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Dietary supplement

Khella Ingredients & Drug Interactions

by Herb Pharm

Khella label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Khella against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Khella is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for asthma and bronchitis, angina and heart-related chest pain, kidney stones.Based on those ingredients, 620 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Khella seed (Ammi visnaga) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Khella by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Khella by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Khella by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This is a straightforward single-ingredient product: Khella seed (Ammi visnaga) extract, which is the active ingredient. The extract is suspended in certified organic cane alcohol and distilled water as inactive carriers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Khella's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: respiratory and skin health support.
  • We looked for evidence on: Psoriasis, Vitiligo, asthma, bronchitis.
  • The closest evidence on file: Khella is rated "Insufficient Reliable Evidence To Rate" for Psoriasis (Natural Medicines).
  • Also on file: Khella is rated "Insufficient Reliable Evidence To Rate" for Vitiligo.

The evidence on khella for psoriasis and vitiligo—the conditions it's traditionally used for—isn't established enough for us to rate it. The data we hold shows insufficient reliable evidence for either condition, so we can't tell you whether it works for these purposes.

The evidence, ingredient by ingredient Khella

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Khella can cause nausea, dizziness, constipation, loss of appetite, headache, itching, and insomnia, especially with prolonged use or higher doses. It may also raise liver enzyme levels.

There's also concern it could increase your skin's sensitivity to sunlight. The safety data is limited, and the product is not recommended during pregnancy—the evidence advises against it.

There isn't enough data on its safety while breastfeeding; talk with your pharmacist or doctor for personalized guidance if you're nursing or planning to breastfeed.

Side effects, ingredient by ingredient Khella

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Khella.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 621 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with us if you're on digoxin (Lanoxin) for your heart—khella can weaken it. Also flag any photosensitizing medications like quinolones (Ciprofloxacin), tetracyclines, sulfa antibiotics (Septra, Bactrim), or amitriptyline (Elavil).

And let us know about any drugs that stress the liver, including acetaminophen (Tylenol), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid, methotrexate (Rheumatrex), or methyldopa (Aldomet).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Khella may be worth considering if you're exploring options for psoriasis or vitiligo, but the evidence of its effectiveness isn't strong. The real concern is that it can interact with heart medications, photosensitizing drugs, and drugs that affect your liver.

If you take any prescription medication at all, check it with us first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Khella, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090700000813
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 239150
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Khella by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
42
UPC/BARCODE
090700000813
IngredientAmount% DV
Khella seed (Ammi visnaga) extract631 mg--

Other ingredients: certified organic Cane Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake well before using Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 3 or 4 times per day. Best taken between meals.

Precautions

Caution: Seek expert medical advice before taking during pregnancy.

Avoid prolonged exposure to sunlight after ingestion.

Keep out of the reach of children

Storage

Store away from heat & light

Formula

Ammi visnaga

Khella liquid extract

Prepared from the seed of Ammi visnaga plants which are certified organically grown or responsibly wildcrafted in their natural habitat.

Formulation

Respiratory system

Gluten-free

Dry herb/menstruum ratio: 1:3

Prepared from the seed of Ammi visnaga plants which are certified organically grown or responsibly wildcrafted in their natural habitat.

FDA Statement of Identity

Herbal Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Khella by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Khella label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Khella by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container42 Amounts shown are per serving.

Khella seed (Ammi visnaga) extract

Interacts with
620 drugs
631 mg per serving

Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels. While it has...

Khella seed (Ammi visnaga) extract monograph & interactions

Other (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Khella by Herb Pharm Drug Interactions

Want to check YOUR meds against Khella?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
620Drugs
620 Moderate

Ingredients driving the most interactions

Khella seed (Ammi visnaga) extract 620

Individual Drug Interactions

The ingredients in Khella interact with 620 drugs. Click any drug to see the details.

1 of the 1 ingredient in Khella interact with drugs. Each result below shows which ingredient is responsible. Khella seed (Ammi visnaga) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Khella with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Khella seed (Ammi visnaga) extract3 drug types · 620 drugs

Digoxin (Lanoxin)

Theoretically, khella might decrease the effectiveness of cardiac glycosides like digoxin. The khella constituent visnadin has negative inotropic effects that might counter the effects of cardiac glycosides.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs. Khella can increase liver transaminases. Some drugs that can adversely affect the liver include acetaminophen (Tylenol), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), and many others.

Likelihood Possible Evidence B
Photosensitizing Drugs

Theoretically, concomitant use might result in increased photosensitivity. Khella constituents can cause photosensitivity. Some drugs that cause photosensitivity include amitriptyline (Elavil), quinolones (Ciprofloxacin, others), sulfa drugs (Septra, Bactrim, others), and tetracycline.

Likelihood Possible Evidence D
Khella seed (Ammi visnaga) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Khella, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Khella by Herb Pharm: Common Questions

Does Khella by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Khella has a known interaction with 620 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Khella contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects does khella cause?
With prolonged use or higher doses, you may experience nausea, dizziness, constipation, appetite loss, headache, itching, and insomnia. Khella can also raise liver enzyme levels and may increase your skin's sensitivity to the sun.
Can I take khella while pregnant?
No—the safety data advises against it. Not enough is known about khella in pregnancy, and the evidence indicates it's likely unsafe. Talk with your doctor before considering it if you're pregnant or planning to become pregnant.
Can I take khella while breastfeeding?
There isn't enough data on khella's safety during breastfeeding. If you're nursing or planning to, talk with your pharmacist or doctor for personalized advice.
Does khella actually work for psoriasis or vitiligo?
The evidence we have is insufficient to rate khella for either condition. While it's been used traditionally for these skin conditions, we can't say whether it's effective based on the data available to us.
Why does khella interact with so many medications?
Khella can weaken heart medications, amplify photosensitivity from certain drugs, and stress your liver when combined with liver-toxic medications. The 602 medication interactions reflect all the individual drugs across these three categories, not unique effects on each one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Khella label
Go deeper

The Full Monographs Behind Khella’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Khella

Interacts with 620 drugs

Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels. While it has a long history of traditional use for br...

Read the full Khella monograph →
Sources

Sources & How We Checked

Khella's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Khella 10 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Abdel-Fattah A, Aboul-Enein MN, Wassel GM, El-Menshawi BS. An approach to the treatment of vitiligo by khellin. Dermatologica 1982;165:136-40. PubMed
  4. Duarte J, Torres AI, Zarzuelo A. Cardiovascular effects of visnagin on rats. Planta Med 2000;66:35-9. PubMed
  5. Abdel-Fattah A, Aboul-Enein MN, Wassel G, El-Menshawi B. Preliminary report on the therapeutic effect of khellin in psoriasis. Dermatologica 1983;167:109-10. PubMed
  6. Ossenkoppele PM, van der Sluis WG, van Vloten WA. [Phototoxic dermatitis following the use of Ammi majus fruit for vitiligo]. Ned Tijdschr Geneeskd 1991;135:478-80.
  7. Harvengt C, Desager JP. HDL-cholesterol increase in normolipaemic subjects on khellin: a pilot study. Int J Clin Pharmacol Res 1983;3:363-6.
  8. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
  9. de Leeuw J, van der BN, Maierhofer G, et al. A case study to evaluate the treatment of vitiligo with khellin encapsulated in L-phenylalanin stabilized phosphatidylcholine liposomes in combination with ultraviolet light therapy. Eur J Dermatol 2003;13(5):
  10. Orecchia G, Perfetti L. Photochemotherapy with topical khellin and sunlight in vitiligo. Dermatology 1992;184(2):120-123. PubMed

See these in context on the Khella monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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