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Dietary supplement

Lime Ingredients & Drug Interactions

by doTERRA

Lime label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lime against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lime is a dietary supplement by doTERRA with 1 active ingredient. Its ingredients are commonly taken for source of vitamin c, digestive upset, skin care.Based on those ingredients, 886 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lime. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lime by doTERRA

Ask about any prescription or over-the-counter medication and we check it for interactions with Lime by doTERRA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lime by doTERRA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

doTERRA Lime is a single-ingredient liquid product. It contains lime, which is the juice or oil from the lime fruit.

There are no inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lime product and its label doesn't state a use — see Lime's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for lime's effectiveness against iron deficiency anemia, malaria, sickle cell disease, and smoking cessation is insufficient to rate in our data. We don't hold effectiveness information for any of those uses, so we can't tell you whether this product would help with them.

The evidence, ingredient by ingredient Lime

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lime in normal food amounts is generally well tolerated. However, concentrated extracts or essential oils—which this product may be—aren't well studied for safety, and the facts advise avoiding them unless your doctor has cleared them for you.

Rare side effects from oral lime juice include diarrhea and tooth sensitivity or wear. Topically, lime oil or juice can rarely cause allergic contact dermatitis, and phytophotodermatitis (a type of sun-related skin reaction) is common when skin is exposed to lime and then to sunlight.

Pregnancy and lactation safety data are not on file for this ingredient.

Side effects, ingredient by ingredient Lime

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lime.
  • The most serious interaction on file is rated Moderate.
  • For scale: 887 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use photosensitizing drugs (medications that make your skin more sun-sensitive) or medications broken down by the cytochrome P450 3A4 enzyme. That second group is very large and includes many blood pressure, cholesterol, and immunosuppressant drugs, so your pharmacist will need to review your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you use doTERRA Lime as a food or beverage flavoring in small amounts, it's generally well tolerated. If you take medications that depend on the cytochrome P450 3A4 enzyme to work, or drugs that increase sun sensitivity, talk with your doctor or pharmacist before using this product—especially if it's a concentrated extract or essential oil.

They can review your specific medications and advise whether it's safe for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lime, straight from the product label.

Brand doTERRA
Net contents 5 mL; 0.16 fl. Oz.
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 267401
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lime by doTERRA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
85
IngredientAmount% DV
Lime60 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

For aromatic or topical use. Diffuse aromatically or, to apply topically, dilute with a carrier oil to minimize skin sensitivity.

For internal use dilute one drop in 4 fl. oz. of liquid.

Precautions

Caution: Possible skin sensitivity.

Keep out of reach of children.

If pregnant or under a doctor's care, consult your physician.

Avoid contact with eyes, inner ears, and sensitive areas. Avoid sunlight or UV rays for up to 12 hours after applying.

Formula

Citrus aurantifolia

FDA Statement of Identity

Essential Oil Supplement

Seals/Symbols

CPTG Certified Pure Tested Grade

General Statements

Peel back for more information.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lime by doTERRA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lime label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lime by doTERRA

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container85 Amounts shown are per serving.

Lime

Interacts with
886 drugs
60 mg per serving

Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people...

Lime monograph & interactions
Interaction report

Lime by doTERRA Drug Interactions

Want to check YOUR meds against Lime?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
886Drugs
886 Moderate

Ingredients driving the most interactions

Lime 886

Individual Drug Interactions

The ingredients in Lime interact with 886 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lime interact with drugs. Each result below shows which ingredient is responsible. Lime

Each ingredient & the kinds of drugs it affects

For each ingredient in Lime with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lime2 drug types · 886 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4. This has been demonstrated in rats treated with sildenafil, a CYP3A4 substrate, and high doses of lime juice.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity.

Likelihood Possible Evidence D
Lime full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lime, from the product label.

doTERRA

See all doTERRA products
Name
doTERRA Intl, LLC
Street Address
389 South 1300 West
City
Pleasant Grove
State
UT
ZipCode
84062
Pharmacist Counseling Corner

Lime by doTERRA: Common Questions

Does Lime by doTERRA interact with any medications?
Yes. Based on its ingredients, Lime has a known interaction with 886 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lime contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is in this product?
doTERRA Lime is a liquid made from lime. It contains no inactive ingredients or fillers — just the lime itself. However, the facts don't specify whether it's pure juice, an extract, or an essential oil, so ask your retailer or check the label if you need that level of detail.
Can I use this if I'm pregnant or breastfeeding?
Safety data for lime in pregnancy and lactation are not on file. Talk with your doctor or midwife before using this product during pregnancy or while breastfeeding so they can give you personalized advice.
What are the side effects?
Taken by mouth, lime juice can rarely cause diarrhea or tooth sensitivity and wear. Applied to skin, it can rarely cause allergic reactions, and it commonly causes a sun-related skin reaction (phytophotodermatitis) if your skin is exposed to lime and then to sunlight. Avoid sun exposure right after using it topically.
Does this product help with anemia, malaria, or quitting smoking?
The evidence for lime's effectiveness against iron deficiency anemia, malaria, sickle cell disease, or smoking cessation is insufficient to rate in our data. We can't tell you whether it would help with any of those uses.
Why should I be careful mixing this with my blood pressure or cholesterol medication?
Compounds in lime can slow the enzyme in your liver (cytochrome P450 3A4) that breaks down many common medications like statins and blood pressure drugs. If that enzyme works slower, the drug may stay in your system longer and build up to higher levels. Your pharmacist can tell you whether your specific medications are affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lime is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lime label
Go deeper

The Full Monographs Behind Lime’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lime

Interacts with 886 drugs

Lime is a common citrus fruit and a good natural source of vitamin C and plant antioxidants. As a food it is generally safe and enjoyed by most people, but evidence that lime treats any spec...

Read the full Lime monograph →
Sources

Sources & How We Checked

Lime's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lime 20 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Roesyanto-Mahadi ID, Geursen-Reitsma AM, van Joost T, et al. Sensitization to fragrance materials in Indonesian cosmetics. Contact Dermatitis 1990;22:212-7. PubMed
  3. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
  4. Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73:529-37. PubMed
  5. Weber, I. C., Davis, C. P., and Greeson, D. M. Phytophotodermatitis: the other "lime" disease. J Emerg.Med 1999;17(2):235-237. PubMed
  6. Wagner, A. M., Wu, J. J., Hansen, R. C., Nigg, H. N., and Beiere, R. C. Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. Am.J Contact Dermat. 2002;13(1):10-14. PubMed
  7. Garcia, O. P., Diaz, M., Rosado, J. L., and Allen, L. H. Ascorbic acid from lime juice does not improve the iron status of iron-deficient women in rural Mexico. Am.J.Clin.Nutr. 2003;78(2):267-273. PubMed
  8. Coffman, K., Boyce, W. T., and Hansen, R. C. Phytophotodermatitis simulating child abuse. Am.J Dis.Child 1985;139(3):239-240. PubMed
  9. Adegoke SA, Oyelami OA, Olatunya OS, Adeyemi LA. Effects of lime juice on malaria parasite clearance. Phytother Res. 2011;25(10):1547-50. PubMed
  10. Adegoke SA, Shehu UA, Mohammed LO, Sanusi Y, Oyelami OA. Influence of lime juice on the severity of sickle cell anemia. J Altern Complement Med. 2013;19(6):588-92. PubMed
  11. Assarian Z, Nixon RL. Protein contact dermatitis caused by lime in a pastry chef. Contact Dermatitis. 2015;73(1):54-6. PubMed
  12. Bamise CT, Dinyain VE, Kolawole KA. Dental erosion due to lime consumption; review of literature and case report. East Afr J Public Health. 2009;6(2):141-3. PubMed
  13. Flugman SL. Mexican beer dermatitis: a unique variant of lime phytophotodermatitis attributable to contemporary beer-drinking practices. Arch Dermatol. 2010;146(10):1194-5. PubMed
  14. Galvañ-Pérez Del Pulgar JI, Linares-Barrios M, Galvañ-Pozo JI Jr. Acropigmentation of the dorsum of the hands from preparing mojitos: A lime-induced phytophotodermatosis. Actas Dermosifiliogr. 2016;107(3):253-5. DOI
  15. Hemmerling A, Potts M, Walsh J, Young-Holt B, Whaley K, Stefanski DA. Lime juice as a candidate microbicide? An open-label safety trial of 10% and 20% lime juice used vaginally. J Womens Health (Larchmt). 2007;16(7):1041-51. PubMed
  16. Mauck CK, Ballagh SA, Creinin MD, et al. Six-day randomized safety trial of intravaginal lime juice. J Acquir Immune Defic Syndr. 2008;49(3):243-50. PubMed
  17. Mioduszewski M, Beecker J. Phytophotodermatitis from making sangria: a phototoxic reaction to lime and lemon juice. CMAJ. 2015;187(10):756. PubMed
  18. Rungruanghiranya S, Ekpanyaskul C, Sakulisariyaporn C, Watcharanat P, Akkalakulawas K. Efficacy of fresh lime for smoking cessation. J Med Assoc Thai. 2012;95 Suppl 12:S76-82.
  19. Swerdlin A, Rainey D, Storrs FJ. Fragrance mix reactions and lime allergic contact dermatitis. Dermatitis. 2010;21(4):214-6. DOI
  20. Ademosun AO, Mohammed A, Oboh G, Ajeigbe OF. Influence of lemon (Citrus limon) and lime (Citrus aurantifolia) juices on the erectogenic properties of sildenafil in rats with L-NAME-induced erectile dysfunction. J Food Biochem 2022;46(2):e14074.

See these in context on the Lime monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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