoided during pregnancy. Since we can't clearly separate how much papaya is in this blend, check with your doctor or pharmacist before taking it while pregnant.
Can I use this if I'm breastfeeding?
Lactase appears likely safe during breastfeeding. The other enzymes and papaya have limited safety data in breastfeeding—check with your doctor or pharmacist before starting, since we don't have enough information to say it's clearly safe.
What's papaya doing in a digestive enzyme supplement?
Papaya contains papain, an enzyme that breaks down protein, similar to the other protein-digesting enzymes in the product. It's included to support overall digestive function, though the evidence that it works for that purpose isn't established in our data.
Has anyone had allergic reactions to this product?
Allergic reactions to papaya and the protease enzymes are rare but have been reported, including severe ones. Papaya may also trigger stronger reactions in people who are allergic to latex. If you have food allergies or latex sensitivity, mention that to your doctor or pharmacist before taking it.
Can I take this with my diabetes medication?
No, not without checking first—fermented papaya can add to the blood-sugar-lowering effect of antidiabetes drugs, and it's unclear whether the whole papaya in this product does the same. Ask your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enhanced Super Digestive Enzymes label
Go deeper

The Full Monographs Behind Enhanced Super Digestive Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Enhanced Super Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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