Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Heart Health Ingredients & Drug Interactions

by UP4

Heart Health label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Heart Health against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Heart Health is a dietary supplement by UP4 with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus DDS-1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Heart Health by UP4

Ask about any prescription or over-the-counter medication and we check it for interactions with Heart Health by UP4 — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Heart Health by UP4

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “A Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (101 mg) without saying how much of each component you get.

UP4 Heart Health is a 3-ingredient probiotic capsule. It contains Lactobacillus acidophilus DDS-1, a well-studied bacterial strain, along with Bifidobacterium lactis UABla-12 and Lactobacillus reuteri NCIMB 30242 (LRC).

The product also includes a proprietary probiotic blend — the specific organisms in that blend aren't listed separately here. The capsule itself is made from plant cellulose, gellan gum, and silicon dioxide.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lactobacillus Acidophilus's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy cholesterol levels and heart health.
  • We looked for evidence on: Hypercholesterolemia, Hypertension, Metabolic syndrome, Obesity, cardiovascular disease, atherosclerosis — and 1 related terms.
  • The closest evidence on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Obesity, Metabolic syndrome.

Lactobacillus acidophilus shows possibly effective evidence for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. For atopic disease (conditions like allergies and eczema), the evidence rates as possibly ineffective.

For acute respiratory distress syndrome, we don't have reliable enough evidence to rate it. We hold no effectiveness data for the other two ingredients.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects like belly discomfort, bloating, gas, and diarrhea can happen when taking it alongside other probiotics, but they're uncommon.

Rarely, live probiotic organisms have been linked to serious infections in vulnerable people — cases of bloodstream infection, sepsis, and other severe conditions — though most occurred when bacteria moved from places they naturally live in the body. One trial reported rash and itching, though it's unclear whether L. acidophilus or something else caused them.

Safety data for Bifidobacterium lactis and Lactobacillus reuteri aren't on file here. Talk with your doctor before starting, especially if you're immunocompromised.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking UP4 Heart Health, double-check with your doctor or pharmacist if you're on antibiotic drugs. The probiotic may work less well if you take them together, so timing matters.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help if you have IBS, antibiotic-related diarrhea, or certain bacterial infections, based on the evidence for Lactobacillus acidophilus. The main thing to watch: don't take it at the same time as antibiotics — space them out so the antibiotic doesn't kill the live organisms you're trying to get.

Check with your own doctor or pharmacist first, especially if you have a weak immune system or are on regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Heart Health, straight from the product label.

Brand UP4
Barcode (UPC) 725334011354
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 176429
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Halal, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Heart Health by UP4, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
725334011354
IngredientAmount% DV
Bifidobacterium lactis UABla-120 NP--
A Proprietary Probiotic Blend101 mg--
Lactobacillus acidophilus DDS-10 NP--
Lactobacillus reuteri NCIMB 30242 (LRC)0 NP--

Other ingredients: Cellulose, Plant, Gellan Gum, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

What are you UP4?

UP4 Heart Health is crafted to help support healthy (total and LDL) cholesterol levels. This formula contains a patented strain that makes UP4 Heart Health unique in the support of heart health. UP4 Heart Health is the first clinically proven heart health probiotic and is the #1 cardiologist preferred probiotic.

Simple goodness UP4 contains the simple goodness and purity of probiotics to natually support your digestive and immune health.

#1 cardiologists preferred probiotic If you care about your heart health but have become aware that diet and exercise may not be enough, UP4 Heart Health is the product for you. UP4 Heart Health probiotics go beyond the digestive and immune benefits of typical probiotics with the inclusion of a patented strain to help maintain healthy levels of cholesterol to help support heart health. UP4 Heart Health is clinically formulated to help support healthy (total and LDL) cholesterol levels.

UP4 and What are you UP4 are trademarks of DSM. DDS, LRC and UABla-12 are trademarks are trademarks of UAS Laboratories LLC. and used under license.

General Statements

Taking care of your heart can be a full-time job. As someone who works constantly to maintain the health of your heart, you know that diet and exercise may not be enough.

Naturally acid & bile resistant strains Shelf stable

Based upon a 2015 survey among cardiologists.

Probiotics Supports healthy cholesterol levels + digestive + immune benefits 10 billion CFUs daily guaranteed Heart health

For questions, concerns or to report an adverse event, please call: 1-800-722-3476

Formulation

Non-dairy Non-gmo Soy free Gluten free Preservative free

Vegan

Seals/Symbols

Non-dairy Non-gmo Soy free Gluten free Preservative free Vegan

M OK D Made in USA with US and imported materials.

Precautions

While there are no dairy-derived ingredients in the product, it is produced in a facility that also handles dairy ingredients.

Caution: Do not take if seal is broken

Keep out of reach of children

As with any supplement, if you are pregnant, nursing, have a medical condition or are taking medication, consult a health practitioner before use

FDA Statement of Identity

Probiotic Supplement

General

UHBM4333

Formula

Strength of LRC Features our patented strain Lactobacillus reueri NCIMB 30242 (LRC), the first clinically studied probiotic shown to help maintain healthy levels of cholesterol in the body.

Digestive & immune support Features our trademark superstrain, Lactobacillus acidophilus DDS-1, and Bifidobacteria UABla-12 for digestive and immune health.

M

OK D

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions for use and storage: For best results take 1 capsule twice daily.

Storage

Store in a cool, dry place away from direct sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Heart Health by UP4 label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Heart Health label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Heart Health by UP4

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

A Proprietary Probiotic Blend

101 mg per serving

Other (inactive) ingredients: Cellulose, Plant, Gellan Gum, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Heart Health by UP4 Drug Interactions

Want to check YOUR meds against Heart Health?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus DDS-1 182

Individual Drug Interactions

The ingredients in Heart Health interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Heart Health interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus DDS-1

Each ingredient & the kinds of drugs it affects

For each ingredient in Heart Health with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus DDS-11 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus DDS-1 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Heart Health, from the product label.

UP4

See all UP4 products
Name
i-Health, Inc.
Street Address
55 Sebethe Drive
City
Cromwell
State
CT
ZipCode
06416
Phone Number
1-800-722-3476
Web Address
www.up4probiotics.com
Pharmacist Counseling Corner

Heart Health by UP4: Common Questions

Does Heart Health by UP4 interact with any medications?
Yes. Based on its ingredients, Heart Health has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Heart Health contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Not at the same time. Antibiotics can kill the live bacteria in this probiotic, making it less effective. Ask your pharmacist or doctor how many hours apart to take them — usually spacing them out by a few hours helps.
What's this probiotic supposed to do?
The Lactobacillus acidophilus in it has evidence supporting use for IBS, antibiotic-related diarrhea, bacterial vaginosis, and H. pylori infection. The other strains here don't have established effectiveness data in our records.
Are there any side effects?
Most people tolerate it well. Some experience mild gas, bloating, or belly discomfort when first taking probiotics — these are usually temporary and uncommon. Very rarely, the live organisms can cause serious infection in people with weakened immune systems.
Is it safe during pregnancy?
Lactobacillus acidophilus rates as possibly safe in pregnancy, but data are limited. Talk with your doctor or midwife before taking it during pregnancy to make sure it's right for you.
What are the inactive ingredients?
The capsule contains plant cellulose, gellan gum, and silicon dioxide — standard capsule materials with no active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Heart Health is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Heart Health label
Go deeper

The Full Monographs Behind Heart Health’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Heart Health's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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