Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Fortify Age 50+ Probiotic + Prebiotics 50 Billion Ingredients & Drug Interactions

by Nature's Way

Fortify Age 50+ Probiotic + Prebiotics 50 Billion label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fortify Age 50+ Probiotic + Prebiotics 50 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fortify Age 50+ Probiotic + Prebiotics 50 Billion is a dietary supplement by Nature's Way with 3 active ingredients. Its ingredients are commonly taken for constipation and digestive health, source of prebiotic fiber (inulin), coffee substitute.Based on those ingredients, 268 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chicory root Fiber. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 11 active ingredients.
  • “Bifidobacteria Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Fortify Age 50+ 50 Billion CFU Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (525 mg) without saying how much of each component you get.
  • “Lactobacilli Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Fortify Age 50+ contains 11 active ingredients: four Bifidobacterium strains (bifidum, longum, lactis Bi-07, and lactis Bl-04), three Lactobacillus strains (plantarum, rhamnosus, paracasei, and acidophilus NCFM), one additional Bifidobacterium lactis strain, chicory root fiber for prebiotic support, and proprietary blends combining multiple probiotic organisms. The inactive ingredients are cellulose, a plant-derived capsule, magnesium stearate, and silica.

The product delivers 50 billion colony-forming units (CFU) per capsule — the live microorganisms that do the work in your gut.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health for adults age 50+.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Diarrhea, Irritable bowel syndrome (IBS), Lactose intolerance, gut flora balance — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for individual strains in this product is mixed. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum is possibly effective for IBS and respiratory tract infections. For most other conditions the product might target — like age-related cognitive decline, allergic rhinitis, anxiety, asthma, and athletic performance — the evidence we hold is insufficient to rate effectiveness.

The chicory root fiber's benefits for liver health, cholesterol, or joint pain are not established in our data.

The evidence, ingredient by ingredient Chicory

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy adults and children. However, those with weakened or compromised immune systems should be cautious, as rare cases of bacterial infection (bacteremia and sepsis) have been reported in critically ill patients and preterm infants using probiotics — though these cases are uncommon and not definitively linked to these specific strains.

Gastrointestinal side effects like bloating, flatulence, abdominal discomfort, and pain have been reported but are generally uncommon. Chicory root fiber may cause gas, bloating, abdominal pain, and belching; it may also trigger allergies in people sensitive to ragweed or related plants (the Asteraceae family).

In pregnancy, Bifidobacterium bifidum and Lactobacillus acidophilus are rated possibly safe; chicory root fiber is rated possibly unsafe and is best avoided in medicinal amounts during pregnancy due to historical concerns about uterine stimulation. Data for breastfeeding are limited — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Chicory

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Chicory, Lactobacillus Acidophilus, Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 268 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antibiotic drugs with your doctor or pharmacist before starting this product — Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus acidophilus, and chicory may decrease effectiveness if taken simultaneously; you'll likely need to space them apart. Also double-check any diabetes medications (antidiabetes drugs) because chicory may increase the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with IBS and some digestive issues if you're an otherwise healthy adult, though the evidence for many claims is still developing. If you take antibiotics or diabetes medications, separate the timing from this probiotic and check with your doctor first.

Anyone with a weakened immune system, serious illness, or allergies to the ragweed family should discuss this with their healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fortify Age 50+ Probiotic + Prebiotics 50 Billion, straight from the product label.

Brand Nature's Way
Net contents 30 Delayed-Release Veg. Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 273394
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Seniors/Mature (>50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus plantarum Lp-1150 NP--
Lactobacillus rhamnosus GG0 NP--
Bifidobacterium lactis Bi-070 NP--
Bifidobacterium lactis Bl-040 NP--
Bifidobacterium bifidum Bb-060 NP--
Bifidobacterium longum Bl-050 NP--
Chicory root Fiber50 mg--
Bifidobacteria Blend0 NP--
Lactobacillus paracasei Lpc-370 NP--
Fortify Age 50+ 50 Billion CFU Proprietary Probiotic Blend525 mg--
HOWARU Lactobacillus acidophilus NCFM0 NP--
HOWARU Bifidobacterium lactis HN0190 NP--
Bifidobacterium bifidum/lactis Bb-020 NP--
Lactobacilli Blend0 NP--

Other ingredients: Cellulose, plant-derived Capsule, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Powerful probiotics for daily digestive & immune health for adults age 50+

Formulated with 10 probiotic strains + prebiotics 50 billion active cultures, guaranteed!

Age 50+ Probiotic +Prebiotics Extra strength Compared to Fortify Age 50 + 30 Billion Probiotic Formula 50 Billion Live probiotic cultures per capsule 10 probiotic strains

Formulation

One capsule, multiple benefits Targeted delivery

Gluten free. No artificial colors.

Non GMO Project Verified nongmoproject.org

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Storage

Keep tightly closed. Can be stored at room temperature or refrigerated. Avoid excessive heat and direct sunlight.

Seals/Symbols

Certified Gluten free GFCO.org

Non GMO Project Verified nongmoproject.org

Brand IP Statement(s)

Howaru probiotic quality you can feel HOWARU is a registered trademark of International Flavors & Fragrances Inc. or its affiliates. HN019 is a trademark of the Fonterra Group of companies used under license. The probiotic strains contained in this product are manufactured by IFF.

Copyright 2022 Distributed by Nature's Way Brands, LLC

FDA Disclaimer Statement

This statement has not been evaluated by the food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 capsule daily. May be taken at any time, with or without food.

General Statements

Questions? 1-800-9NATURE / fortifyprobiotics.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fortify Age 50+ Probiotic + Prebiotics 50 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chicory root Fiber

Interacts with
86 drugs
50 mg per serving

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regular...

Chicory root Fiber monograph & interactions

Fortify Age 50+ 50 Billion CFU Proprietary Probiotic Blend

525 mg per serving
  • › Bifidobacteria Blend
  • › Lactobacilli Blend

Other (inactive) ingredients: Cellulose, Plant-derived Capsule, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way Drug Interactions

Want to check YOUR meds against Fortify Age 50+ Probiotic + Prebiotics 50 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
268Drugs
268 Moderate

Ingredients driving the most interactions

Chicory root Fiber 86

Individual Drug Interactions

The ingredients in Fortify Age 50+ Probiotic + Prebiotics 50 Billion interact with 268 drugs. Click any drug to see the details.

1 of the 3 ingredients in Fortify Age 50+ Probiotic + Prebiotics 50 Billion interact with drugs. Each result below shows which ingredient is responsible. Chicory root Fiber

Each ingredient & the kinds of drugs it affects

For each ingredient in Fortify Age 50+ Probiotic + Prebiotics 50 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chicory root Fiber1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.

Likelihood Possible Evidence D
Chicory root Fiber full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fortify Age 50+ Probiotic + Prebiotics 50 Billion, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
fortifyprobiotics.com
Pharmacist Counseling Corner

Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way: Common Questions

Does Fortify Age 50+ Probiotic + Prebiotics 50 Billion by Nature's Way interact with any medications?
Yes. Based on its ingredients, Fortify Age 50+ Probiotic + Prebiotics 50 Billion has a known interaction with 268 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fortify Age 50+ Probiotic + Prebiotics 50 Billion contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this probiotic really help with IBS?
Lactobacillus acidophilus and Bifidobacterium bifidum in this product are both rated possibly effective for irritable bowel syndrome based on the data we hold, so there's some evidence backing their use for that condition. Results vary by person, so give it time and talk to your doctor if you're not seeing improvement.
What's the difference between the probiotics and the chicory in this product?
The probiotics are live organisms that colonize your gut; the chicory root fiber (prebiotic) is food for those organisms to help them thrive. Think of probiotics as the workers and prebiotics as their fuel.
Is it safe to take this while pregnant or breastfeeding?
Most of the probiotic strains here are rated possibly safe in pregnancy, but chicory root fiber is rated possibly unsafe in medicinal amounts during pregnancy, so it's best avoided. For breastfeeding, the data are limited. Talk with your doctor or pharmacist — they know your situation and can give you personalized advice.
Will this cause bloating or gas?
Bloating and flatulence have been reported with probiotics generally, though these effects aren't specifically documented for all strains in this product. Chicory root fiber can also cause gas and bloating. Side effects tend to be mild and uncommon, but start with a lower dose if you're sensitive.
Can I take this with my antibiotics?
No — you'll want to separate them. The antibiotic can kill the live organisms in this product before they work. Ask your doctor or pharmacist how far apart to space them; often it's a few hours.
Is anyone who shouldn't take this?
If you have a weakened immune system, are critically ill, or have allergies to ragweed or related plants, talk with your doctor first. Rare cases of serious bacterial infection have been reported in very ill patients using probiotics.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fortify Age 50+ Probiotic + Prebiotics 50 Billion is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fortify Age 50+ Probiotic + Prebiotics 50 Billion label
Go deeper

The Full Monographs Behind Fortify Age 50+ Probiotic + Prebiotics 50 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chicory

Interacts with 86 drugs

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...

Read the full Chicory monograph →
Sources

Sources & How We Checked

Fortify Age 50+ Probiotic + Prebiotics 50 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Chicory 13 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Stone-Dorshow T, Levitt MD. Gaseous response to ingestion of a poorly absorbed fructo-oligosaccharide sweetener. Am J Clin Nutr 1987;46:61-5. PubMed
  3. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  4. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  5. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  6. Cadot, P., Kochuyt, A. M., van Ree, R., and Ceuppens, J. L. Oral allergy syndrome to chicory associated with birch pollen allergy. Int.Arch.Allergy Immunol. 2003;131(1):19-24. PubMed
  7. Friis, B., Hjorth, N., Vail, J. T., Jr., and Mitchell, J. C. Occupational contact dermatitis from Cichorium (chicory, endive) and Lactuca (lettuce). Contact Dermatitis 1975;1(5):311-313.
  8. Nemery, B. and Demedts, M. Occupational asthma in a chicory grower. Lancet 3-25-1989;1(8639):672-673. PubMed
  9. Pirson F, Detry B, Pilette C. Occupational rhinoconjunctivitis and asthma caused by chicory and oral allergy syndrome associated with bet v 1-related protein. J Investig Allergol Clin Immunol 2009;19(4):306-10.
  10. Willi R, Pfab F, Huss-Marp J, et al. Contact anaphylaxis and protein contact dermatitis in a cook handling chicory leaves. Contact Dermatitis 2009;60(4):226-7. PubMed
  11. Street RA, Sidana J, Prinsloo G. Cichorium intybus: traditional uses, phytochemistry, pharmacology, and toxicology. Evid Based Complement Alternat Med 2013;2013:579319.
  12. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  13. Devi Kt R, Sivalingam N. Cichorium intybus attenuates Streptozotocin-induced pancreatic ß-cell damage by inhibiting NF-?B activation and oxidative stress. J Appl Biomed 2020;18(2-3):70-9. PubMed

See these in context on the Chicory monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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