Karelahills Ingredients & Drug Interactions
by Herbal Hills
What is this page for?
First and foremost: checking Karelahills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Karelahills is a dietary supplement by Herbal Hills with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 282 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are {Bitter Gourd} Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Karelahills by Herbal Hills
Ask about any prescription or over-the-counter medication and we check it for interactions with Karelahills by Herbal Hills — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Karelahills by Herbal Hills
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Karelahills contains 2 active ingredients, both forms of bitter gourd: a fruit extract and a fruit powder. Bitter gourd (also called bitter melon) is a tropical plant used traditionally to support blood sugar and digestion.
The product also contains inactive ingredients — magnesium stearate, silica, and a gelatin capsule — that help hold it together and deliver the active ingredients.
Does it work?
Couldn't assess
The evidence we have on bitter gourd for the uses claimed here — amenorrhea, athletic performance, liver disease, constipation, diabetes, and indigestion — is insufficient to give it a reliable rating. That doesn't mean it doesn't work; it means the studies so far haven't been strong enough to say.
If you're interested in bitter gourd for a specific condition, talk with your pharmacist or doctor about what the latest research shows for your situation.
How safe is it?
Well-documented data
Bitter gourd is generally well tolerated when used as food, but supplement doses can lower your blood sugar and cause stomach upset. Common side effects in clinical studies include heartburn, nausea, vomiting, diarrhea, constipation, gas, and belly discomfort — these occurred in about 3% to 16% of people who took it.
Rarely, very low blood sugar (hypoglycemic coma) and seizures in children have been reported. One case also documented kidney damage that developed over months of high-dose use and reversed after stopping the supplement.
Bitter gourd is traditionally avoided in pregnancy because seeds and high doses may cause harmful effects to the uterus. There isn't enough reliable safety data for breastfeeding, so it's best avoided then too.
Meds to double-check
Moderate interaction found
Before you take Karelahills, check whether you're on any diabetes medications (blood sugar pills or insulin), the cancer drug pazopanib, or any drugs that use P-glycoprotein to enter your cells — a category that spans many medications. All three are Moderate-severity interactions with bitter gourd.
Use the search tool on this page to look up your exact prescriptions.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Karelahills is worth discussing with your pharmacist if you're curious about bitter gourd for blood sugar or digestion — but only if you don't take diabetes drugs, certain cancer medications, or drugs that depend on a P-glycoprotein pump to work. If you take any prescription medications, check them against this product before you start, because the interaction list is long.
Pregnancy and breastfeeding are times to skip it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2012.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Karelahills, straight from the product label.
| Brand | Herbal Hills |
|---|---|
| Barcode (UPC) | 8906008260953 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2012 |
| DSLD ID | 15540 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Karelahills by Herbal Hills, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bitter Gourd fruit extract | 0 NP | -- |
| {Bitter Gourd} Blend | 450 mg | -- |
| Bitter Gourd fruit powder | 0 NP | -- |
Other ingredients: Magnesium Stearate, Silica, Gelatin Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
MULTIEFFECTIVE HERB
Batch No. : Exp. Date: Neutral Code # MH/PD/AYU/002/10
Healthy Blood Sugar
Pure – Natural – Effective Bitter Gourd is a traditional fruit considered to help maintaining healthy blood sugar level, cholesterol level, triglyceride level. It helps in cleansing toxins in the body and may act as a purgative, appetizer & helps regulate carbohydrate metabolism.
Contents based on standard Raw Material as per Ayurvedic Text
FDA Statement of Identity
HERBAL SUPPLEMENT
Dietary Supplement
Seals/Symbols
HERBALHILLS
GMP Good Manufacturing Practice
ISO 22000:2005 CERTIFIED COMPANY
EXTRACT STANDARDIZED EXTRACT
Storage
Store in a cool dry place away from direct sunlight.
Precautions
Keep out of reach of children.
Do not use if inner seal is broken or missing.
Caution : Pregnant or lactating women are advised to consume herbal products under the advice of the Healthcare Practitioner.
Formula
2% Bitter
Suggested/Recommended/Usage/Directions
Direction for use : As a dietary supplement take 1 capsule twice daily, preferably after meals or as recommended by a Healthcare Practitioner. For better results it should be taken with warm water
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Karelahills by Herbal Hills label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Karelahills by Herbal Hills
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
{Bitter Gourd} Blend
Interacts with282 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
{Bitter Gourd} Blend monograph & interactionsOther (inactive) ingredients: Magnesium Stearate, Silica, Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.
Karelahills by Herbal Hills Drug Interactions
HelloPharmacist Interaction Report
Karelahills by Herbal Hills contains bitter gourd in two forms, and both carry documented interactions with medications.
The most serious concern is with drugs that use a cellular pump called P-glycoprotein to get into your cells — bitter gourd may block that pump and raise their levels in your body, potentially causing harm. This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Bitter gourd also interacts with diabetes medications (Moderate severity). If you're taking pills to lower blood sugar, adding bitter gourd might push your glucose too low and cause dizziness, confusion, or worse.
You'll want to monitor your blood sugar closely if you use both.
One more Moderate-severity interaction: the cancer drug pazopanib (Votrient). There's a case report of a patient who developed acute pancreatitis after starting bitter melon juice while on pazopanib — it happened within days of beginning the supplement.
Altogether, these interactions span 275 individual medications. Please use the search tool on this page to check your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Karelahills?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Karelahills interact with 282 drugs. Click any drug to see the details.
1 of the 1 ingredient in Karelahills interact with drugs. Each result below shows which ingredient is responsible. {Bitter Gourd} Blend
AcalabrutinibCalquence
How Acalabrutinib interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Acetohexamide interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Afatinib Dimaleate interactionAlbiglutideTanzeum
How Albiglutide interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Gourd Fruit Powder + Alogliptin, Pioglitazone interactionAlvimopanEntereg
How Alvimopan interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Ambrisentan interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Amphotericin, Tetracycline interactionAmprenavirAgenerase
How Amprenavir interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApixabanEliquis
How Apixaban interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Apixaban interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Apomorphine Hydrochloride interactionArmodafinilNuvigil
How Armodafinil interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Armodafinil interactionAtogepantQulipta
How Atogepant interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Atogepant interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Atropine, Morphine Sulfate interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Avatrombopag Maleate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Beclomethasone Dipropionate interactionBelinostatBeleodaq
How Belinostat interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Belinostat interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Karelahills — through 1 ingredient. Tap an ingredient for the detail:
Bitter Gourd Fruit PowderP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Gourd Fruit Powder + Betamethasone Valerate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Karelahills with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
{Bitter Gourd} Blend
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Karelahills, from the product label.
Herbal Hills
See all Herbal Hills products- Name
- Isha Agro Developers Pvt. Ltd. (An ISO 22000:2005 Certified Company)
- Street Address
- 55-A/B, Lonavala Indl. Co-op. Est. Ltd.
- City
- Nangargaon
- State
- Lonavala
- Phone Number
- 0091 22 2868 6868
- Web Address
- www.herbalhills.in
Karelahills by Herbal Hills: Common Questions
Does Karelahills by Herbal Hills interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant?
Is it safe while breastfeeding?
What are the most common side effects?
Does bitter gourd actually work for diabetes?
What is bitter gourd supposed to do?
Are there any fillers in this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Karelahills is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Karelahills’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Karelahills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
- Kim B, Lee HS, Kim HJ, et al. Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study. Food Sci Biotechnol 2022;32(5):697-704. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC