L-Citrulline DL-Malate 2:1 Ingredients & Drug Interactions
by Micro Ingredients Muscle Up
What is this page for?
First and foremost: checking L-Citrulline DL-Malate 2:1 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Citrulline DL-Malate 2:1 is a dietary supplement by Micro Ingredients Muscle Up with 2 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline, DL-Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 2 of its 2 active ingredients.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 2 of the 2 matched ingredients can interact with medications — L-citrulline, Malic Acid.
- The most serious interaction on file is rated Moderate.
- For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 2 of 2.
- General safety write-ups exist for 2 of 2.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Citrulline DL-Malate 2:1, straight from the product label.
| Brand | Micro Ingredients Muscle Up |
|---|---|
| Barcode (UPC) | X0014Y24Z1 |
| Net contents | 500 Gram(s); 1.1 lb(s) |
| Market status | Off market |
| Date entered into DSLD | Aug 23, 2020 |
| DSLD ID | 231733 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Citrulline | 2000 mg | -- |
| DL-Malate | 1000 mg | -- |
Other ingredients: None
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement Powder
Formula
Kosher
Formulation
Non-GMO No preservatives Additives free Fillers free Gluten-free
Free of: sugar, soy, dairy, yeast, gluten & additives.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 1 scoop twice daily. For best results, please consult your physician.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
If pregnant/lactating or taking any medications, please consult your physician prior to use.
Keep out of the reach of children.
Storage
Keep in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Gram(s) Dosage formPowder Servings per container167 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Citrulline
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline monograph & interactionsDL-Malate
Interacts with172 drugs
Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....
DL-Malate monograph & interactionsOther (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.
L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up Drug Interactions
L-Citrulline DL-Malate 2:1 contains 2 ingredients, and 2 of them have known drug interactions. Altogether they interact with 178 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against L-Citrulline DL-Malate 2:1?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Citrulline DL-Malate 2:1 interact with 178 drugs. Click any drug to see the details.
2 of the 2 ingredients in L-Citrulline DL-Malate 2:1 interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline DL-Malate
AcebutololRhotral, Sectral
How Acebutolol interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Acebutolol interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Acetazolamide interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Aliskiren interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Ambrisentan interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amiloride interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amiloride, Hydrochlorothiazide interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Amlodipine Benzoate interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine Besilate interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine Besylate interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine Besylate, Benazepril interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Amlodipine, Celecoxib interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Ammonium Chloride interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Ammonium Chloride interactionAprocitentanTryvio
How Aprocitentan interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Aprocitentan interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Aprocitentan interactionAtenololAtenix, Tenormin
How Atenolol interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Atenolol interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Atenolol, Chlortalidone interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Atenolol, Chlorthalidone interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Atenolol, Chlorthalidone interactionAvanafilStendra
How Avanafil interacts with L-Citrulline DL-Malate 2:1 — through 1 ingredient. Tap an ingredient for the detail:
L-citrullinePhosphodiesterase-5 Inhibitors Moderate
Interaction Summary
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
Read the full L-citrulline + Avanafil interactionAzilsartanEdarbi
How Azilsartan interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Azilsartan interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Azilsartan, Chlorthalidone interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Azilsartan, Chlorthalidone interactionBenazeprilLotensin
How Benazepril interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Benazepril interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Benazepril interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Benazepril, Hydrochlorothiazide interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bendroflumethiazide interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bendroflumethiazide, Nadolol interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bendroflumethiazide, Rauwolfia Serpentina interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Benzthiazide interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Benzthiazide interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Betaxolol interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bisoprolol interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bisoprolol, Hydrochlorothiazide interactionDl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with L-Citrulline DL-Malate 2:1 — through 2 ingredients. Tap an ingredient for the detail:
Dl-malateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Dl-malate + Bosentan interactionL-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Bosentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Citrulline DL-Malate 2:1 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Citrulline
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
DL-Malate
Antihypertensive Drugs
Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.
Brand information
Manufacturer and brand details for L-Citrulline DL-Malate 2:1, from the product label.
Micro Ingredients Muscle Up
See all Micro Ingredients Muscle Up products- Name
- Micro Ingredients
- Street Address
- 21660 Copley Dr.
- City
- Diamond Bar
- State
- CA
- ZipCode
- 91765
- Phone Number
- 1-844-836-8200
- Web Address
- www.microingredients.com
L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up: Common Questions
Does L-Citrulline DL-Malate 2:1 by Micro Ingredients Muscle Up interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Citrulline DL-Malate 2:1 is safe with your meds?
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Citrulline DL-Malate 2:1’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
L-citrulline
Interacts with 178 drugsL-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...
Read the full L-citrulline monograph → Herb & supplement monographMalic Acid
Interacts with 172 drugsMalic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...
Read the full Malic Acid monograph →Sources & How We Checked
L-Citrulline DL-Malate 2:1's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 15 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Malic Acid 7 references
- Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8.
- Fiume, Z. Final report on the safety assessment of malic acid and sodium malate. Int J Toxicol 2001;20 Suppl 1:47-55. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 184 - Direct Food Substances Affirmed as Generally Recognized as Safe. Available at: http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&sid=786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view=text&node=21:3.0.1.1
- Saleem R, Ahmad M, Naz A, et al. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch Pharm Res 2004;27(10):1037-42.
- Chiriac A, Brzezinski P. Topical malic acid in combination with citric acid: an option to treat recalcitrant warts. Dermatol Ther. 2015;28(6):336-8. PubMed
- CFR - Code of Federal Regulations Title 21 SUBCHAPTER B. 184.1069 Malic Acid. Food and Drug Administration Department Of Health And Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1069.
- Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel. Updated May 19, 2017. http://www.cir-safety.org/sites/default/files/malic%20acid.pdf. Accessed January 24, 2018.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC