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Dietary supplement

Gentian Root 500 mg Ingredients & Drug Interactions

by Solaray

Gentian Root 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gentian Root 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gentian Root 500 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gentian. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gentian Root 500 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Gentian Root 500 mg by Solaray — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gentian Root 500 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gentian root at 500 mg per capsule. Gentian is a plant root used traditionally to support digestive and other health functions.

The capsule itself is made of vegetable cellulose, an inactive ingredient that holds the gentian powder.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Gentian product and its label doesn't state a use — see Gentian's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for gentian root is limited. Our data shows insufficient reliable evidence to rate it for wound healing, obesity, rhinosinusitis (sinus infection), or gastritis (stomach inflammation).

If you're considering gentian for any of these purposes, the research we hold doesn't yet establish whether it works.

The evidence, ingredient by ingredient Gentian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gentian is generally well tolerated in small amounts by healthy adults, but it can upset your stomach and hasn't been studied at higher doses. Because of limited safety data and traditional concerns, it's best avoided during pregnancy.

There isn't enough reliable safety information to use it while breastfeeding either — talk with your doctor or pharmacist if you're pregnant or nursing and want personalized advice. When gentian was used in combination with turmeric and ginger in a clinical study, some participants experienced nausea, vomiting, diarrhea, and bloating — though it's unclear whether gentian alone or the combination caused these symptoms.

Gastrointestinal side effects are possible, especially at higher doses or when combined with other herbs.

Side effects, ingredient by ingredient Gentian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gentian.
  • The most serious interaction on file is rated Moderate.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any blood pressure medication (antihypertensive drugs), double-check with your doctor or pharmacist before starting gentian. Combining them could theoretically lower your blood pressure too much.

Run your exact medications through the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gentian Root may be worth considering if you're interested in its traditional uses, but the science doesn't yet confirm it works for the conditions commonly claimed. The main caution is its interaction with blood pressure medications — if you take a drug to manage high blood pressure, check with your doctor or pharmacist before adding this supplement.

Pregnancy and breastfeeding are reasons to avoid it unless your healthcare provider advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gentian Root 500 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280392906
Net contents 100 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 24, 2015
DSLD ID 53207
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gentian Root 500 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
076280392906
IngredientAmount% DV
Gentian500 mg--

Other ingredients: Vegetable Cellulose Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

This product contains a substance known to the state of California to cause birth defects or reproductive harm.

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

9314724 0415

FDA Statement of Identity

Dietary Supplement

Formula

Gentiana lutea 500 mg per capsule

Seals/Symbols

Green Screened

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take one vegetarian capsule daily with a meal or glass of water.

Storage

Store in a cool, dry place.

General Statements

Discussion: Gentian root is a bitter herb that comes from the yellow gentian plant. It has been used throughout central and southern Europe dating back over 3,000 years.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gentian Root 500 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gentian Root 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gentian Root 500 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Gentian

Interacts with
172 drugs
500 mg per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gentian Root 500 mg by Solaray Drug Interactions

Want to check YOUR meds against Gentian Root 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Moderate

Ingredients driving the most interactions

Gentian 172

Individual Drug Interactions

The ingredients in Gentian Root 500 mg interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gentian Root 500 mg interact with drugs. Each result below shows which ingredient is responsible. Gentian

Each ingredient & the kinds of drugs it affects

For each ingredient in Gentian Root 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gentian Root 500 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutrafamily.com
Pharmacist Counseling Corner

Gentian Root 500 mg by Solaray: Common Questions

Does Gentian Root 500 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Gentian Root 500 mg has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gentian Root 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Gentian Root if I'm pregnant?
No. There isn't enough safety data, and traditional cautions exist, so gentian is best avoided during pregnancy. Talk with your doctor or pharmacist for personalized advice if you're pregnant or planning to become pregnant.
Can I take Gentian Root while breastfeeding?
No. There isn't enough reliable safety information to use gentian while breastfeeding. Discuss this with your doctor or pharmacist if you're nursing and want to know your options.
What side effects can gentian cause?
Gentian can upset your stomach. In a study using gentian with turmeric and ginger, some participants reported nausea, vomiting, diarrhea, and bloating — though it's unclear if gentian alone caused these. Gastrointestinal upset is possible, especially at higher doses or when combined with other herbs.
Does gentian root actually work for wound healing, weight loss, or sinus problems?
The evidence we have is insufficient to rate gentian for wound healing, obesity, or rhinosinusitis. Research hasn't yet established whether it's effective for these uses, so we can't say one way or the other.
Will gentian interact with my blood pressure medicine?
Possibly. Gentian can theoretically increase the risk of low blood pressure when combined with antihypertensive drugs. Check your exact medications using the search tool on this page, and ask your doctor or pharmacist whether it's safe to take gentian with your prescriptions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gentian Root 500 mg label
Go deeper

The Full Monographs Behind Gentian Root 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph →
Sources

Sources & How We Checked

Gentian Root 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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