Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

LipoXplex Ingredients & Drug Interactions

by WiseLife Naturals

LipoXplex label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking LipoXplex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

LipoXplex is a dietary supplement by WiseLife Naturals with 4 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 860 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Hydroxycitric Acid, Calcium, Tamarind Fruit Rind Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against LipoXplex by WiseLife Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with LipoXplex by WiseLife Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of LipoXplex by WiseLife Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

LipoXplex contains four active ingredients. Calcium supports bone health and helps regulate nerve and muscle function.

Hydroxycitric acid is the main active compound from garcinia fruit, traditionally used to support weight management and metabolic health. Potassium is an essential mineral important for heart rhythm, nerve signaling, and muscle contraction.

Tamarind fruit rind extract comes from the tamarind tree and is used in traditional herbal medicine. The product also contains rice bran extract and a vegetarian capsule as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: reduce lipogenesis boost metabolism reduce hunger.
  • We looked for evidence on: Obesity, Metabolic syndrome, Dyslipidemia, Hyperlipidemia, Weight management, Appetite control — and 1 related terms.
  • The closest evidence on file: Calcium is rated "Possibly Ineffective" for Obesity (Natural Medicines).
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Dyslipidemia, Metabolic syndrome.
  • Also on file: Garcinia is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Obesity.

Calcium is effective for kidney failure, dyspepsia (indigestion), low blood calcium (hypocalcemia), high potassium (hyperkalemia), and likely effective for osteoporosis. Hydroxycitric acid from garcinia has insufficient evidence in our data to rate it for athletic performance, fatty liver disease, high cholesterol, or weight loss — we simply don't have reliable studies on file.

Tamarind fruit rind extract is possibly effective for dry eye and fluorosis (a tooth condition), possibly ineffective for premature ejaculation, and insufficient evidence for knee pain, common cold, and constipation. Potassium effectiveness ratings are not in our data.

The evidence, ingredient by ingredient Calcium Garcinia Potassium Tamarind

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses but high amounts can cause problems. Common side effects are belching, constipation, diarrhea, flatulence, and stomach upset.

Rare serious effects include kidney stones and calciphylaxis (a calcium deposit condition). There is some concern that very high doses (over 1500–2000 mg daily) might slightly increase risk of advanced prostate cancer and possibly cardiovascular disease, though research on this is mixed.

Calcium is likely safe in pregnancy at recommended amounts and likely safe during breastfeeding when dietary needs are met. Hydroxycitric acid from garcinia is generally well tolerated short-term but rare reports of liver injury warrant caution.

Common side effects are diarrhea, gastrointestinal discomfort, headache, and nausea. Rare serious effects include liver damage and failure, mania, and pancreatitis; one case of acute heart inflammation was also reported.

Garcinia should not be used during pregnancy or breastfeeding due to insufficient safety data. Potassium is generally well tolerated orally but can cause abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting.

Serious adverse effects — rare but dangerous — include irregular heartbeat, heart block, low blood pressure, and cardiac arrest, especially at high doses or in people with kidney disease. Potassium is likely safe in pregnancy at normal dietary amounts but supplements should only be used under medical guidance.

Tamarind is generally safe as a food in normal amounts; food amounts are likely fine during pregnancy and breastfeeding, but large medicinal doses have not been well studied.

Side effects, ingredient by ingredient Calcium Garcinia Potassium Tamarind

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Calcium, Garcinia, Tamarind, Potassium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 861 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking LipoXplex if you use HIV integrase inhibitors (dolutegravir, elvitegravir) or the antibiotic ceftriaxone — calcium can significantly reduce their blood levels or cause serious reactions. Thyroid medication (levothyroxine), heart medications (diltiazem, sotalol), potassium-sparing diuretics, ACE inhibitors, ARBs, blood thinners, antidiabetes drugs, antidepressants or other serotonergic drugs, or ibuprofen and aspirin also require a conversation with your healthcare provider before you add this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

LipoXplex may be considered by someone looking to support bone health with calcium and explore traditional herbal support with garcinia, tamarind, and potassium. However, this product carries significant interaction potential — especially if you take HIV antivirals, blood pressure medications, blood thinners, diabetes drugs, or thyroid medication.

Because potassium and calcium supplements can be risky for people with kidney disease or certain heart conditions, and because garcinia carries rare but serious safety concerns, talk with your doctor or pharmacist before starting LipoXplex to confirm it's appropriate for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about LipoXplex, straight from the product label.

Brand WiseLife Naturals
Barcode (UPC) 0852659365708
Net contents 60 Veg Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 258690
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for LipoXplex by WiseLife Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
0852659365708
IngredientAmount% DV
Calcium50 mg5%
Hydroxycitric Acid375 mg--
Potassium70 mg2%
Tamarind Fruit Rind Extract630 mg--

Other ingredients: Rice bran extract, Vegetarian Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

100% natural

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Formulation

Reduce lipogenesis Boost Metabolism

Reduces hunger 100% natural

No caffeine

Free of caffeine, egg, peanut, shellfish, soy, wheat.

Precautions

Caution: Do not exceed recommended dose.

Please consult your healthcare provider before using this product if you are pregnant, breastfeeding, or are currently taking any prescription medications.

Keep out of reach of children.

Free of caffeine, egg, peanut, shellfish, soy, wheat.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

The statements on this product have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice Quality Product Made In An FDA Registered Facility

USA

Formula

(Hydroxycitric acid capsules) 3000 mg daily

30 day supply

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one (2) vegetarian capsule 1 to 2 times daily with food, or as directed by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

LipoXplex by WiseLife Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

LipoXplex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in LipoXplex by WiseLife Naturals

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
50 mg per serving Form: Calcium Hydroxycitrate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Hydroxycitric Acid

Interacts with
704 drugs
375 mg per serving

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...

Hydroxycitric Acid monograph & interactions

Potassium

Interacts with
62 drugs
70 mg per serving Form: Potassium Hydroxycitrate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Tamarind Fruit Rind Extract

Interacts with
130 drugs
630 mg per serving

Tamarind is a tangy tropical fruit widely used in cooking and traditional medicine, mainly for digestion and as a mild laxative. While it is a nutriti...

Tamarind Fruit Rind Extract monograph & interactions

Other (inactive) ingredients: Rice bran extract, Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

LipoXplex by WiseLife Naturals Drug Interactions

Want to check YOUR meds against LipoXplex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
860Drugs
7 Major 840 Moderate 13 Minor

Ingredients driving the most interactions

Hydroxycitric Acid 704
Calcium 168
Tamarind Fruit Rind Extract 130
Potassium 62

Individual Drug Interactions

The ingredients in LipoXplex interact with 860 drugs. Click any drug to see the details.

4 of the 4 ingredients in LipoXplex interact with drugs. Each result below shows which ingredient is responsible. Hydroxycitric Acid Calcium Tamarind Fruit Rind Extract Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in LipoXplex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Hydroxycitric Acid4 drug types · 704 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.

Likelihood Possible Evidence D
Hydroxycitric Acid full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Tamarind Fruit Rind Extract3 drug types · 130 drugs

Antidiabetes Drugs

Theoretically, tamarind seed extract might have additive effects when used with antidiabetes drugs.
Animal research suggests that an extract of tamarind seed can reduce fasting blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Aspirin

Theoretically, tamarind fruit extract might increase the effects and side effects of aspirin.
Taking tamarind fruit extract as a component of millet porridge concurrently with aspirin seems to increase aspirin absorption and blood levels.

Likelihood Possible Evidence B
Ibuprofen (Advil, Others)

Theoretically, tamarind fruit extract might increase the effects and side effects of ibuprofen.
Taking tamarind fruit extract as a component of millet porridge concurrently with ibuprofen seems to increase ibuprofen absorption and blood levels.

Likelihood Possible Evidence B
Tamarind Fruit Rind Extract full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for LipoXplex, from the product label.

WiseLife Naturals

See all WiseLife Naturals products
Name
WiseLifeNaturals Inc
City
Ashland
State
OR
ZipCode
97520
Web Address
WiseLifeNaturals.com
Pharmacist Counseling Corner

LipoXplex by WiseLife Naturals: Common Questions

Does LipoXplex by WiseLife Naturals interact with any medications?
Yes. Based on its ingredients, LipoXplex has a known interaction with 860 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
LipoXplex contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product work for weight loss?
The main ingredient for weight support is hydroxycitric acid from garcinia, but our data shows insufficient evidence to rate it for weight loss. We simply don't have reliable studies on file to confirm it works for that purpose.
Can I take this if I'm pregnant?
Calcium in this product is likely safe during pregnancy at recommended amounts, and potassium from a normal diet is fine. However, garcinia (hydroxycitric acid) should not be used during pregnancy — there isn't enough safety data. Tamarind in food amounts is likely okay, but medicinal doses haven't been well studied. Talk with your doctor or pharmacist for personalized advice before using this product in pregnancy.
Can I take this while breastfeeding?
Calcium and potassium needs can be met during breastfeeding, but garcinia should not be used due to insufficient safety data. Tamarind in food amounts is likely fine, but medicinal doses haven't been well studied. Check with your doctor or pharmacist before using this product while breastfeeding.
What are the most common side effects?
From calcium you may experience belching, constipation, diarrhea, flatulence, or stomach upset. From potassium, abdominal pain, belching, diarrhea, flatulence, nausea, or vomiting. From garcinia, diarrhea, gastrointestinal discomfort, headache, or nausea. These are usually mild, but if they're bothersome, talk with your pharmacist.
What is tamarind fruit rind extract used for?
In traditional herbal medicine, tamarind is used for several purposes. Our data shows it's possibly effective for dry eye and fluorosis (a tooth condition), and possibly ineffective for premature ejaculation. For other uses like knee pain, common cold, and constipation, we don't have enough evidence to rate it.
Is this product safe if I have kidney disease?
This product contains potassium and calcium, both of which can build up to dangerous levels in people with kidney disease and cause serious heart and nerve problems. Do not use this product if you have kidney disease without explicit clearance from your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if LipoXplex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

LipoXplex label
Go deeper

The Full Monographs Behind LipoXplex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Garcinia

Interacts with 704 drugs

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies...

Read the full Garcinia monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Tamarind

Interacts with 130 drugs

Tamarind is a tangy tropical fruit widely used in cooking and traditional medicine, mainly for digestion and as a mild laxative. While it is a nutritious food, strong human evidence for most...

Read the full Tamarind monograph →
Sources

Sources & How We Checked

LipoXplex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 121 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
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Garcinia 44 references
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Potassium 12 references
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Tamarind 3 references
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See these in context on the Tamarind monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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