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Dietary supplement

Guggul Gold 500 mg Ingredients & Drug Interactions

by NutriGold

Guggul Gold 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Guggul Gold 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Guggul Gold 500 mg is a dietary supplement by NutriGold with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, joint pain and arthritis, weight management.Based on those ingredients, 757 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Guggul extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Guggul Gold 500 mg by NutriGold

Ask about any prescription or over-the-counter medication and we check it for interactions with Guggul Gold 500 mg by NutriGold — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Guggul Gold 500 mg by NutriGold

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Guggul Gold contains one active ingredient: organic guggul extract at 500 mg per capsule. Guggul is a resin from the mukul myrrh tree, traditionally used in Ayurvedic medicine.

The capsule itself is vegan, and the product includes organic olive oil and gum acacia as inactive ingredients to help deliver the extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Guggul's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports thyroid health and cholesterol levels.
  • We looked for evidence on: Hypercholesterolemia, thyroid function, lipid management.
  • The closest evidence on file: Guggul is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia (Natural Medicines).

The evidence for guggul's benefits is mixed and limited. For obesity, research suggests it's possibly ineffective.

For acne, hemorrhoids, and high cholesterol, we don't have enough reliable evidence to say whether it works. If you're considering this supplement for any of those reasons, talk it over with your doctor or pharmacist—they can help you weigh what limited data exists against other options.

The evidence, ingredient by ingredient Guggul

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guggul is generally well tolerated when taken by mouth, but digestive upset is common: belching, bloating, diarrhea, headache, nausea, unpleasant taste, and vomiting can all happen. Skin reactions—rashes, itching, and in rare cases more severe reactions like swelling or blistering—have been reported, and the risk goes up with higher doses.

Do not take guggul during pregnancy because it may stimulate the uterus and its safety is not established. There isn't enough safety information to recommend it while breastfeeding, so avoid it during lactation.

Use this supplement only under the guidance of your healthcare provider.

Side effects, ingredient by ingredient Guggul

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Guggul.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 758 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Guggul Gold, double-check with your pharmacist or doctor if you use blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel)—guggul may raise bleeding risk. Also flag birth control pills, estrogen therapy, propranolol, diltiazem, drugs processed through CYP3A4, tamoxifen, and thyroid hormone replacement.

Moderate interactions are documented for all of these drug types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Guggul Gold is a single-ingredient extract with documented interactions across a wide range of medications, especially blood thinners, heart drugs, birth control, and hormone therapy. If you take any prescription medications, check them against the interaction tool on this page before starting.

Talk with your doctor or pharmacist about whether guggul makes sense for your situation and to monitor for digestive or skin side effects.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Guggul Gold 500 mg, straight from the product label.

Brand NutriGold
Barcode (UPC) 859447002302
Net contents 90 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 250943
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Guggul Gold 500 mg by NutriGold, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
859447002302
IngredientAmount% DV
organic Guggul extract500 mg--

Other ingredients: Vegan Capsule, organic extra virgin Olive Oil, organic Gum Acacia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Non-GMO verified, organic Guggul oleoresin standardized to Z & E guggulsterones, and manufactured without the use of chemical additives for exceptional purity.

Health benefits: Supports thyroid health and helps maintain cholesterol levels already within normal range.

Verified free of corn, egg, gluten, milk, peanut, shellfish, and soy allergens by an independent lab. No magnesium stearate, stearic acid, dioxides, sulfates, artificial ingredients, or preservatives.

Gluten-Free

Soy-Free

Certified Vegan vegan.org

Certified organic by SCS Global Services.

Organic gum acacia is part of the ingredient complex and is not added by NutriGold during manufacturing.

Formula

Non-GMO verified, organic Guggul oleoresin standardized to Z & E guggulsterones, and manufactured without the use of chemical additives for exceptional purity.

Made with organic guggul

Ko Kosher Service

General Statements

To learn more about this product, scan QR code or visit nutrigold.com/item/230

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Certified Vegan vegan.org

Certified Organic SCS Global Services

Non GMO Project Verified nongmoproject.org

Ko Kosher Service

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (1) capsule 2 times daily with food, or as directed by a healthcare professional.

Precautions

Caution: Please consult a healthcare professional before taking this supplement if you are pregnant, breastfeeding, or taking any medications.

Keep out of reach of children.

Storage

Store in original container away from moisture and direct sunlight.

FDA Disclaimer Statement

This statement has been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Guggul Gold 500 mg by NutriGold label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Guggul Gold 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Guggul Gold 500 mg by NutriGold

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Organic Guggul extract

Interacts with
757 drugs
500 mg per serving Form: Z & E Guggulsterones

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Organic Guggul extract monograph & interactions

Other (inactive) ingredients: Vegan Capsule, Organic extra virgin Olive Oil, Organic Gum Acacia. These complete the product’s ingredient list but are not active constituents.

Interaction report

Guggul Gold 500 mg by NutriGold Drug Interactions

Want to check YOUR meds against Guggul Gold 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
757Drugs
757 Moderate

Ingredients driving the most interactions

organic Guggul extract 757

Individual Drug Interactions

The ingredients in Guggul Gold 500 mg interact with 757 drugs. Click any drug to see the details.

1 of the 1 ingredient in Guggul Gold 500 mg interact with drugs. Each result below shows which ingredient is responsible. organic Guggul extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Guggul Gold 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Guggul extract9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B
organic Guggul extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Guggul Gold 500 mg, from the product label.

NutriGold

Name
NutriGold Inc.
City
Orem
State
UT
ZipCode
84057
Phone Number
800-476-3542
Web Address
www.nutrigold.com
Pharmacist Counseling Corner

Guggul Gold 500 mg by NutriGold: Common Questions

Does Guggul Gold 500 mg by NutriGold interact with any medications?
Yes. Based on its ingredients, Guggul Gold 500 mg has a known interaction with 757 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Guggul Gold 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take guggul if I'm on birth control?
No—there's a moderate interaction. Guggul acts like estrogen in your body, which could increase your risk of side effects when combined with hormonal birth control. Talk to your doctor before starting guggul if you're using any hormonal contraceptive.
What are the most common side effects?
Digestive issues are most common: belching, bloating, diarrhea, nausea, headache, and an unpleasant taste. Skin reactions like rashes and itching can also occur, especially at higher doses. If either bothers you, stop and check with your pharmacist.
Is guggul safe during pregnancy?
No, guggul is likely unsafe in pregnancy. It may stimulate the uterus, and safety hasn't been established. Avoid it if you're pregnant or planning to become pregnant—talk to your doctor about safer alternatives.
Does guggul really work for weight loss?
Research suggests it's possibly ineffective for obesity. The evidence doesn't support it as a weight-loss aid, so there are likely better-studied options to discuss with your doctor.
What's in this capsule besides guggul?
The capsule itself is vegan, and the product includes organic olive oil and gum acacia as inactive ingredients. There are no fillers or binders beyond those.
Can I take guggul while breastfeeding?
No—there isn't enough safety information, so it's best avoided while breastfeeding. Check with your doctor or pharmacist about whether it's right for you if you're nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Guggul Gold 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Guggul Gold 500 mg label
Go deeper

The Full Monographs Behind Guggul Gold 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Guggul

Interacts with 757 drugs

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...

Read the full Guggul monograph →
Sources

Sources & How We Checked

Guggul Gold 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guggul 21 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Dalvi SS, Nayak VK, Pohujani SM, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Phys India 1994;42:454-5.
  3. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994;8:659-64. PubMed
  4. Tripathi YB, Tripathi P, Malhotra OP, Tripathi SN. Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. Planta Med 1988;54:271-7.
  5. Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid – a new hypolipidemic agent of plant origin in primary hyperlipidemia. Ind J Med Res 1986;84:626-34.
  6. Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977;65:390-5.
  7. Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by "guggulu" steroids. Planta Med 1979;37:367-9. PubMed
  8. Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290:765-72.
  9. Brobst DE, Ding X, Creech KL, et al. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther 2004;310:528-35. PubMed
  10. Bianchi A, Cantu P, Firenzuoli F, et al. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. Ann Pharmacother 2004;38:1222-5.
  11. Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J Am Acad Dermatol 2005;52:533-4 PubMed
  12. Nohr, L. A., Rasmussen, L. B., and Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther.Med. 2009;17(1):16-22. PubMed
  13. Gelfand, J. M., Crawford, G. H., Brod, B. A., and Szazpary, P. O. Adverse cutaneous reactions to guggulipid. J.Am.Acad.Dermatol. 2005;52(3 Pt 1):533-534. PubMed
  14. Kolonte, A., Guillot, B., and Raison-Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis 2006;54(4):226-227. PubMed
  15. Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2007;56(5):286-287. PubMed
  16. Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59:1621-1632.
  17. Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.
  18. Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19:84-86.
  19. Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
  20. Mehdi Z, Fatemeh P, Roja R, et al. Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial. J Tradit Chin Med 2021;41(2):301-307.
  21. Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed

See these in context on the Guggul monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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