Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Kidophilus Plus Ingredients & Drug Interactions

by Zahler

Kidophilus Plus label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Kidophilus Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Kidophilus Plus is a dietary supplement by Zahler with 4 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus, Bifidobacterium bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Kidophilus Plus by Zahler

Ask about any prescription or over-the-counter medication and we check it for interactions with Kidophilus Plus by Zahler — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Kidophilus Plus by Zahler

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Zahler's Proprietary Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Kidophilus Plus is a 4-ingredient probiotic formula containing four live bacterial strains: Lactobacillus acidophilus, Bifidobacterium animalis lactis, Bifidobacterium bifidum, and Lactobacillus plantarum. These are beneficial bacteria meant to support digestive and immune health.

The tablet also contains inactive ingredients including mannitol, sorbitol, natural strawberry and cherry flavor, magnesium stearate, silicon dioxide, and stevia.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: probiotic support for digestive and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Irritable bowel syndrome (IBS), Respiratory tract infections, Allergic rhinitis (hay fever), Atopic dermatitis (eczema) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Respiratory tract infections, Irritable bowel syndrome (IBS).

The evidence for these probiotics varies by use. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, and Helicobacter pylori infection, though the data aren't conclusive.

Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections. For other conditions like hay fever and anxiety, the evidence we have isn't strong enough to rate either ingredient reliably.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Lactobacillus acidophilus and Bifidobacterium bifidum are generally well tolerated in healthy children and adults. The most common side effects — bloating, flatulence, abdominal discomfort, and mild digestive upset — are uncommon and usually mild.

However, these probiotics contain live organisms, so there is a theoretical concern about infection in people with weakened immune systems; ask your doctor if this applies to your child. Since data are limited in some areas, check with your healthcare provider before starting.

For pregnancy and breastfeeding, Lactobacillus acidophilus is rated possibly safe, but we don't have safety data on file for the other ingredients in this product during pregnancy or lactation — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main thing to watch for is antibiotic drugs. Taking this probiotic at the same time as an antibiotic will reduce how well the probiotic works, so you'll need to space them out.

Ask your child's doctor or pharmacist about the best timing. We weren't able to check all ingredients in our data, so look up your child's exact medications using the search tool on this page to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Kidophilus Plus is a kid-friendly probiotic blend that may help with digestive upset and immune function, though the evidence is strongest for irritable bowel syndrome and antibiotic-related diarrhea. If your child is taking antibiotics, you'll need to separate the timing of the antibiotic and this probiotic to keep the bacteria alive and working.

Talk with your child's doctor or pharmacist before starting, especially if they have a weakened immune system or if you're combining it with other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Kidophilus Plus, straight from the product label.

Brand Zahler
Barcode (UPC) 779663111315
Net contents 90 Chewable Tablet(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33291
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Kosher, Children (All), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Kidophilus Plus by Zahler, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
90
UPC/BARCODE
779663111315
IngredientAmount% DV
Lactobacillus acidophilus0 NP--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus plantarum0 NP--
Zahler's Proprietary Probiotic Blend0 NP--

Other ingredients: Mannitol, Sorbitol, Natural Strawberry and Cherry Flavor, Magnesium Stearate, Silicon Dioxide, Stevia

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

You may need additional supplements to support a healthy diet, consult your nutritionist for a formula that is right for you, or call us toll free at 877-ASK-ZAHLER (877-275-9245)

10 Billion Live & Active CFUs With a highly potent blend of four distinct probiotic strains, including the well-known 1, acidophillus, Kidophilus Plus works quickly and effectively to suppress the growth of potentially harmful bacteria, improve immune function, reduce allergies and inflammation, and enhance the protective barrier of the digestive tract. Zahler's Kidophilus Plus contains 10 billion live and active CFUs, which effectively puts the breaks on the growth of disease-causing bacteria, such as salmonella and shigella-caused dysentery, diarrhea, and even virus-caused flu. it also clears up yeast infections, reduces bad breath and flatulence, aids in digestion and reduces the incidence of constipation, thansk to a healthy intestinal flora.

Prevents and Alleviates: ~Diarrhea ~Irritable Bowel Syndrome ~Constipation ~Respiratory Diseases ~Seasonal, Food And Skin Allergies

Probiotic Formula for Children

Seals/Symbols

THIS PRODUCT WAS MANUFACTURED IN A NSF(R) & GMP CERTIFIED FACILITY

MADE IN THE USA {flag}

GLUTEN FREE

D

U

advanced nutrition by ZAHLER(R)

CHILDREN'S HEALTH {tablet}

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

Brand IP Statement(s)

Kidophilus Plus(TM) Viral Nutrition Chart: {chart} Immune 4 Calcium 1 Energy 3 Antioxidant 3 Potency/Strength

Feel Better, Everyday(TM)

Kidophilus Plus(TM) is a trademark of Advanced Nutrition by Zahler(R).

Formula

KOSHER PAREVE

UNDER STRICT SUPERVISION OF RABBI SH. STERN & THE ORTHODOX UNION

10 Billion Live & Active CFU's

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Directions: 1 tablet daily or as directed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Kidophilus Plus by Zahler label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Kidophilus Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Kidophilus Plus by Zahler

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zahler's Proprietary Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Mannitol, Sorbitol, Natural Strawberry and Cherry Flavor, Magnesium Stearate, Silicon Dioxide, Stevia. These complete the product’s ingredient list but are not active constituents.

Interaction report

Kidophilus Plus by Zahler Drug Interactions

Want to check YOUR meds against Kidophilus Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182
Bifidobacterium bifidum 182

Individual Drug Interactions

The ingredients in Kidophilus Plus interact with 182 drugs. Click any drug to see the details.

2 of the 4 ingredients in Kidophilus Plus interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium bifidum

Each ingredient & the kinds of drugs it affects

For each ingredient in Kidophilus Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Kidophilus Plus, from the product label.

Zahler

See all Zahler products
Name
Advanced Nutrition by Zahler(R)
City
Brooklyn
State
NY
ZipCode
11230
Web Address
www.zahlers.com
Pharmacist Counseling Corner

Kidophilus Plus by Zahler: Common Questions

Does Kidophilus Plus by Zahler interact with any medications?
Yes. Based on its ingredients, Kidophilus Plus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Kidophilus Plus contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can my child take this while on antibiotics?
Not at the same time. Antibiotics will kill off the live bacteria in this probiotic, making it less effective. Your doctor or pharmacist can recommend the best spacing — typically several hours apart — so your child gets the benefit of both.
What are probiotics and why are they in this product?
Probiotics are live beneficial bacteria that support digestive and immune health. This product contains four strains — Lactobacillus acidophilus, Bifidobacterium animalis lactis, Bifidobacterium bifidum, and Lactobacillus plantarum — that may help with conditions like irritable bowel syndrome and antibiotic-related diarrhea.
What side effects might my child have?
Most children tolerate this well. Occasionally, mild bloating, gas, abdominal discomfort, or loose stools can happen in the first few days, but these are uncommon. Rare cases of rash or itching have been reported, though it's unclear if they were due to the probiotics themselves.
Is this safe for kids with weak immune systems?
These are live organisms, so there's a caution for children with weakened immune systems. Talk with your child's doctor before starting to make sure it's right for them.
Does this product actually work?
The evidence is strongest for irritable bowel syndrome — both Lactobacillus acidophilus and Bifidobacterium bifidum are possibly effective there. It's also possibly effective for antibiotic-related diarrhea and respiratory infections. For other uses, the evidence isn't strong enough to rate reliably.
Is it safe during pregnancy or breastfeeding?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but we don't have safety data on file for the other three ingredients during pregnancy or lactation. Talk with your doctor or pharmacist for personalized advice if you're pregnant or breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Kidophilus Plus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Kidophilus Plus label
Go deeper

The Full Monographs Behind Kidophilus Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

Kidophilus Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team