Interactions on record — worth a quick check against your medications. Based on 5 of 15 ingredients. Check your meds →
Dietary supplement

High Potency Multi Enzyme Ingredients & Drug Interactions

by Natural Factors

High Potency Multi Enzyme label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Potency Multi Enzyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Potency Multi Enzyme is a dietary supplement by Natural Factors with 15 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Potency Multi Enzyme by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with High Potency Multi Enzyme by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Potency Multi Enzyme by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 15 of its 15 active ingredients.
  • “For Carbohydrate Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “For Protein Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “For Lipid Digestion” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product is a 15-ingredient enzyme blend designed to support digestion across all three macronutrients. You've got carbohydrate-digesting enzymes (Diastase, Glucoamylase, Alpha-Galactosidase, Invertase, and Hemicellulase), protein-digesting enzymes (Bromelain, Papain, and three Proteases), and fat-digesting enzymes (Lipase and Triacylglycerol Lipase).

Lactase, which breaks down milk sugar, rounds it out. The capsule itself and the microcrystalline cellulose and magnesium stearate inside are inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive support and nutrient absorption.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Exercise-induced muscle soreness, Bloating, Indigestion, Nutrient malabsorption.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

For most of these enzymes, the evidence we hold doesn't establish whether they work. Bromelain and papain have been studied for conditions like hay fever, burns, cancer, and muscle soreness, but the data is insufficient to rate them.

Lipase and the proteases have no effectiveness ratings on file. Lactase is the exception — it's effective for lactose intolerance.

For everything else in this formula, we just don't have enough reliable evidence to say whether it does what the label claims.

The evidence, ingredient by ingredient Lactase Bromelain Papain Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated short-term, though long-term safety data is limited. Common side effects are diarrhea, flatulence, stomach upset, and headache; topically, it can cause itching or hives.

Allergic reactions are possible, especially if you're sensitive to pineapple. Papain is similarly tolerated when used appropriately, but high doses may be unsafe and can cause severe stomach inflammation or even esophageal perforation.

Most people experience mild allergic reactions if sensitive. Lactase is generally well tolerated; one case of allergic reaction in a worker exposed to powdered lactase has been reported.

The three proteases are well tolerated for most adults but may cause digestive upset or allergic reactions in some. None of these ingredients have enough pregnancy data — bromelain and papain should be avoided, while Lipase and the proteases lack sufficient information; talk to your doctor or pharmacist before using during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Lactase Bromelain Papain Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs (Moderate severity) — bromelain may increase bleeding risk. Papain may interact specifically with warfarin (Moderate severity).

If you're on tetracycline antibiotics (Minor severity), bromelain might affect how your body absorbs them. We could not check several ingredients in this formula, so bring your medication list to the pharmacy before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This multi-enzyme supplement is aimed at supporting overall digestion. If you take blood thinners like warfarin, aspirin, or clopidogrel, or if you're on tetracycline antibiotics, you need to check this product with your pharmacist first — bromelain and papain carry documented interactions.

Pregnant or breastfeeding individuals should discuss it with their doctor before starting. For anyone with a serious digestive condition, get medical guidance before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Potency Multi Enzyme, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958017457
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2018
DSLD ID 179374
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Potency Multi Enzyme by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
068958017457
IngredientAmount% DV
Diastase20 mg--
Alpha-Galactosidase11.66 mg--
Enzyme Blend283.22 mg--
Bromelain3.48 mg--
Papain2.74 mg--
Amylase76.67 mg--
Triacylglycerol Lipase7.72 mg--
Glucoamylase19.21 mg--
Cellulase3.61 mg--
Hemicellulase1.44 mg--
For Carbohydrate Digestion0 NP--
For Protein Digestion0 NP--
Protease I40 mg--
Protease II58 mg--
Protease III25.54 mg--
For Lipid Digestion0 NP--
Lactase12 mg--
Invertase1.15 mg--

Other ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

isura Non-GMO - Mass spec Documentation - Lab tested

Suggested/Recommended/Usage/Directions

Suggested Usage: 1 capsule per day with food or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

General Statements

Multi Enzyme capsules are the optimal digestive aid containing a full spectrum of plant derived enzymes in a single supplement. To help improve the body's absorption of nutrients, these valuable enzymes break down carbohydrates, proteins, and fats. This includes starch, polysaccharides, lactose, and other sugars. Natural supplementation is an excellent way to replenish enzymes lost from foods during cooking and processing.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada

Purity & potency guaranteed

Recyclable container and label.

Healthy digestion

FCC (Food Chemical Codex), DU (Dextrinizing Unit), CU (Cellulase Unit), ALU (Acid Lactase Unit), DP (Diastatic Power), AGU (Amyloglucosidase Unit), GaIU (a-Galactosidase Unit), SU (Invertase Sumner Unit), HCU (Hemicellulase Unit), HUT (Hemoglobin Unit on the Tyrosine Basis), PC (Proteolytic Activity-Casseins), SAPU (Spectrophotometric Acid Protease Unit), PU (Papain Unit), FIP (International Pharmaceutical Federation).

Formulation

Contains no artificial colors, preservatives, or sweeteners; no dairy, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.

Suitable for vegetarians/vegans.

Vegetarian formula

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General

R6

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Potency Multi Enzyme by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Potency Multi Enzyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Potency Multi Enzyme by Natural Factors

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Enzyme Blend

283.22 mg per serving

For Carbohydrate Digestion

0 NP per serving
  • › Diastase
  • › Alpha-Galactosidase
  • › Amylase
  • › Glucoamylase
  • › Cellulase
  • › Hemicellulase
  • › Lactase
  • › Invertase

For Protein Digestion

0 NP per serving

For Lipid Digestion

0 NP per serving

Other (inactive) ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Potency Multi Enzyme by Natural Factors Drug Interactions

Want to check YOUR meds against High Potency Multi Enzyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in High Potency Multi Enzyme interact with 141 drugs. Click any drug to see the details.

2 of the 15 ingredients in High Potency Multi Enzyme interact with drugs. Each result below shows which ingredient is responsible. Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in High Potency Multi Enzyme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Potency Multi Enzyme, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

High Potency Multi Enzyme by Natural Factors: Common Questions

Does High Potency Multi Enzyme by Natural Factors interact with any medications?
Yes. Based on its ingredients, High Potency Multi Enzyme has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Potency Multi Enzyme contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this work for my digestion?
That depends which enzyme you're counting on. Lactase, which breaks down milk sugar, is proven effective for lactose intolerance. For the others — bromelain, papain, and the various proteases and carbohydrate enzymes — we don't have enough reliable evidence to say whether they work.
What are the most common side effects?
Bromelain and papain can cause diarrhea, gas, stomach upset, and headache when taken by mouth. Some people experience allergic reactions like itching, hives, or (rarely) trouble breathing. The proteases may cause digestive upset or allergic reactions too. Lactase is well tolerated.
Can I take this while pregnant?
Bromelain and papain should be avoided in pregnancy — there isn't enough safety data. The other ingredients (Lipase and the proteases) also lack sufficient pregnancy information. Talk to your doctor or pharmacist before using any of them while pregnant; they can help you decide what's right for you.
Is it safe to breastfeed while taking this?
Most ingredients don't have solid breastfeeding safety data, so the advice is to check with your doctor or pharmacist first. Lactase is the safest option since it acts only in your gut and isn't absorbed into your bloodstream.
Why do I need so many different enzymes?
Each enzyme breaks down a different type of nutrient: carbohydrate enzymes break down starches and sugars, proteases break down protein, and lipase breaks down fat. This blend is meant to support digestion across all three.
Are there any fillers in this?
The capsule itself is vegetarian, and it also contains microcrystalline cellulose and magnesium stearate as inactive ingredients — these are standard binders and flow agents in supplement capsules.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Potency Multi Enzyme label
Go deeper

The Full Monographs Behind High Potency Multi Enzyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

High Potency Multi Enzyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 35 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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