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Dietary supplement

Indolplex Ingredients & Drug Interactions

by Integrative Therapeutics

Indolplex label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Indolplex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Indolplex is a dietary supplement by Integrative Therapeutics with 1 active ingredient. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 269 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Indolplex Diindolylmethane (BR-DIM) Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Indolplex by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Indolplex by Integrative Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Indolplex by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Indolplex contains one active ingredient: diindolylmethane (DIM), a compound found naturally in cruciferous vegetables like broccoli and cabbage. It's been studied for its potential role in hormone metabolism and cellular health.

The capsule also contains several inactive ingredients — cellulose, hypromellose, modified food starch, silica, tocophersolan, phosphatidylcholine, and magnesium stearate — that serve as fillers, binders, and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Diindolylmethane's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Hormone and estrogen balance support.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Breast cancer, Cervical dysplasia, Colorectal cancer, Mastalgia, Premenstrual syndrome (PMS) — and 4 related terms.
  • The closest evidence on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Diindolylmethane is rated "Insufficient Reliable Evidence To Rate" for Breast cancer, Colorectal cancer, Cervical dysplasia, Mastalgia, and more.

The evidence for diindolylmethane isn't yet established for any of the conditions we've reviewed — including benign prostate enlargement (BPH), breast cancer, colorectal cancer, cervical dysplasia, or breast pain (mastalgia). We hold insufficient reliable evidence to rate it for these uses.

If you're considering it for a specific health concern, talk with your pharmacist or doctor about what the current science actually supports.

The evidence, ingredient by ingredient Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated in the short term. The most common side effects are mild — diarrhea, gas, headache, nausea, rash, and vomiting.

A very rare serious reaction called DRESS (drug rash with eosinophilia and systemic symptoms) has been reported. One case of stroke was noted in a patient taking DIM alongside other supplements, though that patient had several stroke risk factors unrelated to DIM, and it's unclear whether DIM played a role.

Long-term safety isn't well established, so use caution if you're taking it beyond short periods. Because diindolylmethane may affect hormones, the safety data advises against use in pregnancy.

There isn't enough data to know whether it's safe while breastfeeding — talk with your pharmacist or doctor for personalized guidance.

Side effects, ingredient by ingredient Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 269 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Indolplex, check with us about estrogens (including birth control and hormone replacement therapy — Moderate risk), diuretic drugs for blood pressure or swelling (Moderate risk), and any medications your liver metabolizes, particularly older antidepressants or pain relievers that are CYP1A2 substrates (Minor risk).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Indolplex may be worth considering if you're interested in DIM and have no reason to avoid it, but check your medications first — especially birth control, hormone therapy, and water pills. Its effectiveness for any specific condition isn't proven yet.

Long-term safety is unknown, so discuss it with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Indolplex, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791000483
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 322140
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Indolplex by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
871791000483
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Indolplex Diindolylmethane (BR-DIM) Complex240 mg--

Other ingredients: Cellulose, Hypromellose, modified Food Starch, Silica, Tocophersolan, Phosphatidylcholine, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

For more information, please visit integrativepro.com

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Not formulated for children.

Warning: Do not take if you are pregnant, nursing, or attempting to become pregnant. If you have a hormone-sensitive condition or other medical condition or are taking any medications, consult a healthcare professional before use.

A harmless but noticeable change in urine color may occur during usage of this product.

Do not exceed recommended dose.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Brand IP Statement(s)

Indolplex and BR-DIM is a proprietary, enhanced bioavailability complex containing Diindolylmethane licensed from BioResponse, LLC., Boulder, CO.

Copyright 2024 Integrative Therapeutics, LLC

Formulation

Vegan

Contains no wheat, soy, gluten, dairy, or artificial colors or flavors.

Seals/Symbols

Vegan Quality Global Sourcing Bottled & Tested in the USA

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Indolplex with BR-DIM Bioavailable diindolylmethane

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 2 capsules daily with food, may reduce to 1 capsule daily with food, or as recommended by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Indolplex by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Indolplex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Indolplex by Integrative Therapeutics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Indolplex Diindolylmethane (BR-DIM) Complex

Interacts with
269 drugs
240 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Indolplex Diindolylmethane (BR-DIM) Complex monograph & interactions

Other (inactive) ingredients: Cellulose, Hypromellose, Modified Food Starch, Silica, Tocophersolan, Phosphatidylcholine, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Indolplex by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Indolplex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
269Drugs
116 Moderate 153 Minor

Ingredients driving the most interactions

Indolplex Diindolylmethane (BR-DIM) Complex 269

Individual Drug Interactions

The ingredients in Indolplex interact with 269 drugs. Click any drug to see the details.

1 of the 1 ingredient in Indolplex interact with drugs. Each result below shows which ingredient is responsible. Indolplex Diindolylmethane (BR-DIM) Complex

Each ingredient & the kinds of drugs it affects

For each ingredient in Indolplex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Indolplex Diindolylmethane (BR-DIM) Complex3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Indolplex Diindolylmethane (BR-DIM) Complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Indolplex, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
800-931-1709
Web Address
integrativepro.com
Pharmacist Counseling Corner

Indolplex by Integrative Therapeutics: Common Questions

Does Indolplex by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Indolplex has a known interaction with 269 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Indolplex contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Indolplex if I'm on birth control or hormone replacement therapy?
Not without checking first. Diindolylmethane may theoretically increase or decrease how your body handles estrogens, which could affect their effectiveness or side effects. Talk with your pharmacist or doctor before you start — they can assess your specific situation.
What side effects should I watch for?
Most common ones are mild: diarrhea, gas, headache, nausea, rash, and vomiting. Very rarely, a serious allergic skin reaction called DRESS has been reported. Stop and call your doctor if you develop a severe rash, fever, or swollen lymph nodes.
Is Indolplex safe to take long-term?
Long-term safety isn't well established. Short-term studies show it's generally well tolerated, but we don't have solid data on what happens with months or years of use. Discuss duration with your pharmacist if you're planning to take it regularly.
Can I take Indolplex while pregnant or breastfeeding?
The data supports use in pregnancy. However, there isn't enough safety information to recommend it while breastfeeding — talk with your pharmacist or doctor before you take it during lactation.
Does Indolplex actually work for prostate health or cancer prevention?
The evidence isn't there yet. We don't have reliable studies showing diindolylmethane works for benign prostate enlargement, any type of cancer, or other conditions it's marketed for. Ask your doctor about proven options for what you're trying to address.
What's diindolylmethane, and where does it come from?
It's a compound found naturally in cruciferous vegetables like broccoli, cabbage, and Brussels sprouts. Your body creates small amounts of DIM when you eat these foods. Indolplex provides a concentrated dose in capsule form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Indolplex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Indolplex label
Go deeper

The Full Monographs Behind Indolplex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

Indolplex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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