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Dietary supplement

Barbed Skullcap Ingredients & Drug Interactions

by Herbal Terra

Barbed Skullcap label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Barbed Skullcap against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Barbed Skullcap is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, nervous tension.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Barbed Skullcap Root Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Barbed Skullcap by Herbal Terra

Ask about any prescription or over-the-counter medication and we check it for interactions with Barbed Skullcap by Herbal Terra — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Barbed Skullcap by Herbal Terra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: a Barbed Skullcap Root Extract in dry form. Skullcap has been used traditionally to support relaxation and calm, though the evidence for most of those uses hasn't been firmly established.

The liquid formulation includes alcohol, water, and glycerin as inactive ingredients to deliver the extract.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Anxiety, stress, and sleep support.
  • We looked for evidence on: Anxiety, Insomnia, Stress, Nervous tension, Relaxation, Sleep quality.
  • The closest evidence on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Skullcap is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence we hold doesn't establish that barbed skullcap is effective for any of the conditions it's been studied for — epilepsy, stress, stroke, spasticity, contact dermatitis, or premenstrual dysphoric disorder (PMDD). All of those have been rated insufficient reliable evidence to rate.

That doesn't mean skullcap doesn't work; it means the data available to us isn't strong enough to say either way.

The evidence, ingredient by ingredient Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Skullcap is often used for short periods, but evidence on its safety is limited and product quality varies, so use it with care. The most commonly reported side effects when taken by mouth are cognitive impairment, digestive disturbances, and sedation.

At a 100 mg dose, adverse effects on the brain weren't seen in research; however, at 200 mg or higher, sedation and cognitive impairment appeared more likely. One person taking 350 mg three times daily for 2 weeks reported vivid dreams, though it's unclear if skullcap caused it.

Mild digestive issues showed up in roughly 9% of people taking the 350 mg three-times-daily dose over 2 weeks. The safety data advises against skullcap during pregnancy.

While breastfeeding, safety is unknown, so it's best to avoid it. If you're pregnant, planning pregnancy, or breastfeeding, talk with your pharmacist or doctor before taking this.

Side effects, ingredient by ingredient Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Skullcap.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check any CNS depressants you're on — that includes sleep aids, benzodiazepines (like diazepam), barbiturates, and opioids. These drugs can have additive sedating effects when combined with skullcap, raising the risk of drowsiness and cognitive impairment.

Use the medication checker on this page to look up your exact prescriptions and over-the-counter medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Barbed Skullcap may be worth considering if you're looking to support relaxation, but the evidence for its effectiveness hasn't been established. If you take any medications — especially sleep aids, benzodiazepines, opioids, or other sedating drugs — you need to check them against the interaction list here first.

Don't use it in pregnancy, and be cautious if breastfeeding. Talk to your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Barbed Skullcap, straight from the product label.

Brand Herbal Terra
Barcode (UPC) 7439500545538
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 324793
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Barbed Skullcap by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
7439500545538
IngredientAmount% DV
Barbed Skullcap Root Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.

Precautions

We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.

Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!

Do not use if you are allergic to any ingredients.

Storage

Store in a cool, dry, dark place.

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

Formulation

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Sugar free

Expertly extracted 100% natural Premium product

Organic alcohol

No artificial ingredients, color additives, fillers or binders.

Natural Gluten free

Formula

Scutellaria barbata

Organic alcohol

FDA Statement of Identity

Herbal Supplement

General Statements

Organic raw material.

Seals/Symbols

Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Barbed Skullcap by Herbal Terra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Barbed Skullcap label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Barbed Skullcap by Herbal Terra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Barbed Skullcap Root Extract, Dry

Interacts with
248 drugs
983 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Barbed Skullcap Root Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Barbed Skullcap by Herbal Terra Drug Interactions

Want to check YOUR meds against Barbed Skullcap?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
248 Moderate

Ingredients driving the most interactions

Barbed Skullcap Root Extract, Dry 248

Individual Drug Interactions

The ingredients in Barbed Skullcap interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Barbed Skullcap interact with drugs. Each result below shows which ingredient is responsible. Barbed Skullcap Root Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Barbed Skullcap with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Barbed Skullcap Root Extract, Dry1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Barbed Skullcap Root Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Barbed Skullcap, from the product label.

Herbal Terra

See all Herbal Terra products
Name
Herbal Terra LLC
Phone Number
+18083857868
Web Address
herbalterra.com
Pharmacist Counseling Corner

Barbed Skullcap by Herbal Terra: Common Questions

Does Barbed Skullcap by Herbal Terra interact with any medications?
Yes. Based on its ingredients, Barbed Skullcap has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Barbed Skullcap contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
No. The safety data advises against skullcap during pregnancy. Talk with your pharmacist or doctor about alternatives if you're pregnant or planning pregnancy.
What are the most common side effects?
The main ones we know about are sedation, cognitive impairment (like trouble thinking clearly), and digestive disturbances. At higher doses, sedation and cognitive issues are more likely. Around 9% of people in trials had mild digestive problems.
Is this proven to help with stress?
The evidence available to us isn't strong enough to say whether it works for stress. It's been studied for that, but the results are rated insufficient reliable evidence to rate.
Can I breastfeed while taking this?
Safety while breastfeeding isn't known, so it's best to avoid it. If you're breastfeeding and interested in skullcap, talk with your pharmacist or doctor first.
Why does this product have alcohol in it?
The alcohol is an inactive ingredient — it's used as a solvent to deliver the skullcap extract in liquid form. It also helps preserve the product. Keep in mind that alcohol can add to any sedating effects of skullcap itself.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Barbed Skullcap is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Barbed Skullcap label
Go deeper

The Full Monographs Behind Barbed Skullcap’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Barbed Skullcap's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Skullcap 3 references
  1. Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med 2003;9:74-8.
  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
  3. Brock C, Whitehouse J, Tewfik I, Towell T. American skullcap (Scutellaria lateriflora): a randomised, double-blind placebo-controlled crossover study of its effects on mood in healthy volunteers. Phytother Res 2014;28(5):692-8.

See these in context on the Skullcap monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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