Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Fortify Adults 50+ Probiotic Extra Strength 50 Billion Ingredients & Drug Interactions

by Nature's Way

Fortify Adults 50+ Probiotic Extra Strength 50 Billion label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fortify Adults 50+ Probiotic Extra Strength 50 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fortify Adults 50+ Probiotic Extra Strength 50 Billion is a dietary supplement by Nature's Way with 3 active ingredients. Its ingredients are commonly taken for constipation and digestive health, source of prebiotic fiber (inulin), coffee substitute.Based on those ingredients, 268 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chicory Fiber. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 12 active ingredients.
  • “Bifidobacteria Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Lactobacilli Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Fortify Age 50+ Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (525 mg) without saying how much of each component you get.

This product contains 12 active ingredients: multiple strains of Bifidobacterium (animalis lactis in several varieties, bifidum, and longum) and Lactobacillus (paracasei, rhamnosus, plantarum, and acidophilus), plus chicory fiber. These are live cultures designed to support digestive and immune health, especially for adults 50 and older.

The inactive ingredients are cellulose, hypromellose, gellan gum, magnesium stearate, and silica—these are fillers, binders, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports regularity and colon health.
  • We looked for evidence on: Constipation, Diarrhea, Irritable bowel syndrome (IBS), Antibiotic-associated diarrhea, Inflammatory bowel disease (IBD), Abdominal pain — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

For IBS, antibiotic-associated diarrhea, Helicobacter pylori infection, bacterial vaginosis, and respiratory tract infections, some of the bacterial strains in this product are rated Possibly Effective. That means there's some evidence they may help, but it's not definitive yet.

For many other conditions—allergies, anxiety, cognitive decline, asthma—the evidence we hold is insufficient to say whether they work. For atopic disease (eczema, asthma, allergies that develop in childhood), one strain is rated Possibly Ineffective.

Chicory fiber has no established evidence in our data for any of the conditions listed.

The evidence, ingredient by ingredient Chicory

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The live bacteria in this product are generally well tolerated in healthy people. However, caution is advised if you have a weakened immune system or are seriously ill—these organisms can rarely cause infection in vulnerable patients.

Chicory may cause gas, bloating, belching, and abdominal discomfort in some people, and it can trigger allergic reactions in those sensitive to the ragweed family of plants. Rare gastrointestinal side effects reported with the bacterial strains include abdominal discomfort, flatulence, constipation, and in one case a dry cough.

One case of vomiting and fever was reported in a child taking similar probiotics, though it's unclear if the probiotics caused it.

Side effects, ingredient by ingredient Chicory

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Chicory, Lactobacillus Acidophilus, Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 268 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any antibiotic drugs you're on—the live bacteria may be killed off if taken at the same time, so timing matters. If you take antidiabetes medications, mention this product to your doctor because chicory may affect blood sugar levels.

Use the medication search tool on this page to run through your full list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a reasonable choice if you're over 50 and looking for digestive support, especially if you've taken antibiotics recently or have IBS. If you take any prescription medications—particularly antibiotics or diabetes drugs—check them against the tool on this page first.

Those with weakened immunity or serious illness should talk to their doctor before starting. A quick conversation with your pharmacist can confirm it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fortify Adults 50+ Probiotic Extra Strength 50 Billion, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674115824
Net contents 30 Delayed-Release Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 333747
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Seniors/Mature (>50 Years) - Women ONLY, Seniors/Mature (>50 Years) - Men ONLY, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
033674115824
IngredientAmount% DV
Bifidobacterium animalis lactis BL-040 NP--
Lactobacillus paracasei LPC-370 NP--
Lactobacillus rhamnosus GG0 NP--
Lactobacillus plantarum LP-1150 NP--
Bifidobacteria Blend0 NP--
Bifidobacterium bifidum BB-60 NP--
Bifidobacterium longum BL-50 NP--
Bifidobacterium animalis lactis Bi-070 NP--
HOWARU Bifidobacterium animalis lactis HN0190 NP--
Bifidobacterium animalis lactis Bb-020 NP--
Chicory Fiber50 mg--
Howaru0 NP--
Lactobacilli Blend0 NP--
Fortify Age 50+ Proprietary Probiotic Blend525 mg--
Bifidobacterium bifidum BB-20 NP--

Other ingredients: Cellulose, Hypromellose, Gellan Gum, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports regularity, reduces occasional constipation & promotes colon health

Gluten free. No soy, dairy, or artificial colors. Certified Gluten free GFCO.org (Gluten-Free Certification Organization) Non GMO Project Verified nongmoproject.org

Bottled and tested in the USA

Fortify promotes colon health

Wellness starts with a healthy gut Promotes healthy gut bacteria Plant-derived, delayed-release capsule survives stomach acid to distribute live cultures where they're needed most - in the intestine and colon

Reduces occasional gas and digestive discomfort Contains the doctor-preferred probiotic for regularity

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Storage

Keep tightly closed. Can be stored at room temperature or refrigerated. Avoid excessive heat and direct sunlight.

No refrigeration needed

Formula

Howaru Probiotic quality you can feel

50 Billion live cultures Fortify Adults 50+ Probiotic Extra Strength 50 Billion Compared to Fortify Adults 50+30 Billion Probiotic Formula

Guarantees 50 billion live probiotic cultures through the date of expiration Formulated with 11 diverse probiotic strains Contains plant-based prebiotic fiber, food for good bacteria

Extra-Strength Probiotic for Digestive and Colon Health for Adults 50+

Promotes colon health with clinically studied probiotic strain B. lactis HN019 Supports digestive balance and immune health with clinically studied probiotic strains B. lactis Bi-07 and B. lactis BL-04

3 clinically studied probiotic strains Fortify Adults 50+ Probiotic Extra Strength 50 Billion With plant-based prebiotic fiber Contains the doctor-preferred probiotic for regularity Based on an IQVIA ProVoice survey of Primary Care Physicians, HOWARU B. lactis HN019 is the Doctor-preferred probiotic strain for Regularity as compared to other strains in leading Probiotic brands, 52-week sales MULO, ending 8/13/23; August 2023. Plus supports regularity & reduces occasional constipation

Brand IP Statement(s)

HOWARU is a registered trademark of IFF and is used under license. HN019 is a trademark of the Fonterra Group of companies used under license. The probiotic strains contained in this product are manufactured by IFF. Copyright 2023 Nature's Way Brands, LLC

Seals/Symbols

Certified Gluten free GFCO.org (Gluten-Free Certification Organization) Non GMO Project Verified nongmoproject.org

General Statements

Questions? 1-800-962-8873 / fortifyprobiotics.com

Explore more products at NATURESWAY.COM

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Prbiotic Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 1 capsule daily. May be taken at any time, with or without food.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fortify Adults 50+ Probiotic Extra Strength 50 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chicory Fiber

Interacts with
86 drugs
50 mg per serving

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regular...

Chicory Fiber monograph & interactions

Fortify Age 50+ Proprietary Probiotic Blend

525 mg per serving
  • › Bifidobacteria Blend
  • › Lactobacilli Blend

Other (inactive) ingredients: Cellulose, Hypromellose, Gellan Gum, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way Drug Interactions

Want to check YOUR meds against Fortify Adults 50+ Probiotic Extra Strength 50 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
268Drugs
268 Moderate

Ingredients driving the most interactions

Chicory Fiber 86

Individual Drug Interactions

The ingredients in Fortify Adults 50+ Probiotic Extra Strength 50 Billion interact with 268 drugs. Click any drug to see the details.

1 of the 3 ingredients in Fortify Adults 50+ Probiotic Extra Strength 50 Billion interact with drugs. Each result below shows which ingredient is responsible. Chicory Fiber

Each ingredient & the kinds of drugs it affects

For each ingredient in Fortify Adults 50+ Probiotic Extra Strength 50 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chicory Fiber1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.

Likelihood Possible Evidence D
Chicory Fiber full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fortify Adults 50+ Probiotic Extra Strength 50 Billion, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way: Common Questions

Does Fortify Adults 50+ Probiotic Extra Strength 50 Billion by Nature's Way interact with any medications?
Yes. Based on its ingredients, Fortify Adults 50+ Probiotic Extra Strength 50 Billion has a known interaction with 268 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fortify Adults 50+ Probiotic Extra Strength 50 Billion contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on an antibiotic?
You can, but timing is important. The antibiotic can kill the beneficial bacteria in this product if you take them together. Space them out by a couple of hours—ask your pharmacist which one to take first and when. That way the probiotic can do its job without being wiped out.
What's chicory fiber doing in a probiotic?
Chicory fiber acts as a prebiotic—it feeds the beneficial bacteria and helps them thrive in your gut. It's a common addition to probiotic formulas for that reason. Just know it can cause gas and bloating in some people, especially if you're not used to extra fiber.
Is this safe if my immune system is weak?
These are live organisms, so caution is advised if you're immunocompromised, seriously ill, or have had recent surgery. Talk with your doctor or pharmacist first—they can help you decide if it's right for you or if you need a different option.
Will this help my IBS?
Some of the bacterial strains in here are rated Possibly Effective for IBS, which means there's some evidence they may help, but results aren't guaranteed. It's worth trying if your doctor or pharmacist thinks it's a good fit, but give it a fair amount of time to work.
Does chicory trigger allergies?
Chicory can cause an allergic reaction in people sensitive to ragweed, chrysanthemums, daisies, and related plants. If you have hay fever or plant allergies, mention this product to your pharmacist before starting.
Is it safe to take while breastfeeding?
One of the Bifidobacterium strains is rated Possibly Safe in pregnancy and lactation, but we don't have safety data on file for chicory fiber during breastfeeding. Check with your doctor or pharmacist to make sure it's okay for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fortify Adults 50+ Probiotic Extra Strength 50 Billion is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fortify Adults 50+ Probiotic Extra Strength 50 Billion label
Go deeper

The Full Monographs Behind Fortify Adults 50+ Probiotic Extra Strength 50 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chicory

Interacts with 86 drugs

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...

Read the full Chicory monograph →
Sources

Sources & How We Checked

Fortify Adults 50+ Probiotic Extra Strength 50 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Chicory 13 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Stone-Dorshow T, Levitt MD. Gaseous response to ingestion of a poorly absorbed fructo-oligosaccharide sweetener. Am J Clin Nutr 1987;46:61-5. PubMed
  3. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  4. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  5. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  6. Cadot, P., Kochuyt, A. M., van Ree, R., and Ceuppens, J. L. Oral allergy syndrome to chicory associated with birch pollen allergy. Int.Arch.Allergy Immunol. 2003;131(1):19-24. PubMed
  7. Friis, B., Hjorth, N., Vail, J. T., Jr., and Mitchell, J. C. Occupational contact dermatitis from Cichorium (chicory, endive) and Lactuca (lettuce). Contact Dermatitis 1975;1(5):311-313.
  8. Nemery, B. and Demedts, M. Occupational asthma in a chicory grower. Lancet 3-25-1989;1(8639):672-673. PubMed
  9. Pirson F, Detry B, Pilette C. Occupational rhinoconjunctivitis and asthma caused by chicory and oral allergy syndrome associated with bet v 1-related protein. J Investig Allergol Clin Immunol 2009;19(4):306-10.
  10. Willi R, Pfab F, Huss-Marp J, et al. Contact anaphylaxis and protein contact dermatitis in a cook handling chicory leaves. Contact Dermatitis 2009;60(4):226-7. PubMed
  11. Street RA, Sidana J, Prinsloo G. Cichorium intybus: traditional uses, phytochemistry, pharmacology, and toxicology. Evid Based Complement Alternat Med 2013;2013:579319.
  12. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  13. Devi Kt R, Sivalingam N. Cichorium intybus attenuates Streptozotocin-induced pancreatic ß-cell damage by inhibiting NF-?B activation and oxidative stress. J Appl Biomed 2020;18(2-3):70-9. PubMed

See these in context on the Chicory monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team