Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Kyo-Dophilus Enzyme+ Probiotic Ingredients & Drug Interactions

by Kyo-Dophilus

Kyo-Dophilus Enzyme+ Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kyo-Dophilus Enzyme+ Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kyo-Dophilus Enzyme+ Probiotic is a dietary supplement by Kyo-Dophilus with 7 active ingredients. Its ingredients are commonly taken for digestive health, weight and belly fat management, vaginal and urinary health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, Bifidobacterium longum MM-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus

Ask about any prescription or over-the-counter medication and we check it for interactions with Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Food Enzyme Complex” is a proprietary blend — the label gives one combined amount (310 mg) without saying how much of each component you get.

This capsule contains 7 active ingredients: two enzymes we couldn't fully evaluate (amylase), three digestive enzymes (protease, lipase, and lactase), and two probiotic bacteria strains (Lactobacillus gasseri KS-13 and Bifidobacterium species). Protease and lipase help break down proteins and fats; lactase breaks down lactose.

The live probiotic bacteria support your gut microbiome. The inactive ingredients include starch, gelatin, dextrin, and other binders and fillers.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Digestive health and enzyme support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Dyspepsia.

Lactase is effective for lactose intolerance — that's well established. Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections.

For the other ingredients and conditions — including what protease and lipase do for digestion, what Lactobacillus gasseri does for your gut, and what Bifidobacterium longum does — the evidence we hold isn't yet established. Your results may vary.

The evidence, ingredient by ingredient Lactobacillus Gasseri Bifidobacterium Bifidum Bifidobacterium Longum Proteolytic Enzymes (proteases) Lipase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The enzymes and probiotics in this product are generally well tolerated in healthy adults. Protease may rarely cause digestive upset or allergic reactions, and occupational exposure to similar enzymes has occasionally triggered allergic rhinitis or asthma; you're taking it by mouth in a supplement, so the risk is much lower.

Bifidobacterium species have rarely caused infection in critically ill or immune-compromised patients, so those folks should check with their doctor first. Lactase allergies are rare but have occurred in people with direct exposure to the powder.

Bloating and flatulence can happen with probiotics, though it hasn't been specifically reported with Bifidobacterium bifidum. Safety data during pregnancy and breastfeeding are limited for protease and lipase — talk to your doctor if you're pregnant or nursing.

Side effects, ingredient by ingredient Lactobacillus Gasseri Bifidobacterium Bifidum Bifidobacterium Longum Proteolytic Enzymes (proteases) Lipase Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 6 matched ingredients can interact with medications — Bifidobacterium Bifidum, Bifidobacterium Longum, Lactobacillus Gasseri.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, tell your pharmacist before starting this product — you'll need to separate when you take them. The live bacteria in here can be killed if you dose them together, making the probiotic less effective.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-enzyme plus probiotic blend that works best for lactose intolerance and possibly for IBS and respiratory health. If you're taking antibiotics, space them apart from this product so the live bacteria aren't killed.

Anyone with a serious digestive condition, a weakened immune system, or who is pregnant or breastfeeding should check with their doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kyo-Dophilus Enzyme+ Probiotic, straight from the product label.

Brand Kyo-Dophilus
Barcode (UPC) 023542602426
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 326195
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
023542602426
IngredientAmount% DV
Proprietary Blend0 NP--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
Food Enzyme Complex310 mg--
Lactobacillus gasseri KS-130 NP--
Bifidobacterium bifidum G9-10 NP--
Bifidobacterium longum MM-20 NP--

Other ingredients: Starch, Gelatin, Dextrin, Carboxymethylcellulose Calcium, Silicon Dioxide, Glucose, Sodium Citrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: adults take two capsules with a meal daily.

Take two capsules of Kyo-Dophilus Enzyme+ Probiotic every day with a meal to aid in nutrient digestion and promote healthy gut function to encourage general wellbeing.

Formulation

Free of: Soy, dairy, yeast, artificial colors and flavors.

The Enzyme+ Probiotic for you To aid in nutrient digestion Relieve occasional digestive discomfort Promote healthy immune function

Nutrient digestion and gut health

Clinically Studied Strains

Dairy Free Soy Free Yeast Free

Kyo-Dophilus Probiotics are formulated to support healthy digestive and immune systems. Our probiotics deliver efficacy, quality and extended live cell viability without refrigeration. The Friendly Trio is the core of our formulations.

Storage

Refrigeration not required. Store in a cool, dry place with cap tight.

Precautions

Keep out of reach of children.

Consult your healthcare professional before using this or any product if you are pregnant, nursing or under medical supervision.

Safety sealed: Do not use if cap drop ring or printed inner seal is broken or missing. Glass bottle, handle with care.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Certified

DNA Sequencing Verified The probiotic strains in this product have been identity-verified using DNA sequencing.

Formula

Kyo-Dophilus Enzyme+ Probiotic contains four key digestive enzymes in combination with three biocompatible human strain probiotics, The Friendly Trio. The powerful enzymes in this formulation assist the body's natural ability to break down proteins, fats, carbohydrates and dairy into absorbable nutritional elements. The probiotic blend supports digestion by helping to regulate the healthy bacteria and normalize the GI system.

4 enzymes + 2 billion CFU guaranteed with live at expiry with The Friendly Trio

A probiotic you can count on The friendly Trio is a clinically studied proprietary blend of human strain Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2. L. gasseri has been shown to support your body's GI function and immune health B. bifidum may regulate healthy gut flora and enhance immunity by reducing inflammation B. longum is known to normalize bowel movements

Brand IP Statement(s)

Kyo-Dophilus Probiotics for you

FDA Statement of Identity

3 Strain Probiotic Supplement

General Statements

Reduce. Reuse. Recycle. Printed with vegetable based inks

Finding the right probiotic means considering more than CFU counts. Colony Forming Units Choose a probiotic with strains that are diverse, compatible and able to survive stomach acid, to encourage implantation and rapid replication in your gut. Scan here or call 1-800-421-2998 for more food information. Scan me To learn more go to www.probiotics.com

Your gut microbiome is as unique as you are.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kyo-Dophilus Enzyme+ Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Food Enzyme Complex

310 mg per serving

Other (inactive) ingredients: Starch, Gelatin, Dextrin, Carboxymethylcellulose Calcium, Silicon Dioxide, Glucose, Sodium Citrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus Drug Interactions

Want to check YOUR meds against Kyo-Dophilus Enzyme+ Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus gasseri KS-13 182
Bifidobacterium bifidum G9-1 182
Bifidobacterium longum MM-2 182

Individual Drug Interactions

The ingredients in Kyo-Dophilus Enzyme+ Probiotic interact with 182 drugs. Click any drug to see the details.

3 of the 7 ingredients in Kyo-Dophilus Enzyme+ Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus gasseri KS-13 Bifidobacterium bifidum G9-1 Bifidobacterium longum MM-2

Each ingredient & the kinds of drugs it affects

For each ingredient in Kyo-Dophilus Enzyme+ Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus gasseri KS-131 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus gasseri KS-13 full monograph & interactions

Bifidobacterium bifidum G9-11 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum G9-1 full monograph & interactions

Bifidobacterium longum MM-21 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum MM-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kyo-Dophilus Enzyme+ Probiotic, from the product label.

Kyo-Dophilus

See all Kyo-Dophilus products
Name
Wakunaga of America Co., Ltd.
City
Mission Viejo
State
CA
ZipCode
92691
Phone Number
800-421-2998
Web Address
www.kyolic.com
Pharmacist Counseling Corner

Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus: Common Questions

Does Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus interact with any medications?
Yes. Based on its ingredients, Kyo-Dophilus Enzyme+ Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kyo-Dophilus Enzyme+ Probiotic contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this help with lactose intolerance?
Yes — lactase, one of the enzymes in here, is effective for lactose intolerance. It breaks down the lactose so your gut can handle it better.
Can I take this with my antibiotics?
You can, but not at the same time. The antibiotics will kill the live probiotic bacteria if you dose them together. Space them out — ask your pharmacist how far apart — so the probiotics can do their job.
What are the bacteria in this for?
The two Bifidobacterium strains are possibly effective for irritable bowel syndrome and respiratory tract infections. Lactobacillus gasseri and the Bifidobacterium species are general gut-health probiotics, though the evidence for many of their uses isn't fully established yet.
Is this safe to use while I'm pregnant?
The probiotic bacteria are possibly safe in pregnancy, but safety data on the enzymes protease and lipase are limited. Talk to your doctor or pharmacist before using it regularly while pregnant.
Will this upset my stomach?
Most people tolerate it well, but bloating and flatulence can happen with probiotics. The enzymes may rarely cause digestive upset or allergic reactions, though that's uncommon at supplement doses.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kyo-Dophilus Enzyme+ Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kyo-Dophilus Enzyme+ Probiotic label
Go deeper

The Full Monographs Behind Kyo-Dophilus Enzyme+ Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Gasseri

Interacts with 182 drugs

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with di...

Read the full Lactobacillus Gasseri monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Kyo-Dophilus Enzyme+ Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 45 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lactobacillus Gasseri 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

See these in context on the Lactobacillus Gasseri monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
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  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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