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Dietary supplement

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored Ingredients & Drug Interactions

by Nature's Way

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored is a dietary supplement by Nature's Way with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus NCFM. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Immunables Proprietary Blend” is a proprietary blend — the label gives one combined amount (172 mg) without saying how much of each component you get.

This product has 2 active ingredients: Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07, both live-culture probiotics (beneficial bacteria) that work in your child's gut. The blend also includes inactive ingredients — potato maltodextrin, xylitol, starch, natural flavor, calcium silicate, and stevia — which help preserve and flavor the powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and immune support for kids.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Lactose intolerance, Respiratory tract infections, Rotaviral diarrhea — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Constipation, Lactose intolerance, Rotaviral diarrhea, and more.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), recovery from Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence is insufficient to rate it for acute respiratory distress syndrome (ARDS), and it appears ineffective for atopic disease (eczema, asthma, allergies).

We hold no effectiveness data for Bifidobacterium lactis Bi-07.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Most kids won't have any trouble with it, though a small number of trial participants reported mild gastrointestinal side effects like stomach discomfort, gas, bloating, or diarrhea when taking probiotics — these are uncommon.

Because this product contains live organisms, there's a theoretical risk of infection in patients with severe immune weakness or critical illness; check with your doctor before use, especially if your child has a serious health condition. We hold no safety data for Bifidobacterium lactis Bi-07.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your child's doctor or pharmacist before combining this product with antibiotic drugs (Moderate severity). Timing matters — antibiotics can reduce how well this probiotic works if taken at the same time.

No other major interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic is a reasonable choice for kids dealing with IBS, diarrhea after antibiotics, or related digestive issues, based on what we know about L. acidophilus. The main thing to watch: if your child is on antibiotics, space them out from this product so the antibiotics don't kill off the beneficial bacteria.

Talk with your child's doctor or pharmacist before starting, especially if they have any serious health conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674105214
Net contents 30 Single Serve Packet(s); 45 Gram(s); 1.58 Oz(s)
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 202109
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Gluten Free, Dairy Free, Sugar Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 Gram(s)
Maximum serving Sizes:
1.5 Gram(s)
UPC/BARCODE
033674105214
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Sugar0 Gram(s)--
Lactobacillus acidophilus NCFM0 NP--
Sugar Alcohol0.05 Gram(s)--
Bifidobacterium lactis Bi-070 NP--
Immunables Proprietary Blend172 mg--

Other ingredients: Potato Maltodextrin, Xylitol, Starch, Natural flavor, Calcium Silicate, Stevia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Shield your kids every day with Primadophilus Optima Kids probiotic. Developed just for kids, our product contains a unique probiotic blend of B. lactis Bi-07 and L. acidophilus NCFM, at the researched potency of 10 billion CFU per serving, so you can be confident that you're helping support your child's immune health. Promote healthy immune function in kids Reduce days absent from school Research involved children between 3-5 years of age

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Easy to use Just 1 packet a day Pour in mouth Add to cold drinks Mix into cold foods

Recommendation: For children 2 years of age and older, empty contents of 1 packet directly into mouth, or mix into cold drinks such as water, milk or juice or add to unheated foods such as cold cereal, yogurt or applesauce. Can be taken everyday.

Recommendation: For children 2 years of age and older, empty contents of 1 packet directly into mouth or mix with cold foods or drinks.

General Statements

LBN10521.04 BLK8858

10 Billion Active Probiotics Per Serving (1.5 g each)

Formulation

Sugar-free Gluten-free

Dairy-free No salt, wheat, soy, artificial colors, flavors or preservatives.

Vegetarian

FDA Statement of Identity

Probiotic Supplement

Precautions

Caution: For children under 2 years of age, consult a healthcare professional before use. Not for use in premature infants. Keep out of reach of children.

Tamper Evident. Do not use if packets are open or torn.

Brand IP Statement(s)

2017 Distributed by Nature's Way Brands, LLC

NCFM and Bi-07 are trademarks of DuPont. In the USA, NCFM is a trademark of the North Carolina Agriculture Foundation, Inc. NCFM and Bi-07 are used under license.

Storage

No refrigeration required. Store in a cool, dry place at 73(0)F (23(0)C) or below. 10 billion CFUs guaranteed until expiration date when stored under recommended conditions.

Seals/Symbols

Vegetarian

General

LPK10521.05 BLK8858

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1.5 Gram(s) Dosage formOther (e.g. Tea Bag) Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 Gram(s) per serving

Immunables Proprietary Blend

172 mg per serving

Other (inactive) ingredients: Potato Maltodextrin, Xylitol, Starch, Natural flavor, Calcium Silicate, Stevia. These complete the product’s ingredient list but are not active constituents.

Interaction report

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way Drug Interactions

Want to check YOUR meds against Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus NCFM 182

Individual Drug Interactions

The ingredients in Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus NCFM

Each ingredient & the kinds of drugs it affects

For each ingredient in Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus NCFM1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus NCFM full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way: Common Questions

Does Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored by Nature's Way interact with any medications?
Yes. Based on its ingredients, Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my child at the same time as an antibiotic?
It's better to space them out. Antibiotics can kill the live bacteria in this probiotic, making it less effective. Ask your child's doctor or pharmacist how far apart to take them — usually a few hours is enough.
Will this help with my kid's diarrhea after antibiotics?
Lactobacillus acidophilus is possibly effective for that. It's a common reason people use probiotics, and the research suggests it may help, though results vary from child to child.
What are the side effects?
Most kids tolerate it well. A small number reported mild stomach discomfort, gas, bloating, or loose stools — these are uncommon and usually temporary. If your child has a serious illness or weak immune system, talk with your doctor first.
Is it safe during pregnancy or breastfeeding?
Lactobacillus acidophilus is rated possibly safe in pregnancy. We don't have safety data on file for breastfeeding. If you're pregnant or nursing and want to use this, talk it over with your doctor or midwife.
What exactly is in this powder?
Two live probiotic bacteria — Lactobacillus acidophilus and Bifidobacterium lactis — plus inactive ingredients like maltodextrin, xylitol, and stevia for texture and taste.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored label
Go deeper

The Full Monographs Behind Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Primadophilus Optima Kids Probiotics 10 Billion Vanilla Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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