Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Fresh Catch Cod Liver Oil Lemonade Flavor Ingredients & Drug Interactions

by Barlean's

Fresh Catch Cod Liver Oil Lemonade Flavor label
See full label image
Liquid Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fresh Catch Cod Liver Oil Lemonade Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fresh Catch Cod Liver Oil Lemonade Flavor is a dietary supplement by Barlean's with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D, Omega-3 Polyunsaturated Fat. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's

Ask about any prescription or over-the-counter medication and we check it for interactions with Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Omega-3 Polyunsaturated Fat” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product is a liquid cod liver oil supplement with 6 active ingredients: eicosapentaenoic acid and docosahexaenoic acid (the two main omega-3 fatty acids), polyunsaturated fat, monounsaturated fat, vitamin D, and other omega-3 fatty acids. Cod liver oil has been used for years as a source of omega-3s and fat-soluble vitamins, and the vitamin D in this formula is included to support bone and immune health.

The inactive ingredients are cod liver oil itself, natural lemonade flavoring, lecithin (an emulsifier), mixed tocopherols and ascorbyl palmitate (preservatives), rosemary extract, ascorbic acid, citric acid, and additional vitamin D3.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Vitamin D's overall clinical evidence instead.

Strong

Strong clinical evidence supports Vitamin D for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Vitamin D deficiency — rated "Effective" (Natural Medicines).
  • On file: Hypoparathyroidism — rated "Effective" (Natural Medicines).
  • On file: Familial hypophosphatemia — rated "Effective" (Natural Medicines).
  • On file: Osteomalacia — rated "Effective" (Natural Medicines).
  • On file: Renal osteodystrophy — rated "Effective" (Natural Medicines).

Vitamin D in this product is effective for treating rickets, osteomalacia (soft bones), renal bone disease, and certain forms of low blood phosphate. These are serious metabolic bone disorders, and vitamin D supplementation in appropriate doses is a proven treatment.

The omega-3 fatty acids themselves — eicosapentaenoic acid and docosahexaenoic acid — are well-researched for cardiovascular and general health support, though the specific effectiveness claims for those ingredients are not in the data we hold for this product.

The evidence, ingredient by ingredient Vitamin D Docosahexaenoic Acid (dha)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, but very high doses over time can cause toxicity with symptoms like high blood calcium, bone loss, and in rare cases vision changes or kidney problems. The safety data advises caution in pregnancy — it's often used at recommended amounts during pregnancy, but only under a doctor's guidance.

For breastfeeding, vitamin D is generally considered acceptable at recommended doses; talk with your doctor before taking higher amounts. We hold no adverse-effect data for the omega-3 ingredients in this product.

Side effects, ingredient by ingredient Vitamin D Docosahexaenoic Acid (dha)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take thiazide diuretics (water pills), digoxin, verapamil, diltiazem, atorvastatin, calcipotriene, or any other medications metabolized by CYP3A4 enzymes. These are the drug types with documented interactions to vitamin D in this supplement.

If you take high-dose aluminum supplements, mention that too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is a straightforward cod liver oil with vitamin D — useful if you need vitamin D for bone health or are looking for omega-3 support. The main caution is vitamin D's interactions with heart, blood-pressure, and water-pill medications.

If you take any of those, or cholesterol drugs like atorvastatin, run this by your doctor or pharmacist before you start. Stick to the recommended dose to avoid toxicity.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fresh Catch Cod Liver Oil Lemonade Flavor, straight from the product label.

Brand Barlean's
Barcode (UPC) 705875600026
Net contents 8 Fluid Ounce(s); 236 Milliliter(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 291821
Product type Fat/fatty Acid
Supplement form Liquid
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 mL
Maximum serving Sizes:
5 mL
Servings per container
47
UPC/BARCODE
705875600026
IngredientAmount% DV
Calories40 Calorie(s)--
Eicosapentaenoic Acid360 mg--
Docosahexaenoic Acid540 mg--
Cholesterol25 mg8%
Total Fat4.5 Gram(s)6%
Polyunsaturated Fat1.5 Gram(s)--
Monounsaturated Fat2.5 Gram(s)--
Saturated Fat0.5 Gram(s)4%
Vitamin D16 mcg81%
Other Omega-3 Fatty Acids225 mg--
Omega-3 Polyunsaturated Fat0 NP--

Other ingredients: Cod Liver Oil, natural Lemonade flavor, Lecithin, Mixed Tocopherols, Rosemary extract, Ascorbyl Palmitate, Ascorbic Acid, Citric Acid, Vitamin D3

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Not your grandmother's cod liver oil Back in the "good old days" kids would line up, holding their noses, to choke down their daily dose of cod liver oil. Oh, how things have changed. Our fresh catch cod liver oil provides a super-boost dose of Omega-3s, but without the fishy taste or fish burps. That's because we use cutting edge technology to bring you the freshest, highest quality fish oils available.

Omega-3 EPA/DHA

Vitamin D 16 mcg per serving

Formulation

Sourced Sustainably from Icelandic Cod Third Party Lab Tested for Purity & Potency Molecularly Distilled & Ultra Purified

Free of PCB's and other Contaminants Non-GMO, Gluten Free

We date our Fresh Catch Fish Oils 12 months (not up to 3 years) to ensure the freshest fish oil available.

Molecularly Distilled Pharmaceutical Grade

Non-GMO Gluten Free

Product of U.S.A.

Suggested/Recommended/Usage/Directions

Suggested Use: 1 tsp daily with a meal. Refrigerate after opening. A cloudy appearance is natural. Shake well.

Precautions

Keep out of reach of children.

General Statements

From our family to yours Barbara Barlean David Barlean Bruce Barlean Freshness Dating

The freshest fish oil See why!

Learn more about a Pathway to a Better Life: barleans.com 800/445-3529

Brand IP Statement(s)

ESTD 1989 Barlean's Pathway To A Better Life

FDA Statement of Identity

Cod Liver Oil Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fresh Catch Cod Liver Oil Lemonade Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 mL Dosage formLiquid Servings per container47 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D

Interacts with
715 drugs
16 mcg per serving

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Omega-3 Polyunsaturated Fat

Interacts with
375 drugs
0 NP per serving

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and gen...

Omega-3 Polyunsaturated Fat monograph & interactions
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Other Omega-3 Fatty Acids

Other (inactive) ingredients: Cod Liver Oil, Natural Lemonade flavor, Lecithin, Mixed Tocopherols, Rosemary extract, Ascorbyl Palmitate, Ascorbic Acid, Citric Acid, Vitamin D3. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's Drug Interactions

Want to check YOUR meds against Fresh Catch Cod Liver Oil Lemonade Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
963Drugs
392 Moderate 571 Minor

Ingredients driving the most interactions

Vitamin D 715
Omega-3 Polyunsaturated Fat 375

Individual Drug Interactions

The ingredients in Fresh Catch Cod Liver Oil Lemonade Flavor interact with 963 drugs. Click any drug to see the details.

2 of the 2 ingredients in Fresh Catch Cod Liver Oil Lemonade Flavor interact with drugs. Each result below shows which ingredient is responsible. Vitamin D Omega-3 Polyunsaturated Fat

Each ingredient & the kinds of drugs it affects

For each ingredient in Fresh Catch Cod Liver Oil Lemonade Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions

Omega-3 Polyunsaturated Fat3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHA may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Although some clinical evidence suggests that DHA might reduce collagen-stimulated platelet aggregation and thromboxane release, most clinical evidence suggests that DHA alone does not affect blood clotting. However, theoretically, when given in combination with EPA as fish oil, concomitant use with anticoagulant or antiplatelet drugs (including aspirin) might increase risk of bleeding.

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, taking DHA with antidiabetes drugs might reduce the effects of these medications.
In people with type 2 diabetes, including those taking oral hypoglycemic medications, DHA seems to increase fasting blood glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking DHA with antihypertensive drugs might increase the risk of hypotension.
Fish oils containing DHA can lower blood pressure and might have additive effects in patients treated with antihypertensives; use with caution.

Likelihood Probable Evidence B
Omega-3 Polyunsaturated Fat full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fresh Catch Cod Liver Oil Lemonade Flavor, from the product label.

Barlean's

See all Barlean's products
Name
Barlean's
City
Ferndale
State
WA
ZipCode
98248
Phone Number
800-445-3529
Web Address
barleans.com
Pharmacist Counseling Corner

Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's: Common Questions

Does Fresh Catch Cod Liver Oil Lemonade Flavor by Barlean's interact with any medications?
Yes. Based on its ingredients, Fresh Catch Cod Liver Oil Lemonade Flavor has a known interaction with 963 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fresh Catch Cod Liver Oil Lemonade Flavor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is vitamin D in this supplement safe during pregnancy?
The data advise caution. Vitamin D is often used at recommended doses during pregnancy, but only under your doctor's guidance — don't adjust the dose on your own. Talk with your obstetrician or midwife before starting this product if you're pregnant or planning to be.
Can I take this if I'm breastfeeding?
Vitamin D is generally considered acceptable at recommended doses while breastfeeding. However, check with your doctor before taking higher amounts.
What's the main difference between this product and plain fish oil?
This is a cod liver oil with added vitamin D. Cod liver oil naturally contains vitamins A and D along with omega-3s, whereas regular fish oil is typically just the omega-3 fatty acids without those fat-soluble vitamins.
Can I take this long-term?
At recommended doses, yes — vitamin D is generally safe for long-term use. Very high doses over time can cause toxicity, so stick to the label dosing and avoid adding other vitamin D supplements without checking with your doctor.
Will this help with my bones?
Vitamin D is proven effective for treating bone disorders like rickets and osteomalacia. For general bone health in otherwise healthy people, the data we hold don't specify how well it works, so talk with your doctor about whether this dose and product fit your needs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fresh Catch Cod Liver Oil Lemonade Flavor is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fresh Catch Cod Liver Oil Lemonade Flavor label
Go deeper

The Full Monographs Behind Fresh Catch Cod Liver Oil Lemonade Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 715 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph → Herb & supplement monograph

Docosahexaenoic Acid (dha)

Interacts with 375 drugs

DHA is an omega-3 fatty acid found in fatty fish and algae that is a building block for the brain, nervous system, and eyes. It is widely used and generally well tolerated, with the stronges...

Read the full Docosahexaenoic Acid (dha) monograph →
Sources

Sources & How We Checked

Fresh Catch Cod Liver Oil Lemonade Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 75 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Docosahexaenoic Acid (dha) 49 references
  1. Akedo I, Ishikawa H, Nakamura T, et al. Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules (abstract). Jpn J Clin Oncol PubMed
  2. Prisco D, Paniccia R, Bandinelli B, et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Thromb Res 1998;1:105-12.
  3. Grimsgaard S, Bonaa KH, Hansen JB, Nordoy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr 1997;66:649-59.
  4. Toft I, Bonaa KH, Ingebretsen OC, et al. Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. Ann Intern Med 1995;123:911-8.
  5. Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
  6. Vandongen R, Mori TA, Burke V, et al. Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease. Hypertension 1993;22:371-9. PubMed
  7. FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
  8. Pedersen HS, Mulvad G, Seidelin KN, et al. N-3 fatty acids as a risk factor for haemorrhagic stroke. Lancet 1999;353:812-3. PubMed
  9. Ito Y, Suzuki K, Imai H, et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. Cancer Lett 2001;163:171-8. PubMed
  10. Kris-Ehterton PM, Harris WS, Appel LJ, et al. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-57. PubMed
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See these in context on the Docosahexaenoic Acid (dha) monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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