Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Herbal Pumpkin Ingredients & Drug Interactions

by Nature's Sunshine

Herbal Pumpkin label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Herbal Pumpkin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Herbal Pumpkin is a dietary supplement by Nature's Sunshine with 7 active ingredients. Its ingredients are commonly taken for sore throat and cough, heartburn and acid reflux, digestive upset and ibs.Based on those ingredients, 2,122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Marshmallow, Slippery Elm, Chamomile. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Herbal Pumpkin by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Herbal Pumpkin by Nature's Sunshine — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Herbal Pumpkin by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (980 mg) without saying how much of each component you get.

Herbal Pumpkin contains seven active ingredients delivered in a proprietary blend. They are slippery elm inner bark, cascara sagrada, black walnut, pumpkin, mullein, German chamomile, and marshmallow root and leaf.

The capsule itself is an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Core health support with herbal combination.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for what this product does is very limited. For the ingredients in this blend, the data we hold shows insufficient reliable evidence for most claims — including slippery elm for constipation, diarrhea, cough, and inflammatory bowel disease; pumpkin for prostate health and urinary tract infections; mullein for bronchitis, asthma, and cough; and chamomile for anxiety and allergies.

Cascara sagrada is possibly ineffective for bowel preparation. Pumpkin is rated possibly effective for benign prostatic hyperplasia (enlarged prostate), though evidence remains limited.

The effectiveness of black walnut, marshmallow, and other indications for these ingredients is not established in the data we hold.

The evidence, ingredient by ingredient Slippery Elm Cascara Sagrada Black Walnut Pumpkin Mullein German Chamomile Marshmallow

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated for short-term use, but long-term safety data are sparse for several of them. Cascara sagrada carries real risks, especially with prolonged use — it can lead to low potassium, liver injury (rare), or serious vomiting if the bark is fresh or improperly aged.

Black walnut leaf, bark, and hull contain high tannins and may cause stomach upset. Slippery elm pollen and contact can trigger allergic reactions including dermatitis and hives.

Chamomile can cause allergic reactions, including severe ones, in people sensitive to ragweed. Pumpkin is generally well tolerated but in rare cases can trigger anaphylaxis; and in isolated reports, high concentrations of bitter-tasting pumpkin or squash have caused temporary hair loss or severe nausea and vomiting.

Marshmallow and mullein have limited human safety data. None of these ingredients have enough pregnancy safety data to confirm they are safe; cascara sagrada and black walnut are best avoided in pregnancy, and cascara sagrada is possibly unsafe while breastfeeding.

Side effects, ingredient by ingredient Slippery Elm Cascara Sagrada Black Walnut Pumpkin Mullein German Chamomile Marshmallow

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Mullein, Cascara Sagrada, Marshmallow, Pumpkin, German Chamomile, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 2,123 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your own doctor or pharmacist if you take warfarin or other blood thinners (Moderate risk from cascara sagrada and chamomile); corticosteroids or water pills (Moderate risk from cascara sagrada); CNS depressants like sleep aids or anxiety medications (Moderate risk from chamomile); medications broken down by your liver, including many heart, blood pressure, and psychiatric drugs (Moderate risk from chamomile); birth control pills or hormone therapy (Moderate risk from chamomile); digoxin (Moderate risk from cascara sagrada); lithium (Moderate risk from pumpkin and marshmallow); stimulant laxatives (Moderate risk from cascara sagrada); or blood-thinning supplements or foods (Minor risk from marshmallow and mullein). If you take oral medications of any kind, note that slippery elm and marshmallow may slow their absorption.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient herbal blend with several documented interactions, particularly with blood thinners, water pills, heart medications, and psychiatric drugs. The evidence for what it actually does is quite limited — most claims lack reliable proof.

If you take any prescription medications, especially warfarin, corticosteroids, diuretics, digoxin, lithium, or medications your liver breaks down, check this product against your exact drugs with your own doctor or pharmacist before starting. Pregnant people and those breastfeeding should discuss it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Herbal Pumpkin, straight from the product label.

Brand Nature's Sunshine
Net contents 20 Packet(s); 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2014
DSLD ID 31166
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Herbal Pumpkin by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
20
IngredientAmount% DV
Proprietary Blend980 mg--
Slippery Elm0 NP--
Cascara Sagrada0 NP--
Black Walnut0 NP--
Pumpkin0 NP--
Mullein0 NP--
Chamomile0 NP--
Marshmallow0 NP--

Other ingredients: Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Core Health Support*

This package contains 20 packets with four different herbal combinations in each packet. This represents a ten-day supply.

Inner packets not intended or labeled for individual retail sale. This carton was sealed for your protection.

Herb Specialists Since 1972

Many people experience undesirable gastrointestinal effects as a result of activities that include: ~ Traveling internationally ~ Eating undercooked foods ~ Drinking contaminated water ~ Exposure to daycare centers ~ Having a pet ~ Use of antibiotic drugs Fortunately, natural herbs included in Para-Cleanse help create an environment that supports the health and vitality of friendly intestinal microorganisms (flora). Some of these key herbs strengthen the body's natural cleansing process and/or help make the intestines inhospitable to foreign invaders.*

HERBAL PUMPKIN

Nature's Sunshine uses natural source materials in its products that are subject to color variation.

Product of U.S.A.

The contents of this pack will support a ten-day program.

10 Day Program

Formula

NOTICE: This product contains cascara sagrada bark.

Precautions

Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain.

Consult your physician if you have frequent diarrhea, or if you are pregnant, nursing, taking medication, or have a medical condition.

Do not exceed recommended dose. Not for long term use.

General

Stock No. 4115-7

Suggested/Recommended/Usage/Directions

DIETARY SUGGESTIONS Eat fresh fruits and vegetables, (especially green leafy) and whole grains such as rice. Avoid red meats, coffee, alcohol, sugary or fried foods. Drink plenty of water.

Candida Clear, LBS II(R) or Cascara Sagrada may be used in conjunction with this program.

RECOMMENDED USE Take the contents of one packet (6 capsules) 15 minutes before breakfast and 15 minutes before dinner daily for 10 days. Drink one glass (8 ounces) of water with the capsules. Continue this program for ten days.

When the contents have been consumed, continue with the dietary suggestions for ten days then repeat the program.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Nature's Sunshine(R) QUALITY, SERVICE, INTEGRITY

FDA Statement of Identity

Herbal Dietary Supplement

Brand IP Statement(s)

(C)2013 Nature's Sunshine Products, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Herbal Pumpkin by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Herbal Pumpkin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Herbal Pumpkin by Nature's Sunshine

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

980 mg per serving

Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Herbal Pumpkin by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Herbal Pumpkin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,122Drugs
2,103 Moderate 19 Minor

Ingredients driving the most interactions

Marshmallow 2,040
Slippery Elm 2,022
Chamomile 960
Cascara Sagrada 745
Mullein 122

Individual Drug Interactions

The ingredients in Herbal Pumpkin interact with 2,122 drugs. Click any drug to see the details.

6 of the 7 ingredients in Herbal Pumpkin interact with drugs. Each result below shows which ingredient is responsible. Marshmallow Slippery Elm Chamomile Cascara Sagrada Mullein Pumpkin

Each ingredient & the kinds of drugs it affects

For each ingredient in Herbal Pumpkin with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow full monograph & interactions

Slippery Elm1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm full monograph & interactions

Chamomile9 drug types · 960 drugs

Cns Depressants

Theoretically, German chamomile might have additive effects when used with CNS depressants.
German chamomile has mild sedative effects. Theoretically, concomitant use with drugs with sedative properties can cause additive effects and side effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, large amounts of German chamomile might reduce the effectiveness of oral contraceptives.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, concomitant use of large amounts of German chamomile might interfere with contraceptive drugs through competition for estrogen receptors.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, German chamomile might inhibit CYP2C9 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2C9. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2C9 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, German chamomile might inhibit CYP2D6 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP2D6. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP2D6 in patients taking German chamomile.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, German chamomile might inhibit CYP3A4 and increase levels of drugs metabolized by these enzymes.
In vitro evidence shows that German chamomile might inhibit CYP3A4. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP3A4 in patients taking German chamomile.

Likelihood Possible Evidence D
Estrogens

Theoretically, large amounts of German chamomile might reduce the effectiveness of estrogens.
In vitro, German chamomile has demonstrated antiestrogenic activity. Theoretically, large amounts of German chamomile might interfere with hormone replacement therapy through competition for estrogen receptors.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, large amounts of German chamomile might interfere with the activity of tamoxifen.
In vitro, German chamomile has demonstrated antiestrogenic activity.

Likelihood Possible Evidence D
Warfarin (Coumadin)

German chamomile might increase the effects of warfarin and increase the risk of bleeding.
In one case, a 70-year-old female taking warfarin developed retroperitoneal hematoma and bilateral recti muscle bleeding along with an INR of 7.9 following ingestion of German chamomile tea 4-5 cups daily and use of a topical chamomile-based lotion applied 4-5 times daily.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, German chamomile might inhibit CYP1A2 and increase levels of drugs metabolized by these enzymes.
In vitro and animal research shows that German chamomile might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, there might be an increase in the levels of drugs metabolized by CYP1A2 in patients taking German chamomile.

Likelihood Possible Evidence D
Chamomile full monograph & interactions

Cascara Sagrada6 drug types · 745 drugs

Corticosteroids

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Cascara Sagrada full monograph & interactions

Mullein1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.

Likelihood Unlikely Evidence A
Mullein full monograph & interactions

Pumpkin1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Herbal Pumpkin, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Herbal Pumpkin by Nature's Sunshine: Common Questions

Does Herbal Pumpkin by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Herbal Pumpkin has a known interaction with 2,122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Herbal Pumpkin contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this really help with digestion or bowel health?
The data we hold show insufficient reliable evidence for most of these ingredients on constipation, diarrhea, and digestive issues. Cascara sagrada is actually rated possibly ineffective for bowel prep. While cascara is a stimulant laxative and might help short-term constipation, it's not recommended for long-term use because of serious risks.
Is it safe to take this while pregnant or breastfeeding?
There isn't enough safety data to know for sure. Cascara sagrada and black walnut are best avoided in pregnancy based on the data we have. Cascara is also possibly unsafe while breastfeeding. For the others, safety data during pregnancy and nursing are too limited — talk with your doctor or pharmacist to decide what's right for you.
Can I take this if I'm on warfarin?
No — not without clearing it with your doctor first. Both cascara sagrada and chamomile in this blend have documented Moderate-risk interactions with warfarin, increasing your bleeding risk. Your prescriber needs to know before you start.
What are the most common side effects?
With cascara sagrada, mild belly cramps and discomfort are most common with short-term use. Black walnut leaf and bark may upset your stomach. Pumpkin can cause abdominal discomfort, diarrhea, nausea, or vomiting. Slippery elm and chamomile can trigger allergic reactions in sensitive people, including skin rashes and severe reactions in rare cases.
I take lithium — can I use this?
Not without talking to your doctor. Both pumpkin and marshmallow in this blend have documented Moderate interactions with lithium; they may reduce lithium excretion and raise its levels to toxic amounts. Your prescriber needs to assess this.
What's in the capsule?
Seven active herbal ingredients — slippery elm, cascara sagrada, black walnut, pumpkin, mullein, chamomile, and marshmallow — combined in a proprietary blend. The capsule shell itself is the only inactive ingredient listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Herbal Pumpkin label
Go deeper

The Full Monographs Behind Herbal Pumpkin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Cascara Sagrada

Interacts with 745 drugs

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...

Read the full Cascara Sagrada monograph → Herb & supplement monograph

Black Walnut

Black walnut is a tree whose green hulls are traditionally used as a natural antiparasitic and digestive remedy, but solid human evidence for these uses is lacking. It contains a compound ca...

Read the full Black Walnut monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Mullein

Interacts with 122 drugs

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...

Read the full Mullein monograph → Herb & supplement monograph

German Chamomile

Interacts with 960 drugs

German chamomile is a widely used herbal remedy taken mainly as a tea for calming, sleep, and digestive complaints. Early research suggests possible benefits for mild anxiety and some skin o...

Read the full German Chamomile monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph →
Sources

Sources & How We Checked

Herbal Pumpkin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 42 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

Cascara Sagrada 9 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  5. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  6. Nadir A, Reddy D, Van Thiel DH. Cascara-sagrada induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000;95:3634-7. PubMed
  7. Nakasone ES, Tokeshi J. A serendipitous find: a case of cholangiocarcinoma identified incidentally after acute liver injury due to cascara sagrada ingestion. Hawaii J Med Public Health 2015;74(6):200-2.
  8. Cirillo C, Capasso R. Constipation and botanical medicines: an overview. Phytother Res 2015;29(10):1488-93. PubMed
  9. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Cascara Sagrada monograph →

Black Walnut 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor

See these in context on the Black Walnut monograph →

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
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See these in context on the Pumpkin monograph →

Mullein 2 references
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  2. Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.

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German Chamomile 15 references
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  9. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
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See these in context on the German Chamomile monograph →

Marshmallow 5 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
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See these in context on the Marshmallow monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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