Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Kyo-Dophilus Kids Probiotic Ingredients & Drug Interactions

by Kyo-Dophilus

Kyo-Dophilus Kids Probiotic label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kyo-Dophilus Kids Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kyo-Dophilus Kids Probiotic is a dietary supplement by Kyo-Dophilus with 3 active ingredients. Its ingredients are commonly taken for digestive health, weight and belly fat management, vaginal and urinary health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, Bifidobacterium longum MM-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Kyo-Dophilus Kids Probiotic by Kyo-Dophilus

Ask about any prescription or over-the-counter medication and we check it for interactions with Kyo-Dophilus Kids Probiotic by Kyo-Dophilus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Kyo-Dophilus Kids Probiotic by Kyo-Dophilus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Kyo-Dophilus Kids contains three active probiotic (beneficial bacteria) ingredients: Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2. These are live microorganisms meant to support gut health.

The product also contains inactive ingredients — fructose, dextrin, corn starch, calcium carbonate, magnesium stearate, and vanilla flavor — that serve as fillers, binders, and flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and gut microbiome support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Diarrhea, Dyspepsia, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Bifidobacterium Bifidum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Constipation, Radiation-induced diarrhea, Necrotizing enterocolitis (NEC), and more.
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea.

The evidence for what these probiotics can do is mixed and often limited. Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections.

For the other conditions the data mentions — hay fever, asthma, common cold, diarrhea, and others — the evidence for all three strains is insufficient to know whether they work. That doesn't mean they don't; it means the studies aren't robust enough yet to say for sure.

The evidence, ingredient by ingredient Lactobacillus Gasseri Bifidobacterium Bifidum Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All three bacterial strains are generally well tolerated in healthy children, but the safety data is limited. The facts note that people with weakened immune systems should be cautious.

Rare side effects reported with probiotics in general include bloating, flatulence, and abdominal discomfort; one case of vomiting and fever was reported in a child taking a similar probiotic blend, though it's unclear if the probiotics caused it. Very rare cases of infection from these bacteria have occurred in critically ill patients, but these are not common.

For Bifidobacterium longum specifically, a single patient reported a dry cough in a trial. Talk with your child's doctor before starting, especially if they have a serious illness or immune system concerns.

Side effects, ingredient by ingredient Lactobacillus Gasseri Bifidobacterium Bifidum Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Bifidobacterium Bifidum, Bifidobacterium Longum, Lactobacillus Gasseri.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If your child takes any antibiotic drugs, you'll want to separate the timing from this probiotic — antibiotics can kill the live bacteria in the product. No other medication interactions are documented for the ingredients we could check, but run their full medication list through the tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Kyo-Dophilus Kids is a multi-strain probiotic for children that's generally well tolerated. The main thing to watch: if your child is on antibiotics, space out the doses so the antibiotic doesn't kill the probiotic bacteria.

Ask your pharmacist or doctor for timing. Because safety data are limited, check with your child's doctor first if they have any chronic illness or immune concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kyo-Dophilus Kids Probiotic, straight from the product label.

Brand Kyo-Dophilus
Barcode (UPC) 023542601320
Net contents 60 Vanilla Chewable Tablet(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 326193
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children (All), Infants/Baby (0 - 1 Year), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kyo-Dophilus Kids Probiotic by Kyo-Dophilus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
023542601320
IngredientAmount% DV
Proprietary Blend0 NP--
Lactobacillus gasseri KS-130 NP--
Bifidobacterium bifidum G9-10 NP--
Bifidobacterium longum MM-20 NP--

Other ingredients: Fructose, Dextrin, Corn Starch, Calcium Carbonate, Magnesium Stearate, Vanilla Flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Chew one tablet with a meal daily. For children under 4 and infants, crush and mix 1/2 tablet in food or juice.

Take one chewable tablet of Kyo-Dophilus Kids Probiotic with a meal every day to promote healthy GI and immune function to encourage general wellbeing.

Formulation

Free of: GMOs, soy, gluten, dairy, sodium, yeast, preservatives, artificial colors and flavors.

Your kid's gut microbiome is unique. Kyo-Dophilus Kids Probiotic is safe, easy to take and great tasting. The three biocompatible human strains in Kids Probiotic, The Friendly Trio, have been the subject of clinical studies that documented the efficacy of these strains to support healthy GI function. Taken daily, Kids Probiotics can help replenish the good bacteria in the microbiome to protect kids from the effects of harmful bacteria. A healthy digestive system can also provide a strong foundation for immune health. Keeping your kids healthy can help keep the whole family feeling good! The Kids Probiotic for your family To maintain good bowel regularity Relieve occasional digestive discomfort Promote healthy immune function

Promotes regularity and immune health

Clinically studied strains

Kyo-Dophilus Probiotics are formulated to support healthy digestive and immune systems. Our probiotics delivery efficacy, quality and extended live cell viability without refrigeration. The Friendly Trio is the core of our formulations.

Storage

Refrigeration not required. Store in a cool, dry place with cap tight.

Our probiotics delivery efficacy, quality and extended live cell viability without refrigeration.

Precautions

Keep out of reach of children.

Safety sealed: Do not use if cap drop ring or printed inner seal is broken or missing. Glass bottle, handle with care.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP certified

DNA Sequencing Verified The probiotic strains in this product have been identity-verified using DNA sequencing.

Brand IP Statement(s)

Kyo-Dophilus Probiotics for you

Formula

1 Billion CFU Guaranteed live at expiry with The Friendly Trio

A probiotic you can count on The Friendly Trio is a clinically studied proprietary blend of human strain Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2. L. gasseri has been shown to support your body's GI function and immune health B. bifidum may regulate healthy gut flora and enhance immunity by reducing inflammation B. longum is known to normalize bowel movements

FDA Statement of Identity

3 Strain Probiotic Supplement

General Statements

Reduce. Reuse. Recycle. Printed with vegetable based inks

Finding the right probiotic means considering more than CFU counts. Colony Forming Units Choose a probiotic with strains that are diverse, compatible and able to survive stomach acid, to encourage implantation and rapid replication in your gut. We offer a variety of formulas and potencies made with clinically proven strains to help meet your specific health needs. You can count on Kyo-Dophilus Probiotics. To learn more go to www.probiotics.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kyo-Dophilus Kids Probiotic by Kyo-Dophilus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kyo-Dophilus Kids Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kyo-Dophilus Kids Probiotic by Kyo-Dophilus

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Fructose, Dextrin, Corn Starch, Calcium Carbonate, Magnesium Stearate, Vanilla Flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kyo-Dophilus Kids Probiotic by Kyo-Dophilus Drug Interactions

Want to check YOUR meds against Kyo-Dophilus Kids Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus gasseri KS-13 182
Bifidobacterium bifidum G9-1 182
Bifidobacterium longum MM-2 182

Individual Drug Interactions

The ingredients in Kyo-Dophilus Kids Probiotic interact with 182 drugs. Click any drug to see the details.

3 of the 3 ingredients in Kyo-Dophilus Kids Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus gasseri KS-13 Bifidobacterium bifidum G9-1 Bifidobacterium longum MM-2

Each ingredient & the kinds of drugs it affects

For each ingredient in Kyo-Dophilus Kids Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus gasseri KS-131 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus gasseri KS-13 full monograph & interactions

Bifidobacterium bifidum G9-11 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum G9-1 full monograph & interactions

Bifidobacterium longum MM-21 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum MM-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kyo-Dophilus Kids Probiotic, from the product label.

Kyo-Dophilus

See all Kyo-Dophilus products
Name
Wakunaga of America Co., Ltd.
City
Mission Viejo
State
CA
ZipCode
92691
Phone Number
800-421-2998
Web Address
www.kyolic.com
Pharmacist Counseling Corner

Kyo-Dophilus Kids Probiotic by Kyo-Dophilus: Common Questions

Does Kyo-Dophilus Kids Probiotic by Kyo-Dophilus interact with any medications?
Yes. Based on its ingredients, Kyo-Dophilus Kids Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kyo-Dophilus Kids Probiotic contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are probiotics, and why are they in a kids' product?
Probiotics are live beneficial bacteria that live naturally in the gut. This product contains three strains meant to support digestive and immune health in children. They're generally considered safe for healthy kids, though the evidence for specific benefits is still being studied.
Can I give this to my child if they're taking antibiotics?
Yes, but you'll need to space them out. Antibiotics kill bacteria — including the beneficial ones in this probiotic — so taking them at the same time makes the probiotic less effective. Ask your pharmacist or doctor how far apart to give them.
What side effects might my child have?
Most children tolerate it well. Rare side effects reported with probiotics include bloating, flatulence, and abdominal discomfort. One case of vomiting and fever was reported in a child on a similar product, but it's unclear if the probiotic caused it.
Is this safe during pregnancy or breastfeeding?
Bifidobacterium longum is rated possibly safe in pregnancy and lactation. No safety data are on file for the other two strains. Talk with your doctor or pharmacist about whether this product is right during those times.
Does this product actually work for colds, diarrhea, or asthma?
The evidence is limited. Bifidobacterium bifidum may help with irritable bowel syndrome and respiratory infections, but for conditions like colds, diarrhea, asthma, and hay fever, the studies aren't robust enough yet to say whether it works.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kyo-Dophilus Kids Probiotic is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kyo-Dophilus Kids Probiotic label
Go deeper

The Full Monographs Behind Kyo-Dophilus Kids Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Gasseri

Interacts with 182 drugs

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with di...

Read the full Lactobacillus Gasseri monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Kyo-Dophilus Kids Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 40 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Gasseri 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

See these in context on the Lactobacillus Gasseri monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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