Four Kings Ingredients & Drug Interactions
by Ron Teeguarden's Dragon Herbs
What is this page for?
First and foremost: checking Four Kings against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Four Kings is a dietary supplement by Ron Teeguarden's Dragon Herbs with 4 active ingredients. Its ingredients are commonly taken for fatigue and low energy, athletic performance and stamina, respiratory and lung support.Based on those ingredients, 502 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Maitake Fruiting Body Extract, Powder, Cordyceps Mycelium Extract, Powder, Agaricus Fruiting Body Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Four Kings by Ron Teeguarden's Dragon Herbs
Ask about any prescription or over-the-counter medication and we check it for interactions with Four Kings by Ron Teeguarden's Dragon Herbs — and tell you which ingredient is responsible.
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HelloPharmacist Scorecard of Four Kings by Ron Teeguarden's Dragon Herbs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Four Kings contains four active ingredients: cordyceps mycelium extract, agaricus fruiting body extract, maitake mushroom fruiting body extract, and reishi fruiting body extract, plus inactive ingredients (pullulan polysaccharide, rice powder, bamboo extract, and rice extract blend) that serve as fillers and capsule material.
Does it work?
Not established
The evidence for Four Kings' ingredients is limited. Cordyceps is rated possibly ineffective for athletic performance, but the data is insufficient to rate it for sexual function, heart rhythm, asthma, lung cancer, or COPD.
For maitake, the evidence is likewise insufficient to rate its use for hay fever, chemotherapy-related anemia, laryngeal cancer, chemotherapy-related diarrhea, or chronic fatigue. We hold no effectiveness ratings for agaricus or reishi from the data on file.
How safe is it?
Well-documented data
Cordyceps is generally well tolerated short-term, though long-term safety data is limited and product quality varies widely. The most common side effects are abdominal discomfort, constipation, and diarrhea — symptoms that may be reduced by taking it with food.
One case report links cordyceps to liver inflammation, though it is unclear whether cordyceps or a contaminant caused it. Maitake is generally well tolerated as a food, though concentrated supplement safety has not been fully studied.
Gastrointestinal effects (diarrhea, stomach pain) are the most common, and rarely a rash or itching has been reported. Cordyceps and maitake should both be avoided during pregnancy and breastfeeding due to insufficient safety data.
We hold no safety information for agaricus or reishi on file.
Meds to double-check
Moderate interaction found
Check with your pharmacist if you take warfarin or other blood thinners — maitake has a documented case of increased bleeding risk with warfarin. Also double-check if you're on blood pressure drugs, diabetes medications, antiplatelet drugs like aspirin, or immunosuppressants — cordyceps and maitake both carry Moderate interactions with these drug types.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Four Kings is a blend of medicinal mushroom extracts. If you take warfarin, blood thinners, blood pressure meds, diabetes drugs, or immunosuppressants, check your exact medications with the tool on this page before starting — the cordyceps and maitake here have documented interactions with these drug classes.
Talk to your pharmacist before use, especially if you're pregnant, breastfeeding, or taking any prescription medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Four Kings, straight from the product label.
| Brand | Ron Teeguarden's Dragon Herbs |
|---|---|
| Barcode (UPC) | 679372001979 |
| Net contents | 100 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 316881 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Four Kings by Ron Teeguarden's Dragon Herbs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Formula | 1500 mg | -- |
| Cordyceps Mycelium Extract, Powder | 0 NP | -- |
| Agaricus Fruiting Body Extract, Powder | 0 NP | -- |
| Maitake Fruiting Body Extract, Powder | 0 NP | -- |
| Duanwood Reishi Fruiting Body Extract, Powder | 0 NP | -- |
Other ingredients: Pullulan Polysaccharide, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Four Kings consists of four mushrooms that are known for their powerful tonic and protective benefits.
Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.
Formulation
This formulation is both safe and effective.
Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Ron Teeguarden's Dragon Herbs Health Deserves Cultivation
FDA Statement of Identity
Dietary Supplement
General Statements
Four Kings 500 mg each
Suggested/Recommended/Usage/Directions
Directions: Take 3 capsules, 2 times per day or as directed by a healthcare professional.
Precautions
Keep out of the reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Four Kings by Ron Teeguarden's Dragon Herbs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Four Kings by Ron Teeguarden's Dragon Herbs
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container33 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Formula
- › Cordyceps Mycelium Extract, Powder
- › Agaricus Fruiting Body Extract, Powder
- › Maitake Fruiting Body Extract, Powder
- › Duanwood Reishi Fruiting Body Extract, Powder
Other (inactive) ingredients: Pullulan Polysaccharide, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend. These complete the product’s ingredient list but are not active constituents.
Four Kings by Ron Teeguarden's Dragon Herbs Drug Interactions
HelloPharmacist Interaction Report
Four Kings by Ron Teeguarden's Dragon Herbs contains two ingredients with documented interactions: cordyceps and maitake mushroom.
The most serious concern is maitake's interaction with warfarin (Coumadin), a blood thinner — a case report showed that maitake increased warfarin's effect enough to raise the patient's INR (a clotting measure) to dangerously high levels.
Read the full breakdown — every affected drug type, severity by severity
Cordyceps carries Moderate-severity interactions with blood thinners and antiplatelet drugs (aspirin, clopidogrel), where it may theoretically raise bleeding risk, though this has not been reported in humans. It also may interfere with immunosuppressants like cyclosporine.
A Minor interaction with testosterone supplements is also noted.
Maitake carries additional Moderate interactions with blood pressure medications and diabetes drugs — theoretically it may lower blood pressure or blood sugar further, raising the risk of dizziness or low blood sugar.
We could not check two other ingredients — agaricus and reishi — because we hold no interaction data for them. Altogether, these interactions span 495 individual medications.
Use the medication checker on this page to look up your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Four Kings?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Four Kings interact with 502 drugs. Click any drug to see the details.
3 of the 4 ingredients in Four Kings interact with drugs. Each result below shows which ingredient is responsible. Maitake Fruiting Body Extract, Powder Cordyceps Mycelium Extract, Powder Agaricus Fruiting Body Extract, Powder
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Four Kings — through 2 ingredients. Tap an ingredient for the detail:
Agaricus Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Fruiting Body Extract, Powder + Acarbose interactionMaitake Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Fruiting Body Extract, Powder + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Maitake Fruiting Body Extract, PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Fruiting Body Extract, Powder + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Maitake Fruiting Body Extract, PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Fruiting Body Extract, Powder + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Four Kings — through 2 ingredients. Tap an ingredient for the detail:
Maitake Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Fruiting Body Extract, Powder + Acetohexamide interactionAgaricus Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Fruiting Body Extract, Powder + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Four Kings — through 2 ingredients. Tap an ingredient for the detail:
Agaricus Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Fruiting Body Extract, Powder + Albiglutide interactionMaitake Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Fruiting Body Extract, Powder + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Mycelium Extract, Powder + Alemtuzumab interactionAliskirenTekturna
How Aliskiren interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Maitake Fruiting Body Extract, PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Fruiting Body Extract, Powder + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Four Kings — through 2 ingredients. Tap an ingredient for the detail:
Maitake Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Fruiting Body Extract, Powder + Alogliptin interactionAgaricus Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Fruiting Body Extract, Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Four Kings — through 2 ingredients. Tap an ingredient for the detail:
Agaricus Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Fruiting Body Extract, Powder + Alogliptin, Metformin interactionMaitake Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Fruiting Body Extract, Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Four Kings — through 2 ingredients. Tap an ingredient for the detail:
Maitake Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Fruiting Body Extract, Powder + Alogliptin, Pioglitazone interactionAgaricus Fruiting Body Extract, PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Agaricus Fruiting Body Extract, Powder + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Cordyceps Mycelium Extract, PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Mycelium Extract, Powder + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Four Kings — through 1 ingredient. Tap an ingredient for the detail:
Maitake Fruiting Body Extract, PowderAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Fruiting Body Extract, Powder + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Four Kings with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Maitake Fruiting Body Extract, Powder
Antidiabetes Drugs
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.
Antihypertensive Drugs
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.
Warfarin (Coumadin)
There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.
Cordyceps Mycelium Extract, Powder
Anticoagulant/Antiplatelet Drugs
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.
Testosterone
Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.
Agaricus Fruiting Body Extract, Powder
Antidiabetes Drugs
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.
Brand information
Manufacturer and brand details for Four Kings, from the product label.
Ron Teeguarden's Dragon Herbs
See all Ron Teeguarden's Dragon Herbs products- Name
- Ron Teeguarden's Dragon Herbs
- City
- Los Angeles
- State
- CA
- ZipCode
- 90036
- Phone Number
- (888) 558-6642
- Web Address
- www.dragonherbs.com
Four Kings by Ron Teeguarden's Dragon Herbs: Common Questions
Does Four Kings by Ron Teeguarden's Dragon Herbs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does cordyceps in Four Kings actually improve athletic performance?
Can I take Four Kings if I'm pregnant or breastfeeding?
What side effects might I experience from Four Kings?
How long can I safely take Four Kings?
Is there a case of someone being harmed by cordyceps in Four Kings?
What are maitake and reishi in this product supposed to do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Four Kings is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Four Kings’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Cordyceps
Interacts with 249 drugsCordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...
Read the full Cordyceps monograph → Herb & supplement monographAgaricus Mushroom
Interacts with 86 drugsAgaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...
Read the full Agaricus Mushroom monograph → Herb & supplement monographMaitake Mushroom
Interacts with 260 drugsMaitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...
Read the full Maitake Mushroom monograph →Sources & How We Checked
Four Kings's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cordyceps 14 references
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
- Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
- Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
- Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
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