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Dietary supplement

Ivy Extract 50 mg Ingredients & Drug Interactions

by Nature's Way

Ivy Extract 50 mg label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ivy Extract 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ivy Extract 50 mg is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for cough and chest congestion, bronchitis, asthma symptoms.Based on those ingredients, 280 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are English Ivy Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ivy Extract 50 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Ivy Extract 50 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ivy Extract 50 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: English Ivy Leaf Extract at 50 mg per dose. The extract is made from the leaf of the English ivy plant and is standardized to provide consistent amounts of the plant's active compounds.

The tablet also contains several inactive ingredients — cellulose, sodium croscarmellose, stearic acid, magnesium stearate, hypromellose, silica, glycerin, and carnauba wax — which are excipients (fillers and binders) that help hold the tablet together and aid absorption.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see English Ivy's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Traditional respiratory support.
  • We looked for evidence on: Bronchitis, Cough, Respiratory tract infections, Chest congestion, Asthma symptoms.
  • The closest evidence on file: English Ivy is rated "Insufficient Reliable Evidence To Rate" for Bronchitis (Natural Medicines).
  • Also on file: English Ivy is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Cough.

The evidence for English ivy leaf extract isn't established in our data. The product is marketed for respiratory conditions (bronchitis and respiratory tract infections), joint and muscle concerns (gout and spasticity), and nerve pain (neuropathic pain), but there's insufficient reliable evidence to rate how well it works for any of these uses.

If you're considering it for one of these purposes, talk with your pharmacist about what the current research actually shows.

The evidence, ingredient by ingredient English Ivy

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The standardized leaf extract in this product is generally well tolerated. The most common side effects reported when taken by mouth are abdominal pain, diarrhea, nausea, and vomiting; skin irritation has also been reported.

It's important to know that raw English ivy plant material is toxic and can cause poisoning or severe skin reactions — but this product uses a standardized extract, which is much safer. During pregnancy, there isn't enough reliable safety information, so it's best avoided.

Safety while breastfeeding is unknown, so don't use it unless your doctor directs you to.

Side effects, ingredient by ingredient English Ivy

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — English Ivy.
  • The most serious interaction on file is rated Moderate.
  • For scale: 280 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take English Ivy Extract, double-check any medications you're on that are processed by CYP2C19, CYP2D6, or CYP2C8 enzymes — a pharmacy checker tool or your pharmacist can tell you if yours are on that list. These interactions are theoretically Moderate in severity, meaning the extract could raise drug levels and potentially cause side effects or reduced effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

English ivy extract has potential interactions with a large number of medications through how your liver processes them — lab evidence is strong but human reports are absent. If you take any prescription drugs or certain over-the-counter medications, check with your pharmacist before starting this supplement.

Pregnant people and those breastfeeding should avoid it without medical direction.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ivy Extract 50 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948082391
Net contents 90 Vegan Tablet(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 293290
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ivy Extract 50 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
45
UPC/BARCODE
763948082391
IngredientAmount% DV
English Ivy Leaf Extract50 mg--

Other ingredients: Cellulose, Sodium Croscarmellose, Stearic Acid, Magnesium Stearate, Hypromellose, Silica, Glycerin, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Traditional respiratory support

Traditional respiratory support

Gluten free. No yeast-derived ingredients, wheat, corn, soy, dairy, or artificial colors.

Vegan

General Statements

At Nature's Way, we believe nature knows best. That's why our mission is to seek out the best herbs the earth has to give. We will go to any continent or country to find where herbs grow best, so we can bring you the purest botanicals possible. It's the way we deliver uncompromising quality and the way to help you live healthier. It's not just our way, it's Nature's Way.

Questions? 1-800-9NATURE / naturesway.com Bottles made from 97% post-consumer recycled plastic

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

From English Ivy Leaf

Ivy Extract 50 mg per serving

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults take 2 tablets three times daily.

Precautions

Warning: Do not use if you are pregnant or nursing. If you are taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Brand IP Statement(s)

Copyright 2022 Nature's Way Brands, LLC

Seals/Symbols

Quality Global Sourcing Bottled & Tested in the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ivy Extract 50 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ivy Extract 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ivy Extract 50 mg by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container45 Amounts shown are per serving.

English Ivy Leaf Extract

Interacts with
280 drugs
50 mg per serving

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many...

English Ivy Leaf Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Sodium Croscarmellose, Stearic Acid, Magnesium Stearate, Hypromellose, Silica, Glycerin, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ivy Extract 50 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Ivy Extract 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
280Drugs
280 Moderate

Ingredients driving the most interactions

English Ivy Leaf Extract 280

Individual Drug Interactions

The ingredients in Ivy Extract 50 mg interact with 280 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ivy Extract 50 mg interact with drugs. Each result below shows which ingredient is responsible. English Ivy Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Ivy Extract 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

English Ivy Leaf Extract3 drug types · 280 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
In vitro research shows that English ivy inhibits CYP2C8 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
English Ivy Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ivy Extract 50 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Ivy Extract 50 mg by Nature's Way: Common Questions

Does Ivy Extract 50 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Ivy Extract 50 mg has a known interaction with 280 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ivy Extract 50 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between this standardized extract and raw English ivy?
Raw English ivy plant is toxic and can cause poisoning or bad skin reactions. This product uses a standardized leaf extract, which is much safer and generally well tolerated. That's why you want the extract, not the raw plant material.
What side effects might I get from taking this?
The most common ones are abdominal pain, diarrhea, nausea, and vomiting when taken by mouth. Skin irritation has also been reported. Most people tolerate it well, but these are the ones to watch for.
Can I take this while I'm pregnant or breastfeeding?
Not during pregnancy — there isn't enough safety data, so it's best avoided. While breastfeeding, safety is unknown, so don't use it unless your doctor tells you to. Talk with your doctor or pharmacist about your situation.
Does English ivy actually work for colds or bronchitis?
The evidence isn't established in our data. It's marketed for respiratory infections and bronchitis, but there's not enough reliable research to say whether it works. Your pharmacist can point you toward what the current science actually shows.
Why do I need to check my medications with a pharmacist?
This extract may inhibit liver enzymes that break down many common drugs — everything from antidepressants to heart meds to pain relievers. That could raise the levels of those drugs in your blood. We can't list them all here, but a quick pharmacy check with your exact medications will tell you if there's a concern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ivy Extract 50 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ivy Extract 50 mg label
Go deeper

The Full Monographs Behind Ivy Extract 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

English Ivy

Interacts with 280 drugs

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many European herbal products. Some research...

Read the full English Ivy monograph →
Sources

Sources & How We Checked

Ivy Extract 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

English Ivy 13 references
  1. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  2. Fazio S, Pouso J, Dolinsky D, et al. Tolerance, safety and efficacy of Hedera helix extract in inflammatory bronchial diseases under clinical practice conditions: a prospective, open, multicentre postmarketing study in 9657 patients. Phytomedicine 2009;16 PubMed
  3. García M, Fernández E, Navarro JA, et al. Allergic contact dermatitis from Hedera helix L. Contact Dermatitis 1995;33(2):133-4.
  4. Hausen BM, Brohan J, Konig WA, et al. Allergic and irritant contact dermatitis from falcarinol and didehydrofalcarinol in common ivy (Hedera helix L.). Contact Dermatitis 1987;17(1):1-9.
  5. Mitchell, J. C. Allergic contact dermatitis from Hedera helix and Brassaia actinophylla (Araliaceae). Contact Dermatitis 1981;7(3):158-159.
  6. Boyle J, Harman RM. Contact dermatitis to Hedera helix (common ivy). Contact Dermatitis 1985;12(2):111-112. PubMed
  7. Yesudian PD, Franks A. Contact dermatitis from Hedera helix in a husband and wife. Contact Dermatitis 2002;46(2):125-126.
  8. Bregnbak D, Menné T, Johansen JD. Airborne contact dermatitis caused by common ivy (Hedera helix L. ssp. helix). Contact Dermatitis. 2015;72(4):243-4.
  9. Jones JM, White IR, White JM, McFadden JP. Allergic contact dermatitis to English ivy (Hedera helix)--a case series. Contact Dermatitis. 2009 Mar;60(3):179-80.
  10. Lurquin E, Swinnen I, Goossens A. Allergic contact dermatitis caused by Hedera helix arborescens and not by Hedera helix L. Contact Dermatitis. 2012;66(6):352-3.
  11. Paulsen E, Christensen LP, Andersen KE. Dermatitis from common ivy (Hedera helix L. subsp. helix) in Europe: past, present, and future. Contact Dermatitis. 2010;62(4):201-9.
  12. Rehman SU, Kim IS, Choi MS, Kim SH, Zhang Y, Yoo HH. Time-dependent Inhibition of CYP2C8 and CYP2C19 by Hedera helix Extracts, A Traditional Respiratory Herbal Medicine. Molecules. 2017;22(7). PubMed
  13. Kruttschnitt E, Wegener T, Zahner C, Henzen-Bücking S. Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis. Evid Based Complement Alternat Med. 2020 May 4;2

See these in context on the English Ivy monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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