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Dietary supplement

Blue Skullcap 425 mg Ingredients & Drug Interactions

by Solaray

Blue Skullcap 425 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Blue Skullcap 425 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Blue Skullcap 425 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Blue Skullcap. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Blue Skullcap 425 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Blue Skullcap 425 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Blue Skullcap 425 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Blue Skullcap (skullcap), 425 mg per capsule. The capsule itself is made with cellulose, an inert filler.

Skullcap is a traditional herb that's been used for various purposes, though the evidence supporting those uses remains incomplete.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: herbal support for relaxation and wellness.
  • We looked for evidence on: Anxiety, Insomnia, Stress, nervous tension, muscle tension.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

We don't have reliable evidence yet for skullcap's effectiveness in any condition. The data we hold rates all six uses we checked — epilepsy, stress, stroke, spasticity, contact dermatitis, and premenstrual dysphoric disorder (mood and physical symptoms around your period) — as insufficient to know whether it works.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is generally well tolerated in short-term use, but the safety picture is incomplete because evidence is limited and product quality varies. The most common side effects reported are sedation, cognitive impairment (trouble thinking clearly or remembering), and digestive upset.

About 9% of people in a trial taking a higher dose experienced mild digestive disturbances. One person reported vivid dreams, though it's unclear whether skullcap caused it.

Don't use this product during pregnancy — there isn't enough safety data. Avoid it while breastfeeding as well, since safety is unknown.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any CNS depressants (sleep aids, anti-anxiety drugs, some antidepressants, narcotic pain relievers) and alcohol before adding this product. Skullcap can add to their sedating effects, so combining them requires a pharmacist's review of your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Blue Skullcap might be worth trying if you're exploring traditional remedies for stress or sleep, but know that evidence for it is incomplete. If you take any CNS depressants — sleep aids, anti-anxiety medications, some antidepressants, pain relievers, or drink alcohol — check with your pharmacist before starting.

And since you're avoiding it in pregnancy and breastfeeding anyway, talk with your doctor or pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Blue Skullcap 425 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280015607
Net contents 100 VegCap(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 338861
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Blue Skullcap 425 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
100
UPC/BARCODE
076280015607
IngredientAmount% DV
Blue Skullcap425 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A brighter way 1973

General Statements

True herbs

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR bottles

Formulation

Herbal support

Non GMO Project Verified nongmoproject.org

Vegan

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Non GMO Project Verified nongmoproject.org Lab Verified Vegan

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product. Directions: Use only as directed.

Keep out of reach of children.

California Residents Only Warning: Reproductive Harm - www.P65Warnings.ca.gov

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 1 VegCap three times daily with a meal or glass of water.

Storage

Store in a cool, dry place.

Formula

Discussion: Skullcap has a long history of use among Native American tribes due to it's soothing properties.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Blue Skullcap 425 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Blue Skullcap 425 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Blue Skullcap 425 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Blue Skullcap

Interacts with
248 drugs
425 mg per serving Form: Scutellaria lateriflora

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Blue Skullcap monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Blue Skullcap 425 mg by Solaray Drug Interactions

Want to check YOUR meds against Blue Skullcap 425 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Blue Skullcap 248

Individual Drug Interactions

The ingredients in Blue Skullcap 425 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Blue Skullcap 425 mg interact with drugs. Each result below shows which ingredient is responsible. Blue Skullcap

Each ingredient & the kinds of drugs it affects

For each ingredient in Blue Skullcap 425 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Blue Skullcap1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Blue Skullcap full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Blue Skullcap 425 mg, from the product label.

Solaray

See all Solaray products
Name
Solaray
City
Salt Lake City
State
UT
ZipCode
84101
Phone Number
800-538-5888
Web Address
www.solaray.com
Pharmacist Counseling Corner

Blue Skullcap 425 mg by Solaray: Common Questions

Does Blue Skullcap 425 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Blue Skullcap 425 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Blue Skullcap 425 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects might I experience from Blue Skullcap?
The most commonly reported side effects are sedation, trouble thinking clearly or remembering, and digestive upset. One person reported vivid dreams, though we can't say for sure skullcap caused it. Data on side effects is limited overall.
Can I take this if I'm pregnant or breastfeeding?
No — skip it during pregnancy because there isn't enough safety data. Avoid it while breastfeeding too, since safety is unknown. Talk with your doctor or pharmacist about alternatives.
Does skullcap actually work for stress or sleep?
We don't have reliable evidence yet that it works for stress. The evidence is too incomplete to know either way right now.
Is this safe to use long-term?
Skullcap is typically used short-term, and that's what the evidence focuses on. Because product quality varies and safety data is limited, use it with care and talk with your pharmacist about how long is appropriate for you.
Why does this interact with so many medications?
The 248 medications reflect one interaction category: CNS depressants. That's a broad class of drugs (sleep aids, anxiety medications, some antidepressants, pain relievers, and alcohol) that all slow brain activity, so skullcap's own sedating effects can add to theirs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Blue Skullcap 425 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Blue Skullcap 425 mg label
Go deeper

The Full Monographs Behind Blue Skullcap 425 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Blue Skullcap 425 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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