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Dietary supplement

Horny Goat Weed Extract Ingredients & Drug Interactions

by BulkSupplements.com

Horny Goat Weed Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horny Goat Weed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horny Goat Weed Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for erectile dysfunction, low libido, fatigue and low energy.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed Leaf, Stem Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Horny Goat Weed Extract by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Horny Goat Weed Extract by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Horny Goat Weed Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Horny Goat Weed Leaf, Stem Extract, Powder. It's a concentrated extract made from the leaf and stem of the horny goat weed plant, supplied as a powder you can mix or take with food or drink.

There are no other inactive ingredients listed.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Sexual function and libido support.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual dysfunction, Fatigue, Postmenopausal conditions, Low sexual desire, Vitality.
  • The closest evidence on file: Horny Goat Weed is rated "Insufficient Reliable Evidence To Rate" for Sexual dysfunction (Natural Medicines).
  • Also on file: Horny Goat Weed is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Fatigue, Postmenopausal conditions.

The evidence isn't established in the data we hold. For the uses listed — bronchitis, sexual dysfunction, osteoporosis, and coronary heart disease — all carry a rating of insufficient reliable evidence.

That means we don't have enough solid clinical studies to say whether this extract actually works for any of these conditions.

The evidence, ingredient by ingredient Horny Goat Weed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of horny goat weed seems to be generally well tolerated, though human safety data is limited and quality varies between products. The most common side effects reported are dizziness, dry mouth, nosebleed, thirst, and vomiting.

Long-term use has been linked to some of those same effects. A rare serious effect — respiratory arrest — has been reported, and one case of abnormal heartbeat (tachyarrhythmia) was noted in a man with existing heart disease, though causality wasn't clear.

During pregnancy, the safety data advises against use — it's rated possibly unsafe. While breastfeeding, there isn't enough safety data to know either way; talk with your doctor or pharmacist about whether it's right for you.

Because quality varies, also check the label for third-party testing or purity certification if that matters to you.

Side effects, ingredient by ingredient Horny Goat Weed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horny Goat Weed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 964 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on any blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin), blood pressure medications, estrogen-based birth control or hormone therapy, or any drug that depends on liver enzymes CYP1A2, CYP2B6, or CYP3A4 to be broken down — all carry Moderate interaction severity with horny goat weed. Use the medication checker on this page with your exact drugs to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Horny Goat Weed Extract might interest people looking to experiment with traditional remedies, but the evidence for its effectiveness isn't established yet. If you take any blood thinners, blood pressure medications, estrogen-based drugs, or medications processed by your liver, you need to check with us or your pharmacist first — the interaction risk is real.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or have heart issues.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horny Goat Weed Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000Y6TDX1
Net contents 500 Gram(s); 17.6 Ounce(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294899
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horny Goat Weed Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1000 mg
Maximum serving Sizes:
1000 mg
Servings per container
500
UPC/BARCODE
X000Y6TDX1
IngredientAmount% DV
Horny Goat Weed Leaf, Stem Extract, Powder1000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Aphrodisiac for women - goat weed for men

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1000 mg (about 2/5 tsp) once daily, or as directed by a physician.

Storage

Store in a dry, cool place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horny Goat Weed Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horny Goat Weed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horny Goat Weed Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1000 mg Dosage formPowder Servings per container500 Amounts shown are per serving.

Horny Goat Weed Leaf, Stem Extract, Powder

Interacts with
963 drugs
1000 mg per serving Form: Epimedium sagittatum Leaf Extract, Powder, Epimedium sagittatum Stem Extract, Powder

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...

Horny Goat Weed Leaf, Stem Extract, Powder monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horny Goat Weed Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Horny Goat Weed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
963Drugs
963 Moderate

Ingredients driving the most interactions

Horny Goat Weed Leaf, Stem Extract, Powder 963

Individual Drug Interactions

The ingredients in Horny Goat Weed Extract interact with 963 drugs. Click any drug to see the details.

1 of the 1 ingredient in Horny Goat Weed Extract interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed Leaf, Stem Extract, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Horny Goat Weed Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed Leaf, Stem Extract, Powder6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed Leaf, Stem Extract, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horny Goat Weed Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Horny Goat Weed Extract by BulkSupplements.com: Common Questions

Does Horny Goat Weed Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Horny Goat Weed Extract has a known interaction with 963 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horny Goat Weed Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does horny goat weed actually work for sexual dysfunction?
The evidence isn't established yet. The data we hold rates sexual dysfunction as having insufficient reliable evidence, so we can't say whether it truly works for that purpose.
What are the most common side effects?
Dizziness, dry mouth, nosebleed, thirst, and vomiting have been reported most often. These seem mild in short-term use, but you should know they're possible.
Can I take this while pregnant?
No — the safety data advises against it during pregnancy. If you're pregnant or planning to be, talk with your doctor or pharmacist before using this product.
Can I take this while breastfeeding?
There isn't enough safety data to know either way. Talk with your doctor or pharmacist for personalized advice on whether it's right for you.
Is this just horny goat weed, or does it have other stuff in it?
It's just the horny goat weed extract — no other active ingredients. There are no other inactive ingredients (fillers or binders) listed either.
Why does quality vary between products?
The safety data notes that human data is limited and quality varies between horny goat weed products. That's why checking the label for third-party testing or purity certification can help you pick a reliable one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Horny Goat Weed Extract is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horny Goat Weed Extract label
Go deeper

The Full Monographs Behind Horny Goat Weed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph →
Sources

Sources & How We Checked

Horny Goat Weed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horny Goat Weed 11 references
  1. Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
  2. Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
  3. De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
  4. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  5. Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. PubMed
  6. Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. PubMed
  7. Ramanathan VS, Mitropoulos E, Shlopov B, et al. An Enzyte'ing' case of acute hepatitis. J Clin Gastroenterol 2011;45(9):834-5. PubMed
  8. Zhong Q, Shi Z, Zhang L, et al. The potential of Epimedium koreanum Nakai for herb-drug interaction. J Pharm Pharmacol 2017;69(10):1398-408. doi: 10.1111/jphp.12773.
  9. Irfan M, Kwon TH, Lee DH, et al. Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. Evid Based Complement Alternat Med. Apr 2021;2021:7071987. PubMed
  10. Tan K, Yang W, Pang L, Hou F. Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury. Medicine (Baltimore) 2022;101(32):e29909. PubMed
  11. Li K, Yu XH, Maskey AR, et al. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol 2023;13:1042756. PubMed

See these in context on the Horny Goat Weed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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