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Dietary supplement

L-Citrulline 750 mg Ingredients & Drug Interactions

by Amazing Muscle

Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

L-Citrulline 750 mg is a dietary supplement by Amazing Muscle with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Citrulline 750 mg by Amazing Muscle

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

L-Citrulline 750 mg by Amazing Muscle contains one active ingredient: L-Citrulline, an amino acid your body converts to another amino acid called L-arginine, which plays a role in blood vessel function and circulation. The capsule also contains inactive ingredients—cellulose, stearic acid, silicon dioxide, magnesium stearate, and gelatin—which are fillers and binders that help form and stabilize the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports athletic performance and workout recovery.
  • We looked for evidence on: Athletic performance, Muscle strength, exercise endurance, muscle fatigue.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: L-citrulline is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

L-Citrulline is possibly effective for athletic performance, based on the evidence we hold. For sarcopenia (age-related muscle loss), it's rated possibly ineffective.

The evidence is not yet strong enough to rate its use in cardiovascular disease, heart failure, Reye syndrome, or diabetes. If you're considering it for one of those conditions, talk it over with your doctor about whether the current data supports a trial.

The evidence, ingredient by ingredient L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal—stomach discomfort, heartburn, and digestive upset.

A small number of people with pulmonary hypertension reported cough while taking it. There isn't enough safety data to know whether it's safe during pregnancy or breastfeeding, so it's best to avoid it during those times and talk with your doctor or pharmacist if you're considering it.

Side effects, ingredient by ingredient L-citrulline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take L-Citrulline, double-check any blood pressure–lowering medications (antihypertensives) you're on — there's a Moderate risk of your blood pressure dropping too low. Also flag any erectile dysfunction drugs like sildenafil or tadalafil (phosphodiesterase-5 inhibitors) — they also carry a Moderate risk of extra vasodilation and low blood pressure when combined with L-Citrulline.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-Citrulline may help with athletic performance if you're an active person, but it's not a proven fix for muscle loss or heart conditions. The main caution is that it can lower blood pressure, so if you take blood pressure or erectile dysfunction medications, you'll want to check with your doctor or pharmacist before adding it.

Pregnancy and breastfeeding are times to skip it unless you've talked it over with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Citrulline 750 mg, straight from the product label.

Brand Amazing Muscle
Barcode (UPC) 819209022931
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 251171
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Citrulline 750 mg by Amazing Muscle, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
819209022931
IngredientAmount% DV
L-Citrulline750 mg--

Other ingredients: Cellulose, Stearic Acid, Silicon Dioxide, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

Supports protein metabolism

Supports muscular detoxification Promotes athletic performance Assists in faster workout recovery

Contains No: Preservatives, artificial colors, flavors or sweeteners, sugar, starch, milk, lactose, soy, gluten, wheat, yeast, or fish.

An FDA regulated facility

L-Citrulline is an amino acid and precursor of L-Arginine; it is converted into L-Arginine once inside the body. L-Citrulline helps increase nitric oxide levels in the blood. Higher nitric oxide levels may help relax dilate blood vessels, thus increasing blood circulation to various organs, including the heart, skin and sexual organs. L-Citrulline supports cardiovascular health. It may also help the body rid itself of ammonia, a by-product of exercise. This clearing may enable the body to recover faster after a workout.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule daily, preferably with a meal or as directed by a health care professional.

Seals/Symbols

GMP Good Manufacturing Practice Quality Product Made in USA

General Statements

Vitamin angels Proud supporter

Customer Service: 1-800-526-0177 Mon - Fri 9am - 5pm EST

Precautions

Caution: Do not exceed recommended dose.

If you are pregnant, nursing, under the age of 18, taking any medication(s), planning any medical procedure or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

L-Citrulline 750 mg by Amazing Muscle label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Citrulline 750 mg by Amazing Muscle

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

L-Citrulline

Interacts with
178 drugs
750 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid, Silicon Dioxide, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Citrulline 750 mg by Amazing Muscle Drug Interactions

Want to check YOUR meds against L-Citrulline 750 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Citrulline 750 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for L-Citrulline 750 mg, from the product label.

Amazing Muscle

See all Amazing Muscle products
Name
Amazing Muscle
City
Jersey City
State
NJ
ZipCode
07310
Phone Number
1-800-526-0177
Web Address
www.AmazingMuscle.com
Pharmacist Counseling Corner

L-Citrulline 750 mg by Amazing Muscle: Common Questions

Does L-Citrulline 750 mg by Amazing Muscle interact with any medications?
Yes. Based on its ingredients, L-Citrulline 750 mg has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Citrulline 750 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does L-Citrulline actually improve athletic performance?
Yes, the evidence rates it as possibly effective for athletic performance. Whether it'll help you depends on your training, diet, and individual response — it's not a guarantee, and it works best alongside solid training and recovery.
What are the most common side effects?
Gastrointestinal discomfort, heartburn, and stomach upset are the most common complaints. Most people tolerate it well, but if you have a sensitive stomach, start with a lower dose and see how you feel.
Is it safe to take L-Citrulline if I'm pregnant or breastfeeding?
No, there isn't enough safety data. It's best to avoid it during pregnancy and breastfeeding. If you're considering it while pregnant or nursing, talk with your doctor or pharmacist first.
Can I take L-Citrulline long-term?
The evidence we hold shows it's generally well tolerated in healthy adults, but long-term safety hasn't been fully studied. If you're thinking about taking it regularly over months or years, check in with your doctor.
What is L-Citrulline, and how does it work?
L-Citrulline is an amino acid your body converts into another amino acid called L-arginine, which helps your blood vessels relax and widen. That vasodilation is why it may help with athletic performance and blood flow.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Citrulline 750 mg label
Sources

Sources & How We Checked

L-Citrulline 750 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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