Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Kyo-Dophilus Enzyme+ Probiotic Ingredients & Drug Interactions

by Kyo-Dophilus

Kyo-Dophilus Enzyme+ Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kyo-Dophilus Enzyme+ Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kyo-Dophilus Enzyme+ Probiotic is a dietary supplement by Kyo-Dophilus with 7 active ingredients. Its ingredients are commonly taken for digestive health, weight and belly fat management, vaginal and urinary health.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, Bifidobacterium longum MM-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus

Ask about any prescription or over-the-counter medication and we check it for interactions with Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Food Enzyme Complex” is a proprietary blend — the label gives one combined amount (310 mg) without saying how much of each component you get.

This product has 7 active ingredients: three live probiotic bacteria (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2), three digestive enzymes (protease, lipase, and lactase), and amylase. The probiotics are meant to support your gut bacteria balance, while the enzymes help break down different components of food—proteins, fats, and carbohydrates, respectively.

The product also contains inactive ingredients like starch, gelatin, and dextrin, which are standard capsule fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and enzyme support.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia — and 4 related terms.
  • The strongest evidence on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Dyspepsia.
  • Also on file: Bifidobacterium Bifidum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Constipation, Radiation-induced diarrhea, Helicobacter pylori.

Lactase—the enzyme that breaks down milk sugar—is effective for lactose intolerance. Bifidobacterium bifidum is possibly effective for irritable bowel syndrome (IBS) and respiratory tract infections.

For the other ingredients and conditions, the evidence in our data is insufficient to rate how well they work, including the other probiotic strains, the other enzymes, and both bacteria for hay fever, anxiety, and asthma. If you're hoping this will help with a specific condition, check with your pharmacist about what the broader research shows.

The evidence, ingredient by ingredient Lactobacillus Gasseri Bifidobacterium Bifidum Bifidobacterium Longum Proteolytic Enzymes (proteases) Lipase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotic bacteria and enzymes are generally well tolerated in healthy adults. However, a few cautions apply.

Protease and the probiotic strains can occasionally trigger allergic reactions in susceptible people—rare but possible. Lipase should be used only under medical guidance if you have serious digestive conditions like inflammatory bowel disease.

For pregnancy and breastfeeding: lactase is likely safe in pregnancy; the other ingredients have limited safety data, so talk with your doctor before regular use. Bifidobacterium longum is possibly safe in pregnancy, but protease, lipase, Lactobacillus gasseri, and Bifidobacterium bifidum all lack enough data—check with your doctor first.

Side effects, ingredient by ingredient Lactobacillus Gasseri Bifidobacterium Bifidum Bifidobacterium Longum Proteolytic Enzymes (proteases) Lipase Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 6 matched ingredients can interact with medications — Bifidobacterium Bifidum, Bifidobacterium Longum, Lactobacillus Gasseri.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, you must separate them from this product by several hours—the live bacteria in it can be killed off by antibiotics, making both less effective. Ask your pharmacist for the best timing.

Use the medication checker below to verify your exact prescriptions, since no other drug interactions are documented for the enzyme components.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a reasonable choice if you're looking for digestive enzyme and probiotic support and you don't take antibiotics regularly. If you do take antibiotics, you'll need to space them several hours apart from this product.

Anyone with a serious digestive condition, a weakened immune system, or plans to become pregnant should talk with their doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kyo-Dophilus Enzyme+ Probiotic, straight from the product label.

Brand Kyo-Dophilus
Barcode (UPC) 023542602419
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 326194
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
023542602419
IngredientAmount% DV
Proprietary Blend0 NP--
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
Food Enzyme Complex310 mg--
Lactobacillus gasseri KS-130 NP--
Bifidobacterium bifidum G9-10 NP--
Bifidobacterium longum MM-20 NP--

Other ingredients: Starch, Gelatin, Dextrin, Carboxymethylcellulose Calcium, Silicon Dioxide, Glucose, Sodium Citrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: adults take two capsules with a meal daily.

Take two capsules of Kyo-Dophilus Enzyme+ Probiotic every day with a meal to aid in nutrient digestion and promote healthy gut function to encourage general wellbeing.

Formulation

Free of: Soy, dairy, yeast, artificial colors and flavors.

To aid in nutrient digestion Relieve occasional digestive discomfort Promote healthy immune function

Nutrient digestion and gut health

Clinically Studied Strains

Dairy Free Soy Free Yeast Free

Kyo-Dophilus Probiotics are formulated to support healthy digestive and immune systems. Our probiotics deliver efficacy, quality and extended live cell viability without refrigeration. The Friendly Trio is the core of our formulations.

Storage

Refrigeration not required. Store in a cool, dry place with cap tight.

Precautions

Keep out of reach of children.

Consult your healthcare professional before using this or any product if you are pregnant, nursing or under medical supervision.

Safety sealed: Do not use if cap drop ring or printed inner seal is broken or missing. Glass bottle, handle with care.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Certified

DNA Sequencing Verified The probiotic strains in this product have been identity-verified using DNA sequencing.

Formula

Your gut microbiome is as unique as you are. Kyo-Dophilus Enzyme+ Probiotic contains four key digestive enzymes in combination with three biocompatible human strain probiotics, The Friendly Trio. The powerful enzymes in this formulation assist the body's natural ability to break down proteins, fats, carbohydrates and dairy into absorbable nutritional elements. The probiotic blend supports digestion by helping to regulate the healthy bacteria and normalize the GI system. The Enzyme+ Probiotic for you

4 enzymes + 2 billion CFU with The Friendly Trio

A probiotic you can count on The Friendly Trio is a clinically studied proprietary blend of human strain Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2. L. gasseri has been shown to support your body's GI function and immune health B. bifidum may regulate healthy gut flora and enhance immunity by reducing inflammation B. longum is known to normalize bowel movements

Brand IP Statement(s)

Kyo-Dophilus Probiotics for you

FDA Statement of Identity

3 Strain Probiotic Supplement

General Statements

Reduce. Reuse. Recycle. Printed with vegetable based inks

Finding the right probiotic means considering more than CFU counts. Colony Forming Units Choose a probiotic with strains that are diverse, compatible and able to survive stomach acid, to encourage implantation and rapid replication in your gut. Scan here or call 1-800-421-2998 for more food information. Scan me To learn more go to www.probiotics.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kyo-Dophilus Enzyme+ Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Food Enzyme Complex

310 mg per serving

Other (inactive) ingredients: Starch, Gelatin, Dextrin, Carboxymethylcellulose Calcium, Silicon Dioxide, Glucose, Sodium Citrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus Drug Interactions

Want to check YOUR meds against Kyo-Dophilus Enzyme+ Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus gasseri KS-13 182
Bifidobacterium bifidum G9-1 182
Bifidobacterium longum MM-2 182

Individual Drug Interactions

The ingredients in Kyo-Dophilus Enzyme+ Probiotic interact with 182 drugs. Click any drug to see the details.

3 of the 7 ingredients in Kyo-Dophilus Enzyme+ Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus gasseri KS-13 Bifidobacterium bifidum G9-1 Bifidobacterium longum MM-2

Each ingredient & the kinds of drugs it affects

For each ingredient in Kyo-Dophilus Enzyme+ Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus gasseri KS-131 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus gasseri KS-13 full monograph & interactions

Bifidobacterium bifidum G9-11 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum G9-1 full monograph & interactions

Bifidobacterium longum MM-21 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum MM-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kyo-Dophilus Enzyme+ Probiotic, from the product label.

Kyo-Dophilus

See all Kyo-Dophilus products
Name
Wakunaga of America Co., Ltd.
City
Mission Viejo
State
CA
ZipCode
92691
Phone Number
800-421-2998
Web Address
www.kyolic.com
Pharmacist Counseling Corner

Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus: Common Questions

Does Kyo-Dophilus Enzyme+ Probiotic by Kyo-Dophilus interact with any medications?
Yes. Based on its ingredients, Kyo-Dophilus Enzyme+ Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kyo-Dophilus Enzyme+ Probiotic contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotics?
Not at the same time. The live bacteria in this product can be killed by antibiotics, which defeats the purpose of taking the probiotic. Space them out by several hours—ask your pharmacist for a schedule that works with your antibiotic dose.
Is lactase safe if I'm lactose intolerant?
Yes—lactase is the enzyme that breaks down milk sugar, and it's effective for lactose intolerance. It's also generally well tolerated and likely safe in pregnancy.
Can I take this if I'm pregnant or breastfeeding?
It depends on the ingredient. Lactase is likely safe in pregnancy. The other ingredients—protease, lipase, and the probiotic strains—don't have enough safety data yet. Talk with your doctor or pharmacist to weigh the pros and cons for your situation.
What do the enzymes in this product actually do?
Protease breaks down proteins, lipase breaks down fats, lactase breaks down milk sugar, and amylase breaks down carbohydrates. Together, they're meant to help your digestive system work more efficiently.
Will this help my IBS or hay fever?
Bifidobacterium bifidum in this product is possibly effective for IBS. For hay fever and other respiratory conditions, the evidence in our data is insufficient to say whether it helps. Your doctor can advise whether this is worth trying for your situation.
Are there any common side effects from the probiotics?
The probiotics are generally well tolerated, though bloating and flatulence have been reported with probiotic use in general. Allergic reactions are rare but possible. If you notice any unusual symptoms, stop and talk with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kyo-Dophilus Enzyme+ Probiotic is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kyo-Dophilus Enzyme+ Probiotic label
Go deeper

The Full Monographs Behind Kyo-Dophilus Enzyme+ Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Gasseri

Interacts with 182 drugs

Lactobacillus gasseri is a 'friendly' probiotic bacterium found naturally in the human gut, mouth, and vaginal tract, and in some fermented foods. Early research suggests it may help with di...

Read the full Lactobacillus Gasseri monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Kyo-Dophilus Enzyme+ Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 45 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lactobacillus Gasseri 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

See these in context on the Lactobacillus Gasseri monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
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  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
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  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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