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Dietary supplement

Ultimate Flora Colon Care Probiotic Ingredients & Drug Interactions

by Renew Life

Ultimate Flora Colon Care Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate Flora Colon Care Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate Flora Colon Care Probiotic is a dietary supplement by Renew Life with 2 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate Flora Colon Care Probiotic by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate Flora Colon Care Probiotic by Renew Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultimate Flora Colon Care Probiotic by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Colon Care Probiotic Culture Blend” is a proprietary blend — the label gives one combined amount (241 mg) without saying how much of each component you get.
  • “Bifido Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Lacto Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Ultimate Flora Colon Care Probiotic contains 12 active ingredients — all live probiotic strains. The lineup includes two Lactobacillus acidophilus strains (LA-14 and NCFM), plus Bifidobacterium infantis and seven other named bacterial strains grouped into three blend categories.

These are live microorganisms meant to support your gut's natural flora. The capsule itself is made of inactive ingredients: microcrystalline cellulose, hypromellose, gellan gum, and medium chain triglyceride — these are just the filler and capsule materials that hold the probiotics together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Relieves occasional constipation and supports colon health.
  • We looked for evidence on: Constipation, Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Rotaviral diarrhea, Ulcerative colitis, and more.

The data we hold covers two of the probiotic strains in this product. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis; it's rated possibly ineffective for atopic disease, and there's insufficient evidence for acute respiratory distress syndrome.

Bifidobacterium infantis shows insufficient evidence for allergic rhinitis, antibiotic-associated diarrhea, and atopic disease, and is rated possibly ineffective for age-related cognitive decline and sepsis. We don't have effectiveness ratings for the other ten strains in this product, so the evidence for the full formula isn't established in our data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Uncommon gastrointestinal side effects — like stomach discomfort, bloating, flatulence, diarrhea, and burping — can occur when taking it combined with other probiotics, and rare cases of skin rash and itching have been reported in trials, though it's unclear if those were due to this ingredient alone.

Bifidobacterium infantis is generally well tolerated in healthy people, but caution is advised for those who are very ill or immunocompromised. Rare cases of bacterial bloodstream infection (bacteremia) have occurred with Bifidobacterium use in critically ill patients and preterm infants.

Bloating and flatulence have been reported with probiotics in general. Because safety data are limited for some strains in this product, talk with your doctor before starting.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Breve.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check antibiotic drugs before you start. Antibiotics might kill the live organisms in this supplement, so you'll need to space them apart.

Run your exact medications through the checker on this page, or ask your pharmacist — the product interacts with a broad range of drugs across all its strains.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This colon-support probiotic is generally well tolerated in healthy adults, but you should double-check it with your exact medications — especially if you take antibiotics — because the antibiotics can interfere with how well the probiotics work. If you're very ill or immunocompromised, talk with your doctor first.

Your pharmacist can help you time this supplement and any medications you're on.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Flora Colon Care Probiotic, straight from the product label.

Brand Renew Life
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 306956
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Flora Colon Care Probiotic by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Lactococcus lactis LL-230 NP--
Lactobacillus casei LC-110 NP--
Lactobacillus paracasei LPC-370 NP--
Lactobacillus acidophilus LA-140 NP--
Lactobacillus brevis LBR-350 NP--
Bifidobacterium lactis Bl-040 NP--
Lactobacillus rhamnosus GG0 NP--
Colon Care Probiotic Culture Blend241 mg--
Bifido Probiotic Blend0 NP--
Bifidobacterium lactis Bi-070 NP--
Bifidobacterium infantis BI-260 NP--
Lactobacillus acidophilus NCFM0 NP--
Bifidobacterium lactis HN-190 NP--
Lactobacillus plantarum LP-1150 NP--
Lacto Probiotic Blend0 NP--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Gellan Gum, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

#1 most studied strain L. rhamnosus GG strain, PubMed Clinical Trials More clinically studied strains than the leading brand Relieves occasional constipation

Non GMO Project Verified nongmoproject.org A gluten, dairy and soy-free formula

Potency, quality and purity guaranteed through expiration

Made in the USA of global ingredients.

We've improved RenewLife probiotics with world-class strains to help your natural rhythms thrive. Inside, you can find: Digestive and immune health support The #1 most-studied probiotic strain A Non-GMO Project Verified formula Smaller, easier-to-swallow capsules And a recyclable bottle

Formula

80 billion live cultures 12 Probiotic strains

We don't compromise on quality. You trust us with your health and we take that seriously, which is why Renew Life Colon Care probiotic guarantees: A formula containing world-class strains backed by science Potency through expiration A blend of 12 different strains to support colon, digestive and immune health Delayed-release capsules that help the probiotics reach your gut alive

FDA Statement of Identity

Probiotic Supplement

Seals/Symbols

Non GMO Project Verified nongmoproject.org

General Statements

For over 20 years, Renew Life has been a pioneer in gut wellness.

Questions or comments? 1-800-830-1800 or www.renewlife.com

At Renew Life, we are 100% devoted to your well-being. That's why we use more clinically studied strains than the leading brand.

Our guarantee We stand by our products. Visit renewlife.com/customer-service for our 60-day satisfaction guarantee.

Suggested/Recommended/Usage/Directions

Directions: For best results, take one (1) capsule daily, with or without food.

Storage

Store at 77 degrees F (25 degrees C) or below. Best if refrigerated.

Precautions

Keep out of reach of children.

Consult your physician prior to using this or any product if you are pregnant, nursing, taking any medication or have a medical condition.

Brand IP Statement(s)

Copyright 2019 Patents: www.renewlife.com/patents

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate Flora Colon Care Probiotic by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate Flora Colon Care Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate Flora Colon Care Probiotic by Renew Life

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Colon Care Probiotic Culture Blend

241 mg per serving
  • › Bifido Probiotic Blend
  • › Lacto Probiotic Blend

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Gellan Gum, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Flora Colon Care Probiotic by Renew Life Drug Interactions

Want to check YOUR meds against Ultimate Flora Colon Care Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Ultimate Flora Colon Care Probiotic interact with 182 drugs. Click any drug to see the details.

0 of the 2 ingredients in Ultimate Flora Colon Care Probiotic interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Flora Colon Care Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Ultimate Flora Colon Care Probiotic, from the product label.

Renew Life

Name
Renew Life Formulas, Inc.
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Ultimate Flora Colon Care Probiotic by Renew Life: Common Questions

Does Ultimate Flora Colon Care Probiotic by Renew Life interact with any medications?
Yes. Based on its ingredients, Ultimate Flora Colon Care Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Flora Colon Care Probiotic contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on antibiotics?
Not at the same time. The antibiotics can kill the live probiotic organisms, which defeats the purpose. You'll want to separate them — your pharmacist can tell you how far apart to take them based on which antibiotic you're on.
Will this help my irritable bowel syndrome (IBS)?
Lactobacillus acidophilus, which is in this product, is rated possibly effective for IBS. But probiotics don't work the same way for everyone, so talk with your doctor about whether this is right for you.
What side effects should I watch for?
Most people have no problems, but uncommon side effects include stomach discomfort, bloating, flatulence, diarrhea, and burping. Rare cases of rash have been reported. If you're very ill or have a weak immune system, there's a small risk of infection — ask your doctor first.
Is it safe to take while I'm breastfeeding or pregnant?
We don't have pregnancy or breastfeeding safety data on file for the strains in this product. Talk with your doctor or pharmacist — they can tell you whether it's okay for your situation.
What are these probiotic strains supposed to do?
They're live beneficial bacteria meant to support your gut's natural flora and digestive health. The product's name points to colon support, but we only have effectiveness data for a couple of the strains inside.
Do I need to keep this in the refrigerator?
The facts we have don't specify storage instructions, so check the label on your bottle or ask your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultimate Flora Colon Care Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Flora Colon Care Probiotic label
Sources

Sources & How We Checked

Ultimate Flora Colon Care Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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