Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Genius Lion's Mane Ingredients & Drug Interactions

by The Genius Brand

Genius Lion's Mane label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Genius Lion's Mane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Genius Lion's Mane is a dietary supplement by The Genius Brand with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Genius Lion's Mane by The Genius Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Genius Lion's Mane by The Genius Brand — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Genius Lion's Mane by The Genius Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Genius Lion's Mane is a single-ingredient supplement — just lion's mane mushroom in capsule form. The capsules also contain inactive ingredients (hypromellose, rice husk, and rice flour) that help hold the capsule together and keep the powder stable on the shelf.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports focus, memory, and mood.
  • We looked for evidence on: Memory, Cognitive function, Anxiety, Depression, Mental clarity, Emotional wellness — and 1 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Depression, Memory.

The evidence for lion's mane isn't established yet. Our data shows insufficient reliable evidence to rate it for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment — all the main reasons people try it.

That doesn't mean it doesn't work; it means the research we have so far isn't solid enough to make a claim either way. If you're considering it for one of these reasons, talk with your doctor about what the current science actually shows.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated when used as a food, but how safe it is as a long-term supplement hasn't been studied much. The most common side effects are gastrointestinal discomfort, nausea, and skin rash.

The safety data available doesn't support use during pregnancy or while breastfeeding — there simply isn't enough information to know whether it's safe for your baby, so it's best to avoid it during those times.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you're on blood thinners or antiplatelet drugs (like warfarin or aspirin), diabetes medications, or immunosuppressants, double-check with your pharmacist before taking this product. These are Moderate-severity interactions that could affect how your medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane might appeal to you if you're interested in cognitive support, but the evidence isn't there yet to back that up. If you take blood thinners, diabetes medications, or immunosuppressants, check with your pharmacist before starting — these interactions matter.

For everyone else, the main caution is that long-term safety data is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Genius Lion's Mane, straight from the product label.

Brand The Genius Brand
Net contents 120 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 312633
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Genius Lion's Mane by The Genius Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
60
IngredientAmount% DV
Lion's Mane1200 mg--

Other ingredients: Hypromellose, Rice Husk, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Organic mushrooms

Grown in the USA

Supports focus, memory, & mood

Organic & Non-GMO

Nurture mind, body & spirit

No: Banned substances Proprietary blends Artificial flavors Unnecessary fillers Preservatives GMO Soy

Formula

Genius Lion's Mane 1200mg per serving

FDA Statement of Identity

Dietary Supplement

General Statements

Two months supply

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Genius Lion's Mane by The Genius Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Genius Lion's Mane label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Genius Lion's Mane by The Genius Brand

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Lion's Mane

Interacts with
327 drugs
1200 mg per serving Form: Hericium erinaceus Fruiting Body Extract, Hericium erinaceus, Oats

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Husk, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Genius Lion's Mane by The Genius Brand Drug Interactions

Want to check YOUR meds against Genius Lion's Mane?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane 327

Individual Drug Interactions

The ingredients in Genius Lion's Mane interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Genius Lion's Mane interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane

Each ingredient & the kinds of drugs it affects

For each ingredient in Genius Lion's Mane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Genius Lion's Mane, from the product label.

The Genius Brand

See all The Genius Brand products
Name
The Genius Brand
Pharmacist Counseling Corner

Genius Lion's Mane by The Genius Brand: Common Questions

Does Genius Lion's Mane by The Genius Brand interact with any medications?
Yes. Based on its ingredients, Genius Lion's Mane has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Genius Lion's Mane contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is lion's mane safe during pregnancy or breastfeeding?
The safety data doesn't support it during either pregnancy or breastfeeding — there simply isn't enough information to know either way. Talk with your OB or pharmacist about whether it's right for you during these times.
What side effects might I notice?
Most people tolerate it well, but some experience gastrointestinal discomfort, nausea, or a skin rash. If any of these bother you, stop and let us know.
Does lion's mane actually work for memory or focus?
The evidence isn't solid enough yet to say for certain. We have insufficient reliable evidence to rate it for cognitive function, cognitive impairment, or Alzheimer disease — the main reasons people try it.
Why does this product only have one ingredient?
This is a single-herb supplement, so it's just lion's mane mushroom. The other ingredients listed (rice husk, rice flour, hypromellose) are inactive — they're just there to make the capsule and keep it stable.
Can I take this if I'm on a blood thinner?
Not without checking with your pharmacist first. Lion's mane may increase your bleeding risk when combined with blood thinners or antiplatelet drugs like aspirin or warfarin. Get personalized advice before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Genius Lion's Mane is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Genius Lion's Mane label
Go deeper

The Full Monographs Behind Genius Lion's Mane’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Genius Lion's Mane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team