Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Immune Formula with Colostrum Plus Ingredients & Drug Interactions

by Symbiotics

Immune Formula with Colostrum Plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Immune Formula with Colostrum Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Immune Formula with Colostrum Plus is a dietary supplement by Symbiotics with 5 active ingredients. Its ingredients are commonly taken for iron deficiency and anemia support, immune support, gut health.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta 1-3 Glucans, Arabinogalactan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Immune Formula with Colostrum Plus by Symbiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with Immune Formula with Colostrum Plus by Symbiotics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Immune Formula with Colostrum Plus by Symbiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Bovine Colostrum” is listed as a grouped ingredient — the label gives one combined amount (645 mg) without saying how much of each component you get.

This formula contains 6 active ingredients. Lactoferrin is an iron-binding protein that occurs naturally in breast milk and other body fluids.

Larch arabinogalactan is a fiber derived from larch wood. Olive leaf extract is a concentrated form of compounds from the olive plant.

Beta-glucans are naturally occurring polysaccharides found in fungi and grains. The product also contains Immunoglobulins, Proline-rich Polypeptides, and Bovine Colostrum (early milk from cows, which contains antibodies and other immune factors).

The inactive ingredients include medium-chain triglycerides, sunflower lecithin, silicon dioxide, and HPMC (a capsule material).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: immune support during environmental or physical stress.
  • We looked for evidence on: Common cold, Influenza, Respiratory tract infections, Exercise-induced respiratory infections, Lower respiratory tract infections, Chemotherapy-related infection — and 4 related terms.
  • The closest evidence on file: Lactoferrin is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactoferrin is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections.
  • Also on file: Olive is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced respiratory infections, Influenza.

The evidence for this product's ingredients is mixed. Beta-glucans are likely effective for high cholesterol (dyslipidemia) and coronary heart disease.

Lactoferrin is possibly effective for sepsis and pregnancy-related iron deficiency, but is likely ineffective for preventing necrotizing enterocolitis and reducing fetal and premature infant mortality. For larch arabinogalactan and olive leaf extract, the evidence isn't established — we have insufficient reliable data on whether they work for common cold, high cholesterol, bone health, joint health, or viral infections.

The effectiveness of Immunoglobulins and Proline-rich Polypeptides is not rated in our data.

The evidence, ingredient by ingredient Lactoferrin Larch Arabinogalactan Olive Bovine Colostrum Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactoferrin is generally well tolerated at typical doses, though at very high doses (7.2 grams daily) constipation, diarrhea, fatigue, and chills have been reported. Long-term safety data are limited.

In pregnancy, some research exists but safety is not fully established — use only under medical supervision. Its safety while breastfeeding is not well studied, though lactoferrin occurs naturally in breast milk.

Larch arabinogalactan is generally well tolerated as a fiber but may cause bloating and flatulence; long-term safety data are limited, and not enough safety data exist for pregnancy or breastfeeding — talk with your doctor before use. Olive leaf extract appears well tolerated in typical amounts; headache and stomach discomfort have been reported rarely, and one patient reported skin/acne.

Concentrated olive supplements are less studied than the food forms. Beta-glucans from food sources are generally well tolerated, but concentrated supplements lack safety data.

During breastfeeding, there is little research on supplement doses. We hold no pregnancy/lactation data on file for arabinogalactan, olive leaf extract, or beta-glucans — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Lactoferrin Larch Arabinogalactan Olive Bovine Colostrum Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Larch Arabinogalactan, Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your immunosuppressant medications (such as cyclosporine, tacrolimus, azathioprine, mycophenolate, and others) with your pharmacist before starting — larch arabinogalactan and beta-glucans may interfere with them (Moderate risk). Also check any blood pressure medications you take, as beta-glucans might lower your blood pressure further (Moderate risk).

No interactions are documented for lactoferrin or olive leaf extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to people looking for immune support with research-backed ingredients like beta-glucans. If you take immunosuppressant drugs (after a transplant or for an autoimmune disease) or blood pressure medications, check with your pharmacist before adding this formula — it could interfere with how those drugs work.

Lactoferrin and the other ingredients are generally well tolerated, but long-term safety data are limited for most of them. If you're pregnant or breastfeeding, discuss this product with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Immune Formula with Colostrum Plus, straight from the product label.

Brand Symbiotics
Barcode (UPC) 647303040076
Net contents 120 Veg Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 275846
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Immune Formula with Colostrum Plus by Symbiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
647303040076
IngredientAmount% DV
Calories7 Calorie(s)--
Lactoferrin57 mg--
Arabinogalactan100 mg--
Olive leaf extract100 mg--
Immunoglobulins126 mg--
Proline-rich Polypeptides31 mg--
Bovine Colostrum645 mg--
Beta 1-3 Glucans50 mg--

Other ingredients: Medium Chain Triglycerides, Sunflower Lecithin, Silicon Dioxide, HPMC

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Notes: Immune Factors Fight back with Symbiotics Multi-Nutrient Immune formula to provide extra support when your body is under environmental or physical stress. Arabinogalactan, Beta 1-3 Glucan, Lactoferrin and Olive Leaf Extract contribute immune boosting properties to help you maintain good health. Symbiotics Immune Formula also contains Colostrum Plus Immulox. Colostrum is a uniquely helpful supplement that contains Lactoferrin, Immunoglobulins and Proline-Rich Polypeptides (PRPs) and Immulox contributes additional PRPs to help stabilize your immune system.

With Immulox 10% immune system stabilizer

Formulation

Quality and Purity Assured. Symbiotics Colostrum is exclusively from USDA Grade A dairies. Only from first milking.

Laboratory tested and verified free from pesticides, antibiotics and rBHT hormones.

Colostrum may vary in taste, aroma, consistency and color.

Stimulates immune activity Supports normal GI tract health

Gluten free

Made in the U.S.A. with U.S.A. Colostrum and Imported Ingredients.

Precautions

Each bottle is double sealed for quality and safety. If either seal is broken or missing, do not use and call 1-800-421-1830.

Warning: If you have a physician-diagnosed health condition, consult your doctor before taking this product. Discontinue use if you experience adverse reactions and consult your doctor.

Contains: Milk

Storage

Close tightly and store in cool, dry place (below 75 degrees F), away from heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Symbiotics and Colostrum Plus are registered trademarks of Prevention, LLC. Nature's First Immune Defense is a trademark of Prevention, LLC. Immulox is a registered trademark of APS Biogroup.

Copyright 2016 Prevention, LLC.

Symbiotics Nature's First Immune Defense

General Statements

New veg caps

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules, twice daily, with water or your drink of choice, on empty stomach. Triple this amount in times of environmental or physical stress.

Seals/Symbols

Quality Assured Purity

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Immune Formula with Colostrum Plus by Symbiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Immune Formula with Colostrum Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Immune Formula with Colostrum Plus by Symbiotics

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactoferrin

No known
interactions
57 mg per serving

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is...

Lactoferrin monograph & interactions

Arabinogalactan

Interacts with
121 drugs
100 mg per serving

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but...

Arabinogalactan monograph & interactions

Olive leaf extract

No known
interactions
100 mg per serving

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive leaf extract monograph & interactions

Bovine Colostrum

No known
interactions
645 mg per serving Form: Milk

Bovine colostrum is the nutrient-rich first milk from cows, packed with antibodies, growth factors, and protein. Early research suggests it may help w...

Bovine Colostrum monograph & interactions
  • › Immunoglobulins
  • › Proline-rich Polypeptides

Beta 1-3 Glucans

Interacts with
293 drugs
50 mg per serving

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly low...

Beta 1-3 Glucans monograph & interactions

Other (inactive) ingredients: Medium Chain Triglycerides, Sunflower Lecithin, Silicon Dioxide, HPMC. These complete the product’s ingredient list but are not active constituents.

Interaction report

Immune Formula with Colostrum Plus by Symbiotics Drug Interactions

Want to check YOUR meds against Immune Formula with Colostrum Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Beta 1-3 Glucans 293
Arabinogalactan 121

Individual Drug Interactions

The ingredients in Immune Formula with Colostrum Plus interact with 293 drugs. Click any drug to see the details.

2 of the 5 ingredients in Immune Formula with Colostrum Plus interact with drugs. Each result below shows which ingredient is responsible. Beta 1-3 Glucans Arabinogalactan

Each ingredient & the kinds of drugs it affects

For each ingredient in Immune Formula with Colostrum Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta 1-3 Glucans2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Beta 1-3 Glucans full monograph & interactions

Arabinogalactan1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D
Arabinogalactan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Immune Formula with Colostrum Plus, from the product label.

Symbiotics

See all Symbiotics products
Name
Naturade a division of Prevention, LLC
City
Irvine
State
CA
ZipCode
92614
Phone Number
1-800-421-1830
Web Address
www.symbiotics.com
Pharmacist Counseling Corner

Immune Formula with Colostrum Plus by Symbiotics: Common Questions

Does Immune Formula with Colostrum Plus by Symbiotics interact with any medications?
Yes. Based on its ingredients, Immune Formula with Colostrum Plus has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Immune Formula with Colostrum Plus contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually work for boosting immunity?
The evidence varies by ingredient. Beta-glucans are likely effective for cholesterol and heart health. Lactoferrin is possibly effective for sepsis and pregnancy-related iron deficiency but likely won't prevent serious neonatal infections. For the other ingredients — larch arabinogalactan, olive leaf extract, and the colostrum components — we don't have enough reliable data to say whether they work. Talk with your pharmacist about what you're hoping to achieve.
Is it safe to take while I'm breastfeeding?
There isn't enough safety data on this product during breastfeeding. Although lactoferrin occurs naturally in breast milk, the safety of taking a concentrated supplement while nursing is not well studied. The same goes for the other ingredients. Discuss this product with your doctor or pharmacist before using it while breastfeeding.
Can I take this if I'm pregnant?
The safety data are not well established for pregnancy. Lactoferrin has been studied in some pregnant people, but safety is not fully confirmed — use only under medical supervision if at all. For the other ingredients, there isn't enough data. Talk with your doctor or pharmacist before taking this product while pregnant.
What are the most common side effects I might notice?
At typical doses, these ingredients are generally well tolerated. Larch arabinogalactan may cause bloating and flatulence because it's a fiber. Lactoferrin can occasionally cause diarrhea or constipation. Olive leaf extract has rarely caused headache or stomach discomfort. At much higher doses than recommended, lactoferrin may cause fatigue or chills.
Does this product contain any fillers?
Yes. In addition to the active ingredients, the capsules contain medium-chain triglycerides, sunflower lecithin, silicon dioxide, and HPMC (a capsule material). These are inactive excipients — standard ingredients that help deliver the active components.
What is colostrum and why is it in this formula?
Colostrum is the early milk produced by cows after giving birth. It's rich in antibodies, immunoglobulins, and other compounds thought to support immune function. This product's colostrum is listed as a blend — meaning some of its individual components (like Immunoglobulins and Proline-rich Polypeptides) are shown separately in the label.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Immune Formula with Colostrum Plus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Immune Formula with Colostrum Plus label
Go deeper

The Full Monographs Behind Immune Formula with Colostrum Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactoferrin

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is being studied for immune support, iron l...

Read the full Lactoferrin monograph → Herb & supplement monograph

Larch Arabinogalactan

Interacts with 121 drugs

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...

Read the full Larch Arabinogalactan monograph → Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph → Herb & supplement monograph

Bovine Colostrum

Bovine colostrum is the nutrient-rich first milk from cows, packed with antibodies, growth factors, and protein. Early research suggests it may help with gut health, certain types of diarrhe...

Read the full Bovine Colostrum monograph → Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Immune Formula with Colostrum Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 35 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactoferrin 6 references
  1. Food and Drug Administration, CFSAN/Office of Food Additive Safety. Agency Response Letter GRAS Notice No. GRN 000130. 2003. Available at: http://www.cfsan.fda.gov/~rdb/opa-g130.html (Accessed 29 June 2005).
  2. Okada S, Tanaka K, Sato T, et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res 2002;93:1063-9. PubMed
  3. Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017;219:45-52. PubMed
  4. Tarnow-Mordi WO, Abdel-Latif ME, Martin A, et al. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. Lancet Child Adolesc Health. 2020 Jun PubMed
  5. ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019 Feb 2;393(10170):423-433. doi: 10.1016/S0140-6736(18)32221-9.
  6. Lepanto MS, Rosa L, Cutone A, Conte MP, Paesano R, Valenti P. Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: An interventional study. Front Immunol. 2018 Sep 21;9:2123. PubMed

See these in context on the Lactoferrin monograph →

Larch Arabinogalactan 8 references
  1. D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
  2. Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  3. Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
  4. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. PubMed
  5. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. PubMed
  6. Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8. DOI
  7. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. PubMed
  8. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.

See these in context on the Larch Arabinogalactan monograph →

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Bovine Colostrum 8 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Greenberg PD, Cello JP. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:348-54. PubMed
  3. Duff WR, Chilibeck PD, Rooke JJ, Kaviani M, Krentz JR, Haines DM. The effect of bovine colostrum supplementation in older adults during resistance training. Int J Sport Nutr Exerc Metab. 2014 Jun;24(3):276-85. PubMed
  4. Sanctuary MR, Kain JN, Chen SY, et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLoS One. 2019;14(1):e0210064. PubMed
  5. Porcaro F, Caminiti L, Crisafulli G, Guglielmo F, Pajno GB. Anaphylaxis to cutaneous exposure to bovine colostrum based cream. Asian Pac J Allergy Immunol. 2019;37(1):9-11.
  6. Yan X, Pan X, Ding L, et al. Bovine colostrum to supplement the first feeding of very preterm infants: The PreColos randomized controlled trial. Clin Nutr 2023;42(8):1408-1417. PubMed
  7. Halasa M, Skonieczna-Zydecka K, Machalinski B, Bühner L, Baskiewicz-Halasa M. Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children. Nutrients 2023;15(16):3626 PubMed
  8. Simonsen MB, Kappel SS, Aunsholt L, Möller S, Sangild PT, Zachariassen G. Mineral supplementation for very preterm infants fed fortified human milk. J Pediatr Gastroenterol Nutr 2024;78(6):1389-1397. PubMed

See these in context on the Bovine Colostrum monograph →

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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