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Dietary supplement

Horny Goat Weed 600 mg Ingredients & Drug Interactions

by Nutricost

Horny Goat Weed 600 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horny Goat Weed 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horny Goat Weed 600 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for erectile dysfunction, low libido, fatigue and low energy.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed Leaf and Stem Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Horny Goat Weed 600 mg by Nutricost

Ask about any prescription or over-the-counter medication and we check it for interactions with Horny Goat Weed 600 mg by Nutricost — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Horny Goat Weed 600 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Horny Goat Weed Leaf and Stem Extract at 600 mg per capsule. The extract comes from the leaf and stem parts of the horny goat weed plant.

The capsule itself is made with gelatin and silicon dioxide, which are inactive ingredients that hold the extract together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Horny Goat Weed product and its label doesn't state a use — see Horny Goat Weed's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold doesn't establish that horny goat weed works for any of the conditions listed — sexual dysfunction, bronchitis, osteoporosis, and heart disease all have insufficient reliable evidence to rate. That doesn't mean it doesn't work; it means robust clinical trials in humans haven't yet proven it does.

If you're considering this for a specific health concern, talk with your pharmacist about what the stronger evidence says for your situation.

The evidence, ingredient by ingredient Horny Goat Weed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of horny goat weed appears generally well tolerated, though quality varies between products and human safety data is limited. The most common side effects reported are dizziness, dry mouth, nosebleed, thirst, and vomiting.

Long-term use has been linked to the same effects. A rare serious adverse effect — respiratory arrest — has been reported, though it's uncommon.

Because there isn't enough safety data, the evidence advises against use during pregnancy and while breastfeeding; talk with your doctor or pharmacist if you're in either situation and considering this supplement.

Side effects, ingredient by ingredient Horny Goat Weed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horny Goat Weed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 964 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check your medications against these types: blood thinners and antiplatelet drugs (like warfarin and aspirin), blood pressure medications, estrogen or hormone therapy, and any drug metabolized by your liver enzymes CYP1A2, CYP2B6, or CYP3A4 — which covers hundreds of common prescriptions. Use the checker on this page with your exact medication names and doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Horny Goat Weed may be worth considering if you're interested in its traditional uses and have no drug interactions, but the evidence doesn't yet prove it works for the major conditions it's marketed for. If you take blood pressure medications, blood thinners, hormone therapy, or any prescription metabolized by your liver, check with your pharmacist first — this product interacts with a broad range of medications.

Pregnant or breastfeeding? Skip it and ask your pharmacist for safer options.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horny Goat Weed 600 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 702669931472
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269548
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horny Goat Weed 600 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
180
UPC/BARCODE
702669931472
IngredientAmount% DV
Horny Goat Weed Leaf and Stem Extract600 mg--

Other ingredients: Gelatin, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 1 capsule daily with 8-12 oz of water or as directed by your healthcare professional.

Precautions

Warning: For healthy individuals 18 years and older.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Notice: Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

600 mg per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Guaranteed Nutricost

Third Party Tested

Formulation

Non GMO Gluten Free Product

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horny Goat Weed 600 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horny Goat Weed 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horny Goat Weed 600 mg by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Horny Goat Weed Leaf and Stem Extract

Interacts with
963 drugs
600 mg per serving Form: Epimedium sagittatum Leaf Extract, Epimedium sagitatum Stem Extract

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...

Horny Goat Weed Leaf and Stem Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horny Goat Weed 600 mg by Nutricost Drug Interactions

Want to check YOUR meds against Horny Goat Weed 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
963Drugs
963 Moderate

Ingredients driving the most interactions

Horny Goat Weed Leaf and Stem Extract 963

Individual Drug Interactions

The ingredients in Horny Goat Weed 600 mg interact with 963 drugs. Click any drug to see the details.

1 of the 1 ingredient in Horny Goat Weed 600 mg interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed Leaf and Stem Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Horny Goat Weed 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed Leaf and Stem Extract6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed Leaf and Stem Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horny Goat Weed 600 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

Horny Goat Weed 600 mg by Nutricost: Common Questions

Does Horny Goat Weed 600 mg by Nutricost interact with any medications?
Yes. Based on its ingredients, Horny Goat Weed 600 mg has a known interaction with 963 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horny Goat Weed 600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin or aspirin?
You shouldn't without checking with your pharmacist first. Horny goat weed may increase bleeding risk based on lab studies, though we haven't seen this happen in people yet. Your pharmacist can tell you whether your specific blood thinner and this supplement are safe together.
What are the most common side effects?
Dizziness, dry mouth, nosebleed, thirst, and vomiting have been reported. They're mild, but they can happen. Long-term use has been tied to the same effects.
Is this safe to take while pregnant or breastfeeding?
The safety data advises against it. There isn't enough information to know whether it's safe during pregnancy or while breastfeeding, so talk with your doctor or pharmacist for personalized advice if you're in either situation.
Does horny goat weed actually improve sexual function?
The evidence we hold is insufficient to say. There haven't been enough robust clinical trials to prove it works for sexual dysfunction, even though that's what it's often marketed for.
Can this affect my blood pressure?
Lab research suggests horny goat weed might lower blood pressure, but this hasn't been reported in people. If you're on blood pressure medication or have blood pressure concerns, mention this supplement to your pharmacist before starting it.
Why does quality vary between products if this is just one ingredient?
Even though horny goat weed is the only active ingredient listed, the amount and purity of the actual extract can differ between manufacturers. That's why it matters where you buy from and to stick with a brand you trust.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Horny Goat Weed 600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horny Goat Weed 600 mg label
Go deeper

The Full Monographs Behind Horny Goat Weed 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph →
Sources

Sources & How We Checked

Horny Goat Weed 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horny Goat Weed 11 references
  1. Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
  2. Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
  3. De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
  4. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  5. Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. PubMed
  6. Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. PubMed
  7. Ramanathan VS, Mitropoulos E, Shlopov B, et al. An Enzyte'ing' case of acute hepatitis. J Clin Gastroenterol 2011;45(9):834-5. PubMed
  8. Zhong Q, Shi Z, Zhang L, et al. The potential of Epimedium koreanum Nakai for herb-drug interaction. J Pharm Pharmacol 2017;69(10):1398-408. doi: 10.1111/jphp.12773.
  9. Irfan M, Kwon TH, Lee DH, et al. Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. Evid Based Complement Alternat Med. Apr 2021;2021:7071987. PubMed
  10. Tan K, Yang W, Pang L, Hou F. Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury. Medicine (Baltimore) 2022;101(32):e29909. PubMed
  11. Li K, Yu XH, Maskey AR, et al. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol 2023;13:1042756. PubMed

See these in context on the Horny Goat Weed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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