Interactions on record — worth a quick check against your medications. Based on 7 of 9 ingredients. Check your meds →
Dietary supplement

G-Curve Ingredients & Drug Interactions

by Nature's Craft

G-Curve label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking G-Curve against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

G-Curve is a dietary supplement by Nature's Craft with 9 active ingredients. Its ingredients are commonly taken for erectile dysfunction, low libido, fatigue and low energy.Based on those ingredients, 1,082 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed Aerial Parts Extract, L-Arginine, Tribulus terrestris Aerial Parts Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against G-Curve by Nature's Craft

Ask about any prescription or over-the-counter medication and we check it for interactions with G-Curve by Nature's Craft — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of G-Curve by Nature's Craft

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.
  • “Horny Goat Weed Aerial Parts Extract” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.
  • “G-Curve Proprietary Blend” is a proprietary blend — the label gives one combined amount (590 mg) without saying how much of each component you get.

G-Curve contains 9 ingredients. The active ones are L-arginine (which widens blood vessels and increases nitric oxide), Panax ginseng, saw palmetto, muira puama, maca, tongkat ali, tribulus terrestris, polypodium vulgare, and icariins.

The product also contains inactive ingredients (rice flour, bovine gelatin, and magnesium stearate) as fillers and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Sexual function and athletic performance support.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual dysfunction, Sexual desire, Male infertility, Athletic performance, Muscle strength — and 4 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire.
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.

The evidence is mixed and mostly limited. L-arginine has no effectiveness rating on file here.

Saw palmetto is possibly ineffective for benign prostatic hyperplasia (enlarged prostate) but possibly effective for transurethral resection of the prostate (TURP); for other uses like hair loss and urinary symptoms, the evidence is insufficient to rate. Tongkat ali is possibly effective for sexual desire but possibly ineffective for athletic performance; evidence is insufficient for back pain, osteoporosis, and diabetes.

Tribulus terrestris is possibly effective for sexual dysfunction but possibly ineffective for athletic performance; evidence is insufficient for benign prostatic hyperplasia. For muira puama, maca, and polypodium vulgare, the evidence for their intended uses is insufficient to rate.

We hold no effectiveness data for Panax ginseng or icariins.

The evidence, ingredient by ingredient Horny Goat Weed L-arginine Saw Palmetto Muira Puama Maca Eurycoma Longifolia Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated short-term, but important cautions apply. L-arginine often causes stomach upset — abdominal pain, bloating, nausea, diarrhea, headache, and flushing — and can lower blood pressure, so it's not safe for everyone.

Saw palmetto is generally well tolerated with mild side effects (abdominal pain, constipation, diarrhea, headache, nausea), though rare heart problems have been reported; it is likely unsafe in pregnancy and while breastfeeding. Muira puama, maca, and tribulus terrestris have limited human safety data; tribulus has rare reports of liver and kidney injury and seizures.

Tongkat ali may increase testosterone beyond safe ranges, risking acne, insulin resistance, and liver damage. Maca may cause stomach pain if consumed uncooked.

None of these ingredients should be used during pregnancy or while breastfeeding except L-arginine, which is possibly safe in pregnancy — but you must talk to your doctor first before using any of them.

Side effects, ingredient by ingredient Horny Goat Weed L-arginine Saw Palmetto Muira Puama Maca Eurycoma Longifolia Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Tribulus, L-arginine, Saw Palmetto, Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 621 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking G-Curve, have your pharmacist check your exact medications against these drug types: blood pressure medications (antihypertensives), ACE inhibitors, ARBs, blood thinners (anticoagulants and antiplatelet drugs), potassium-sparing diuretics, diabetes medications, birth control pills and estrogen therapy, propranolol (a beta-blocker), lithium, and sildenafil (Viagra). All of these have documented moderate interactions with one or more ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

G-Curve is marketed for sexual function and performance, but the evidence for most of its ingredients is insufficient or mixed. More importantly, it carries moderate to serious interaction risks with blood pressure medications, blood thinners, diabetes drugs, birth control, and several others.

If you take any prescription medications — especially for heart, blood pressure, blood clotting, diabetes, or hormones — check with your pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about G-Curve, straight from the product label.

Brand Nature's Craft
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 296798
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Female (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for G-Curve by Nature's Craft, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
L-Arginine0 NP--
Panax ginseng, Powder0 NP--
Saw Palmetto, Powder0 NP--
Muira Puama, Powder0 NP--
Maca, Powder0 NP--
Tongkat Ali, Powder0 NP--
Tribulus terrestris Aerial Parts Extract0 NP--
Polypodium vulgare, Powder0 NP--
Horny Goat Weed Aerial Parts Extract1000 mg--
Icariins10 mg--
G-Curve Proprietary Blend590 mg--

Other ingredients: Rice Flour, Bovine Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 2 capsules daily preferably with food 1 to 2 hours prior to physical activity or as directed by a healthcare professional.

Precautions

Caution: Do not exceed recommended dose.

This product is not intended for pregnant or nursing mothers, children under the age of 18, or individuals with a known medical condition. If you are taking medication or have questions about the advisability of taking this product, consult you physician prior to use.

This product is not intended for pregnant or nursing mothers, children under the age of 18, or individuals with a known medical condition. If you are taking medication or have questions about the advisability of taking this product, consult you physician prior to use. Keep out of the reach of children.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Follow us on: Twitter Facebook Instagram bynaturescraft

Please recycle.

Brand IP Statement(s)

New look Same craft Nature's Craft

Formula

Advanced formula for women

With Maca Root Powder

Women's wellness

Formulation

Female enhancement Mood & energy support

Non GMO

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in the USA with Global Ingredients Sourced from a GMP Certified Facility Made in an FDA Inspected Facility 3rd Party Lab Verified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

G-Curve by Nature's Craft label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

G-Curve label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in G-Curve by Nature's Craft

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Horny Goat Weed Aerial Parts Extract

Interacts with
963 drugs
1000 mg per serving Form: Epimedium sagittatum Aerial Parts Extract

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...

Horny Goat Weed Aerial Parts Extract monograph & interactions
  • › Icariins

G-Curve Proprietary Blend

590 mg per serving

Other (inactive) ingredients: Rice Flour, Bovine Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

G-Curve by Nature's Craft Drug Interactions

Want to check YOUR meds against G-Curve?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,082Drugs
1,058 Moderate 24 Minor

Ingredients driving the most interactions

Horny Goat Weed Aerial Parts Extract 963
L-Arginine 403
Tribulus terrestris Aerial Parts Extract 259
Tongkat Ali, Powder 248
Saw Palmetto, Powder 174

Individual Drug Interactions

The ingredients in G-Curve interact with 1,082 drugs. Click any drug to see the details.

5 of the 9 ingredients in G-Curve interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed Aerial Parts Extract L-Arginine Tribulus terrestris Aerial Parts Extract Tongkat Ali, Powder Saw Palmetto, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in G-Curve with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed Aerial Parts Extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed Aerial Parts Extract full monograph & interactions

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

Tribulus terrestris Aerial Parts Extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris Aerial Parts Extract full monograph & interactions

Tongkat Ali, Powder5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali, Powder full monograph & interactions

Saw Palmetto, Powder3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for G-Curve, from the product label.

Nature's Craft

See all Nature's Craft products
Name
Nature's Craft
City
Pomona
State
NY
ZipCode
10970
Phone Number
408-599-3841
Web Address
shopnaturescraft.com
Pharmacist Counseling Corner

G-Curve by Nature's Craft: Common Questions

Does G-Curve by Nature's Craft interact with any medications?
Yes. Based on its ingredients, G-Curve has a known interaction with 1,082 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
G-Curve contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-arginine safe to take if I have high blood pressure?
Not without your doctor's input. L-arginine lowers blood pressure and can cause dangerously low pressure (hypotension) when combined with blood pressure medications, ACE inhibitors, or ARBs. If you're on any of these, talk to your doctor before using this product.
Can this product affect my birth control?
Yes. Saw palmetto in this formula might reduce the effectiveness of birth control pills and hormone therapy because it may have anti-estrogen effects. If you rely on hormonal contraception, check with your pharmacist first.
What are the most common side effects I might notice?
L-arginine commonly causes abdominal pain, bloating, nausea, diarrhea, headache, and flushing. Saw palmetto may cause abdominal pain, constipation, diarrhea, headache, and nausea. Most side effects are mild and reversible, but stop the product and call your pharmacist if they're severe or persistent.
Is this safe to use during pregnancy or while breastfeeding?
L-arginine is possibly safe in pregnancy, but the other ingredients — saw palmetto, muira puama, maca, tongkat ali, and tribulus terrestris — lack sufficient safety data or are likely unsafe. Don't use this product during pregnancy or while breastfeeding unless your doctor advises otherwise.
Does this product actually work for sexual function?
Tribulus and tongkat ali are possibly effective for sexual dysfunction based on the evidence we hold, but the data are limited. For most of the other ingredients, evidence is insufficient to say whether they work. Results vary widely, and this product is not a substitute for medical care if you have underlying health issues.
Can this product affect my diabetes medications?
Yes. Both L-arginine and tribulus can lower blood sugar, so taking them with diabetes medications might lower your blood sugar too much (hypoglycemia). Your doctor may need to adjust your diabetes medication dose if you use this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

G-Curve label
Go deeper

The Full Monographs Behind G-Curve’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Muira Puama

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limited, so its benefits are not well proven,...

Read the full Muira Puama monograph → Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

G-Curve's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 116 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
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Saw Palmetto 22 references
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Muira Puama 2 references
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Maca 1 reference
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Eurycoma Longifolia 4 references
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Tribulus 10 references
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Horny Goat Weed 11 references
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