Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Homocysteine Supreme Ingredients & Drug Interactions

by Designs for Health

Homocysteine Supreme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Homocysteine Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Homocysteine Supreme is a dietary supplement by Designs for Health with 6 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are N-Acetyl-Cysteine, Vitamin B-6, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Homocysteine Supreme by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Homocysteine Supreme by Designs for Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Homocysteine Supreme by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (3,400 mcg) without saying how much of each component you get.

Homocysteine Supreme contains 6 active ingredients: vitamin B12, vitamin B-6, N-acetyl cysteine (NAC), riboflavin, folate (listed as a blend), and trimethylglycine. These are combined with inactive ingredients including cellulose, microcrystalline cellulose, dicalcium phosphate, silicon dioxide, and vegetable stearate.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Acetaminophen poisoning — rated "Effective" (N-acetyl Cysteine (nac)) (Natural Medicines).
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Atelectasis — rated "Effective" (N-acetyl Cysteine (nac)) (Natural Medicines).
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Tracheostomy care — rated "Effective" (N-acetyl Cysteine (nac)) (Natural Medicines).

Vitamin B12 in this product is effective for B12 deficiency and Imerslund-Grasbeck disease (a rare genetic disorder affecting B12 absorption), and likely effective for cyanide poisoning; it's possibly effective for canker sores and postherpetic neuralgia (nerve pain after shingles). Vitamin B-6 is effective for sideroblastic anemia and B6 deficiency, and likely effective for high homocysteine (hyperhomocysteinemia).

N-acetyl cysteine is effective for acetaminophen (Tylenol) poisoning and possibly effective for bronchitis. We don't have effectiveness data on file for riboflavin, folate blend components, trimethylglycine, or the specific folate form (Quatrefolic) in this product.

The evidence, ingredient by ingredient Vitamin B12 Vitamin B6 N-acetyl Cysteine (nac) Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very safe with no established upper limit since excess is removed in the urine; it's considered safe during pregnancy and breastfeeding at recommended amounts. Vitamin B-6 is safe at normal dietary amounts and standard supplement doses, but high doses over time can harm nerves (sensory neuropathy), especially at 1,000 mg daily or higher or with prolonged use.

It's possibly unsafe in pregnancy—follow your provider's guidance. N-acetyl cysteine is generally well tolerated at typical doses but hasn't been well studied in pregnancy; use only under a doctor's supervision.

Riboflavin is very safe and needed in pregnancy and breastfeeding at recommended amounts. Most adverse effects from these ingredients are mild: B6 can cause headache, nausea, or loss of appetite at standard doses; NAC may cause diarrhea, dry mouth, or nausea; riboflavin commonly causes bright yellow urine and rarely nausea.

Serious side effects are rare.

Side effects, ingredient by ingredient Vitamin B12 Vitamin B6 N-acetyl Cysteine (nac) Riboflavin

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Vitamin B12, Vitamin B6, Riboflavin, N-acetyl Cysteine (nac).
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; Parkinson's medications.
  • For scale: 370 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use nitroglycerin or other heart medications—N-acetyl cysteine can cause dangerous drops in blood pressure and severe headaches with nitroglycerin. Also clear it if you take blood pressure medications, seizure drugs (phenobarbital or phenytoin), amiodarone, blood thinners, the diabetes drug metformin, the antimalarial chloroquine, or tetracycline antibiotics.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

This product is designed to help manage homocysteine levels through B vitamins and related compounds. If you take medications for blood pressure, heart rhythm, seizures, diabetes, blood thinning, or use nitroglycerin or tetracycline antibiotics, talk with your doctor or pharmacist before starting it.

Even though some interactions are theoretical, the nitroglycerin risk is real and serious. Use it only as directed and discuss with your healthcare provider whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Homocysteine Supreme, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452000704
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2020
DSLD ID 239497
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Homocysteine Supreme by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
879452000704
IngredientAmount% DV
Folate3400 mcg850%
Vitamin B121000 mcg41667%
Quatrefolic (6S)-5-Methyltetrahydrofolate, Glucosamine Salt4000 mcg--
Vitamin B-610 mg588%
N-Acetyl-Cysteine100 mg--
Riboflavin30 mg2308%
Trimethylgylcine900 mg--

Other ingredients: Cellulose, Microcrystalline Cellulose, Dicalcium Phosphate, Silicon Dioxide, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Report any adverse reactions to 860-623-6314

For professional use only

Keep out of reach of children.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Guaranteed GMP Compliant Products

Formulation

Manufactured in a GMP Registered Facility in the USA

Does not contain gluten.

Notice: Color, size or shape may appear different between lots.

Made with non-GMO ingredients

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take two capsules per day with meals, or as directed by your health care practitioner.

Brand IP Statement(s)

Quatrefolic is covered by U.S. Patent No. 7,947,662 and is a registered trademark of Gnosis S.p.A.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Homocysteine Supreme by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Homocysteine Supreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Homocysteine Supreme by Designs for Health

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Folate

3400 mcg per serving
  • › Quatrefolic (6S)-5-Methyltetrahydrofolate, Glucosamine Salt

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Vitamin B-6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B-6 monograph & interactions

N-Acetyl-Cysteine

Interacts with
294 drugs
100 mg per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl-Cysteine monograph & interactions

Riboflavin

Interacts with
20 drugs
30 mg per serving Form: Riboflavin 5-Phosphate

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Trimethylgylcine

900 mg per serving

Other (inactive) ingredients: Cellulose, Microcrystalline Cellulose, Dicalcium Phosphate, Silicon Dioxide, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Homocysteine Supreme by Designs for Health Drug Interactions

Want to check YOUR meds against Homocysteine Supreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
1 Major 344 Moderate 25 Minor

Ingredients driving the most interactions

N-Acetyl-Cysteine 294
Vitamin B-6 210
Vitamin B12 20
Riboflavin 20

Individual Drug Interactions

The ingredients in Homocysteine Supreme interact with 370 drugs. Click any drug to see the details.

4 of the 6 ingredients in Homocysteine Supreme interact with drugs. Each result below shows which ingredient is responsible. N-Acetyl-Cysteine Vitamin B-6 Vitamin B12 Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Homocysteine Supreme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

N-Acetyl-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl-Cysteine full monograph & interactions

Vitamin B-65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B-6 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Homocysteine Supreme, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Phone Number
860-623-6314
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

Homocysteine Supreme by Designs for Health: Common Questions

Does Homocysteine Supreme by Designs for Health interact with any medications?
Yes. Based on its ingredients, Homocysteine Supreme has a known interaction with 370 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Homocysteine Supreme contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant?
The ingredients have mixed safety ratings in pregnancy. Vitamin B12 and riboflavin are considered safe at recommended amounts, and B12 is actually needed during pregnancy. Vitamin B-6 is likely safe but possibly unsafe—your doctor should weigh the benefit for you. N-acetyl cysteine hasn't been well studied in pregnancy. Talk with your provider before starting any supplement during pregnancy; they know your individual situation.
Can I take this while breastfeeding?
Vitamin B12 and riboflavin are safe and actually important during breastfeeding at recommended amounts. Vitamin B-6 is considered safe at normal levels while breastfeeding. Safety data for N-acetyl cysteine during breastfeeding isn't available—check with your doctor or pharmacist to be sure.
What does N-acetyl cysteine do in this formula?
N-acetyl cysteine (NAC) is included to support overall wellness as part of the homocysteine-lowering blend. On its own, it's effective for acetaminophen poisoning and possibly effective for bronchitis, but in this product it's one piece of a multi-ingredient formula designed for homocysteine support.
Will this cause any common side effects?
Most users tolerate it well. At normal doses, the main side effects are mild: nausea, headache, diarrhea, dry mouth, or loss of appetite are possible but uncommon. Riboflavin may turn your urine bright yellow—that's harmless. High doses of B-6 over time can cause nerve damage, but this product is dosed for safety.
Does this product contain any fillers?
Yes—there are inactive ingredients listed, including cellulose, dicalcium phosphate, silicon dioxide, and vegetable stearate. These are standard excipients used to make the capsule and help the product hold together.
Can I take this if I'm on metformin for diabetes?
Metformin can lower vitamin B12 levels over time, which is why some people taking it need B12 supplementation. This product contains B12, which may help offset that effect, but the interaction is only Minor. Still, mention it to your doctor or pharmacist so they can monitor your B12 status if needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Homocysteine Supreme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Homocysteine Supreme label
Go deeper

The Full Monographs Behind Homocysteine Supreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Homocysteine Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 153 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
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Vitamin B6 32 references
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N-acetyl Cysteine (nac) 86 references
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See these in context on the N-acetyl Cysteine (nac) monograph →

Riboflavin 5 references
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