Liberty Ballz Ingredients & Drug Interactions
by Merica Labz
What is this page for?
First and foremost: checking Liberty Ballz against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Liberty Ballz is a dietary supplement by Merica Labz with 6 active ingredients. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 690 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Fenugreek Seed Extract, 3,3 Diindolylmethane, Eurycoma longifolia Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Liberty Ballz by Merica Labz
Ask about any prescription or over-the-counter medication and we check it for interactions with Liberty Ballz by Merica Labz — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Liberty Ballz by Merica Labz
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Liberty Ballz contains 6 active ingredients. Eurycoma longifolia root extract is a traditional herb sometimes used for sexual desire.
Fenugreek seed extract is a legume extract studied for sexual function and diabetes support. Mucuna pruriens seed extract is a tropical plant that naturally contains levodopa, a potent compound related to Parkinson's medication.
3,3-Diindolylmethane (DIM) is derived from cruciferous vegetables. Anacyclus pyrethrum root extract and Spilanthes acmella flower extract are botanical extracts with limited clinical research.
The capsules also contain inactive ingredients: gelatin, rice flour, magnesium stearate, silicon dioxide, titanium dioxide, and FD&C Blue #1.
Does it work?
Moderate evidence
Evidence for this product's ingredients is mixed and often limited. Eurycoma longifolia is possibly effective for sexual desire but possibly ineffective for athletic performance; evidence is insufficient for back pain, osteoporosis, and diabetes.
Fenugreek is possibly effective for sexual dysfunction, sexual arousal, dysmenorrhea, and diabetes. Diindolylmethane, Mucuna pruriens, Anacyclus pyrethrum, and Spilanthes acmella have insufficient evidence to rate them for their intended uses in this product.
None of these ingredients has strong clinical proof of benefit.
How safe is it?
Well-documented data
Eurycoma longifolia is generally tolerated short-term, but long-term safety is uncertain. It may raise testosterone, which can cause acne, insulin resistance, liver toxicity, and other side effects if levels go too high.
Fenugreek is generally tolerated in food amounts; supplement doses may cause abdominal pain, bloating, diarrhea, nausea, or (rarely) severe allergic reactions including difficulty breathing. Diindolylmethane is generally tolerated short-term and may cause diarrhea, gas, headache, nausea, rash, or vomiting.
Mucuna pruriens is considered to have rare adverse effects when taken by mouth, but can cause diarrhea, gas, or mucosal irritation; about 3% of trial participants reported insomnia with high doses. Anacyclus pyrethrum has limited safety data and may cause mouth or skin irritation or allergic reactions.
Safety data for Spilanthes acmella is not on file.
Meds to double-check
Major interaction found
Check these medication types before using this product: monoamine oxidase inhibitors (MAOIs) — major risk; methyldopa, levodopa, non-selective MAOIs, or other antidepressants, especially tricyclic types; blood thinners like warfarin or antiplatelet drugs; diabetes medications; beta-blockers like propranolol or metoprolol; antipsychotics; seizure drugs like phenytoin; diuretics; estrogen therapy; and any anesthetics you may need. If you're on any of these, do not start without talking to your pharmacist first.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This is a multi-ingredient product with serious drug interactions — especially if you take blood pressure meds, psychiatric drugs, seizure medication, blood thinners, diabetes drugs, or heart medication. Talk to your pharmacist or doctor before you start, and run your medications through the checker on this page.
The evidence for whether it actually works is weak to modest.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Liberty Ballz, straight from the product label.
| Brand | Merica Labz |
|---|---|
| Barcode (UPC) | 672975315856 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 327222 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Liberty Ballz by Merica Labz, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Eurycoma longifolia Root Extract | 250 mg | -- |
| Fenugreek Seed Extract | 600 mg | -- |
| 3,3 Diindolylmethane | 300 mg | -- |
| Mucuna pruriens Seed Extract | 500 mg | -- |
| Anacyclus pyrethrum Root Extract | 1800 mg | -- |
| Spilanthes Acmella Flower Extract | 400 mg | -- |
Other ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, FD&C Blue #1
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
'Merica Labz Never Big Enough
General Statements
"Proclaim Liberty throughout all the pants unto the inhabitants thereof." We print this screed as a testament to the power of Liberty Ballz to liberate balls, big and small, from the tyranny of beta-hood. The product contained herein is your declaration of ball-independence; a solemn proclamation to never again cast aside your balls to the prison of purses, watching The View, or drinking mocha Frappuccino. For now and forever, stand tall on the shoulders of giants who lost their balls to protect yours.
Formulation
Liberty Ballz represents the pinnacle in safe and natural testosterone support. Key ingredients in Liberty Ballz have been shown to support healthy testosterone function and hormone balance.
Healthy testosterone support
Manufactured in a U.S. cGMP Facility.
Precautions
Warning: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.
Warning: This product is only intended for use in healthy adults 18 years of age or older. Keep out of reach of children.
Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.
Immediately discontinue use and consult your health care professional if you experience adverse reaction to this product. Discontinue use two weeks prior to surgery. Do not exceed recommended serving. Do not use if safety seal is broken or missing.
Suggested/Recommended/Usage/Directions
Directions: Take 6 capsules preworkout on training days. On non training days, take 6 capsules with any meal.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Liberty Ballz by Merica Labz label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Liberty Ballz by Merica Labz
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size6 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Eurycoma longifolia Root Extract
Interacts with248 drugs
Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...
Eurycoma longifolia Root Extract monograph & interactionsFenugreek Seed Extract
Interacts with389 drugs
Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...
Fenugreek Seed Extract monograph & interactions3,3 Diindolylmethane
Interacts with269 drugs
Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...
3,3 Diindolylmethane monograph & interactionsMucuna pruriens Seed Extract
Interacts with193 drugs
Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...
Mucuna pruriens Seed Extract monograph & interactionsAnacyclus pyrethrum Root Extract
No knowninteractions
Pellitory (often Anacyclus pyrethrum, the root traditionally called 'pellitory of Spain') is an herb chiefly known in folk and traditional medicine fo...
Anacyclus pyrethrum Root Extract monograph & interactionsSpilanthes Acmella Flower Extract
Other (inactive) ingredients: Gelatin, Rice Flour, Magnesium Stearate, Silicon Dioxide, Titanium Dioxide, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.
Liberty Ballz by Merica Labz Drug Interactions
HelloPharmacist Interaction Report
Liberty Ballz by Merica Labz contains ingredients that do interact with medications, and the most serious concerns are with certain blood pressure and psychiatric drugs.
Mucuna pruriens seed extract contains levodopa (an active drug compound), which carries major interactions: it can cause dangerous blood pressure spikes if combined with monoamine oxidase inhibitors (MAOIs), dangerous blood pressure drops with methyldopa, and increased side effects if taken alongside other levodopa products. It also moderately interacts with diabetes drugs, antipsychotics, tricyclic antidepressants, some anesthetics, and guanethidine.
Read the full breakdown — every affected drug type, severity by severity
Fenugreek seed extract has moderate interactions with blood thinners and antiplatelet drugs (including warfarin and clopidogrel), diabetes medications, the heart drug metoprolol, the seizure drug phenytoin, the erectile dysfunction drug sildenafil, and theophylline. Eurycoma longifolia root extract moderately reduces the effect of the beta-blocker propranolol and has minor interactions with several enzyme-metabolized drugs and testosterone.
Diindolylmethane has moderate interactions with estrogen medications and diuretics (water pills). Anacyclus pyrethrum root extract was not checked — we hold no interaction data for it.
Spilanthes acmella flower extract also could not be checked for interactions.
Altogether, these interactions span 687 individual medications. Use the search tool below to check your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Liberty Ballz?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Liberty Ballz interact with 690 drugs. Click any drug to see the details.
4 of the 6 ingredients in Liberty Ballz interact with drugs. Each result below shows which ingredient is responsible. Fenugreek Seed Extract 3,3 Diindolylmethane Eurycoma longifolia Root Extract Mucuna pruriens Seed Extract
AmphetamineAdensys XR-ODT, Adzenys ER, Dyanavel XR, Mydayis
How Amphetamine interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Amphetamine interactionBenserazide, LevodopaMadopar, Prolopa
How Benserazide, Levodopa interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Seed Extract + Benserazide, Levodopa interactionCarbidopa, LevodopaDhivy, Rytary, Sinemet, Sinemet CR
How Carbidopa, Levodopa interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Seed Extract + Carbidopa, Levodopa interactionCarbidopa, Levodopa, EntacaponeStalevo
How Carbidopa, Levodopa, Entacapone interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Seed Extract + Carbidopa, Levodopa, Entacapone interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Liberty Ballz — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Seed Extract + Chlorothiazide, Methyldopa interaction3,3 DiindolylmethaneDiuretic Drugs Moderate
Interaction Summary
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Read the full 3,3 Diindolylmethane + Chlorothiazide, Methyldopa interactionFenugreek Seed ExtractAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek Seed Extract + Chlorothiazide, Methyldopa interactionHydrochlorothiazide, MethyldopaAldoril 15, Aldoril 25, Aldoril D30, Methazide
How Hydrochlorothiazide, Methyldopa interacts with Liberty Ballz — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Seed Extract + Hydrochlorothiazide, Methyldopa interaction3,3 DiindolylmethaneDiuretic Drugs Moderate
Interaction Summary
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Read the full 3,3 Diindolylmethane + Hydrochlorothiazide, Methyldopa interactionFenugreek Seed ExtractAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek Seed Extract + Hydrochlorothiazide, Methyldopa interactionIsocarboxazidMarplan
How Isocarboxazid interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Isocarboxazid interactionLevodopaInbrija, Larodopa
How Levodopa interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Seed Extract + Levodopa interactionLevodopa, CarbidopaDuodopa
How Levodopa, Carbidopa interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractLevodopa Major
Interaction Summary
Concomitant use can increase the risk of levodopa-related adverse effects.
Read the full Mucuna Pruriens Seed Extract + Levodopa, Carbidopa interactionMethyldopaAldomet, Methyldopa
How Methyldopa interacts with Liberty Ballz — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMethyldopa (aldomet) Major
Interaction Summary
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Read the full Mucuna Pruriens Seed Extract + Methyldopa interactionFenugreek Seed ExtractAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek Seed Extract + Methyldopa interactionMoclobemideManerix, Moclobemide
How Moclobemide interacts with Liberty Ballz — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Moclobemide interactionEurycoma Longifolia Root ExtractCytochrome P450 2c19 (cyp2c19) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
Read the full Eurycoma Longifolia Root Extract + Moclobemide interactionOzanimod HydrochlorideZeposia
How Ozanimod Hydrochloride interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Ozanimod Hydrochloride interactionPhenelzine SulfateNardil
How Phenelzine Sulfate interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Phenelzine Sulfate interactionRasagilineAzilect
How Rasagiline interacts with Liberty Ballz — through 3 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Rasagiline interaction3,3 DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3 Diindolylmethane + Rasagiline interactionEurycoma Longifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia Root Extract + Rasagiline interactionSafinamide MesylateXadago
How Safinamide Mesylate interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Safinamide Mesylate interactionSelegilineCarbex, Eldepryl, Emsam, Zelapar
How Selegiline interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Selegiline interactionTranylcypromineParnate
How Tranylcypromine interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractMonoamine Oxidase Inhibitors (maois) Major
Interaction Summary
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Read the full Mucuna Pruriens Seed Extract + Tranylcypromine interactionAbciximabReoPro
How Abciximab interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Liberty Ballz — through 2 ingredients. Tap an ingredient for the detail:
Fenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Abrocitinib interactionEurycoma Longifolia Root ExtractCytochrome P450 2c19 (cyp2c19) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
Read the full Eurycoma Longifolia Root Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Liberty Ballz — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Seed Extract + Acarbose interactionFenugreek Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Fenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Seed Extract + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Liberty Ballz — through 3 ingredients. Tap an ingredient for the detail:
Fenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Acetaminophen, Aspirin interactionEurycoma Longifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia Root Extract + Acetaminophen, Aspirin interaction3,3 DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3 Diindolylmethane + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Liberty Ballz — through 3 ingredients. Tap an ingredient for the detail:
Fenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Acetaminophen, Aspirin, Caffeine interactionEurycoma Longifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia Root Extract + Acetaminophen, Aspirin, Caffeine interaction3,3 DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3 Diindolylmethane + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Liberty Ballz — through 2 ingredients. Tap an ingredient for the detail:
3,3 DiindolylmethaneDiuretic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Read the full 3,3 Diindolylmethane + Acetaminophen, Caffeine, Pyrilamine interactionEurycoma Longifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia Root Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Liberty Ballz — through 3 ingredients. Tap an ingredient for the detail:
Fenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Acetaminophen, Ibuprofen interactionEurycoma Longifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia Root Extract + Acetaminophen, Ibuprofen interaction3,3 DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3 Diindolylmethane + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Liberty Ballz — through 2 ingredients. Tap an ingredient for the detail:
3,3 DiindolylmethaneDiuretic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Read the full 3,3 Diindolylmethane + Acetaminophen, Pamabrom, Pyrilamine interactionEurycoma Longifolia Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Eurycoma Longifolia Root Extract + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Liberty Ballz — through 2 ingredients. Tap an ingredient for the detail:
3,3 DiindolylmethaneDiuretic Drugs Moderate
Interaction Summary
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Read the full 3,3 Diindolylmethane + Acetazolamide interactionFenugreek Seed ExtractAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek Seed Extract + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Liberty Ballz — through 2 ingredients. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Mucuna Pruriens Seed Extract + Acetohexamide interactionFenugreek Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract + Acetohexamide interactionAcetophenazineTindal
How Acetophenazine interacts with Liberty Ballz — through 1 ingredient. Tap an ingredient for the detail:
Mucuna Pruriens Seed ExtractAntipsychotic Drugs Moderate
Interaction Summary
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Read the full Mucuna Pruriens Seed Extract + Acetophenazine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Liberty Ballz with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Fenugreek Seed Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
3,3 Diindolylmethane
Diuretic Drugs
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.
Estrogens
Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.
Eurycoma longifolia Root Extract
Propranolol (Inderal)
Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.
Cytochrome P450 2A6 (Cyp2A6) Substrates
Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.
Testosterone
Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.
Mucuna pruriens Seed Extract
Levodopa
Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.
Methyldopa (Aldomet)
Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.
Anesthesia
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.
Antidiabetes Drugs
Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.
Antipsychotic Drugs
Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.
Guanethidine (Ismelin)
Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.
Tricyclic Antidepressants (Tcas)
Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.
Brand information
Manufacturer and brand details for Liberty Ballz, from the product label.
Merica Labz
- Name
- 'Merica Labz LLC
- City
- Statesville
- State
- NC
- ZipCode
- 28625
- Phone Number
- (888) 978-2332
- Web Address
- mericalabz.com
Liberty Ballz by Merica Labz: Common Questions
Does Liberty Ballz by Merica Labz interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product really improve sexual function?
What's levodopa and why is Mucuna pruriens a concern?
Can I take this while pregnant?
Is this safe to breastfeed while taking?
What are the most common side effects?
Is there anything in this product I should know about if I have allergies?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Liberty Ballz is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Liberty Ballz’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Eurycoma Longifolia
Interacts with 248 drugsEurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....
Read the full Eurycoma Longifolia monograph → Herb & supplement monographFenugreek
Interacts with 389 drugsFenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...
Read the full Fenugreek monograph → Herb & supplement monographDiindolylmethane
Interacts with 269 drugsDiindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...
Read the full Diindolylmethane monograph → Herb & supplement monographCowhage
Interacts with 193 drugsCowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...
Read the full Cowhage monograph → Herb & supplement monographPellitory
Pellitory (often Anacyclus pyrethrum, the root traditionally called 'pellitory of Spain') is an herb chiefly known in folk and traditional medicine for numbing toothache and stimulating sali...
Read the full Pellitory monograph →Sources & How We Checked
Liberty Ballz's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 61 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Eurycoma Longifolia 4 references
- Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
- Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
- Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
- Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent
Fenugreek 30 references
- Madar Z, Thorne R. Dietary fiber. Prog Food Nutr Sci 1987;11:153-74.
- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
- Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
- Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
- Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
- Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
- Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
- Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
- Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
- Swafford S, Berens P. Effect of fenugreek on breast milk volume. Abstract presented at: 5th International Meeting of the Academy of Breastfeeding Medicine; September 11-13,2000, Tucson, Arizona.
- Abdel-Barry, J. A., Abdel-Hassan, I. A., Jawad, A. M., and al Hakiem, M. H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr.Health J 2000;6(1):83-88. DOI
- Parvizpur, A., Ahmadiani, A., and Kamalinejad, M. Probable role of spinal purinoceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. J Ethnopharmacol 3-8-2006;104(1-2):108-112. PubMed
- Mora, A., Herrrera, A., Lopez, C., Dahbi, G., Mamani, R., Pita, J. M., Alonso, M. P., Llovo, J., Bernardez, M. I., Blanco, J. E., Blanco, M., and Blanco, J. Characteristics of the Shiga-toxin-producing enteroaggregative Escherichia coli O104:H4 German ou
- Blanco, J. [Stx2a-producing enteroaggregative Escherichia coli O104:H4-ST678. Microbiological diagnostic already, for this and other STEC/VTEC serotypes!]. Enferm.Infecc.Microbiol.Clin. 2012;30(2):84-89.
- Beutin, L. and Martin, A. Outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 infection in Germany causes a paradigm shift with regard to human pathogenicity of STEC strains. J Food Prot. 2012;75(2):408-418. PubMed
- King LA, Nogareda F, Weill FX, Mariani-Kurkdjian P, Loukiadis E, Gault G, Jourdan-DaSilva N, Bingen E, Macé M, Thevenot D, Ong N, Castor C, Noël H, Van Cauteren D, Charron M, Vaillant V, Aldabe B, Goulet V, Delmas G, Couturier E, Le Strat Y, Combe C, Delm
- Reeder C, Legrand A, O'Connor-Von SK. The Effect of Fenugreek on Milk Production and Prolactin Levels in Mothers of Preterm Infants. Clinical Lactation 2013;4(4):159-165. DOI
- Al-Jenoobi FI, Ahad A, Mahrous GM, Al-Mohizea AM, AlKharfy KM, Al-Suwayeh SA. Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs. Pharm Biol 2015;53(2):296-300. PubMed
- Rao A, Steels E, Inder WJ, Abraham S, Vitetta L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a doubl
- Steels E, Rao A, Vitetta L. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytother Res. 2011 Sep;25(9):1294-300.
- Gong J, Fang K, Dong H, Wang D, Hu M, Lu F. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis. J Ethnopharmacol. 2016 Dec 24;194:260-268. PubMed
- Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016 Oct;96:145-54. PubMed
- Khodamoradi K, Khosropanah MH, Ayati Z, et al. The Effects of Fenugreek on Cardiometabolic Risk Factors in Adults: A Systematic Review and Meta-analysis. Complement Ther Med. 2020;52:102416. PubMed
- Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
- Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
- Al-Mohizea AM, Ahad A, El-Maghraby GM, et al. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur J Drug Metab Pharmacokinet. 2015;40(2):219-24. PubMed
- Alkharfy KM, Al-Jenoobi FI, Al-Mohizea AM, et al. Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs. Phytother Res. 2013;27(12):1800-4.
Diindolylmethane 14 references
- Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
- Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
- Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
- Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
- Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
- Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
- Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
- Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
- Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
- Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
- Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
- Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
- Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
- Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed
Cowhage 12 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
- HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
- Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
- Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
- Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
- Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
- Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
- Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
- Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
- Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed
Pellitory 1 reference
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC