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Dietary supplement

Skullcap Alcohol-Free Ingredients & Drug Interactions

by Herb Pharm

Skullcap Alcohol-Free label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Skullcap Alcohol-Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Skullcap Alcohol-Free is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Skullcap Flowering Aerial Parts Extract, Fresh, Undried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Skullcap Alcohol-Free by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Skullcap Alcohol-Free by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Skullcap Alcohol-Free by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: skullcap flowering aerial parts extract made from fresh, undried plants. The liquid is prepared with glycerin and distilled water as inactive ingredients.

Skullcap has a long history in herbal medicine, though clinical evidence on how well it actually works remains limited.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Skullcap's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: nervous system restore and tone.
  • We looked for evidence on: Anxiety, Insomnia, Stress, Spasticity, Nervousness, Muscle tension — and 2 related terms.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress, Spasticity.

The evidence we hold doesn't establish that skullcap is effective for any of its traditional uses — epilepsy, stress, stroke recovery, spasticity, contact dermatitis, or premenstrual dysphoric disorder (PMDD) — because the reliable data just isn't there yet. That doesn't mean it doesn't work; it means researchers haven't confirmed it in the quality of studies needed to make that call.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap can cause sedation, cognitive impairment (trouble thinking clearly), and digestive upset. In one small study, about 9% of people taking skullcap three times daily reported mild digestive disturbances.

Single lower doses seem gentler, but higher doses — especially over time — carry a bigger risk of sedation and muddiness. One person reported vivid dreams at a very high dose, though it's unclear whether skullcap caused it.

The safety data during pregnancy advises against use. Breastfeeding safety isn't known, so it's best avoided then too.

Talk with your doctor or pharmacist if you're pregnant, planning to be, or breastfeeding and considering this product.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use any CNS depressants — sedatives, sleep aids, anti-anxiety medications, opioid painkillers, or products that list drowsiness as a side effect. Skullcap can add to that drowsiness and make it harder to think clearly.

The interaction is Moderate, not Major, but it's real enough to confirm your medications are safe to combine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Skullcap Alcohol-Free is generally well tolerated at lower doses but carries a Moderate interaction risk with sedating medications and other CNS depressants. If you take any drug that makes you drowsy or affects your brain function, check with your doctor or pharmacist before starting.

Avoid it during pregnancy and breastfeeding, and be aware that the evidence for what it actually does is still limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Skullcap Alcohol-Free, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700002916
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307685
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Skullcap Alcohol-Free by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
168
UPC/BARCODE
090700002916
IngredientAmount% DV
Skullcap Flowering Aerial Parts Extract, Fresh, Undried810 mg--

Other ingredients: Glycerin, Water, Distilled

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake well before using Adults: Add 1 squeeze of the dropper bulb to 2 oz of water or juice, 2 to 5 times per day. Best taken between meals.

Precautions

Keep out of the reach of children

Storage

Store away from heat & light

Formula

Scutellaria lateriflora

Skullcap glycerite

Formulation

Nervous system Restore & tone

Gluten-free Contains no alcohol

Certified organic by Organic Certifiers

Seals/Symbols

USDA Organic

FDA Statement of Identity

Herbal Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Skullcap Alcohol-Free by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Skullcap Alcohol-Free label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Skullcap Alcohol-Free by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container168 Amounts shown are per serving.

Skullcap Flowering Aerial Parts Extract, Fresh, Undried

Interacts with
248 drugs
810 mg per serving Form: Scutellaria lateriflora Flowering Aerial Parts Extract, Fresh, Undried

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Skullcap Flowering Aerial Parts Extract, Fresh, Undried monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Distilled. These complete the product’s ingredient list but are not active constituents.

Interaction report

Skullcap Alcohol-Free by Herb Pharm Drug Interactions

Want to check YOUR meds against Skullcap Alcohol-Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Skullcap Flowering Aerial Parts Extract, Fresh, Undried 248

Individual Drug Interactions

The ingredients in Skullcap Alcohol-Free interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Skullcap Alcohol-Free interact with drugs. Each result below shows which ingredient is responsible. Skullcap Flowering Aerial Parts Extract, Fresh, Undried

Each ingredient & the kinds of drugs it affects

For each ingredient in Skullcap Alcohol-Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Skullcap Flowering Aerial Parts Extract, Fresh, Undried1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Skullcap Flowering Aerial Parts Extract, Fresh, Undried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Skullcap Alcohol-Free, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Skullcap Alcohol-Free by Herb Pharm: Common Questions

Does Skullcap Alcohol-Free by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Skullcap Alcohol-Free has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Skullcap Alcohol-Free contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's in this skullcap product?
It's a liquid extract made from fresh, undried skullcap flowering aerial parts (the upper leaves and flowers), prepared with glycerin and distilled water. There's one active ingredient total.
Does skullcap actually work for anxiety or sleep?
The reliable evidence we have doesn't establish that it does — not yet, anyway. Skullcap is used traditionally for stress and other conditions, but clinical studies haven't confirmed it works for any of those uses.
What are the main side effects?
Sedation, trouble thinking clearly, and digestive upset are the most common ones reported. About 9% of people in one study had mild digestive problems. Higher doses carry a bigger risk of these effects.
Is it safe to take while pregnant or breastfeeding?
No — the safety data advises against use during pregnancy, and breastfeeding safety isn't known, so it's best avoided then too. Talk with your doctor or pharmacist if you're pregnant, planning to be, or breastfeeding.
Does this interact with sleeping pills or anxiety medications?
Yes — it's a Moderate interaction. Skullcap causes sedation and cognitive impairment itself, so combining it with CNS depressants (sedatives, sleep aids, anti-anxiety drugs, painkillers) can add to those effects. Check with your doctor or pharmacist first.
How long can you take skullcap safely?
It's usually used short-term, but evidence on long-term safety is limited and product quality varies. Talk with your doctor or pharmacist about how long is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Skullcap Alcohol-Free label
Go deeper

The Full Monographs Behind Skullcap Alcohol-Free’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Skullcap Alcohol-Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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