Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

PM Formula Ingredients & Drug Interactions

by Nature's Way

PM Formula label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PM Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PM Formula is a dietary supplement by Nature's Way with 4 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,263 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian Root Extract, Hops Flower Extract, Black Cohosh Rhizome, Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PM Formula by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with PM Formula by Nature's Way — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of PM Formula by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Valerian Root Extract” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.
  • “Black Cohosh Rhizome, Root Extract” is listed as a grouped ingredient — the label gives one combined amount (20 mg) without saying how much of each component you get.

PM Formula contains 4 active ingredients. Suntheanine is theanine, an amino acid derived from tea.

Hops Flower Extract comes from the female flowers of the hop plant and is used traditionally in sleep and relaxation supplements. Valerian Root Extract and Black Cohosh Rhizome Root Extract are herbal extracts — the product also includes Triterpene Glycosides and Valerenic Acid, compounds that are components or metabolites of these plants.

The tablet also contains inactive ingredients (binders, capsule material, and other excipients) including cellulose, hypromellose, sodium croscarmellose, magnesium stearate, glycerin, silica, carrot extract, and paprika extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: sleep support and menopausal symptom relief.
  • We looked for evidence on: Insomnia, Menopausal symptoms, Premenstrual syndrome (PMS), Anxiety, Stress, Night sweats — and 1 related terms.
  • The closest evidence on file: Hops is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Hops is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Menopausal symptoms.
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Generalized anxiety disorder (GAD), Insomnia, Stress.

The evidence for this product's ingredients is mixed and mostly limited. Suntheanine (theanine) is possibly effective for cognitive function, but the evidence for age-related cognitive decline, Alzheimer disease, anxiety disorders, and cancer is insufficient to rate.

Hops Flower Extract shows insufficient evidence for age-related cognitive decline, sexual dysfunction, anxiety, ADHD, indigestion, and insomnia — so we don't have solid data that it works for the sleep or relaxation claims this type of product usually makes. We hold no effectiveness data for Valerian Root Extract, Triterpene Glycosides, Black Cohosh, or Valerenic Acid in our monographs.

The evidence, ingredient by ingredient Theanine Valerian Hops Black Cohosh

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Suntheanine is generally well tolerated in healthy adults for short-term use, but long-term safety isn't well studied. Some people report headaches, drowsiness, longer sleep, or more vivid dreams.

Hops is also generally well tolerated short-term and may cause drowsiness; long-term safety is unclear. Occupational exposure to hops dust can cause chronic respiratory symptoms, though this is mainly a concern for workers.

A few cases of postmenopausal bleeding have been associated with supplements containing hops and soy together, though it's unclear which ingredient (or the combination) was responsible. Allergic contact reactions to fresh hops plant material have been reported.

During pregnancy, there isn't enough safety data for Suntheanine or Hops, so it's best to avoid these ingredients. While breastfeeding, safety data is unknown for both — avoid use and talk with your pharmacist or doctor for personalized guidance.

Side effects, ingredient by ingredient Theanine Valerian Hops Black Cohosh

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Hops, Theanine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1,058 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check the following before taking PM Formula: antihypertensive medications (blood pressure drugs), CNS depressants (sleep aids, sedatives, anxiety medications, certain pain relievers), hormone replacement therapy, and medications processed by your liver's CYP1A2 and CYP3A4 enzymes — ask your pharmacist to screen your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medication, antidepressants, sleep aids, hormone therapy, or medications metabolized by your liver, check your specific drugs with the interaction checker before starting PM Formula. The product is generally well tolerated short-term, but we don't have strong evidence it works for sleep or cognitive issues, and long-term safety isn't established.

Pregnant or breastfeeding? Skip it and talk to your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PM Formula, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948072361
Net contents 30 PM Tablet(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333903
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Women (not pregnant or lactating), Girls: (All), Adult Female (18 - 50 Years), Menopause
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PM Formula by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
763948072361
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Suntheanine50 mg--
Valerian Root Extract200 mg--
Triterpene Glycosides0.5 mg--
Hops Flower Extract100 mg--
Black Cohosh Rhizome, Root Extract20 mg--
Valerenic Acid1.6 mg--

Other ingredients: Cellulose, Hypromellose, Sodium Croscarmellose, Magnesium Stearate, Glycerin, Silica, Carrot Extract, Paprika extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

PM Occasional sleeplessness Nights sweats

Hormone free formula supports: Nighttime restful sleep

Hormone free Drug free

Day & night relief for PMS & perimenopausal symptoms Plant powered

Gluten free. No wheat, soy, dairy, or gelatin.

Day & night symptom relief Support for physical and emotional symptoms of PMS and perimenopause PM formula - Helps with: Night sweats Restful sleep A relaxed mental state

Packaged and tested in the USA

Vegan Gelatin Free

Vegan Gelatin Free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

2 Dietary Supplements

General Statements

30 AM Tablets and 30 PM Tablets

Explore more products at naturesway.com

Brand IP Statement(s)

Suntheanine and Sunphenon are registered trademarks of Taiyo International, Inc.

Copyright 2024 Nature's Way Brands, LLC

Precautions

Keep out of reach of children.

This product has a tamper-evident foil pouch. Do not use if foil or plastic is punctured.

Do not take other Cimicifuga (black cohosh) containing products concurrently.

Warning for PM tablet: Do not use if you are pregnant or nursing. If you are taking sedatives, tranquilizers, or any other medications, consult a healthcare professional before use.

Avoid alcohol and do not drive or operate machinery while taking this product as it may cause drowsiness. Discontinue use and consult a healthcare professional if you have a liver disorder or develop symptoms of liver trouble, such as abdominal pain, dark urine, or jaundice.

Storage

Store at room temperature. Avoid excessive heat and direct sunlight.

Suggested/Recommended/Usage/Directions

Recommendation: PM: Women take 1 (purple) tablet 30-60 minutes before bedtime. May take four to five weeks to achieve full benefits. Continue use to maintain benefits.

Seals/Symbols

Vegan Gelatin Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PM Formula by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PM Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PM Formula by Nature's Way

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Suntheanine

Interacts with
565 drugs
50 mg per serving Form: L-Theanine

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

Suntheanine monograph & interactions

Valerian Root Extract

Interacts with
902 drugs
200 mg per serving

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...

Valerian Root Extract monograph & interactions
  • › Valerenic Acid

Hops Flower Extract

Interacts with
863 drugs
100 mg per serving

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Hops Flower Extract monograph & interactions

Black Cohosh Rhizome, Root Extract

Interacts with
652 drugs
20 mg per serving Form: Black Cohosh Rhizome Extract, Black Cohosh Root Extract

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It...

Black Cohosh Rhizome, Root Extract monograph & interactions
  • › Triterpene Glycosides

Other (inactive) ingredients: Cellulose, Hypromellose, Sodium Croscarmellose, Magnesium Stearate, Glycerin, Silica, Carrot Extract, Paprika extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

PM Formula by Nature's Way Drug Interactions

Want to check YOUR meds against PM Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,263Drugs
943 Moderate 320 Minor

Ingredients driving the most interactions

Valerian Root Extract 902
Hops Flower Extract 863
Black Cohosh Rhizome, Root Extract 652
Suntheanine 565

Individual Drug Interactions

The ingredients in PM Formula interact with 1,263 drugs. Click any drug to see the details.

4 of the 4 ingredients in PM Formula interact with drugs. Each result below shows which ingredient is responsible. Valerian Root Extract Hops Flower Extract Black Cohosh Rhizome, Root Extract Suntheanine

Each ingredient & the kinds of drugs it affects

For each ingredient in PM Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Valerian Root Extract6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
Valerian Root Extract full monograph & interactions

Hops Flower Extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Hops Flower Extract full monograph & interactions

Black Cohosh Rhizome, Root Extract7 drug types · 652 drugs

Atorvastatin (Lipitor)

Taking black cohosh with atorvastatin might increase the risk for elevated liver function tests.
In one case report, a patient taking atorvastatin (Lipitor) developed significantly elevated liver function enzymes after starting black cohosh 100 mg four times daily. Liver enzymes returned to normal when black cohosh was discontinued. It is unclear whether the elevated liver enzymes were due to black cohosh itself or an interaction between atorvastatin and black cohosh.

Likelihood Possible Evidence D
Cisplatin (Platinol-Aq)

Theoretically, black cohosh may reduce the clinical effects of cisplatin.
Animal research suggests that black cohosh might decrease the cytotoxic effect of cisplatin on breast cancer cells.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Some research suggests that black cohosh might inhibit CYP2D6, but there is conflicting evidence.
Some clinical research suggests that black cohosh might modestly inhibit CYP2D6 and increase levels of drugs metabolized by this enzyme. However, contradictory clinical research shows a specific black cohosh product (Remifemin, Enzymatic Therapy) 40 mg twice daily does not significantly inhibit metabolism of a CYP2D6 substrate in healthy study volunteers. Until more is known, use black cohosh cautiously in patients taking drugs metabolized by CYP2D6.

Likelihood Possible Evidence B
Estrogens

Theoretically, black cohosh may alter the effects of estrogen therapy.
Some research suggests that black cohosh has estrogenic effects. This may enhance or inhibit the effects of estrogen therapy.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.
There is concern that black cohosh might be linked to cases of liver failure and autoimmune hepatitis.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with black cohosh might cause additive serotonergic effects.
Black cohosh might increase the risk of serotonin syndrome when combined with other serotonergic drugs. Black cohosh acts as an agonist at several serotonin receptor subtypes and might interact with other serotonergic medications. In one case, a 55-year-old female who had been on stable treatment with sertraline 50 mg and duloxetine 60 mg daily developed serotonin syndrome after taking black cohosh extract 40 mg daily for 3 days.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Black cohosh may inhibit one form of OATP, OATP2B1, which could reduce the bioavailability and clinical effects of OATP2B1 substrates.
In vitro research shows that black cohosh modestly inhibits OATP2B1. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Black Cohosh Rhizome, Root Extract full monograph & interactions

Suntheanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
Suntheanine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PM Formula, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

PM Formula by Nature's Way: Common Questions

Does PM Formula by Nature's Way interact with any medications?
Yes. Based on its ingredients, PM Formula has a known interaction with 1,263 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PM Formula contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Suntheanine and what does it do?
Suntheanine is theanine, an amino acid from tea. The evidence suggests it's possibly effective for cognitive function, but we don't have reliable data that it helps with age-related cognitive decline, Alzheimer disease, or anxiety disorders.
Can I take this while I'm pregnant or breastfeeding?
No — there isn't enough safety data for Suntheanine or Hops during pregnancy or while breastfeeding. Talk to your pharmacist or doctor about whether this product is right for you.
What side effects might I experience?
Suntheanine may cause headaches, drowsiness, longer sleep, or more vivid dreams in some people. Hops may cause drowsiness. If you're sensitive to hops dust or the fresh plant, allergic reactions are possible, though they're rare with oral supplements.
Does this product actually help with sleep?
We don't have reliable evidence that Hops Flower Extract works for insomnia — the data is insufficient to rate. This product is marketed as a sleep aid, but we can't confirm that claim from the studies we hold.
Is this safe to take long-term?
Long-term safety for Suntheanine and Hops hasn't been well studied. Both are generally well tolerated for short-term use, but we don't have solid data on extended use. Talk to your pharmacist if you're thinking of taking it regularly.
What are the inactive ingredients and do they matter?
The tablet contains cellulose, hypromellose, sodium croscarmellose, magnesium stearate, glycerin, silica, carrot extract, and paprika extract — these are binders and fillers. For most people they don't cause issues, but if you have a sensitivity to any of them, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PM Formula is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PM Formula label
Go deeper

The Full Monographs Behind PM Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph → Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph → Herb & supplement monograph

Black Cohosh

Interacts with 652 drugs

Black cohosh is a North American plant most often used to ease menopause symptoms like hot flashes, but the research is mixed and far from settled. It is generally well tolerated for short-t...

Read the full Black Cohosh monograph →
Sources

Sources & How We Checked

PM Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 126 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Valerian 37 references
  1. Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
  2. Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
  3. Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
  4. Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
  5. Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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