Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Heartburn Prevention Ingredients & Drug Interactions

by Renew Life

Heartburn Prevention label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Heartburn Prevention against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Heartburn Prevention is a dietary supplement by Renew Life with 4 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Heartburn Prevention by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Heartburn Prevention by Renew Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Heartburn Prevention by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Plant-based Enzyme Blend” is a proprietary blend — the label gives one combined amount (525 mg) without saying how much of each component you get.

This product contains 4 active ingredients: protease, lipase, amylase, and betaine HCl. Protease and lipase are digestive enzymes that break down protein and fat; amylase breaks down carbohydrates.

Betaine HCl is a compound that increases stomach acid. The capsule itself is made from vegetable material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: help prevent occasional heartburn and indigestion.
  • We looked for evidence on: Dyspepsia, gastroesophageal reflux disease (GERD), acid reflux, stomach upset.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence we hold doesn't establish how well these ingredients work for heartburn prevention. Lipase and betaine HCl both show insufficient evidence for conditions like indigestion and inflammatory bowel disease.

Protease and amylase don't have effectiveness ratings in our data. If you're considering this for heartburn, talk with your doctor or pharmacist about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease and lipase are generally well tolerated but may cause digestive upset in some people. Betaine HCl may irritate the stomach and isn't safe if you have ulcers, gastritis, or true acid reflux—ironically, the condition this product aims to prevent.

Rare allergic reactions to protease have been reported in occupational settings. During pregnancy, protease is best avoided unless prescribed, and betaine HCl should be avoided—there isn't enough safety data.

Lipase use in pregnancy should only happen if your doctor advises it. During breastfeeding, protease and lipase are not recommended without medical advice; betaine HCl safety hasn't been established, so avoid it.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product with your pharmacist or doctor if you take H2-blockers, antacids, or proton pump inhibitors (PPIs) for heartburn or acid reflux—betaine HCl may reduce how well these drugs work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product combines digestive enzymes with an acid-boosting compound, but the evidence for heartburn prevention isn't established in our data. If you take acid-reducing medications, this product may interfere with them.

Talk with your doctor or pharmacist before starting, especially if you have a history of ulcers, reflux, or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Heartburn Prevention, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257535580
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Aug 26, 2014
DSLD ID 36749
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Heartburn Prevention by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
631257535580
IngredientAmount% DV
Amylase20000 DU--
Protease100000 HUT--
Lipase2000 FIP--
Betaine HCl650 mg--
Plant-based Enzyme Blend525 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Heartburn Prevention(TM) is formulated to help prevent occasional heartburn and indigestion using hydrochloric acid (HCl) and three plant-based enzymes in a natural digestive supplement.

General Statements

HCl production decreases as you age. The HCl in Heartburn Prevention provides a missing component for proper digestion and stomach function in those individuals who product too little stomach acid.

Quality and Purity Guaranteed

MADE IN USA

Power Enzyme Formula with HCl Helps Prevent Occasional Heartburn

Manufactured in a GMP and Kosher facility.

ReNewLife uses an exclusive SmartZYME blend of enzymes that represent multiple strains blended to increase the potency of the enzymes over a broader pH range. These enzymes are more broadly effective in the human digestive system.

Formulation

Contains no yeast, corn, gluten, salt, sugar, dairy, animal products, binders, fillers or artificial ingredients

Gluten-Free

Precautions

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT: DO NOT USE IF SAFETY SEAL IS BROKEN OR MISSING.

WARNING: Consult your physician before using this or any product if you are pregnant, nursing, trying to conceive, taking medication, or have a medical condition.

Notice: Do not use if you have gastritis, gastroesophageal reflux disease (GERD) or peptic ulcer disease. Discontinue use, if abdominal pain, nausea or vomiting occur, unless directed by your physician.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

HCl for Enhanced Digestion With SmartZYME(TM) BLend

Suggested/Recommended/Usage/Directions

Directions: Take 1 to 2 capsules with meals as needed.

Storage

Store in a dry place at 59-86 (o)F (15-30(o)C).

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

RENEW LIFE(R) The Digestive Care Company

General

0410

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Heartburn Prevention by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Heartburn Prevention label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Heartburn Prevention by Renew Life

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine HCl

Interacts with
36 drugs
650 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Plant-based Enzyme Blend

525 mg per serving

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Heartburn Prevention by Renew Life Drug Interactions

Want to check YOUR meds against Heartburn Prevention?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine HCl 36

Individual Drug Interactions

The ingredients in Heartburn Prevention interact with 36 drugs. Click any drug to see the details.

1 of the 4 ingredients in Heartburn Prevention interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Heartburn Prevention with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Heartburn Prevention, from the product label.

Renew Life

Web Address
www.renewlife.com
Pharmacist Counseling Corner

Heartburn Prevention by Renew Life: Common Questions

Does Heartburn Prevention by Renew Life interact with any medications?
Yes. Based on its ingredients, Heartburn Prevention has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Heartburn Prevention contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my heartburn?
The evidence we hold doesn't establish whether these ingredients work for heartburn prevention. If you're considering it for that purpose, ask your doctor or pharmacist whether it's a good fit for your situation.
Can I take this if I'm on antacids or acid-reducer pills?
Probably not—betaine HCl in this product increases stomach acid, which directly works against H2-blockers, antacids, and PPIs. Check with your pharmacist or doctor before combining them.
Is this safe if I have an ulcer?
No. Betaine HCl may irritate or delay healing of ulcers and gastritis, so this product isn't recommended if you have those conditions.
Is it safe to take while pregnant?
There isn't enough safety data to recommend it during pregnancy. Protease and betaine HCl should be avoided, and lipase only if your doctor advises it. Talk with your doctor before starting.
What do the digestive enzymes in this do?
Protease breaks down protein, lipase breaks down fat, and amylase breaks down carbohydrates. Together they're meant to support digestion, though the evidence for heartburn prevention specifically isn't established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Heartburn Prevention is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Heartburn Prevention label
Go deeper

The Full Monographs Behind Heartburn Prevention’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

Heartburn Prevention's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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