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Dietary supplement

HCl & Pepsin Ingredients & Drug Interactions

by Genestra Brands

HCl & Pepsin label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HCl & Pepsin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

HCl & Pepsin is a dietary supplement by Genestra Brands with 3 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against HCl & Pepsin by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with HCl & Pepsin by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of HCl & Pepsin by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains three active ingredients: betaine hydrochloride, lipase, and pepsin. Betaine hydrochloride is a source of hydrochloric acid, which increases stomach acidity.

Lipase and pepsin are digestive enzymes — lipase breaks down fats, and pepsin breaks down proteins. The product also contains several inactive ingredients (hypromellose, silica, and magnesium stearate), which are standard capsule materials and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence supporting these ingredients is limited. Betaine hydrochloride has insufficient reliable evidence for dyspepsia (indigestion), hypothyroidism, diarrhea, rheumatoid arthritis, food allergies, and allergic rhinitis (hay fever).

Lipase has insufficient reliable evidence for inflammatory bowel disease and dyspepsia. For pepsin, no effectiveness data are on file in our system.

If you're considering this product for a specific condition, talk it over with your doctor or pharmacist to see whether the evidence supports using it.

The evidence, ingredient by ingredient Betaine Hydrochloride Lipase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride may irritate the stomach and is not safe for people with ulcers, gastritis, or true acid reflux — it can theoretically irritate or slow healing of ulcers and may cause heartburn. Lipase is generally well tolerated in supplement form, but people with serious digestive conditions should use it only under medical guidance.

Pepsin is generally well tolerated for most adults, though it may cause digestive upset or allergic reactions. Rarely, occupational exposure to pepsin has led to allergic reactions like allergic rhinitis or asthma, though this is uncommon in supplement users.

Side effects, ingredient by ingredient Betaine Hydrochloride Lipase Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you're on H2-blockers (like famotidine or ranitidine), antacids, or proton pump inhibitors (like omeprazole or lansoprazole) — betaine hydrochloride may reduce how well these work. No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product is aimed at supporting digestion through stomach acid and digestive enzymes, but the evidence for its effectiveness is not yet established in our data. It's not appropriate if you have ulcers, gastritis, or acid reflux — and it may interfere with acid-reducing medications.

If you have digestive concerns or take any stomach-related medications, talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HCl & Pepsin, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 88319614550
Net contents 180 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 70779
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HCl & Pepsin by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
88319614550
IngredientAmount% DV
Betaine Hydrochloride650 mg--
Lipase10 mg--
Pepsin150 mg--

Other ingredients: Hypromellose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Adult Dose: Take one capsule with a meal or as recommended by your healthcare practitioner.

Precautions

Risk Information: If you are pregnant or breastfeeding, consult your healthcare practitioner prior to use.

Hypersensitivity/allergy to lipase and pepsin has been known to occur, in which case, discontinue use.

Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken.

Formulation

Guaranteed to contain no added wheat, starch, yeast, gluten, corn, soy, sodium, sugar, artificial coloring or flavoring or antimicrobial preservatives.

The capsules are made from 100% pure vegetable sources, free of preservatives and additives.

Formula

The capsules are made from 100% pure vegetable sources, free of preservatives and additives.

Storage

Store in a cool, dry place.

General

V1.0 362

FDA Statement of Identity

Enzyme Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HCl & Pepsin by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HCl & Pepsin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HCl & Pepsin by Genestra Brands

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
650 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Lipase

No known
interactions
10 mg per serving Form: Rhizopus oryzae

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Pepsin

No known
interactions
150 mg per serving Form: Porcine Stomach

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Other (inactive) ingredients: Hypromellose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

HCl & Pepsin by Genestra Brands Drug Interactions

Want to check YOUR meds against HCl & Pepsin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36

Individual Drug Interactions

The ingredients in HCl & Pepsin interact with 36 drugs. Click any drug to see the details.

1 of the 3 ingredients in HCl & Pepsin interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in HCl & Pepsin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HCl & Pepsin, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

HCl & Pepsin by Genestra Brands: Common Questions

Does HCl & Pepsin by Genestra Brands interact with any medications?
Yes. Based on its ingredients, HCl & Pepsin has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HCl & Pepsin contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux?
No — the facts specifically advise against it. Betaine hydrochloride increases stomach acid, which can worsen acid reflux. If you have reflux or heartburn, talk with your doctor or pharmacist before considering any hydrochloric acid supplement.
What does pepsin do in this product?
Pepsin is a digestive enzyme that breaks down proteins in your stomach. It's included to support protein digestion as part of the product's overall digestive support formula.
Is this safe during pregnancy?
The safety data advises against betaine hydrochloride during pregnancy. For lipase and pepsin, there isn't enough safety information to say either way. If you're pregnant or planning to be, talk with your doctor before taking this product.
Is this safe while breastfeeding?
Safety while breastfeeding has not been established for betaine hydrochloride or pepsin, so both are best avoided unless your doctor advises otherwise. Lipase has little safety data during breastfeeding — check with your healthcare provider first.
What are the inactive ingredients?
The product contains hypromellose (a capsule material), silica, and magnesium stearate (a binder). These are standard non-active ingredients used to form and stabilize the capsule.
Can pepsin cause allergies?
Pepsin is generally well tolerated, but allergic reactions are possible. Rarely, occupational exposure to airborne pepsin has caused allergic rhinitis or asthma — though this is uncommon in people taking it as a supplement. If you have a history of enzyme allergies or asthma, mention this product to your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HCl & Pepsin label
Go deeper

The Full Monographs Behind HCl & Pepsin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

HCl & Pepsin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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