Digest Smart Kids Enzyme Berry Blast Ingredients & Drug Interactions
by Renew Life
What is this page for?
First and foremost: checking Digest Smart Kids Enzyme Berry Blast against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digest Smart Kids Enzyme Berry Blast is a dietary supplement by Renew Life with 13 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 221 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are N-Acetyl D-Glucosamine, L-Glutamine, Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Digest Smart Kids Enzyme Berry Blast by Renew Life
Ask about any prescription or over-the-counter medication and we check it for interactions with Digest Smart Kids Enzyme Berry Blast by Renew Life — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Digest Smart Kids Enzyme Berry Blast by Renew Life
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Digest Smart Kids has 11 active ingredients — mostly digestive enzymes and amino acids. L-Glutamine and Glycine are amino acids that support digestive and metabolic function.
The enzyme blend includes Protease (breaks down protein), Lipase (breaks down fat), Lactase (breaks down milk sugar for kids who have trouble digesting it), and Gamma Oryzanol, which may help with cholesterol levels. N-Acetyl D-Glucosamine supports joint and digestive-tract lining health.
The product also contains Amylase, Cellulase, Invertase, and Alpha-Galactosidase — digestive enzymes that help break down carbohydrates and plant fibers. The remaining ingredients are inactive — fillers, flavors (berry and raspberry), and binders like xylitol, stearic acid, magnesium stearate, and silica that make the tablet hold together.
Does it work?
Strong evidence
The evidence for effectiveness varies by ingredient and purpose. Glucosamine is likely effective for osteoarthritis, though this product is marketed for kids and general digestion.
L-Glutamine is rated effective for sickle cell disease and possibly effective for recovery after surgery and critical illness, but the data we hold don't speak to its role in general digestive support for children. Lactase is effective for lactose intolerance — useful if your child has trouble digesting milk products.
Gamma Oryzanol is possibly effective for cholesterol (dyslipidemia). For the other enzymes — lipase, protease, cellulase, invertase, and alpha-galactosidase — we don't have effectiveness ratings on file.
Glycine is possibly effective for schizophrenia, not a typical use for a kids' enzyme product. The evidence on this product's overall digestive benefit for healthy children isn't established in the data we hold.
How safe is it?
Well-documented data
L-Glutamine and Glycine are generally well tolerated at typical doses, though long-term safety data are limited for both. L-Glutamine's most common side effects are belching, bloating, constipation, nausea, and vomiting — mostly digestive.
Glycine rarely causes mild sedation, and there are scattered reports of irritability, insomnia, and headache, though any link to glycine is unclear. Protease and Lipase are generally well tolerated for most adults; protease can rarely trigger allergic reactions or digestive upset.
Lactase is generally well tolerated and is likely safe in pregnancy and lactation. Glucosamine is generally well tolerated orally, with common side effects being bloating, constipation, diarrhea, nausea, and heartburn.
Rare allergic reactions have been reported in sensitive people, including severe cases. Gamma Oryzanol has limited long-term safety data.
Because this is a kids' product, talk with your child's doctor or pharmacist about whether it's right for your child's age and health.
Meds to double-check
Major interaction found
Before starting Digest Smart Kids, double-check these medication types: blood thinners like warfarin (Major risk of bleeding), seizure medications (anticonvulsants), antipsychotics like clozapine, and chemotherapy drugs like etoposide or doxorubicin. Minor caution applies to diabetes medications and acetaminophen.
If your child takes any prescription medicine, run it through the checker on this page.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This is a multi-enzyme digestive supplement for children. It works best for kids with lactose intolerance (thanks to lactase) or those needing digestive enzyme support, but the overall benefit for healthy kids isn't proven in our data.
If your child takes any medications — especially blood thinners like warfarin, seizure drugs, antipsychotics, chemotherapy, or diabetes medications — check with us or your pharmacist first. The product is generally well tolerated, though digestive side effects like bloating and nausea can happen.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 7 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digest Smart Kids Enzyme Berry Blast, straight from the product label.
| Brand | Renew Life |
|---|---|
| Barcode (UPC) | 631257157201 |
| Net contents | 60 Chewable Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2018 |
| DSLD ID | 179034 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Children more than 1 but less than 4 |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digest Smart Kids Enzyme Berry Blast by Renew Life, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 3 Calorie(s) | -- |
| Total Carbohydrates | 0.7 Gram(s) | 1% |
| L-Glutamine | 0 NP | -- |
| Sugar | 0 NP | -- |
| Calories from Fat | 1 Calorie(s) | -- |
| Total Fat | 0.1 Gram(s) | 1% |
| Glycine | 0 NP | -- |
| Gamma Oryzanol | 0 NP | -- |
| Amylase | 0 NP | -- |
| Protein | 0.1 Gram(s) | 1%, 1% |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Sugar Alcohol | 0.7 Gram(s) | -- |
| Invertase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Amino Acid Blend | 120 mg | -- |
| N-Acetyl D-Glucosamine | 0 NP | -- |
| Plant Enzyme Blend | 0 NP | -- |
Other ingredients: Xylitol, Stearic Acid, natural Berry flavor, Raspberry, Citric Acid, Maltodextrin, Magnesium Stearate, Silica, Malic Acid, Monk Fruit
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Tamper Evident: Do not use if safety seal on bottle is broken or missing.
Contains an ingredient derived from crustacean shells (shrimp, lobster, crab).
May contain traces of soy, milk, and wheat from ingredients used in the fermentation process to make enzymes.
Keep out of reach of children.
Consult your healthcare professional before using this or any product if your child is taking medication or has a medical condition.
General Statements
Digestive wellness, naturally
At Renew Life, we believe a healthy gut is a happy gut.
For nearly two decades, we have pioneered superior-quality digestive care supplements to help adults and kids alike achieve optimal health from the inside out.
Healthy kids = happy kids Keep your child’s tummy in tip-top spirits every day.
Multi-enzyme benefits Good digestive balance is key to your child’s well-being. Digest Smart is made with multiple enzymes to support the breakdown of proteins, carbohydrates, and fats for digestive balance and harmony.
New look, improved taste. Formerly Buddy Bear Digest
Buddy Bear
65505A
Formula
Digestive enzyme just for kids
It also contains other soothing ingredients to help promote a healthy intestinal lining.
Safe & effective Made from plant-based ingredients and nothing artificial, our kid-friendly formula works gently to help break down foods in the digestive tract to keep your little one's digestive system running smoothly everyday.
Formulation
Digest Smart Kids Enzyme is a delicious, chewable enzyme formula that helps break down proteins, carbohydrates, and fats to support your child’s digestive health.
Each tablet is bursting with natural Berry Blast flavor, but no artificial ingredients.
Plant-based formula
Helps digest all types of food Supports healthy digestion Great tasting chewable tablet
No Artificial Ingredients
Quality, purity, and potency guaranteed through expiration.
Manufactured in USA in a GMP facility.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
When taken with a meal, Digest Smart Kids Enzyme promotes digestive health and helps kids feel healthier and happier whether at school or at play.
Directions: Children 2 years and older, chew one bear tablet with a meal twice daily.
FDA Statement of Identity
Enzyme Supplement
Storage
Store in a cool, dry place at 77 degrees F (25 degrees C) or below.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digest Smart Kids Enzyme Berry Blast by Renew Life label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digest Smart Kids Enzyme Berry Blast by Renew Life
These are the 13 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Protein
Amino Acid Blend
Other (inactive) ingredients: Xylitol, Stearic Acid, Natural Berry flavor, Raspberry, Citric Acid, Maltodextrin, Magnesium Stearate, Silica, Malic Acid, Monk Fruit. These complete the product’s ingredient list but are not active constituents.
Digest Smart Kids Enzyme Berry Blast by Renew Life Drug Interactions
HelloPharmacist Interaction Report
Digest Smart Kids Enzyme Berry Blast by Renew Life contains ingredients with documented interactions affecting medications.
The most serious is N-Acetyl D-Glucosamine, which may increase the blood-thinning effects of warfarin (Coumadin), raising the risk of bleeding and bruising — this is a Major interaction. Two case reports show glucosamine/chondroitin combinations significantly increased bleeding markers in patients on warfarin.
Read the full breakdown — every affected drug type, severity by severity
Glucosamine also has Moderate interactions with topoisomerase II inhibitors (chemotherapy drugs like etoposide and doxorubicin), where it may theoretically reduce their effectiveness, though this hasn't been seen in humans yet. It carries Minor interactions with antidiabetes drugs and acetaminophen (Tylenol), though the evidence suggests the practical risk is low.
L-Glutamine has a Moderate theoretical interaction with anticonvulsants (seizure medications), where glutamine's metabolism to glutamate might work against these drugs, but this has not yet been reported in people.
Glycine carries a Moderate interaction with clozapine (Clozaril), an antipsychotic — one small study showed adding glycine actually worsened schizophrenia symptoms when combined with clozapine. We could not check amylase, cellulase, invertase, or alpha-galactosidase for interactions because we hold no safety data for them.
Altogether, these interactions span 220 individual medications.
Use the medication checker on this page to search your exact drugs before giving this product to your child.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Digest Smart Kids Enzyme Berry Blast?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Digest Smart Kids Enzyme Berry Blast interact with 221 drugs. Click any drug to see the details.
3 of the 13 ingredients in Digest Smart Kids Enzyme Berry Blast interact with drugs. Each result below shows which ingredient is responsible. N-Acetyl D-Glucosamine L-Glutamine Glycine
WarfarinWarfarin
How Warfarin interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineWarfarin (coumadin) Major
Interaction Summary
Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
Read the full N-acetyl D-glucosamine + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineWarfarin (coumadin) Major
Interaction Summary
Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
Read the full N-acetyl D-glucosamine + Warfarin Sodium interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Acetazolamide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Aminophylline, Amobarbital, Ephedrine interactionAmobarbitalAmytal
How Amobarbital interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Amobarbital, Secobarbital interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Aprobarbital, Butabarbital, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Belladonna, Phenobarbital interactionBellafoline, Caffeine, Ergotamine Tartrate, PentobarbitalCafergot PB
How Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interactionButalbital, Phenobarbital, SecobarbitalTribarb
How Butalbital, Phenobarbital, Secobarbital interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Butalbital, Phenobarbital, Secobarbital interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Carbamazepine interactionCenobamateXcopri
How Cenobamate interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Cenobamate interactionClobazamFrisium, Onfi, Sympazan
How Clobazam interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clobazam interactionClonazepamCeberclon, Klonopin, Rivotril
How Clonazepam interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clonazepam interactionClorazepateTranxene, Tranxene SD, Tranxene T-Tab
How Clorazepate interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Clorazepate interactionClozapineClozaril, Versacloz
How Clozapine interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionDaunorubicin CitrateDaunoXome
How Daunorubicin Citrate interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Daunorubicin Citrate interactionDaunorubicin HydrochlorideCerubidine
How Daunorubicin Hydrochloride interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Daunorubicin Hydrochloride interactionDaunorubicin, CytarabineVyxeos
How Daunorubicin, Cytarabine interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Daunorubicin, Cytarabine interactionDiazepamDiastat AcuDial, Valium, Valium injection, Valtoco
How Diazepam interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Diazepam interactionDivalproex SodiumDepakote
How Divalproex Sodium interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Divalproex Sodium interactionDoxorubicinAdriamycin, Caelyx, Doxil, Myocet, Rubex
How Doxorubicin interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Doxorubicin interactionEphedrine, Phenobarbital, TheophyllineTedral
How Ephedrine, Phenobarbital, Theophylline interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ephedrine, Phenobarbital, Theophylline interactionEpirubicinEllence
How Epirubicin interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Epirubicin interactionEthosuximideZarontin
How Ethosuximide interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ethosuximide interactionEthotoinPaganone
How Ethotoin interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Ethotoin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
N-acetyl D-glucosamineTopoisomerase Ii Inhibitors Moderate
Interaction Summary
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
Read the full N-acetyl D-glucosamine + Etoposide interactionFelbamateFelbatol
How Felbamate interacts with Digest Smart Kids Enzyme Berry Blast — through 1 ingredient. Tap an ingredient for the detail:
L-glutamineAnticonvulsants Moderate
Interaction Summary
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Read the full L-glutamine + Felbamate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Digest Smart Kids Enzyme Berry Blast with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
N-Acetyl D-Glucosamine
Warfarin (Coumadin)
Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.
Topoisomerase Ii Inhibitors
Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.
Acetaminophen (Tylenol, Others)
Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.
Antidiabetes Drugs
Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.
L-Glutamine
Anticonvulsants
Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Digest Smart Kids Enzyme Berry Blast, from the product label.
Renew Life
- Name
- Renew Life Formulas
- City
- Palm Harbor
- State
- FL
- ZipCode
- 34683
- Phone Number
- 1-800-830-1800
Digest Smart Kids Enzyme Berry Blast by Renew Life: Common Questions
Does Digest Smart Kids Enzyme Berry Blast by Renew Life interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to give during pregnancy or while breastfeeding?
What are the most common side effects?
Will this help my child's digestion?
Can my child take this with their asthma or seizure medication?
Is there any risk if my child is on antibiotics or other common drugs?
What if my child has a shellfish allergy?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digest Smart Kids Enzyme Berry Blast’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Glutamine
Interacts with 50 drugsGlutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...
Read the full Glutamine monograph → Herb & supplement monographGlycine
Interacts with 1 drugGlycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...
Read the full Glycine monograph → Herb & supplement monographGamma-oryzanol
Gamma-oryzanol is a mix of plant compounds taken from rice bran oil, used mainly for cholesterol, menopause symptoms, and as a sports supplement. The evidence is limited and mostly comes fro...
Read the full Gamma-oryzanol monograph → Herb & supplement monographGlucosamine
Interacts with 170 drugsGlucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...
Read the full Glucosamine monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Digest Smart Kids Enzyme Berry Blast's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 79 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glutamine 11 references
- Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
- Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
- Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
- Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
- Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
- Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
- Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
- Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
- Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
- Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
- Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Glucosamine 58 references
- Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. PubMed
- Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. PubMed
- Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. PubMed
- Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. PubMed
- Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.
- Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9.
- Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism 1998;47:573-7.
- Almada A, Harvey P, Platt K. Effects of chronic oral glucosamine sulfate on fasting insulin resistance index (FIRI) in non-diabetic individuals. FASEB J 2000;14:A750.
- Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled trial. Lancet 2001;357:251-6.
- Does glucosamine increase serum lipid levels and blood pressure? Pharmacist's Letter/Prescriber's Letter 2001;17(11):171115.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes 2000;49:926-35. PubMed
- Pouwels MJ, Jacobs JR, Span PN, et al. Short-term glucosamine infusion does not affect insulin sensitivity in humans. J Clin Endocrinol Metab 2001;86:2099-103. DOI
- Yun J, Tomida A, Nagata K, Tsuruo T. Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncol Res 1995;7:583-90.
- Pavelka K, Gatterova J, Olejarova M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-23. PubMed
- Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4..
- Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Arch Intern Med 2003; PubMed
- Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.. PubMed
- Yu JG, Boies SM, Olefsky JM. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care 2003;26:1941-2. PubMed
- Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. PubMed
- Guillaume MP, Peretz A. Possible association between glucosamine treatment and renal toxicity: comment on the letter by Danao-Camara. Arthritis Rheum 2001;44:2943-4. PubMed
- Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. PubMed
- Tannis AJ, Barban J, Conquer JA. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis Cartilage 2004;12:506-11. PubMed
- Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
- Stumpf JL, Lin SW. Effect of glucosamine on glucose control. Ann Pharmacother 2006;40:694-8. PubMed
- Pham T, Cornea A, Blick KE, et al. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. Am J Med Sci 2007;333:333-9. PubMed
- Muniyappa R, Karne RJ, Hall G, et al. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes 2006;55:3142-50. PubMed
- Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. PubMed
- Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine potentiates the effect of warfarin. Jan 2006. Drug Safety 29(10):911-1010. DOI
- Rozendaal RM, Koes BW, van Osch GJVM, et al. Effect of glucosamine sulfate on hip osteoarthritis: A randomized trial. Ann Intern Med 2008;148:268-77. PubMed
- Baron AD, Zhu JS, Zhu JH, et al. Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity. J Clin Invest 1995;96(6):2792-801. PubMed
- Nelson BA, Robinson KA, Buse MG. High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. Diabetes 2000;49(6):981-91. PubMed
- Giordano N, Fioravanti A, Papakostas P, et al. The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Curr Ther Res Clin Exp 2009;70(3):185-196. PubMed
- Shaygannejad, V., Janghorbani, M., Savoj, M. R., and Ashtari, F. Effects of adjunct glucosamine sulfate on relapsing-remitting multiple sclerosis progression: preliminary findings of a randomized, placebo-controlled trial. Neurol Res 2010;32(9):981-985. PubMed
- Cahlin, B. J. and Dahlstrom, L. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112(6):760-766. PubMed
- Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013;19(32):5381-4. PubMed
- Hochberg MC, Martel-Pelletier J, Monfort J, Möller I, Castillo JR, Arden N,Berenbaum F, Blanco FJ, Conaghan PG, Doménech G, Henrotin Y, Pap T, Richette P, Sawitzke A, du Souich P, Pelletier JP; on behalf of the MOVES Investigation Group. Combined chondroi
- von Felden J, Montani M, Kessebohm K, Stickel F. Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate. Int J Clin Pharmacol Ther 2013;51(3):219-23. PubMed
- Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol 2015;34:1455-62. PubMed
- Ossendza RA, Grandval P, Chinoune F, Rocher F, Chapel F, Bernardini D. [Acute cholestatic hepatitis due to glucosamine forte]. Gastroenterol Clin Biol. 2007 Apr;31(4):449-50.
- Audimoolam VK, Bhandari S. Acute interstitial nephritis induced by glucosamine. Nephrol Dial Transplant 2006;21(7):2031. PubMed
- Greenlee H, Crew KD, Shao T, Kranwinkel G, Kalinsky K, Maurer M, Brafman L, Insel B, Tsai WY, Hershman DL. Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer. Support Care Cancer 201 PubMed
- Wilkens, P., Scheel, I. B., Grundnes, O., Hellum, C., and Storheim, K. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial. JAMA 2010;304(1):45-52. PubMed
- Simon RR, Marks V, Leeds AR, Anderson JW. A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals. Diabetes Metab Res Rev 2011;27(1):14-27. PubMed
- Smidt D, Torpet LA, Nauntofte B, Heegaard KM, Pedersen AM. Associations between labial and whole salivary flow rates, systemic diseases and medications in a sample of older people. Community Dent Oral Epidemiol 2010;38(5):422-35. PubMed
- Wangroongsub Y, Tanavalee A, Wilairatana V, Ngarmukos S. Comparable clinical outcomes between glucosamine sulfate-potassium chloride and glucosamine sulfate sodium chloride in patients with mild and moderate knee osteoarthritis: a randomized, double-blind
- Chopra A, Saluja M, Tillu G, Venugopalan A, Sarmukaddam S, Raut AK, Bichile L, Narsimulu G, Handa R, Patwardhan B. A Randomized Controlled Exploratory Evaluation of Standardized Ayurvedic Formulations in Symptomatic Osteoarthritis Knees: A Government of I
- Swinburne LM. Glucosamine sulphate and osteoarthritis. Lancet 2001;357(9268):1617. PubMed
- Murphy RK, Ketzler L, Rice RD, Johnson SM, Doss MS, Jaccoma EH. Oral glucosamine supplements as a possible ocular hypertensive agent. JAMA Ophthalmol 2013;131(7):955-7. PubMed
- Kimball AB, Kaczvinsky JR, Li J, et al. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial.
- Ma H, Li X, Sun D, et al. Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank. BMJ. 2019 May 14;365:l1628. PubMed
- Hoban C, Byard R, Musgrave I. Hypersensitive adverse drug reactions to glucosamine and chondroitin preparations in Australia between 2000 and 2011. Postgrad Med J. 2019 Oct 9. pii: postgradmedj-2019-136957. PubMed
- Tenti S, Veronese N, Cheleschi S, et al. Prescription-grade crystalline glucosamine sulfate as an add-on therapy to conventional treatments in erosive osteoarthritis of the hand: results from a 6-month observational retrospective study. Aging Clin Exp Res PubMed
- Yu H, Wu J, Chen H, et al. Glucosamine use is associated with a higher risk of cardiovascular diseases in patients with osteoarthritis: results from a large study in 685,778 subjects. Nutrients 2022;14(18):3694. PubMed
- Chu EC, Huang KHK, Cheung G, Ng G, Lin A. Delayed Skin Allergy to Glucosamine Chondroitin Supplement. Cureus 2023;15(3):e36310. PubMed
- Lila AM, Alekseeva LI, Baranov AA, et al. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: A long-term observational study in Russia. World J Orthop 2023;14(6):443-457. PubMed
- Lehrer S, Morello T, Karrasch C, Rheinstein PH, Danias J. Effect of Glucosamine on Intraocular Pressure and Risk of Developing Glaucoma. J Glaucoma 2023. PubMed
- Rabade A, Viswanatha GL, Nandakumar K, Kishore A. Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis. Inflammopharmac PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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